Abstract: A compound of formula (XXIII) and methods for preparation thereof are provided (XXIII).

Abstract: An apparatus for containing, positioning and thermally insulating plural axially aligned beverage containers provides an elongate body, a retention collar that is threadably engaged with the body, a handle carried by the body and a puck that is movable, by a user, between a first position adjacent to an opening of the body and a second position adjacent to an interior bottom surface of the body.

Abstract: Systems, methods and containers for forming a beverage. A beverage container includes an enclosure arranged with a movable element that is movable to pierce a membrane and permit beverage material in the container to exit. The movable element can also be moveable to permit pressurized gas entry into the container and through the membrane. Gas can be introduced into the container to force beverage material to exit the container. A gas inlet port can be provided with the enclosure and arranged to mate with a gas source of a beverage machine.

Abstract: A beverage pod for a beverage machine is provided. The beverage pod can include a container having an internal space and a container flange defining an opening to the internal space, a plug sealing the opening of the container, and a cap secured to the container flange. A beverage medium can be located within the internal space of the container. The cap can be operable to selectively engage a portion of the plug to release the beverage medium through the plug and the cap.

Abstract: Disclosed herein are novel formulations containing relacorilant ((R)-(1-(4-fluorophenyl)-6-(1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone) that are suitable for administration, including oral administration, to patients suffering from disorders amenable to treatment by glucocorticoid receptor modulators (GRMs). Single unit dosage forms comprise softgel capsules containing these formulations. Such softgel capsules may contain, e.g., relacorilant formulations containing 25 milligrams (mg), 50 mg, 100 mg, 200 mg, 300 mg, 400 mg, 500 mg, or other amounts of relacorilant. These novel formulations and single unit dosage forms may be used to treat diseases and disorders including Cushing's syndrome, Cushing's Disease, and other disorders.

Abstract: An automatic vertical farming system may include a frame defining at least one growth area and configured to support a plurality of vertical plant growth structures within the at least one growth area. The system may include at least one light, at least one liquid conduit, and at least one gas conduit. The system may include at least one robot disposed on a top side of the frame and movably supported by the frame. The at least one robot may include at least one tool configured to manipulate the plurality of vertical plant growth structures. The system may include a control system including at least one processor configured to automatically control illumination by the at least one light, liquid flow through the at least one liquid conduit, gas flow through the at least one gas conduit, and operation of the at least one robot.

Abstract: The invention relates to methods of synthesizing 2?-deoxy-2?,2?-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.

Abstract: An automatic vertical farming system may include a frame defining at least one growth area and configured to support a plurality of vertical plant growth structures within the at least one growth area. The system may include at least one light, at least one liquid conduit, and at least one gas conduit. The system may include at least one robot disposed on a top side of the frame and movably supported by the frame. The at least one robot may include at least one tool configured to manipulate the plurality of vertical plant growth structures. The system may include a control system including at least one processor configured to automatically control illumination by the at least one light, liquid flow through the at least one liquid conduit, gas flow through the at least one gas conduit, and operation of the at least one robot.

Abstract: Based on an analysis of example content items, a proposed initial version of an application to be generated on behalf of a client is determined. At least a portion of a software program implementing the application is generated, and an indication of the software program is provided to the client. Based on input received from the client, additional operations associated with the program are initiated.

Abstract: Disclosed herein are novel formulations containing relacorilant ((R)-(1-(4-fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone) that are suitable for administration, including oral administration, to patients suffering from disorders amenable to treatment by glucocorticoid receptor modulators (GRMs). Single unit dosage forms comprise softgel capsules containing these formulations. Such softgel capsules may contain, e.g., relacorilant formulations containing 25 milligrams (mg), 50 mg, 100 mg, 200 mg, 300 mg, 400 mg, 500 mg, or other amounts of relacorilant. These novel formulations and single unit dosage forms may be used to treat diseases and disorders including Cushing's syndrome, Cushing's Disease, and other disorders.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Abstract: There is disclosed a pole support for removably supporting a hollow tubular pole, wherein the pole has a latching recess provided along its length. The pole support includes a housing defining a socket that is open at its operative upper end for receiving the pole. A latch is located within the socket and is mounted on a pivot to be pivotally movable between a latched position and an unlatched position. The latch has a latching arm extending on one side of the pivot and a ballast arm extending on an opposed side of the pivot, wherein a centre-of-weight of the latch is located off-centre from the pivot in the ballast arm so that ballast arm normally biases latch under gravity into its latched position.

Abstract: The present disclosure provides, in part, pharmaceutical compositions that comprise a spray dried dispersion which contains the disclosed compound, and optionally, pharmaceutical excipients. The pharmaceutical compositions of the disclosure may be used in the treatment of Hepatitis B (HBV).

Abstract: Based on an analysis of example content items, a proposed initial version of an application to be generated on behalf of a client is determined. At least a portion of a software program implementing the application is generated, and an indication of the software program is provided to the client. Based on input received from the client, additional operations associated with the program are initiated.

Abstract: The present disclosure relates to amorphous and crystalline forms of (R)-N-(4-chlorophenyl)-2-(1S,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Abstract: The present disclosure relates to amorphous and crystalline forms of (R)-N-(4-chlorophenyl)-2-((1S,4S)-4-(6-fluoro-quinolin-4-yl) cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.

Abstract: Systems, methods and containers for forming a beverage. A container includes a closure arranged with a movable element that is movable to pierce a membrane and permit beverage material in the container to exit. The movable element can include a piercing element that pierces the membrane. Gas can be introduced into the container to force beverage material to exit the container. A gas inlet port can be provided with the closure and arranged to mate with a gas source of a beverage machine.

Abstract: Systems, methods and containers for forming a beverage. A container includes a closure arranged with a movable element that is movable to pierce a membrane and permit beverage material in the container to exit. The movable element can include a piercing element that pierces the membrane. Gas can be introduced into the container to force beverage material to exit the container. A gas inlet port can be provided with the closure and arranged to mate with a gas source of a beverage machine.