Abstract: The invention relates to sulphonamide compounds of formula (I) or a salt thereof having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders, wherein: Ar is an optionally substituted mono- or bicyclic aromatic or heteroaromatic ring; Ar' is an optionally substituted mono- or bicyclic aromatic or heteroaromatic ring; R.sup.1 is C.sub.1-6 alkyl or together with the group R.sup.3 form a 5-8 membered ring containing one or two heteroatoms optionally substituted by C.sub.1-6 alkyl; R.sup.2 is hydrogen or C.sub.1-6 alkyl; R.sup.3 is hydrogen, C.sub.1-6 alkyl or together with the group R.sup.1 form a 5-8 membered ring containing one or two heteroatoms optionally substituted by C.sub.1-6 alkyl; R.sup.4 is hydrogen or C.sub.1-6 alkyl; R.sup.5 and R.sup.6 are independently hydrogen or C.sub.1-6 alkyl; p is 1, 2 or 3; q is 1 to 3; and r is 1 or 2.

Abstract: A compound of formula (I) or a salt thereof: ##STR1## wherein: P.sup.1 is pyridyl;P.sup.2 is phenyl;A is a bond or a chain of 1 to 5 atoms optionally substituted by C.sub.1-6 alkyl;R.sup.1 and R.sup.2 groups are each independently hydrogen, C.sub.1-6 alkyl optionally substituted by NR.sup.12 R.sup.13, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, cyano, halogen, CF.sub.3, NR.sup.12 R.sup.13, CHO, OCF.sub.3, COR.sup.14, CH.sub.2 OR.sup.14 or OR.sup.14 where R.sup.12, R.sup.13 and R.sup.14 are independently hydrogen or C.sub.1-6 alkyl;n and m are independently 0, 1 or 2;R.sup.3 is hydrogen or C.sub.1-6 alkyl;R.sup.4 is a group of formula (i): ##STR2## in which: R.sup.6 and R.sup.7 are independently hydrogen, C.sub.1-6 alkyl optionally substituted by one or more fluorine atoms, C.sub.1-6 alkylthio, C.sub.1-6 alkoxy or halogen.

Abstract: Novel heterocyclic compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders are disclosed.

Abstract: The invention relates to heterocyclic compounds of formula (I) having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders, wherein P represents phenyl, a quinoline or isoquinoline residue, or a 5 -membered or 6 -membered aromatic heterocyclic ring containing up to three heteroatoms selected from nitrogen, oxygen or sulphur; R.sup.3 is a group of formula (i) or (ii).

Abstract: Compounds of formula (I), processes for their preparation and their use in medicine are disclosed: ##STR1## wherein: P represents phenyl, a quinoline or isoquinoline residue, or a 5-membered or 6-membered aromatic heterocyclic ring containing up to three heteroatoms selected from nitrogen, oxygen or sulphur;R.sup.1 is hydrogen, C.sub.1-6 alkyl, halogen, CF.sub.3, NR.sup.7 R.sup.8 or OR.sup.9 where R.sup.7, R.sup.8 and R.sup.9 are independently hydrogen, C.sub.1-6 alkyl or arylC.sub.1-6 alkyl;R.sup.2 is hydrogen or C.sub.1-6 alkyl;R.sup.3 is C.sub.1-6 alkyl;n is 0 to 3;m is 0 to 4; andR.sup.4 groups are independently C.sub.1-6 alkyl optionally substituted by one or more halogen atoms, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl-C.sub.1-6 alkyl, C.sub.1-6 alkylthio, C.sub.3-6 cycloalkylthio, C.sub.3-6 cycloalkylC.sub.1 C.sub.6 alkylthio, halogen, nitro, CF.sub.3, OCF.sub.3, SCF.sub.3, SO.sub.2 CF.sub.3, SO.sub.2 F, formyl, C.sub.

Abstract: This invention describes a flexible radiation probe which has a pair of insulated gate field effect transistors integrated into the same substrate each having a gate, source and drain. The transistors are mounted at the end of a flexible circuit board. The flexible circuit board has conductive tracks which connect the gate, source and drains of each of the transistors to a connection at an opposite end of the flexible circuit board. This connection end may then be connected to a suitable differential biasing circuit for biasing the transistors, and a circuit for reading the differential threshold voltages of the transistors. This differential threshold voltage being indicative of radiation received by the transistors when exposed in the bias mode. The flexible circuit allows the probe to be used in catheters or similar medical equipment.

Abstract: The invention relates to a radiation dosimeter having a pair of insulated gate field effect transistors integrated into the same silicon substrate, in which each of the transistors are operable in a bias mode and a test mode. A circuit element for biasing each of the transistors, during said test mode is provide, so that one of the transistors is more sensitive to ionizing radiation than the other of the transistors. A circuit element is provided for determining, during the test mode, the difference in the threshold voltages of the transistors, whereby the difference voltage is indicative of the radiation dose, and a circuit element is provided for continuously switching the transistors between the bias mode and the test mode, whereby the period of operation of the transistors in the test mode time period is small in comparison to the period of operation of the transistors in the bias mode.

Abstract: A radon gas detector instrument comprising: a filter for trapping alpha radon daughters of said gas, an air pump for drawing ambient air through the filter, a DRAM devoid of an alpha particle barrier layer, located adjacent the filter, for exposure to alpha particles trapped by the filter, apparatus for cyclically relaxing all cells of the DRAM, waiting for a significant period of time for cells of the DRAM to become charged by said alpha particles, then reading the DRAM to determine the number of charged cells in the DRAM, a display connected to the relaxing, waiting and reading means for displaying a count of the number of charged cells in units correlated to the intensity of radon gas in the ambient air.

Abstract: The invention is a radiation dosimeter and method of operation of its elements comprising a pair of silicon insulated gate field effect transistors integrated into the same substrate, each having a gate, a source and a drain. The dosimeter includes apparatus for measuring a first differential threshold votlage between the transistors, appartus for forward biasing the gate of the first transistor and inhibiting operation of the second, while allowing both to be subjected to ionizing radiation, and apparatus for measuring a second differential threshold voltage between the transistors following the irradiation. The first differential threshold voltage can be subtracted from the second to obtain a measure of the radiation dosage. Threshold drift and offset is thereby substantially eliminated.

Abstract: A direct reading dosimeter having a range such that it can be used by personnel workers in the medical, nuclear and industrial fields, and provides and indication of dose rate as well as total received dosage. The dosimeter uses a semiconductor sensor of MOS or bipolar transistor or MOS capacitor form which traps positive charge under the influence of ionizing radiation. A current is applied to the sensor substrate, the voltage across a portion of the substrate is sensed, differentiated and displayed. The dosimeter circuit can be integrated and packaged in a wrist watchcase, in a probe, or other convenient form.