Abstract: A manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack comprises a body, the body defining a chimney having a chimney inlet and a chimney exit for directing airflow from said chimney inlet to the chimney exit; the body further defining a chamber having a chamber inlet and a chamber exit, wherein the chimney exit and the chamber inlet lie side-by-side each other such that when the open blister pocket of the blister pack is positioned adjacent thereto the airflow is directed from the chimney exit to the chamber inlet via the open blister pocket to entrain the medicament powder and enable transport thereof in the airflow from the chamber inlet to the chamber exit, and wherein one or more bleed holes are provided between the chimney and the chamber such that bleed airflow is able to be directed into the chamber to disruptively impact the airflow that transports the entrained medicament powder.

Abstract: A laminate assembly, comprising a base sheet having at least one blister formed therein, a pharmaceutical composition displaced in the blister, a lid sheet bonded to the base sheet to form a primary seal therebetween, thus forming a primarily sealed laminate assembly; the primary sealed laminate assembly having a secondary seal formed therein, and related manufacturing method and system of manufacture.

Abstract: Combinations of cell lines are provided for allogeneic immunotherapy agents in the treatment of cancer. Cancer vaccines generally have been limited to the use of cells that contain at least some tumor specific antigens (“TSAs”) and/or tumor associated antigens (“TAAs”) having shared identity with antigens in a targeted tumor. In such cases, tumor cells often are utilized as a starting point on the premise that only tumor cells will contain TSAs or TAAs or relevance, and the tissue origins of the cells are matched to the tumor site in patients. A primary aspect of the invention is the use of immortalized normal, non-malignant cells, in combination with primary and/or metastatic tumor cells, as the basis of an allogeneic cell cancer vaccine. Normal cells do not posses TSAs or relevant concentrations of TAAs and hence it is surprising that normal cells are effective as anti-cancer vaccines when administered in combination with primary and/or metastatic tumor cells.

Abstract: A lid sheet for use in a blister form pack for packaging of pharmaceutical and medical products, wherein said lid sheet is a laminate comprising four layers A, B, C and D with the layer sequence A-B-C-D and the layers comprising as follows: (Layer A) a layer A material selected from the group consisting of cellulose material; aluminium foil; plastic film with a temperature resistance of at least 1 second at 220° C.; lacquer with a temperature resistance of at least 1 second at 220° C.

Abstract: An inhalation device is described for use with a medicament pack in which at least one container for medicament in powder form is defined between two sheets peelably secured to one another. The device comprises means for peeling the sheets apart at an opening station to open the container; and an outlet, communicating with the opened container, through which a user can inhale medicament in powder form from the opened container.

Abstract: An inhalation device is described for use with a medicament pack in which at least one container for medicament in powder form is defined between two sheets peelably secured to one another. The device comprises means for peeling the sheets apart at an opening station to open the container; and an outlet, communicating with the opened container, through which a user can inhale medicament in powder form from the opened container.

Abstract: An impeller for use in a centrifugal pump, the impeller including a shroud having opposed faces, an outer peripheral edge portion and a rotation axis, a plurality of pumping vanes on one of the faces of the shroud and extending away from the rotation axis, each pumping vane having an outer peripheral edge portion, and a plurality of auxiliary vanes on the other face of the shroud, the auxiliary vanes of each having an outer edge portion wherein the dimension Da from the rotation axis to the outer peripheral edge portion of the shroud is greater than the dimension Db from the rotation axis to the outer edge portion of the auxiliary vanes.

Abstract: An inhalation device is described for use with a medicament pack in which at least one container for medicament in powder form is defined between two sheets peelably secured to one another. The device comprises means for peeling the sheets apart at an opening station to open the container; and an outlet, communicating with the opened container, through which a user can inhale medicament in powder form from the opened container.

Abstract: A leg wrap structure is provided in a disposable absorbent garment such as a diaper or training pants. The leg wrap structure has a base layer, a top layer, and an elastic construction disposed therebetween. The elastic construction includes a plurality of spaced apart (e.g. generally equally spaced apart) elastic elements (e.g. strands or threads) that are aligned in a generally in generally parallel relation. Further, the top and base layers define a region of inelasticity. The leg wrap structure provides for the efficient formation of a reservoir and a plurality of fluid dams each capable of capturing a quantity of fluid to minimize the occurrence of fluid leaks from the absorbent article. Methods of forming such absorbent articles are disclosed.

Abstract: The invention relates to a molecular sieve catalyst composition, to a method of making or forming the molecular sieve catalyst composition, and to a conversion process using the catalyst composition. In particular, the invention is directed to a catalyst composition comprising a molecular sieve having a framework including at least [AlO4] and [PO4] tetrahedral units, at least one of a binder and a matrix material and at least one phosphorus compound separate from said molecular sieve wherein, after calcination at 760° C. for 3 hours, said catalyst composition has a microporous surface area in excess of 20% of the microporous surface area of said molecular sieve after calcination at 650° C. in nitrogen for 2 hours. The catalyst composition is particularly useful in a conversion process for producing olefin(s), preferably ethylene and/or propylene, from a feedstock, preferably an oxygenate containing feedstock.

Abstract: The invention here relates to a product comprised of a cell line or lines intended for use as an allogeneic immunotherapy agent for the treatment of cancer in mammals and humans. All of the studies of cell-based cancer vaccines to date have one feature in common, namely the intention to use cells that contain at least some TSAs and/or TAAs that are shared with the antigens present in patients' tumour. In each case, tumour cells are utilised as the starting point on the premise that only tumour cells will contain TSAs or TAAs of relevance, and the tissue origins of the cells are matched to the tumour site in patients. A primary aspect of the invention is the use of immortalised normal, non-malignant cells as the basis of an allogeneic cell cancer vaccine. Normal cells do not possess TSAs or relevant concentrations of TAAs and hence it is surprising that normal cells are effective as anti-cancer vaccines.

Abstract: A method of determining disturbances when discharging molten metal from a metallurgical container having an outlet into a receiving container. In steps of this process, a real time video image of the teeming stream is monitored to detect the presence of a slag phase, or conditions conducive to the presence of such a phase in steel being transferred, the monitored images are processed to provide data used to assess the quantity of slag passed, parameters of data generated representing characteristics of the teeming stream image are compared with threshold values to generate at least one signal indicative of the passage of slag, and the threshold values are progressively adjusted responsive to data collected by monitoring plural parameters of the teeming operation selected from predicted teeming duration, weight of the receiving vessel, condition of means controlling teeming rate, and oxygen content of the molten steel.

Abstract: A valve for use with an aerosol container including a valve body, a valve stem having a dispensing passage, and a sealing ring contacting the valve stem. The sealing ring includes a sealing portion. The valve stem is slidably moveable relative to the sealing ring from a valve-closed position to a valve-open position. The interior of the valve body is in communication with the dispensing passage when the valve stem is in the valve-open position. The sealing ring also includes a wiper component to wipe the valve stem. The valve is preferably a metering valve.

Abstract: An inhalation device is described for use with a medicament pack in which at least one container for medicament in powder form is defined between two sheets peelably secured to one another. The device comprises means for peeling the sheets apart at an opening station to open the container; and an outlet, communicating with the opened container, through which a user can inhale medicament in powder form from the opened container.

Abstract: A method of determining disturbances when discharging molten metal from a metallurgical container having an outlet into a receiving container. In steps of this process, a real time video image of the teeming stream is monitored to detect the presence of a slag phase, or conditions conducive to the presence of such a phase in steel being transferred, the monitored images are processed to provide data used to assess the quantity of slag passed, parameters of data generated representing characteristics of the teeming stream image are compared with threshold values to generate at least one signal indicative of the passage of slag, and the threshold values are progressively adjusted responsive to data collected by monitoring plural parameters of the teeming operation selected from predicted teeming duration, weight of the receiving vessel, condition of means controlling teeming rate, and oxygen content of the molten steel.

Abstract: An inhalation device is described for use with a medicament pack in which at least one container for medicament in powder form is defined between two sheets peelably secured to one another. The device comprises means for peeling the sheets apart at an opening station to open the container; and an outlet, communicating with the opened container, through which a user can inhale medicament in powder form from the opened container.

Abstract: The invention relates to a product comprised of specific combinations of cell lines intended for use as an allogeneic immunotherapy agent for the treatment of prostate cancer in humans. The heterogeneity of the immunotherapeutic matches the heterogeneity of the antigenic profile in the target prostate cancer and immunises the recipients with many of the potential TAA and TSA which are expressed at various stages of the disease. The invention discloses a vaccine comprising a combination of three different cell lines prepared from primary or metastatic prostate cancer biopsy material. The cell lines are lethally irradiated utilising gamma irradiation at 50-300 Gy to ensure that they are replication incompetent.

Abstract: A method and package for storing a pressurized container which is filled with a drug formulation at a predetermined pressure. The drug formulation includes a mixture of a drug and a propellant. The package which encloses the pressurized container substantially prevents ingression of water vapor and particulate matter into the package while permitting egression of the propellant which may leak from the pressurized container.

Abstract: A method and package for storing a pressurized container which is filled with a drug formulation at a predetermined pressure. The drug formulation includes a mixture of a drug and a propellant. The package which endoses the pressurized container substantially prevents ingression of water vapor and particulate matter into the package while permitting egression of the propellant which may leak from the pressurized container.