Abstract: Provided is a method for identifying a coughing event, the method including obtaining, from a sensor included in a monitoring device worn by a patient, a plurality of digital voltage values, analyzing the plurality of digital voltage values to identify a physiological event based on (i) a change in magnitude of the digital voltage values and (ii) a duration of the change in the magnitude of the digital voltage values, the change in the magnitude of the digital voltage values and the duration of the change in the magnitude of the digital voltage values representing a first point in a two-dimensional feature space, and categorizing the identified physiological event as the coughing event based on a threshold hyperplane existing in the two-dimensional feature space.

Abstract: A portable, personal apparatus for transporting liquid having a bottle configured to contain liquid. The bottle has a longitudinal axis. A first opening open in a direction generally parallel with the longitudinal axis in a pour position. A first cover coupled to the bottle and configured to close the first opening in a closed position. A second opening open in a direction generally orthogonal with the longitudinal axis in a fill position. A second cover coupled to the bottle and configured to close the second opening in a storage position. The second cover remaining coupled to the bottle when the second cover is in the fill position.

Abstract: The present invention provides a triple-mode antibody display system that simultaneously matures, displays and secretes an antibody to a target of interest. An antibody in vivo-matured and complexed with membrane anchored bait can be expressed on the surface of the host cell, while complexed with a soluble bait the antibody is secreted from the host cell. Methods of using the system for identifying binders that bind specifically to an antigen of interest are also provided.

Abstract: The present invention provides a method for preparing a modular scaffold that can bind to a target antigen and a method for engineering a bispecific functional agent consisting of an existing polypeptide binder fused at its C-terminus with said modular scaffold.

Abstract: Pill dispensers including a housing, a bottom cap that engages an open bottom end of the housing, and a base that engages the bottom cap such that the bottom cap is spaced from the base. The bottom cap is adapted to facilitate movement of pills into a transport member, which is moveable with respect to the remainder of the bottom cap from a first position aligned with an upper opening in the bottom cap to a second position aligned with a lower opening in the bottom cap, through which a pill is dispensed.

Abstract: A portable, personal apparatus for transporting liquid having a bottle configured to contain liquid. The bottle has a longitudinal axis. A first opening open in a direction generally parallel with the longitudinal axis in a pour position. A first cover coupled to the bottle and configured to close the first opening in a closed position. A second opening open in a direction generally orthogonal with the longitudinal axis in a fill position. A second cover coupled to the bottle and configured to close the second opening in a storage position. The second cover remaining coupled to the bottle when the second cover is in the fill position.

Abstract: A computer-based method for use in geotargeting online ads to users of search engines by allowing comparison of user's search terms with a set of geo-keywords. The method includes providing a geographic keyword generator on a server that is linked to the Internet. The method includes providing a spatial database storing classes of geographic keywords. The method continues with receiving a keyword request including a business address from a client node. The keyword generator determines a service area based on this location, and a set of geographic keywords is retrieved from the spatial database that are associated (e.g., within) the determined service area. This set of keywords is transmitted or reported to the client node (e.g., displayed in a web browser or user interface) for use in geotargeting of their online advertisements. The keyword request includes a business type, and the service area is sized based on the business type.

Abstract: Pill dispensers including a housing, a bottom cap that engages an open bottom end of the housing, and a base that engages the bottom cap such that the bottom cap is spaced from the base. The bottom cap is adapted to facilitate movement of pills into a transport member, which is moveable with respect to the remainder of the bottom cap from a first position aligned with an upper opening in the bottom cap to a second position aligned with a lower opening in the bottom cap, through which a pill is dispensed.

Abstract: The present invention provides an apparatus comprising a plurality of planar waveguides and method of making the same. The apparatus includes first, second, and third layers formed above a substrate and adjacent each other. The second layer is formed between the first and third layers of a material and comprises a plurality of organofunctional siloxane-based resin or polymer waveguides. Each waveguide has an input on one edge of the second layer and an output on one edge of the second layer so that the input and output are on different line-of-sight paths. The plurality of waveguides is formed such that intersections of the waveguides occur at approximately right angles and the outputs and inputs located on edges that are opposite one another are offset from each other in a direction that is perpendicular to the direction of the corresponding input or output signal.

Abstract: The present invention provides an apparatus comprising a plurality of planar waveguides and method of making the same. The apparatus includes first, second, and third layers formed above a substrate and adjacent each other. The second layer is formed between the first and third layers of a material and comprises a plurality of organofunctional siloxane-based resin or polymer waveguides. Each waveguide has an input on one edge of the second layer and an output on one edge of the second layer so that the input and output are on different line-of-sight paths. The plurality of waveguides is formed such that intersections of the waveguides occur at approximately right angles and the outputs and inputs located on edges that are opposite one another are offset from each other in a direction that is perpendicular to the direction of the corresponding input or output signal.

Abstract: A computer-based method for use in geotargeting online ads to users of search engines by allowing comparison of user's search terms with a set of geo-keywords. The method includes providing a geographic keyword generator on a server that is linked to the Internet. The method includes providing a spatial database storing classes of geographic keywords. The method continues with receiving a keyword request including a business address from a client node. The keyword generator determines a service area based on this location, and a set of geographic keywords is retrieved from the spatial database that are associated (e.g., within) the determined service area. This set of keywords is transmitted or reported to the client node (e.g., displayed in a web browser or user interface) for use in geotargeting of their online advertisements. The keyword request includes a business type, and the service area is sized based on the business type.

Abstract: The present invention provides a planar waveguide. In one embodiment, the planar waveguide includes first and third layers formed above a substrate and adjacent each other. The first and third layers are formed of a first material having a first index of refraction. The planar waveguide also includes a second layer formed between the first and third layers of a second material having a second index of refraction that is larger than the first index of refraction. The planar waveguide further includes a plurality of organo-functional siloxane based resin or polymer waveguides formed in the second layer. Each organo-functional siloxane based resin or polymer waveguide has an input on one edge of the second layer and an output on one edge of the second layer so that the input and output are on different line-of-sight paths.

Abstract: A computer-based method for use in geotargeting online ads to users of search engines by allowing comparison of user's search terms with a set of geo-keywords. The method includes providing a geographic keyword generator on a server that is linked to the Internet. The method includes providing a spatial database storing classes of geographic keywords. The method continues with receiving a keyword request including a business address from a client node. The keyword generator determines a service area based on this location, and a set of geographic keywords is retrieved from the spatial database that are associated (e.g., within) the determined service area. This set of keywords is transmitted or reported to the client node (e.g., displayed in a web browser or user interface) for use in geotargeting of their online advertisements. The keyword request includes a business type, and the service area is sized based on the business type.

Abstract: The micropatch of the present invention provides a reliable and effective system of elicitation necessary for the diagnostic identification of allergy cases whilst substantially reducing the chances of sensitising subjects, the present invention employs a micropatch.

Abstract: A portable, personal apparatus for transporting liquid having a bottle configured to contain liquid. The bottle has a longitudinal axis. A first opening open in a direction generally parallel with the longitudinal axis in a pour position. A first cover coupled to the bottle and configured to close the first opening in a closed position. A second opening open in a direction generally orthogonal with the longitudinal axis in a fill position. A second cover coupled to the bottle and configured to close the second opening in a storage position. The second cover remaining coupled to the bottle when the second cover is in the fill position.

Abstract: A shoe has a sole with a toe, heel and arch. A two part heel has a low heel block attached to the sole heel and includes a slot therein. A high heel extension is attached to the low heel block through a support beam having a substantially rectangular cross-section capable of limited axial and pivotal movement. The fit between the beam and the slot prevents rotational movement of the high heel about its axis. The high heel extension can be pivoted between a first position where it underlies the low heel block and a second position where it lies beneath the sole arch. The bottom of the low heel block has a heel lift extending downwardly engaging the ground when the high heel is stowed. This low heel lift is enclosed by a beveled edge at the top of the high heel piece when it is vertical.

Abstract: Conventional commercial hair dyes form potent allergens and may also have irritant properties. If they were not already well established in the market and the side effects tolerated by consumers they would likely be deemed unsafe for use. The invention relates to compounds, compositions, formulations and methods for reducing, avoiding or eliminating allergic contact dermatitis reactions to conventional commercial hair dyes.

Abstract: The present invention provides a planar waveguide. In one embodiment, the planar waveguide includes first and third layers formed above a substrate and adjacent each other. The first and third layers are formed of a first material having a first index of refraction. The planar waveguide also includes a second layer formed between the first and third layers of a second material having a second index of refraction that is larger than the first index of refraction. The planar waveguide further includes a plurality of organo-functional siloxane based resin or polymer waveguides formed in the second layer. Each organo-functional siloxane based resin or polymer waveguide has an input on one edge of the second layer and an output on one edge of the second layer so that the input and output are on different line-of-sight paths.