Abstract: The invention provides arrays of molecules where the molecules (e.g., glycans) are attached to the arrays by cleavable linkers. The invention also provides methods for using these arrays, methods for identifying the structural elements of molecules bound to these arrays by using the cleavable linkers, especially the structural elements that are important for binding to test samples. The invention further provides methods for evaluating whether test samples and test molecules can bind to distinct glycans on the arrays and useful glycans identified using the methods and arrays provided herein.

Abstract: Potent human inhibitors of human glycinamide ribonucleotide transformylase and of aminoimidazole carboxamide ribonucleotide transformylase are designed, synthesized, and characterized.

Abstract: The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.

Abstract: A mixer apparatus comprising a pair of counter rotating beater elements operating in a rotating bowl for the mixing of food ingredients; at least one of said beater elements provided with urging means adapted to urging small quantities of said food ingredients from a thin distributed layer into a mixable concentration of said ingredients.

Abstract: Synthetic analogues of lysine and glutamine are provided which function as substrates for the fibrin-stabilising enzyme Factor XIIIa even when labelled with a detectable moiety. The use of suitable protecting groups provides compounds which possess reduced susceptibility to in vivo metabolism especially by peptidases, and are hence useful agents for the diagnosis of thrombosis, embolism, atherosclerosis, inflammation or cancer.

Abstract: Methods and apparatus for sending a redirect packet to a host are disclosed. In a first router that supports a virtual router protocol, a method of sending a redirect packet to a host, the redirect packet notifying the host that specific packets are to be redirected to a second router, includes receiving a packet from a host, the packet including a source address identifying the host and a destination address identifying a destination network. The first router ascertains the destination network of the packet from the destination address and obtains from a routing table an address of a next router to the packet's destination network. The first router then determines whether to send a redirect packet to the host. In accordance with one embodiment, this is performed by determining whether the next router and the host identified by the source address of the packet are on the same network.

Abstract: The present invention is in the field of diagnostic imaging. In one aspect, the invention relates to novel imaging agents comprising synthetic macrophage scavenger receptor A antagonists, said imaging agents being useful in the diagnostic imaging of cardiovascular disease. Also claimed in the present invention is a pharmaceutical composition comprising the novel imaging agents of the invention, said pharmaceutical composition being useful for the diagnostic imaging of cardiovascular disease in humans. Another aspect of the present invention is a kit useful in the preparation of the pharmaceutical composition of the invention. Furthermore, the use of the imaging agent of the invention for the diagnostic imaging of cardiovascular disease is also claimed.

Abstract: An electric deep frying appliance adapted for the heating of cooking oil comprising a bowl and heating assembly; said heating assembly including a heat distributor wherein said heat distributor is in the form of an annular dished member; said heating assembly further including a control pylon adapted to provide power and temperature control to said heat distributor.

Abstract: A device and method are provided for reducing impedance, impedance discontinuities, and signal-loop area in flex cables used for a signal path. In one embodiment of the invention, a flex cable is provided for reducing the impedance and length of a return-signal path. The flex cable includes a signal conductor, and a return-signal conductor not connected to ground. The flex cable may also include a ground conductor. Such a flex cable provides a shorter- and lower-impedance return-signal path between a signal source and receiver than do conventional flex cables. In another embodiment of the invention, a method is provided that includes the steps of delivering a signal from a signal source to a signal receiver with a flexible conductor, and returning the signal from the signal receiver to the signal source with another flexible conductor other than ground.

Abstract: The invention features computer-assisted methods for identifying molecules which will bind to the EPO receptor and act as an erythropoietin (EPO) mimetic. Preferred EPO mimetics identified using the method of the invention act as agonists of the EPO receptor in one or more in vitro or in vivo biological assays of EPO activity.

Abstract: The present invention relates to the structure of Fab 4E10, e.g., as a complex with herein identified peptide KGND, herein identified as a 4E10 mimetope on gp41, as determined by crystallographic techniques, and the confirmation that peptide KGND has a functional relevant conformation, as well as the determination of key residues on 4E10, and uses thereof and compounds and compositions therefrom. Furthermore, the invention also relates to other peptides and mimetic peptides which bind to Fab 4E10.

Abstract: The invention provides use of a compound of formula (I): or a salt thereof, wherein: R1 is 125I, 124I, 123I, 75Br, 76Br, or 18F; R2 is C1-6 alkyl; and R3 is selected from hydrogen, C1-6 alkyl, —C(O)C1-6 alkyl, —C(O)C1-6 haloalkyl, and —C(O)CH(R4)NH2; wherein R4 is selected from hydrogen, C1-6alkyl, C1-6hydroxyalkyl, and C1-6aminoalkyl; for the manufacture of a radiopharmaceutical for the in vivo diagnosis or imaging of an amyloid-associated disease, particularly Alzheimer's disease.

Abstract: Methods and apparatus for sending a redirect packet to a host by a first router that supports a virtual router protocol are disclosed. Specifically, the redirect packet notifies the host that specific packets are to be redirected to a second router. First, the first router receives a packet from a host, where the packet includes a source address identifying the host and a destination address identifying a destination network. The first router ascertains the destination network of the packet from the destination address and obtains from a routing table an address of a next router that is coupled to the packet's destination network. The first router then determines whether to send a redirect packet to the host. In accordance with one embodiment, this is performed by determining whether the next router and the host identified by the source address of the packet are on the same network.

Abstract: The distribution of traffic flows in a load-sharing redundancy group that includes a first gateway device and a second gateway device includes assigning a first set of forwarding addresses to the first gateway device and a second set of forwarding addresses to the second gateway device. The redundancy group distributes forwarding addresses to hosts which in turn use the distributed forwarding addresses to send packets to the redundancy group. The traffic flow for each of the assigned forwarding addresses is measured and may be compared to a target traffic flow. The traffic flow is adjusted to close in on the target traffic flow. Adjustment of the traffic flow can be accomplished either by changing the existing measured traffic flow by re-assigning a forwarding address originally assigned to one gateway device to a different gateway device or by altering future distribution of forwarding addresses so that additional traffic is sent to one or more forwarding addresses having lower measured traffic.

Abstract: An embodiment of a cable system includes a cable that has a conductor, a power layer and dielectric material. The conductor is operative to carry a signal, the dielectric material is located at least partially between the conductor and the power layer, and the power layer is operative as ground. The power layer is formed of a conductive material and includes a first region and an adjacent second region. The first region includes a greater amount of the conductive material than the second region so that the power layer is less resistant to bending along the second region than along the first region. Methods and other systems are also provided.

Abstract: Methods for random or rational design of high affinity domain exchanged binding molecules and methods of use are provided herein. Also provided are libraries containing a plurality of such domain exchanged binding molecules.

Abstract: A device and method are provided for reducing impedance, impedance discontinuities, and signal-loop area in flex cables used for a signal path. In one embodiment of the invention, a flex cable is provided for reducing the impedance and length of a return-signal path. The flex cable includes a signal conductor, and a return-signal conductor not connected to ground. The flex cable may also include a ground conductor. Such a flex cable provides a shorter- and lower-impedance return-signal path between a signal source and receiver than do conventional flex cables. In another embodiment of the invention, a method is provided that includes the steps of delivering a signal from a signal source to a signal receiver with a flexible conductor, and returning the signal from the signal receiver to the signal source with another flexible conductor other than ground.

Abstract: A food mixer 10 having a turntable 22 that receives a bowl 23. Projecting into a bowl 23 are beaters 24 that are driven by means of a motor 13. The turntable 22 is driven by means of a motor 25. A common speed control member in the form of a dial 29 operates a pair of potentiometers 31 that control the motors 13 and 25 so that there is a correlation between the speeds thereof.

Abstract: System for electrically interconnecting components are provided. One such system comprises: a flex cable having a first end and a second end; a first connector attached to a electrically communicating with the first end of the flex cable; a second connector attached to and electrically communicating with the second end of the flex cable; and a first retention member extending outwardly from the flex cable.

Abstract: An embodiment of a cable system includes a cable that has a conductor, a power layer and dielectric material. The conductor is operative to carry a signal, the dielectric material is located at least partially between the conductor and the power layer, and the power layer is operative as ground. The power layer is formed of a conductive material and includes a first region and an adjacent second region. The first region includes a greater amount of the conductive material than the second region so that the power layer is less resistant to bending along the second region than along the first region. Methods and other systems are also provided.