Abstract: A power supply system for illuminating an LED lamp unit, having a normal mode of operation in which a mains input of a driver of the LED lamp unit is supplied by mains power, and an emergency mode of operation, in which the LED lamp unit is supplied by a charge storage device, is disclosed. The system includes an emergency mode converter operable to step-up the voltage from the charge storage device and to supply the mains driver input for illuminating the LED lamp unit.

Abstract: An integrated control circuit (SE) and method for operating luminaries are provided. The integrated control circuit has at least one output for supplying a signal controlling a switch, such as a transistor, in an operating circuit (OM), in particular controlling directly or indirectly a dimming level of the luminaries, and a common input (Ts) arranged for being supplied with a combination of a temperature indicating signal and a presence indicating signal, the integrated control circuit (SE) being designed to adjust a switch control signal as a function of the electrical signal (ES) at the common input (Ts).

Abstract: The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron microscopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention.

Abstract: Methods for Identifying protein modulators of eukaryotic cells by expressing a combinatorial library of potential agonists inside a eukaryotic cell and then directly selecting for an agonist of a target molecule. Some methods involve co-culturing a cell expressing a combinatorial library of potential agonists and a second cell, and then selecting agents that modulate a phenotype of or a desired cellular response in the second cell. Preferably, the agonists are antibodies introduced into and expressed in the starting cells, such as agonist anti-EpoR, anti-TpoR, or G-CSFR antibodies. Also disclosed are methods for selecting from combinatorial antibody libraries bispecific antibodies that can regulate cell phenotypes.

Abstract: The invention relates to an operating device (10) for at least one light-emitting diode (9) having an input (11) for coupling to a DC bus (6) in order to receive a DC supply voltage. The operating device (10) has a configurable emergency light function. The operating device (10) is designed to produce, in the emergency light case, the LED currently for the at least one light-emitting diode (9) in dependence on how the emergency light function is configured.

Abstract: Provided herein methods of alleviating the symptoms of multiple myeloma in a patient or subject in need thereof, methods of treating multiple myeloma in a patient or subject, and methods of preventing development of multiple myeloma in a patient at risk thereof, such as a patient with monoclonal gammopathy of undetermined significance (MGUS), which methods include administering an agent effective to treat a Mycoplasma infection. The invention also relates to a new class of antigen, MG281 protein {also referenced as Protein M), that binds to various immunoglobulins with high affinity, and their uses in purifying immunoglobulins. The invention additionally relates to using MG281 protein and analog or derivative molecules for treating autoimmune diseases. Further provided are antigens and antibodies for use in the disclosed methods, and the identification of molecules that bind to MG281 protein.

Abstract: Lighting power supply system (1) including a mains input converter (11) operable to provide power, a controller (17) operable to control at least one element of the lighting system, a controller bus (26) and a controller interface (25) operable to provide control signals from the bus to the lighting system. An auxiliary converter (43) powers the lighting system from the bus and it may allow the controller to continue to be powered when the mains input is absent and an emergency battery (19) is depleted.

Abstract: An integrated control circuit for operating means for lighting means, the integrated control circuit is provided having at least one output for supplying a signal controlling a switch, such as e.g. a transistor, of the operating means, in particular controlling directly or indirectly a dimming level of a lighting means, and a common input arranged for being supplied with a combination of a temperature indicating signal and a presence indicating signal, the integrated control circuit being designed to adjust the switch control signal as a function of the signal at the common input.

Abstract: Methods for Identifying protein modulators of eukaryotic cells by expressing a combinatorial library of potential agonists inside a eukaryotic cell and then directly selecting for an agonist of a target molecule. Some methods involve co-culturing a cell expressing a combinatorial library of potential agonists and a second cell, and then selecting agents that modulate a phenotype of or a desired cellular response in the second cell. Preferably, the agonists are antibodies introduced into and expressed in the starting cells, such as agonist anti-EpoR, anti-TpoR, or G-CSFR antibodies. Also disclosed are methods for selecting from combinatorial antibody libraries bispecific antibodies that can regulate cell phenotypes.

Abstract: Provided herein methods of alleviating the symptoms of multiple myeloma in a patient or subject in need thereof, methods of treating multiple myeloma in a patient or subject, and methods of preventing development of multiple myeloma in a patient at risk thereof, such as a patient with monoclonal gammopathy of undetermined significance (MGUS), which methods include administering an agent effective to treat a Mycoplasma infection. The invention also relates to a new class of antigen, MG281 protein {also referenced as Protein M), that binds to various immunoglobulins with high affinity, and their uses in purifying immunoglobulins. The invention additionally relates to using MG281 protein and analog or derivative molecules for treating autoimmune diseases. Further provided are antigens and antibodies for use in the disclosed methods, and the identification of molecules that bind to MG281 protein.

Abstract: The invention relates to an emergency lighting device for controlling a lighting means, comprising an energy store, such as a battery or an accumulator, a charging circuit for the energy store having connections for an AC voltage (alternating voltage), wherein the charging circuit has a potential isolation element, a potentially isolated clocked converter supplied from the energy store and having a switch, preferably a flyback converter, wherein the converter preferably can be supplied only by the energy store, a control circuit for controlling the switch, and a supply path from the secondary side of the converter to connections for the lighting means.

Abstract: A power supply system for illuminating an LED lamp unit 5, having a normal mode of operation in which a mains input 4 of a driver 3 of the LED lamp unit is supplied by mains power 1, and an emergency mode of operation, in which the LED lamp unit is supplied by a charge storage device 19, is disclosed. The system includes an emergency mode converter 21 operable to step-up the voltage from the charge storage device and to supply the mains driver input for illuminating the LED lamp unit.

Abstract: A power supply system supplies gas discharge lamp unit (5) arc power and cathode power. The system includes an emergency driver (17) for receiving power from a power supply (15). The driver provides the lamp arc power and the cathode power. The driver adjusts the total power provided to the lamp unit and varies the proportion of the total power provided as the arc power and as the cathode power in order to provide optimised arc power and cathode power according to the circumstances.

Abstract: Lighting power supply system (1) including a mains input converter (11) operable to provide power, a controller (17) operable to control at least one element of the lighting system, a controller bus (26) and a controller interface (25) operable to provide control signals from the bus to the lighting system. An auxiliary converter (43) powers the lighting system from the bus and it may allow the controller to continue to be powered when the mains input is absent and an emergency battery (19) is depleted.

Abstract: The invention relates to an immunogenic HIV-1 gp120 mini V3 loop, which is a truncated version of the full-length gp120 V3 loop useful for crystallization with antibodies that recognize carbohydrate moieties. The invention also relates to the structure of a broadly neutralizing antibody as a complex with a glycosylated gp120 outer domain, as determined by crystallographic techniques, and the confirmation that a glycosylated gp120 outer domain has a functional relevant conformation, as well as the determination of key residues on a glycosylated gp120 outer domain, and uses thereof and compounds and compositions therefrom. Furthermore, the invention also relates to other peptides and mimetic peptides, which bind to broadly neutralizing antibodies.

Abstract: The present invention relates to a series of compounds useful for effecting purification, in particular for use in purification of synthetic peptides and proteins. The compounds of the invention are particularly efficient at securely anchoring peptides or proteins to a surface and allowing the peptide or protein to become uniformly orientated, thus ensuring that substantially all of the peptide or protein is available for molecular binding to a substrate.

Abstract: The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron micrsocopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention.

Abstract: An erosion control barrier for installation in a drainage path in a service environment. The erosion control barrier includes a unitary permeable sheet which is bent along a longitudinal axis to provide an upslope side, a downslope side and a longitudinally extending apex. The permeable sheet is constructed of a degradable material so that the erosion control barrier has a design service life in the service environment and a design material life in the service environment. The design material life is longer than the design service life. The permeable sheet is designed to be sufficiently transversely stiff and resilient during the design service life to enable the erosion control barrier to be self-supporting. The permeable sheet is designed to substantially disintegrate within the design material life.

Abstract: The present invention relates to a method to assist in the determination of therapy for a patient suffering from Barrett's oesophagus, especially where first-line therapy has been unsuccessful and when dysplasia has been diagnosed. The method comprises the use of an imaging agent comprising a vector which targets (a) Her2, (b) cMet, (c) guanylyl cyclase or (d) IGF1R. The imaging agent is suitable for radioisotope or optical imaging in vitro or preferably in vivo.

Abstract: The present invention relates to a series of compounds useful for effecting purification, in particular for use in purification of synthetic peptides and proteins. The compounds of the invention are particularly efficient at securely anchoring peptides or proteins to a surface and allowing the peptide or protein to become uniformly orientated, thus ensuring that substantially all of the peptide or protein is available for molecular binding to a substrate.