Patents by Inventor Igor Nikolaev
Igor Nikolaev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8679816Abstract: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.Type: GrantFiled: June 3, 2010Date of Patent: March 25, 2014Assignee: Danisco US Inc.Inventors: Wolfgang Aehle, Richard R. Bott, Benjamin Bower, Jonathan Caspi, David A. Estell, Frits Goedegebuur, Ronaldus W. J. Hommes, Thijs Kaper, Bradley Kelemen, Slavko Kralj, Johan Van Lieshout, Igor Nikolaev, Sander Van Stigt Thans, Louise Wallace, Gudrun Vogtentanz, Mats Sandgren
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Publication number: 20140073017Abstract: The present invention relates to compositions that can be used in hydrolyzing biomass such as compositions comprising a polypeptide having ?-glucosidase activity, methods for hydrolyzing biomass material, and methods for improving the stability and saccharification efficacy of a composition comprising such ?-glucosidase polypeptides and/or activity.Type: ApplicationFiled: March 16, 2012Publication date: March 13, 2014Applicant: DANISCO US INC.Inventors: Thijs Kaper, Igor Nikolaev, Suzanne E. Lantz, Meredith K. Fujdala, Megan Y. Hsi
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Patent number: 8626698Abstract: A computer-implemented method is provided for developing a model to estimate a probability of project success. The method includes maintaining a database of historical project management performance data including i) task information associated with at least one completed task and ii) member information associated with at least one team member. The method includes forming a predictive model based on the historical project management performance data. Forming a predictive model further includes formulating probability distributions to characterize one or more dependency relationships in the predictive model. Each probability distribution includes at least one probability determined based on the historical project management performance data.Type: GrantFiled: January 14, 2013Date of Patent: January 7, 2014Assignee: FMR LLCInventors: Igor Nikolaev, Dmitry Bisikalo, Tom Mulligan
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Patent number: 8592194Abstract: The present invention relates to variant glucoamylases wherein the variant has altered properties (e.g., improved thermostability and/or specific activity) compared to a corresponding parent glucoamylase. The present invention also relates to enzyme compositions comprising a variant glucoamylase (e.g., starch hydrolyzing compositions); DNA constructs comprising polynucleotides encoding the variants and methods of producing the variant glucoamylases in host cells.Type: GrantFiled: April 8, 2008Date of Patent: November 26, 2013Assignee: Danisco US Inc.Inventors: Wolfgang Aehle, Richard R. Bott, Igor Nikolaev, Martijn Scheffers, Piet Van Solingen, Casper Vroemen
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Patent number: 8583467Abstract: A computer-implemented method is provided for optimizing scheduling and resource allocation for a workflow. The method includes receiving i) resource information representing resources available for allocation to the workflow and ii) one or more workflow constraints. The method determines one or more probable sequences for executing the workflow. Each probable sequence includes tasks usable to execute at least a portion of the workflow. Each task is assigned a probability of task execution. The method assigns a probability of sequence execution to each of the probable sequences based on the probability of task execution of the tasks forming the probable sequence. The method further determines an optimized scenario for scheduling the workflow based on the probable sequences. The optimized scenario can have an optimized probability of completion.Type: GrantFiled: August 23, 2012Date of Patent: November 12, 2013Assignee: FMR LLCInventors: Sean Morris, Peter Keane, Igor Nikolaev, Tom Mulligan
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Patent number: 8551755Abstract: The present invention relates to glucoamylase variants. In particular, the invention relates to variants in the starch binding domain (SBD) of a glucoamylase. The invention also relates to variants having altered properties (e.g., improved thermostability and/or increased specific activity) as compared to a corresponding parent glucoamylase. The present invention also provides enzyme compositions comprising the variant glucoamylases; DNA constructs comprising polynucleotides encoding the variants; and methods of producing the glucoamylase variants in host cells.Type: GrantFiled: April 8, 2008Date of Patent: October 8, 2013Assignee: Danisco US Inc.Inventors: Wolfgang Aehle, Richard R. Bott, Igor Nikolaev, Martijn Scheffers, Piet Van Solingen, Casper Vroemen
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Publication number: 20130216654Abstract: The present invention relates to amidase enzymes and a feed or food additive comprising the amidase enzyme capable of degrading ochratoxin.Type: ApplicationFiled: September 6, 2011Publication date: August 22, 2013Applicant: DUPONT NUTRITION BIOSCIENCES APSInventors: Shukun Yu, Charlotte Horsmans Poulsen, Soren Dalsgaard, Huaming Wang, Igor Nikolaev
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Publication number: 20130143301Abstract: The present disclosure is generally directed to enzymes and in particular beta-glucosidase variants. Also described are nucleic acids encoding beta-glucosidase variants, compositions comprising beta-glucosidase variants, methods of using beta-glucosidase variants, and methods of identifying additional useful beta-glucosidase variants.Type: ApplicationFiled: November 19, 2010Publication date: June 6, 2013Applicant: Danisco US Inc.Inventors: Richard R. Bott, Thijs Kaper, Bradley Kelemen, Frits Goedegebuur, Ronaldus Hommes, Slavko Kralj, Paulien Kruithof, Igor Nikolaev
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Publication number: 20130090971Abstract: A computer-implemented method is provided for optimizing allocation of resources across stories for a release within an Agile development environment. The method includes receiving (i) resource information representing a plurality of resources available for allocation to the stories, (ii) one or more story definitions, each story definition comprising a unique identifier and one or more story-level constraints corresponding to a story, (iii) release information, (iv) iteration information, and (iv) one or more optimization criteria. The method also includes generating a plurality of story-level allocation scenarios and determining one or more optimized story-level allocation scenarios from the plurality of story-level allocation scenarios. Each story-level allocation scenario satisfies the one or more story-level constraints associated with each story definition.Type: ApplicationFiled: October 11, 2011Publication date: April 11, 2013Inventors: Sean Morris, Keith Kroeger, Thomas McGuire, Igor Nikolaev
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Patent number: 8332251Abstract: A computer-implemented method is provided for optimizing allocation of resources across stories for a release within an Agile development environment. The method includes receiving (i) resource information representing a plurality of resources available for allocation to the stories, (ii) one or more story definitions, each story definition comprising a unique identifier and one or more story-level constraints corresponding to a story, (iii) release information, (iv) iteration information, and (iv) one or more optimization criteria. The method also includes generating a plurality of story-level allocation scenarios and determining one or more optimized story-level allocation scenarios from the plurality of story-level allocation scenarios. Each story-level allocation scenario satisfies the one or more story-level constraints associated with each story definition.Type: GrantFiled: February 28, 2012Date of Patent: December 11, 2012Assignee: FMR LLCInventors: Sean Morris, Keith Kroeger, Thomas McGuire, Igor Nikolaev
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Patent number: 8214240Abstract: Described are methods and apparatuses, including computer program products, for optimizing allocation of resources across projects in a project portfolio. The method includes receiving, at a computing device, (i) resource information, (ii) a portfolio of project definitions and (iii) one or more portfolio-level optimization criteria. The resource information representing a plurality of resources available for allocation to the projects, and each project definition includes a unique identifier and one or more project-level constraints. The method also includes generating, using the computing device, a plurality of project portfolio allocation scenarios and determining one or more optimized project portfolio allocation scenarios from the plurality of project portfolio allocation scenarios. Each project portfolio allocation scenario satisfies the one or more project-level constraints associated with each project definition.Type: GrantFiled: July 26, 2011Date of Patent: July 3, 2012Assignee: FMR LLCInventors: Sean Morris, Keith Kroeger, Thomas McGuire, Igor Nikolaev
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Publication number: 20120135500Abstract: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.Type: ApplicationFiled: June 3, 2010Publication date: May 31, 2012Applicant: Danisco US Inc.Inventors: Wolfgang Aehle, Richard R. Bott, Benjamin Bower, Jonathan Caspi, David A. Estell, Frits Goedegebuur, Ronaldus W.J. Hommes, Thijs Kaper, Bradley Kelemen, Slavko Kralj, Johan Van Lieshout, Igor Nikolaev, Sander Van Stigt Thans, Louise Wallace, Gudrun Vogtentanz, Mats Sandgren
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Publication number: 20110256571Abstract: An amino acid sequence is described. The amino acid may comprise a signal sequence that is SEQ ID NO. 1a (or a variant or homologue or derivative or fragment thereof) that is expressed as a fusion protein that comprises a protein of interest. The signal sequence directs secretion of the protein of interest. The protein of interest may be a heterologous protein. Secretion of the fusion protein aids purification.Type: ApplicationFiled: October 29, 2010Publication date: October 20, 2011Inventors: Patrick Maria Franciscus Derkx, Harm Mulder, Igor Nikolaev
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Publication number: 20110236935Abstract: A method of oxidising a saccharide, by contacting the saccharide with an alcohol dehydrogenase (ADH) enzyme selected from a quinone redox cofactor-dependent ADH, a nicotinamide adenine dinucleotide (NAD+) redox cofactor-dependent ADH, a nicotinamide adenine dinucleotide phosphate (NADP+) redox cofactor-dependent ADH, and any combination thereof is described. An oxidised saccharide obtainable by the method and products, in particular food products and paper products, containing the oxidised saccharide, are also described.Type: ApplicationFiled: October 29, 2010Publication date: September 29, 2011Inventors: Jørn Dalgaard Mikkelsen, Karsten Matthias Kragh, Rene Mikkelsen, Patrick Maria Franciscus Derkx, Shukun Yu, Harm Mulder, Igor Nikolaev
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Patent number: 8017341Abstract: The present invention relates to an isolated nucleic acid sequence coding for a PntR transcription factor comprising a nucleotide sequence that is the same as, or is complementary to, or contains any suitable codon substitutions for any of those of SEQ ID NOs: 1, 3 or 5 or comprises a sequence which has at least 60% sequence homology with any of SEQ ID NOs: 1, 3 or 5, as well as corresponding polypeptides, vector systems and host cells comprising the same. In particular, the invention relates to sequences which are obtained from an Aspergillus, Trichoderma or Penicillium cell. The invention further relates to methods for disrupting PntR expression in a cell as well as methods for expression or production of a POI in a host cell in which PntR expression has been disrupted.Type: GrantFiled: April 20, 2007Date of Patent: September 13, 2011Assignee: Danisco A/SInventors: Igor Nikolaev, Susan Mampusti Madrid
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Patent number: 7991632Abstract: Described are methods and apparatuses, including computer program products, for optimizing allocation of resources across projects in a project portfolio. The method includes receiving, at a computing device, (i) resource information, (ii) a portfolio of project definitions and (iii) one or more portfolio-level optimization criteria. The resource information representing a plurality of resources available for allocation to the projects, and each project definition includes a unique identifier and one or more project-level constraints. The method also includes generating, using the computing device, a plurality of project portfolio allocation scenarios and determining one or more optimized project portfolio allocation scenarios from the plurality of project portfolio allocation scenarios. Each project portfolio allocation scenario satisfies the one or more project-level constraints associated with each project definition.Type: GrantFiled: January 28, 2011Date of Patent: August 2, 2011Assignee: FMR LLCInventors: Sean Morris, Keith Kroeger, Thomas McGuire, Igor Nikolaev
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Publication number: 20110020899Abstract: The present invention relates to variant glucoamylases wherein the variant has altered properties (e.g., improved thermostability and/or specific activity) compared to a corresponding parent glucoamylase. The present invention also relates to enzyme compositions comprising a variant glucoamylase (e.g.Type: ApplicationFiled: April 8, 2008Publication date: January 27, 2011Inventors: Wolfgang Aehle, Richard R. Bott, Igor Nikolaev, Martijn Scheffers, Piet Van Solingen, Casper Vroemen
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Publication number: 20110014681Abstract: The present invention relates to glucoamylase variants. In particular, the invention relates to variants in the starch binding domain (SBD) of a glucoamylase. The invention also relates to variants having altered properties (e.g., improved thermostability and/or increased specific activity) as compared to a corresponding parent glucoamylase. The present invention also provides enzyme compositions comprising the variant glucoamylases; DNA constructs comprising polynucleotides encoding the variants; and methods of producing the glucoamylase variants in host cells.Type: ApplicationFiled: April 8, 2008Publication date: January 20, 2011Inventors: Wolfgang Aehle, Richard R. Bott, Igor Nikolaev, Martijn Scheffers, Piet Van Solingen, Casper Vroemen
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Publication number: 20070254336Abstract: The present invention relates to an isolated nucleic acid sequence coding for a PntR transcription factor comprising a nucleotide sequence that is the same as, or is complementary to, or contains any suitable codon substitutions for any of those of SEQ ID NOs: 1, 3 or 5 or comprises a sequence which has at least 60% sequence homology with any of SEQ ID NOs: 1, 3 or 5, as well as corresponding polypeptides, vector systems and host cells comprising the same. In particular, the invention relates to sequences which are obtained from an Aspergillus, Trichoderma or Penicillium cell. The invention further relates to methods for disrupting PntR expression in a cell as well as methods for expression or production of a POI in a host cell in which PntR expression has been disrupted.Type: ApplicationFiled: April 20, 2007Publication date: November 1, 2007Inventors: Igor Nikolaev, Susan Madrid