Abstract: A system comprising surgical instruments of different types. Each surgical instrument includes a body member and a leg having a first end integrated with and a leg portion extending from the body member. The instrument includes a head cavity formed in a free end of the leg. The cavity holds a head. A channel is formed along a portion of a longitudinal length of the leg. The instrument includes an elongated rocker assembly pivotally coupled within the channel, with a spring actuation tab in proximity to the body member. The instrument includes a collar slidably coupled around the body member and having a first position located between the body member and the actuation tab such that a portion of the collar is under the actuation tab to limit pivotal motion of the rocker assembly and a second position of the collar has a clearance from under the actuation tab.

Abstract: A network-based service may be provided for facilitating queries for a number of items, such as travel services. A user may submit a query including criteria for determining one or more relevant items. Based on the submitted query, the network-based service may present the user with information regarding the actions of other similar users of the network-based service, such as searches performed by the other users. Based on this information, the user may elect to supplement the current query to conform to the actions for other users. In some embodiments, actions by other users may be based at least in part on a category of the querying user. By presenting actions of similar users, a current user may be enabled to select the most relevant query terms for identifying a desired item.

Abstract: A surgical system including a combination instrument for breaking of tabs of a reduction connector and providing a counter torque for a driver is disclosed. The combination instrument may have an elongated rigid structure and include an internal shaft and a magazine portion configured to store at least one tab of a reduction connector. The combination instrument may further include a cut-out portion configured to retain the at least one tab within the magazine portion. In some embodiments, the driver may be configured to be inserted into the internal shaft of the combination instrument. In some embodiments, the driver is rotatable within the internal shaft of the combination instrument and configured to drive a set screw within the reduction connector. Disclosed drivers may be manual drivers or powered drivers. Some embodiments, may include a collar or a cap from which the broken off tabs may be ejected.

Abstract: An energy storage assembly includes an energy storage unit. A supervisor is operable to determine a power reference set point based upon a cost function. A storage unit controller is configured to control the energy storage unit to provide electric energy to at least one load based upon a power reference input that is based upon the power reference set point and at least one dynamically changing power profile from the at least one load.

Abstract: A surgical system includes a first surgical instrument having a selected configuration and an image guide disposed relative to a sensor to communicate a signal representative of a position of the image guide. A passive image guide is fixed with vertebral tissue and is disposed relative to the sensor to communicate a signal representative of a position of the passive image guide. The passive image guide includes a first surface. A second surgical instrument is connectable with the first surgical instrument and includes a second surface engageable with the first surface in a mating configuration to provide verification of the selected configuration. Surgical instruments, implants, spinal constructs and methods are disclosed.

Abstract: Pink noise analysis, along with unique properties of the photovoltaic (PV) operating point of both the instantaneous current and voltage signal, is used to distinguish arc faults from other noisy loads or PV degradations.

Abstract: A surgical system including a combination instrument for breaking of tabs of a reduction connector and providing a counter torque for a driver is disclosed. The combination instrument may have an elongated rigid structure and include an internal shaft and a magazine portion configured to store at least one tab of a reduction connector. The combination instrument may further include a cut-out portion configured to retain the at least one tab within the magazine portion. In some embodiments, the driver may be configured to be inserted into the internal shaft of the combination instrument. In some embodiments, the driver is rotatable within the internal shaft of the combination instrument and configured to drive a set screw within the reduction connector. Disclosed drivers may be manual drivers or powered drivers. Some embodiments, may include a collar or a cap from which the broken off tabs may be ejected.

Abstract: A user input device may include a shaft carried by a housing and having a first end extending outwardly beyond the housing for manipulation by a user and a second end within the housing. A set of one or more sensors may be carried by the housing to sense shaft movement. A first contact member may be within the housing, and a spring may be coupled between the first contact member and the shaft to urge the first contact member and the shaft apart. A motor may be carried within the housing and may have a rotatable output extending therefrom. A second contact member may be coupled to the rotatable output and may be in contact with the first contact member to be selectively moveable based upon motor rotation to set a spring compression and thereby set a return-to-center bias for the shaft while being manipulated.

Abstract: Methods of treating a subject in need thereof are provided which include: administering a recombinant platelet derived growth factor D (PDGF D) composition to a mesenchymal stem cell of the subject and/or a progenitor derived therefrom, in vivo, or ex vivo, producing a treated mesenchymal stem cell of the subject and/or a progenitor derived therefrom, thereby stimulating the mesenchymal stem cell (MSC) and/or a progenitor derived therefrom. Cells expressing a recombinant PDGF D composition of the present are administered to the subject for in vivo delivery of the recombinant PDGF D composition according to aspects of the present disclosure. Methods and compositions are provided including recombinant PDGF D hemidimer (HD) including a full-length PDGF D polypeptide and a C-terminal growth factor domain of PDGF D, which lacks a CUB domain, promoting regulation of bone marrow MSC differentiation into osteogenic lineage cells.

Abstract: A user input device may include a shaft carried by a housing and having a first end extending outwardly beyond the housing for manipulation by a user and a second end within the housing. A set of one or more sensors may be carried by the housing to sense shaft movement. A first contact member may be within the housing, and a spring may be coupled between the first contact member and the shaft to urge the first contact member and the shaft apart. A motor may be carried within the housing and may have a rotatable output extending therefrom. A second contact member may be coupled to the rotatable output and may be in contact with the first contact member to be selectively moveable based upon motor rotation to set a spring compression and thereby set a return-to-center bias for the shaft while being manipulated.

Abstract: The present disclosure provides for a compound according to formula (I) or a pharmaceutically acceptable salt thereof as CaV1.22 activators for the treatment of schizophrenia, bipolar disorder, major depressive disorder, substance use disorder, ADHD, Phelan-McDermid Syndrome, autism spectrum disorder, multiple sclerosis, frontotemporal dementia, Alzheimer's disease, Brugada Syndrome, Short QT syndrome, or early repolarization syndrome.

Abstract: The present invention relates to a system and methods generally aimed at monitoring the angular orientation between two locations within a fluoroscopic image and especially for monitoring the angular orientation between two locations within a fluoroscopic image and a predetermined target angle.

Abstract: A surgical instrument includes a body member and a leg having a first end integrated with and extending from the body member. A head cavity is in the leg portion to hold a head. A channel is formed along a longitudinal length of the leg. An elongated rocker assembly includes an elongated lever arm coupled within the channel about a fulcrum and a spring actuation. A projection of the arm projects in a direction of the head cavity. A rocker slide lock has a collar slidably coupled around the body member and having a first position located between the body member and the actuation tab, such that a portion of the collar is under the actuation tab to limit pivotal motion of the rocker assembly, and a second position having a clearance from under the actuation tab.

Abstract: A system comprising surgical instruments of different types. Each surgical instrument includes a body member and a leg having a first end integrated with and a leg portion extending from the body member. The instrument includes a head cavity formed in a free end of the leg. The cavity holds a head. A channel is formed along a portion of a longitudinal length of the leg. The instrument includes an elongated rocker assembly pivotally coupled within the channel, with a spring actuation tab in proximity to the body member. The instrument includes a collar slidably coupled around the body member and having a first position located between the body member and the actuation tab such that a portion of the collar is under the actuation tab to limit pivotal motion of the rocker assembly and a second position of the collar has a clearance from under the actuation tab.

Abstract: A method is provided for making an appendage of a soft surgical tool, including: receiving a set of mechanical constraints for a surgical procedure; calculating a set of articulation states based on the set of mechanical constraints; generating a plurality of print commands for printing an appendage configured to form the set of articulation states based on the calculation; and printing an appendage based on the plurality of print commands. Multiple printed appendages can be formed into an orienting assembly.

Abstract: A thumbstick user input device may include a shaft carried by a housing and having an upper end extending outwardly beyond the housing for manipulation by the user's thumb and a lower end within the housing. Sensors may be carried by the housing to sense shaft movement. A first contact member may be within the housing, and a spring may be between the first contact member and the shaft to urge the first contact member and the shaft apart. A motor may be carried at a bottom of the housing and may have a rotatable output extending upwardly therefrom. A second contact member may be coupled to the rotatable output and in contact with the first contact member to be selectively moveable upward or downward based upon motor rotation to set a spring compression and thereby set a return-to-center bias for the shaft while being manipulated by the user's thumb.

Abstract: The present invention relates to a system and methods generally aimed at monitoring the angular orientation between two locations within a fluoroscopic image and especially for monitoring the angular orientation between two locations within a fluoroscopic image and a predetermined target angle.

Abstract: A user of a personal computing device may interact with a network-based travel service with respect to one or more travel items. The network-based travel service may monitor the users' interactions, determine user's travel interests, and provide relevant travel item provider devices information for generating user-specific offers. For example, anonymized user statistics, suggested terms for a user-specific offer, or estimated likelihood of acceptance may be provided to the travel item provider. The network-based travel service may receive and evaluate user-specific offers submitted by the travel item provider, cause presentation to corresponding users, and enable the users to accept, decline or propose modifications to the offers.

Abstract: Provided herein are methods and systems for detecting genetic variants from sequencing data. The methods and systems provided herein can be useful for identifying the presence or absence of clinically actionable variants from a sequencing data set and reporting the clinically actionable variants to a user of the methods and systems.

Abstract: Described herein are an apparatus and methods for automating subtasks in surgery and interventional medical procedures. The apparatus consists of a robotic positioning platform, an operating system with automation programs, and end-effector tools to carry out a task under supervised autonomy. The operating system executes an automation program, based on one or a fusion of two or more imaging modalities, guides real-time tracking of mobile and deformable targets in unstructured environment while the end-effector tools execute surgical interventional subtasks that require precision, accuracy, maneuverability and repetition. The apparatus and methods make these medical procedures more efficient and effective allowing a wider access and more standardized outcomes and improved safety.