Abstract: Patient specific instruments, systems and methods for maintaining, correcting and/or resurfacing joint surfaces. A tibia alignment guide including a body with a first surface and a second surface, a base portion coupled to and extending away from the first surface of the body, and a tower portion coupled to and extending away from a top surface of the body.

Abstract: A panel assembly for a mobility vehicle is introduced, in which when the external plate is joined to the vehicle body frame, a bent portion is accommodated on and joined to the vehicle body frame, and a fixed state is maintained by a fastening method or a fitting method when the external plate is joined to the vehicle body frame so that a robust fixed state is maintained. Even though the specifications of a vehicle body frame are changed, some of a plurality of parts, which forms an external plate, may be changed and applied to the changed vehicle body frame, which makes it possible to flexibly cope with the specifications of various mobility vehicles.

Abstract: A vehicular air conditioning system includes: a refrigerant circulation line including first and second evaporators through which refrigerant can flow in a cooling mode, and first and second expansion valves configured to depressurize and expand the refrigerant introduced into each of the first and second evaporators; and refrigerant flow control part provided in front of the first evaporator and the first expansion valve and configured to control refrigerant flow. The first evaporator is used for cooling rear seat region of a passenger room and the refrigerant flow control part is configured to supply and block the refrigerant with respect to the first evaporator and the first expansion valve and is configured to block the refrigerant when the cooling governed by the first evaporator is controlled in a turn-off mode and supply the refrigerant to the first evaporator and the first expansion valve depending on the on/off condition of the cooling governed by the second evaporator.

Abstract: A marine waste disposal apparatus according to an embodiment of the present invention comprise a satellite image processing unit that receives satellite images to identify and locate marine waste, and generates a map of marine waste, a waste change reasoning unit for receiving at least one or more pieces of information selected from the group consisting of tide, temperature, wind direction/speed, seawater flow, and wave height information to reason changes in the marine waste map, a ship control and management units that control general ships and control waste disposal ships based on marine waste maps.

Abstract: The present invention relates to an integrated cooling module applied to a vehicle cooling system, and more particularly, to an integrated cooling module in which components are integrated with a manifold to eliminate a hose or pipe and reduce a size and weight of the entire cooling system, and the manifold is elongated in a gravitational direction to advantageously store a coolant therein and intensively mount the components, and an internal heat exchanger is provided in the manifold to maximize spatial efficiency.

Abstract: The present disclosure relates to a heteroaryl derivative and uses thereof. The heteroaryl derivative of the present disclosure exhibits excellent inhibitory activity against EGFR and/or HER2, and thus may be usefully employed as a therapeutic agent for EGFR- and/or HER2-related diseases.

Abstract: A toilet seat cleaning apparatus includes: a seat part including a lower surface facing an upper surface of a ceramic toilet bowl and an upper surface provided to enable a user's lower body to be in contact therewith; a cover part covering or opening the upper surface of the seat part; a drain part provided under the seat part and guiding cleaning water flowing outside the outline of the seat part to a discharge hole in the ceramic toilet bowl; and a body part to which one side of the cover part is rotatably coupled. In a state where the cover part is opened, the other side of the seat part protrudes more forward than the other side of the drain part. In a state where the cover part is closed, the other side of the drain part protrudes more forward than the other side of the seat part.

Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: A method of managing a filter apparatus a filter apparatus positionable outside a washing machine and connectable to a drain device of the washing machine to filter water discharged from the washing machine, the method comprising: storing, by a server, information of the washing machine; registering, by the server, the filter apparatus in association with a user account based on receiving a registration request signal to register the filter apparatus; and transmitting, by the server, the information of the washing machine to the filter apparatus based on the filter apparatus being registered in association with the user account.

Abstract: The present invention relates to a novel use of a peptide for inhibiting the functions and expressions of multiple disease biomarkers, and more specifically, to a pharmaceutical composition for treating or preventing inflammation, metabolic diseases or fibrotic diseases, the composition comprising, as an active ingredient, any one or more peptide among peptides which are represented by the amino acid sequences of SEQ ID NOs: 1 to 8, and which, for histone deacetylase 5 (HDAC5), GDF15 and ATF3 which are biomarkers associated with inflammation, metabolic diseases or fibrotic diseases, have the functions of inhibiting HDAC5 phosphorylation, inhibiting the expression of the GDF15 protein and inhibiting the expression of the ATF3 protein.

Abstract: Disclosed herein is a catalyst for an upgrading reaction of biomass pyrolysis oil, a method for preparing the same, and a method for upgrading biomass pyrolysis oil using the same. The catalyst is a composite inorganic oxide, and the composite inorganic oxide includes lanthanum, nickel, titanium, and cerium. When a metal catalyst supported on carbon is used as a catalyst for a first step reaction, by using the catalyst as a catalyst for a second step reaction, the efficiency of the upgrading reaction of bio-oil is increased and a continuous reaction is possible without clogging of a continuous reactor.

Abstract: Provided herein are variant human IL18 proteins including proteins and constructs including such. Various variant IL18 proteins with modifications to reduce heterogeneity and/or reduce affinity/potency and/or improve stability and/or improve production yield are also described. Also provided are IL18-Fc fusion proteins that include an empty-Fc domain and an IL18 protein connected to another Fc domain. Also provided herein are IL18Fc fusion proteins that bind CD3 and a tumor target antigen.

Abstract: Inhaler testing apparatus includes a frame, a rotatable carousel rotatably mounted on said frame and that support tubes each having a closed end and an open end, an inhaler retaining apparatus on said frame that retains an inhaler being tested, and actuating mechanisms on the frame for moving the inhaler retaining apparatus in two directions, for shaking and actuating the inhaler being tested. A control unit controls rotation of the carousel and the actuating mechanisms to move the carousal relative to the inhaler being tested to cause controlled shaking of the inhaler and delivery of material from the inhaler into each tube. Analysis of the material in the tubes constitutes a test of the inhaler.

Abstract: A tower lift includes a rail module extending in a vertical direction, a carriage module configured to be movable along the rail module by a magnetic levitation method, and a brake device configured to move along the rail module integrally with the carriage module, wherein the brake device includes a first brake body and a second brake body, which are configured to selectively come into contact with the rail module to prevent the carriage module from falling, and a link unit configured to connect the first brake body to the second brake body, and the link unit transfers force from one of the first brake body and the second brake body to the other of the first brake body and the second brake body.

Abstract: An apparatus for monitoring sleep quality includes a plurality of sensors, a plurality of actuator modules, a transceiver, and a processor operatively coupled with the plurality of sensor modules, the plurality of actuator modules, and the transceiver. The processor is configured to monitor a sleep session of a user utilizing the apparatus. To monitor the sleep session, the processor is further configured to monitor a sleep state of the user, monitor a sleep stage of the user, and monitor a sleep condition. The processor is further configured to select a sleep facilitating action, control the sleep facilitating action based on the monitoring, and collect data related to the sleep session, and update a sleep history database associated with the user based on the data related to the sleep session.

Abstract: Disclosed is a method of producing lithium sulfide (Li2S) without using hydrogen sulfide (H2S) gas. Particularly, the method of producing lithium sulfide (Li2S) includes preparing a starting material including a metal oxide by subjecting a mixed powder including an inorganic compound containing lithium and oxygen, a metal reducing agent, and sulfur (S) to synthesis reaction using mechanical force, preparing a mixed solution by mixing the starting material and a solvent, and obtaining a lithium sulfide (Li2S) powder by removing the metal oxide from the mixed solution and then performing drying.

Abstract: A percutaneous circulatory support system includes a percutaneous circulatory support device. The device includes a housing, an impeller carried in the housing, and a guidewire insertion aide removably carried in the housing. The guidewire insertion aide lacks a through lumen.

Abstract: The present invention provides: a method for preparing a petcoke-based artificial graphite negative electrode material for a lithium secondary battery, in which low-grade petcoke is used as a raw material, and artificial graphite having a high degree of graphitization is prepared through leaching and acid treatment of pulverized/classified low-grade petcoke in an acidic solution, followed by carbonization and graphitization; an artificial graphite negative electrode material for a lithium secondary battery, prepared thereby; and a lithium secondary battery.

Abstract: A semiconductor device is provided. The semiconductor device includes: a lower structure including a bit line; a cell semiconductor body vertically overlapping the bit line, on the lower structure; a peripheral semiconductor body including a portion disposed on a same level as at least a portion of the cell semiconductor body, on the lower structure; and a peripheral gate on the peripheral semiconductor body, wherein the peripheral semiconductor body includes a lower region having a first width and an upper region having a second width, greater than the first width on the lower region.

Abstract: Control systems and methods for an electrified powertrain of an electrified vehicle include performing, by a main control system, a sequence of first processes based on an initial input including a set of signals indicative of at least one of a driver torque request and expected vehicle behavior and other intermediary inputs to generate a sequence of first outputs and performing, by a secondary monitoring system distinct from the main control system, a sequence of second processes based on the initial input and other intermediary inputs to generate a sequence of second outputs. The secondary monitoring system then attempts to rationalize each first output relative to its respective second output. Based on the rationalization, one of these outputs is used as an intermediary output in the sequence until a rationalized final output is obtained and used to generate control commands for torque actuators of the electrified powertrain.