Abstract: Variants of human PD-1 comprising one or more of amino acid substitutions in residues corresponding to N74, T76 and A132 of SEQ ID NO:1 are described. Also described are structures, obtained using X-ray crystallography, of the human PD-1/PD-L2 complex and mutant PD-1 variants. The structures of human PD-1 described in the present disclosure are useful in drug discovery, including small-molecule drug discovery. Accordingly, methods of using the structures in drug discovery are also described.

Abstract: The description relates to devices that can include first and second portions. A virtual magnetic hinge assembly can rotationally secure the two portions yet a user can separate the device portions as desired. One example can include a first elongate magnetic hinge assembly encapsulated in a first end of the first portion and a second elongate magnetic hinge assembly encapsulated in a first end of the second portion. The first and second elongate magnetic hinge assemblies can bias the first ends together while allowing the first and second portions to be rotated through a range of rotations.

Abstract: Generic adjustable in-ear monitors (IEMs) may suffer from a limited range of resilient ear plugs that may not adequately fit each user, and the user may prefer different ear plugs for different purposes (e.g., the user's interest in secure fitment may be higher when exercising, while the user's interest in comfort may be higher when the user is relaxing). The presently disclosed technology is directed to IEMs that permit a user to adjust without removing and replacing an associated ear plug. Instead, the ear plug is adjustable by the user to achieve a desired fit and may be adjusted repeatedly for different desired fits and/or different users.

Abstract: Method and apparatus are disclosed for vehicle airbags for occupants in rear-facing seats. An example vehicle includes an instrument panel, a rear-facing seat adjacent the instrument panel and including a seatback and a headrest, and an airbag including a lower portion and an upper portion. When undeployed, the airbag is stored in the instrument panel. When the airbag deploys, the lower portion presses onto a back of the seatback and the upper portion presses onto a back of the headrest.

Abstract: A method for processing a substrate includes providing a substrate with a layer including a material selected from a group consisting of silicon (Si), germanium (Ge) and silicon germanium. The method includes depositing a first layer on the layer of the substrate using atomic layer deposition (ALD). The method includes depositing a second layer on the first layer using ALD. Depositing one of the first layer and the second layer includes depositing phosphorus oxide and depositing the other one of the first layer and the second layer includes depositing antimony oxide. The method includes annealing the substrate to drive antimony and phosphorus from the first layer and the second layer into the layer of the substrate to create a junction.

Abstract: The present disclosure provides compositions and methods for treating an auditory disease in a subject in need thereof comprising administering an effective amount of a gel-based precursor that includes an inner ear-specific therapeutic compound directly into the cochlea of the subject.

Abstract: In an example, an overhead payload module is described. The overhead payload module comprises a ceiling assembly, an aisle floor assembly, a first payload assembly attached to the ceiling assembly and the aisle floor assembly to form a first side of the overhead payload module, and a second payload assembly attached to the ceiling assembly and the aisle floor assembly to form a second side of the overhead payload module. The first payload assembly comprises a first payload module and a first overhead stowbin module structurally integrated with the first payload module and having a first stowage area configured to receive stowbins. The second payload assembly is positioned opposite the first payload assembly to form an aisle therebetween and comprises a second payload module and a second overhead stowbin module structurally integrated with the second payload module and having a second stowage area configured to receive stowbins.

Abstract: In an example, an overhead payload module is described. The overhead payload module comprises a ceiling assembly, an aisle floor assembly, a first payload assembly attached to the ceiling assembly and the aisle floor assembly to form a first side of the overhead payload module, and a second payload assembly attached to the ceiling assembly and the aisle floor assembly to form a second side of the overhead payload module. The first payload assembly comprises a first payload module and a first overhead stowbin module structurally integrated with the first payload module and having a first stowage area configured to receive stowbins. The second payload assembly is positioned opposite the first payload assembly to form an aisle therebetween and comprises a second payload module and a second overhead stowbin module structurally integrated with the second payload module and having a second stowage area configured to receive stowbins.

Abstract: The description relates to computing devices that have one or more displays. One example can manage the display as a unit and identify a change in a condition associated with the display. The example can alter at least one of a location, aspect ratio, or size of the unit based on the condition.

Abstract: A system for automatically adjusting a steering wheel of a vehicle may include a controller configured to generate a control signal for retracting a steering wheel to a collapsed position. The steering wheel may include a first half and a second half, and the system may include an actuator configured to collapse the steering wheel in response to the control signal. The actuator may be configured to fold the first and second halves of the steering wheel in a direction orthogonal to a direction of a longitudinal axis defined by a steering column, and retract the steering wheel along the direction of the longitudinal axis, towards a dashboard.

Abstract: The description relates to hinged devices, such as hinged computing devices and associated input devices. One example can include first and second device portions and a hinge assembly rotatably securing the first portion and the second portion through a range of orientations. This example can also include a wedge-shaped input device extending between a first end having a first thickness and a second end having a second greater thickness. In a closed orientation the first and second portions simultaneously contact the first end and the second end.

Abstract: An electro-optical directional coupler is provided having a substrate and a first and second optical waveguide formed on the substrate, where the second waveguide extends adjacent to and parallel with the first waveguide for at least one interaction length. The interaction length has a first end and a second end such that an optical signal applied only to one of the first and second waveguides couples to the other of the first and second waveguides between the ends. A first electrode is proximate the first and second waveguides and between the ends of the interaction length. A first voltage applied to the first electrode independently tunes a coupling of a TE mode. A second electrode located proximate the first and second waveguides and the first electrode and between the ends of the interaction length. A second voltage applied to the second electrode independently tunes a coupling of a TM mode.

Abstract: An in-vehicle locking safe system comprising a lockbox having one or more walls defining an enclosure, wherein the lockbox is configured with one or more apertures in one or more lockbox walls. The in-vehicle locking safe system further comprises a vehicle structural element including one or more studs configured to be inserted within one or more apertures in one or more lockbox walls, and a fastener component coupled to a portion of the one or more studs at a location inside the enclosure of the lockbox. In some embodiments, the vehicle structural element includes one or more of a vehicle chassis, a slider rail, a slider track, and/or a floor layer.

Abstract: A method for processing a substrate includes providing a substrate with a layer including a material selected from a group consisting of silicon (Si), germanium (Ge) and silicon germanium. The method includes depositing a first layer on the layer of the substrate using atomic layer deposition (ALD). The method includes depositing a second layer on the first layer using ALD. Depositing one of the first layer and the second layer includes depositing phosphorus oxide and depositing the other one of the first layer and the second layer includes depositing antimony oxide. The method includes annealing the substrate to drive antimony and phosphorus from the first layer and the second layer into the layer of the substrate to create a junction.

Abstract: An in-vehicle bed assembly includes a passenger seat having a seat cushion and an extendable leg rest, and a movable ottoman positioned in front of the passenger seat. When the leg rest extends from the passenger seat, the seat cushion, the extended leg rest, and the ottoman form a substantially flat surface for an occupant to lie in a horizontal position.

Abstract: In-pipe leak detection systems and related methods are disclosed for detecting in-pipe leaks while fluid is actively flowing through the pipe. The system can include a sensing element coupled to a membrane that are disposed parallel to or in-line with an axial direction of a fluid flow. The membrane is configured to be drawn into contact with the inner wall in response to a suction force caused by a leak. The leak is detected based on a transient output from the sensing element indicative of a stretch or strain on the membrane. The sensing element and the membrane is coupled to a support structure configured to position the membrane adjacent to an inner wall of a pipe. The support structure can include a mechanism that couples the membrane and the sensing element to the support structure and is configured to help in discriminating between leaks and false detections.