Abstract: This disclosure relates to protease-cleavable IL-2 cytokine prodrugs. In some embodiments, the prodrugs comprise a pharmacokinetic modulator.

Abstract: The present application discloses a previously unknown function of CD24 expressed on a subset of dendritic cells. The invention encompasses regulating CD24 on these cells to regulate erythropoiesis, induce EPO production and levels, increase RBC levels, and to treat, for example, stress-mediated erythropoiesis. The compositions and methods of the invention are useful, for example, in treating anemia.

Abstract: A method for providing user feedback and recommendations regarding the likelihood that a fund transfer transaction will be completed can include receiving a first message and a second message, from an external device, that includes first transaction data and second transaction data for a proposed transaction. The method can further include generating a first assessment and a second assessment, responsive to receiving the first message and the second message and based at least in part on the first transaction data and the second transaction data, of the likelihood that the transaction will be successful if initiated. The method can further include providing user feedback to the external device to indicate the likelihood. Other systems, apparatuses, and methods are also described.

Abstract: In an example, an overhead payload module is described. The overhead payload module comprises a ceiling assembly, an aisle floor assembly, a first payload assembly attached to the ceiling assembly and the aisle floor assembly to form a first side of the overhead payload module, and a second payload assembly attached to the ceiling assembly and the aisle floor assembly to form a second side of the overhead payload module. The first payload assembly comprises a first payload module and a first overhead stowbin module structurally integrated with the first payload module and having a first stowage area configured to receive stowbins. The second payload assembly is positioned opposite the first payload assembly to form an aisle therebetween and comprises a second payload module and a second overhead stowbin module structurally integrated with the second payload module and having a second stowage area configured to receive stowbins.

Abstract: Disclosed herein are emulsions comprising testosterone or related androgens, castor oil, cyclodextrin, Pemulen TR-2, Polyoxyl 40, and other ingredients. The compositions are useful for treating keratoconjunctivitis sicca and meibomian gland disease.

Abstract: An intubation device utilizes a steerable endotracheal tube guide, a novel mechanism to automatically position an endotracheal tube at the laryngeal opening, and a novel system for soft tissue retraction to improve visualization of the laryngeal opening. An ETT is positioned within an overtube having proximal and distal ends and a flexible tip. The distal end houses a feeder mechanism for displacing the endotracheal tube through the overtube. A hood includes a stem, base, and expandable body, and may be affixed to the overtube's distal end. The ETT-containing overtube is precisely positioned at a laryngeal opening via positioning effects of body expansion, activation of a tip director, and/or flexible tip articulation. Unhindered visualization of the laryngeal opening is achieved by the expandable body, pushing the soft tissue outwardly and extensibly. An actuation module controls the feeder mechanism as well as the flexible tip to position flexible tip and endotracheal tube.

Abstract: The present disclosure discussed a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. Because the therapeutic substance is delivery directly to the inner ear the delivery of the therapeutic substance is not subject to limitations on molecule size and inconsistent diffusion rates that are present when therapeutic substances are diffused across the round window membrane.

Abstract: Providing recommendations for first responders can include receiving, using a processor, real time sensor data from a plurality of sensors, correlating, using the processor, the real time sensor data with historical data for a plurality of prior incidents to determine a selected prior incident matching the real time sensor data, and determining a recommended next action from an operating procedure based upon a next action taken for the selected prior incident.

Abstract: A cooling unit has an internal chamber having a linear lighting source (an in-line lighting source) that has a row of light sources. The row of light sources are has at least one visible light section and at least one ultraviolet light section. The visible light sections and the ultraviolet light sections are all aligned in a single line and the visible light section and the ultraviolet light section are alternatingly placed in the line so a visible light section is adjacent to a ultraviolet light section. The visible light section has one or more visible light emitting LEDs and the ultraviolet light section has one or more ultraviolet light emitting LEDs. Each of the visible light emitting LEDs and the ultraviolet light emitting LEDs are all aligned in the line, as well as the visible light sections and the ultraviolet light sections.

Abstract: A seat includes a seatback. The seat includes a seat bottom extending away from the seatback in a seat-forward direction to a front of the seat bottom distal to the seatback. The seat bottom has a top surface defining an occupant-leg area. The seat includes an airbag supported by the seat bottom at the front of the seat bottom and inflatable from an uninflated position to an inflated position. The airbag in the inflated position extends away from the seat bottom in the seat-forward direction and includes an uppermost surface positioned below the occupant-leg area of the seat bottom.

Abstract: A seat includes a seatback. The seat includes a seat bottom extending away from the seatback in a seat-forward direction to a front of the seat bottom distal to the seatback. The seat bottom has a top surface defining an occupant-leg area. The seat includes an airbag supported by the seat bottom at the front of the seat bottom and inflatable from an uninflated position to an inflated position. The airbag in the inflated position extends away from the seat bottom in the seat-forward direction and includes an uppermost surface positioned below the occupant-leg area of the seat bottom.

Abstract: A method creates a virtual ensemble file by receiving, at a central assembler node, recorded performance files from a recording node(s). The recording nodes generate a respective one of the performance files concurrently with playing a backing track and/or nodal metronome signal. Each performance file includes audio and/or visual data. The assembler node generates the ensemble file as a digital output file. Another method creates the ensemble file by receiving input signals inclusive of the backing track and/or metronome signal at the recording node(s), and generating the performance files at the recording node(s) concurrently with playing the backing track and/or metronome signal. The performance files are transmitted to the assembler node. A computer-readable medium or media has instructions for creating the ensemble file, with execution causing a first node to generate the performance files, and a second node to receive the same and generate the ensemble file.

Abstract: A guided implant drill system includes a guided implant drill bit with a cutting cylinder having a cutting diameter corresponding to a selected dental implant anchor and a noncutting guide portion having a diameter corresponding to a selected pilot drill bit, and a corresponding guided implant final drill bit having a noncutting guide cylinder portion and a cutting tip extending therefrom, with final drill bit noncutting cylinder portion and cutting tip diameters matching the guided implant drill bit cutting cylinder, and the final drill bit cutting tip depth matching the guided implant drill bit guide portion depth. A method of use for the guided implant drill system is also provided.

Abstract: A side airbag inflatable between an occupant of a vehicle seat and structure of the vehicle adjacent the vehicle seat. The side airbag includes a first airbag panel for being positioned facing away from the vehicle seat and a second airbag panel for being positioned facing the vehicle seat. The first and second panels define an inflatable volume of the side airbag. A tether assembly includes a first anchor panel attached to a first portion of the first airbag panel, a second anchor panel attached to a second portion of the first airbag panel, and a strap that interconnects the first anchor panel and the second anchor panel. The tether assembly is dimensioned and configured to limit movement of the first and second portions away from each other in response to inflation of the side airbag so that the side airbag assumes a curved shape when inflated.

Abstract: The present invention relates to accessory systems for enhancing the security of restraint system used in a vehicle with a lap seatbelt system. A plurality of straps can placed on the upper surface of a vehicle seat and configured to provide a secure connection between the shoulders of the restraint system and an upper portion of the vehicle seat, the anchoring system securing the torso of the individual to the seat back. An optional plurality of straps are configured to provide a supplemental connection between the anchoring system and a rear portion of the seat, tethering the anchoring system to the vehicle to anchoring structures in the floor of the vehicle or the bottom portion of the seat. The straps can be adjusted to accommodate different heights in wearers, seats backs, and vehicle seats, making the restraint user adjustable for use by different wearers and in different vehicles.

Abstract: The present invention relates to accessory systems for enhancing the security of restraint system used in a vehicle with a lap seatbelt system. A plurality of straps can placed on the upper surface of a vehicle seat and configured to provide a secure connection between the shoulders of the restraint system and an upper portion of the vehicle seat, the anchoring system securing the torso of the individual to the seat back. An optional plurality of straps are configured to provide a supplemental connection between the anchoring system and a rear portion of the seat, tethering the anchoring system to the vehicle to anchoring structures in the floor of the vehicle or the bottom portion of the seat. The straps can be adjusted to accommodate different heights in wearers, seats backs, and vehicle seats, making the restraint user adjustable for use by different wearers and in different vehicles.