Abstract: In some embodiments, a computer-implemented method of matching parties in a set of parties with counter-parties in a set of counter-parties is provided. A computing system receives counter-party preferences from each party in the set of parties. The computing system receives party preferences and indications of available positions from each counter-party in the set of counter-parties. The computing system computes a globally optimal pairing of parties of the set of parties with counter-parties of the set of counter-parties. The computing system stores the globally optimal pairing.

Abstract: The present disclosure relates to pyrrolobenzodiazepine dimer prodrugs and ligand-linker conjugates thereof. The present disclosure also relates to compositions and uses of said prodrugs and conjugates.

Abstract: Provided herein are methods and related compositions and kits for dissolution of platelet clumps formed in collected blood samples. The present methods, compositions and kits are useful for improving blood sample quality and blood assay accuracy in a lab setting, especially in preventing misdiagnosis such as pseudothrombocytopenia or pseudoleukocytosis.

Abstract: A tire damage detection system for a vehicle includes: a tire; at least one sensor disposed in association with the tire to detect a noise signal when the tire rolls on a road surface to move the vehicle, the noise signal having a plurality of frequency peaks in a frequency spectrum of the noise signal; and a processor to monitor target frequency peaks of the frequency spectrum to detect damage of the tire, and to generate an alert signal in response to the detection of the damage of the tire.

Abstract: An Internet of Things (IoT) technique for vehicular traffic management, including an IoT sensor to measure traffic data of vehicular traffic, a traffic analyzer to determine a traffic event based on the traffic data, and an IoT gateway to issue a response based on the traffic event.

Abstract: A tire for a vehicle includes: a tread extending in a circumferential direction about a rotational axis of the tire; and wear indicators disposed in the tread and spaced apart from each other to be arranged in the circumferential direction. A harmonic noise signal caused by the tire when the tire rolls on a road surface to move the vehicle has neighboring first and second frequency peaks in a frequency spectrum of the harmonic noise signal, and the number of the wear indicators is in a range of 16 to 96 to generate, and when the tire rolls to move the vehicle at a speed in a target range, the wear indicators cause an additional frequency peak positioned between the first and second frequency peaks in the frequency spectrum when the tread is worn to reach a wear threshold.

Abstract: The present disclosure provides monoclonal antibodies that bind ?-Synuclein. In certain aspects, the antibodies preferentially bind to ?-Synuclein fibrils over ?-Synuclein monomer. In other aspects, the invention comprises a method of treating ?-Synucleopathic disease in a subject, comprising administering any of the antibodies of the invention to the subject. In yet other aspects, the invention comprises methods of detecting ?-Synuclein fibrils using any of the antibodies of the invention.

Abstract: A method of fabricating a polishing layer of a polishing pad includes successively depositing a plurality of layers with a 3D printer, each layer of the plurality of polishing layers deposited by ejecting a pad material precursor from a nozzle and solidifying the pad material precursor to form a solidified pad material.

Abstract: A magnetic fastener such as for an article of footwear comprises a male fastener portion and a female fastener portion. The male fastener portion is configured to magnetically fasten to the female fastener portion. The female fastener portion defines a recess with an outer periphery that is asymmetric about a center axis of the recess. The male fastener portion fits into the recess when the male fastener portion is in a first orientation relative to the female fastener portion, and interferes with the female fastener portion when the male fastener portion is urged to rotate about the center axis of the recess away from the first orientation.

Abstract: A method of preserving tissue includes loading the tissue with a solution with a cryoprotective agent and susceptor particles; freezing the tissue; thawing the tissue; and after freezing and thawing, further processing the tissue. Further processing may include slicing the tissue or digesting the tissue and recovering isolated cells from the digested tissue. The tissue may include at least a portion of an organ. The tissue may include a whole organ. The loading of the solution may be done via the vasculature of the organ. The tissue may be thawed using inductive heating. The susceptor particles may include nanoparticles.

Abstract: Methods, systems, and media are disclosed for detrending a bioelectric signal. In some embodiments, the disclosed system can include a processor configured to receive the bioelectric signal, identify at least one breakpoint section corresponds to a rapid change of amplitude of the bioelectric signal, smooth an amplitude of the bioelectric signal after the at least one breakpoint section; and reconstruct the bioelectric signal based on the smoothed amplitude of the bioelectric signal and a reset of the breakpoint section to remove extrinsic components caused by a non-biological factor from the bioelectric signal.

Abstract: A method and an apparatus for implementing a buffer cache for a persistent file system in a non-volatile memory is provided. A set of data is maintained in one or more extents in a non-volatile random-access memory (NVRAM) of a computing device. At least one buffer header is allocated in a dynamic random-access memory (DRAM) of the computing device. In response to a read request by a first process executing on the computing device to access one or more first data blocks in a first extent of the one or more extents, the first process is granted direct read access of the first extent in the NVRAM. A reference to the first extent in the NVRAM is stored in a first buffer header. The first buffer header is associated with the first process. The first process uses the first buffer header to directly access the one or more first data blocks in the NVRAM.

Abstract: An electronic device monitors accelerations using a motion sensor. The electronic device determines a current motion state based on the accelerations. The electronic device identifies a plurality of applications that subscribe to a motion state identification service and notifies a subset of the applications of the current motion state, the subset meeting notification criteria associated with the current motion state.

Abstract: The present disclosure provides monoclonal antibodies that bind ?-Synuclein. In certain aspects, the antibodies preferentially bind to ?-Synuclein fibrils over ?-Synuclein monomer. In other aspects, the invention comprises a method of treating ?-Synucleopathic disease in a subject, comprising administering any of the antibodies of the invention to the subject. In yet other aspects, the invention comprises methods of detecting ?-Synuclein fibrils using any of the antibodies of the invention.

Abstract: The present disclosure provides monoclonal antibodies that bind ?-Synuclein. In certain aspects, the antibodies preferentially bind to ?-Synuclein fibrils over ?-Synuclein monomer. In other aspects, the invention comprises a method of treating ?-Synucleopathic disease in a subject, comprising administering any of the antibodies of the invention to the subject. In yet other aspects, the invention comprises methods of detecting ?-Synuclein fibrils using any of the antibodies of the invention.

Abstract: There is disclosed ultrathin film material templating layers that force the morphology of subsequently grown electrically active thin films have been found to increase the performance of small molecule organic photovoltaic (OPV) cells. There is disclosed electron-transporting material, such as hexaazatriphenylene-hexacarbonitrile (HAT-CN) can be used as a templating material that forces donor materials, such as copper phthalocyanine (CuPc) to assume a vertical-standing morphology when deposited onto its surface on an electrode, such as an indium tin oxide (ITO) electrode. It has been shown that for a device with HAT-CN as the templating buffer layer, the fill factor and short circuit current of CuPc:C60 OPVs were both improved compared with cells lacking the HAT-CN template. This is explained by the reduction of the series resistance due to the improved crystallinity of CuPc grown onto the ITO surface.