Patents by Inventor Ingemar Starke

Ingemar Starke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL COMBINATION COMPRISING AN IBAT INHIBITOR AND A BILE ACID BINDER
    Publication number: 20200330545
    Abstract: The present invention relates to a combination comprising a substance with inhibiting effect on the ileal bile acid transport system (IBAT) and at least one other active substance selected from an IBAT inhibitor; an enteroendocrine peptide or enhancer thereof; a dipeptidyl peptidase-IV inhibitor; a biguanidine; an incretin mimetic; a thiazolidinone; a PPAR agonist; a HMG Co-A reductase inhibitor; a bile acid binder; and a TGR5 receptor modulator; wherein the IBAT inhibitor compound and the at least one other active substance are administered simultaneously, sequentially or separately.
    Type: Application
    Filed: December 11, 2019
    Publication date: October 22, 2020
    Inventors: Per-Göran Gillberg, Hans Graffner, Ingemar Starke
  • Benzothia(di)azepine compounds and their use as bile acid modulators
    Patent number: 10793534
    Abstract: The invention relates to 1,5-benzothiazepine and 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: October 6, 2020
    Assignee: Albireo AB
    Inventors: Per-Göran Gillberg, Jan Mattsson, Ingemar Starke, Santosh S. Kulkarni
  • BENZOTHIADIAZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS
    Publication number: 20200247769
    Abstract: The invention relates to 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.
    Type: Application
    Filed: February 28, 2020
    Publication date: August 6, 2020
    Inventors: Per-Göran Gillberg, Jan Mattsson, Ingemar Starke, Santosh S. Kulkarni
  • BENZOTHIAZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS
    Publication number: 20200247768
    Abstract: The invention relates to 1,5-benzothiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.
    Type: Application
    Filed: February 28, 2020
    Publication date: August 6, 2020
    Inventors: Per-Göran Gillberg, Jan Mattsson, Ingemar Starke, Santosh S. Kulkarni
  • IBAT INHIBITORS FOR THE TREATMENT OF LIVER DISEASES
    Publication number: 20200140484
    Abstract: The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising these IBAT inhibitors, a method for treatment of the disorders and a kit comprising the substances or the compositions.
    Type: Application
    Filed: January 8, 2020
    Publication date: May 7, 2020
    Inventors: Per-Göran Gillberg, Hans Graffner, Ingemar Starke
  • BENZOTHIA(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS
    Publication number: 20190367467
    Abstract: The invention relates to 1,5-benzothiazepine and 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.
    Type: Application
    Filed: July 10, 2019
    Publication date: December 5, 2019
    Inventors: Per-Göran Gillberg, Jan Mattsson, Ingemar Starke, Santosh S. Kulkarni
  • IBAT inhibitors for the treatment of liver diseases
    Patent number: 10487111
    Abstract: The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising these IBAT inhibitors, a method for treatment of the disorders and a kit comprising the substances or the compositions.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: November 26, 2019
    Assignee: Albireo AB
    Inventors: Per-Göran Gillberg, Hans Graffner, Ingemar Starke
  • IBAT inhibitors for the treatment of liver diseases
    Patent number: 10221212
    Abstract: The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising these IBAT inhibitors, a method for treatment of the disorders and a kit comprising the substances or the compositions.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: March 5, 2019
    Assignee: Albireo AB
    Inventors: Per-Göran Gillberg, Hans Graffner, Ingemar Starke
  • IBAT INHIBITORS FOR THE TREATMENT OF LIVER DISEASES
    Publication number: 20180362577
    Abstract: The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising these IBAT inhibitors, a method for treatment of the disorders and a kit comprising the substances or the compositions.
    Type: Application
    Filed: May 10, 2018
    Publication date: December 20, 2018
    Inventors: Per-Göran Gillberg, Hans Graffner, Ingemar Starke
  • Diarylmethylidene piperidine derivatives and their use as delta opoid receptor agnists
    Patent number: 10118921
    Abstract: A compound of formula I, for use in pain therapy and a pharmaceutical composition comprising said compound.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: November 6, 2018
    Assignee: PHARMNOVO AB
    Inventors: Bengt Von Mentzer, Ingemar Starke, Peter Brandt
  • IBAT inhibitors for the treatment of liver diseases
    Patent number: 10093697
    Abstract: The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising these IBAT inhibitors, a method for treatment of the disorders and a kit comprising the substances or the compositions.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: October 9, 2018
    Inventors: Per-Göran Gillberg, Hans Graffner, Ingemar Starke
  • IBAT inhibitors for the treatment of liver diseases
    Patent number: 10011633
    Abstract: The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising these IBAT inhibitors, a method for treatment of the disorders and a kit comprising the substances or the compositions.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: July 3, 2018
    Assignee: Albireo AB
    Inventors: Per-Göran Gillberg, Hans Graffner, Ingemar Starke
  • IBAT inhibitors for the treatment of liver diseases
    Patent number: 10000528
    Abstract: The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising these IBAT inhibitors, a method for treatment of the disorders and a kit comprising the substances or the compositions.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: June 19, 2018
    Assignee: Albireo AB
    Inventors: Per-Göran Gillberg, Hans Graffner, Ingemar Starke
  • IBAT INHIBITORS FOR THE TREATMENT OF LIVER DISEASES
    Publication number: 20180162904
    Abstract: The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising these IBAT inhibitors, a method for treatment of the disorders and a kit comprising the substances or the compositions.
    Type: Application
    Filed: February 12, 2018
    Publication date: June 14, 2018
    Inventors: Per-Göran Gillberg, Hans Graffner, Ingemar Starke
  • IBAT INHIBITORS FOR THE TREATMENT OF LIVER DISEASES
    Publication number: 20180030088
    Abstract: The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising these IBAT inhibitors, a method for treatment of the disorders and a kit comprising the substances or the compositions.
    Type: Application
    Filed: October 5, 2017
    Publication date: February 1, 2018
    Inventors: Per-Göran Gillberg, Hans Graffner, Ingemar Starke
  • IBAT INHIBITORS FOR THE TREATMENT OF LIVER DISEASES
    Publication number: 20180030089
    Abstract: The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising these IBAT inhibitors, a method for treatment of the disorders and a kit comprising the substances or the compositions.
    Type: Application
    Filed: October 5, 2017
    Publication date: February 1, 2018
    Inventors: Per-Göran Gillberg, Hans Graffner, Ingemar Starke
  • IBAT INHIBITORS FOR THE TREATMENT OF LIVER DISEASES
    Publication number: 20180022776
    Abstract: The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising these IBAT inhibitors, a method for treatment of the disorders and a kit comprising the substances or the compositions.
    Type: Application
    Filed: October 2, 2017
    Publication date: January 25, 2018
    Inventors: Per-Göran Gillberg, Hans Graffner, Ingemar Starke
  • DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES AND THEIR USE AS DELTA OPOID RECEPTOR AGNISTS
    Publication number: 20170327491
    Abstract: A compound of formula I, for use in pain therapy and a pharmaceutical composition comprising said compound.
    Type: Application
    Filed: December 17, 2015
    Publication date: November 16, 2017
    Inventors: Bengt VON MENTZER, Ingemar STARKE, Peter Brandt
  • IBAT inhibitors for the treatment of liver disease
    Patent number: 9694018
    Abstract: The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising these IBAT inhibitors, a method for treatment of the disorders and a kit comprising the substances or the compositions.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: July 4, 2017
    Assignee: Albireo AB
    Inventors: Per-Göran Gillberg, Hans Graffner, Ingemar Starke
  • IBAT Inhibitors for the Treatment of Liver Disease
    Publication number: 20170182059
    Abstract: The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising these IBAT inhibitors, a method for treatment of the disorders and a kit comprising the substances or the compositions.
    Type: Application
    Filed: September 26, 2016
    Publication date: June 29, 2017
    Inventors: Per-Göran Gillberg, Hans Graffner, Ingemar Starke