Patents by Inventor J. Clarke

J. Clarke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SIMULATION OF HEALTH STATES AND NEED FOR FUTURE MEDICAL SERVICES
    Publication number: 20210210207
    Abstract: Systems and methods are provided for simulating a patient health state by determining one or more relationships within patient data, creating enriched data elements based on the determined relationships, and using a machine learning module to simulate a future health state of the patient and predict a future medical service need.
    Type: Application
    Filed: March 17, 2021
    Publication date: July 8, 2021
    Applicant: hc1.com Inc.
    Inventors: Bradley A. Bostic, Charles J. Clarke, Ryan C. Kennedy, Peter J. Plantes, Charles David Girard, JR.
  • CREATION AND MANAGEMENT OF DIGITAL TWINS OF HEALTHCARE PATIENTS
    Publication number: 20210202098
    Abstract: Systems and methods are provided for creating and using healthcare patients' digital twins based on data related to a patient, and a plurality of patient populations, to monitor and manage healthcare services by forming a digital twin of individual patients based on their health information, where the digital twin of a patient is a digital representation of at least one health state of the patient.
    Type: Application
    Filed: March 17, 2021
    Publication date: July 1, 2021
    Applicant: hc1.com Inc.
    Inventors: Bradley A. Bostic, Charles J. Clarke, Ryan C. Kennedy, Peter J. Plantes, Charles David Girard, JR.
  • DETERMINING AND MODELING THE EFFICACY OF DRUG TREATMENT PLANS
    Publication number: 20210202102
    Abstract: Systems and methods are provided for simulating patient risk using patient data relating to a plurality of patients received from patient data providers, determining relationships among the data, receiving simulation instructions that are indicative of one or more drug treatment plans, and using a machine learning module to simulate the one or more drug treatment plans and evaluate the efficacy of the plans.
    Type: Application
    Filed: March 17, 2021
    Publication date: July 1, 2021
    Applicant: hc1.com Inc.
    Inventors: Bradley A. Bostic, Charles J. Clarke, Ryan C. Kennedy, Peter J. Plantes, Charles David Girard, JR.
  • MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA
    Publication number: 20210199675
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Application
    Filed: March 11, 2021
    Publication date: July 1, 2021
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • DETECTION OF PATIENT MISUSE OF PRESCRIPTION MEDICATION
    Publication number: 20210202106
    Abstract: Systems and methods are provided for detecting a patient's misuse of a controlled medication of a patient using lab test results and patient attributes to generate a usage profile that is used to determine whether the usage profile is indicative of potential misuse of the controlled medication based on one or more features of the usage profile and, in response to determining potential misuse of the controlled medication, transmitting a notification that indicates the potential misuse by the patient.
    Type: Application
    Filed: March 18, 2021
    Publication date: July 1, 2021
    Applicant: hc1.com Inc.
    Inventors: Bradley A. Bostic, Charles J. Clarke, Ryan C. Kennedy, Peter J. Plantes, Charles David Girard, JR.
  • IDENTIFICATION OF MEDICAL CODING INCONSISTENCIES
    Publication number: 20210202100
    Abstract: Systems and methods are provided for using a machine learning device to receive demographic records, diagnosis records, prescription records, and testing records from a plurality of healthcare databases, from a plurality of healthcare providers, to identify inconsistencies in the names and/or codes used by the healthcare providers.
    Type: Application
    Filed: March 17, 2021
    Publication date: July 1, 2021
    Applicant: hc1.com Inc.
    Inventors: Bradley A. Bostic, Charles J. Clarke, Ryan C. Kennedy, Peter J. Plantes, Charles David Girard, JR.
  • DETECTION AND MODELING OF DRUG DISPENSING BEHAVIORS BY HEALTHCARE PROVIDERS
    Publication number: 20210202101
    Abstract: Systems and methods are provided for determining drug dispensing consistency based on using patient data from at least one healthcare provider that includes at least one of drug toxicology data, metabolite data, patient-reported symptoms, and patient prescriptions, computing relationships among the data, transmitting an enriched data set to a machine learning module, and using the machine learning module to analyze the enriched data set to determine if a patient metabolite reported in a toxicology test is consistent with a known patient prescription.
    Type: Application
    Filed: March 17, 2021
    Publication date: July 1, 2021
    Applicant: hc1.com Inc.
    Inventors: Bradley A. Bostic, Charles J. Clarke, Ryan C. Kennedy, Peter J. Plantes, Charles David Girard, JR.
  • IDENTIFYING AND MEASURING PATIENT OVERDOSE RISK
    Publication number: 20210202104
    Abstract: Systems and methods are provided for identifying patient overdose risk using patient data including at least one of drug toxicology data, metabolite data, patient-reported symptoms, patient prescriptions, and patient adverse events, and using a machine learning module to compute a patient drug profile based on the patient data and at least one patient population drug profile and calculating an overdose risk score for a patient within the ingested patient data, wherein the overdose risk score is based at least in part on an association between a patient drug profile and a population drug profile.
    Type: Application
    Filed: March 17, 2021
    Publication date: July 1, 2021
    Applicant: hc1.com Inc.
    Inventors: Bradley A. Bostic, Charles J. Clarke, Ryan C. Kennedy, Peter J. Plantes, Charles David Girard, JR.
  • MODELING AND SIMULATION OF CURRENT AND FUTURE HEALTH STATES
    Publication number: 20210202103
    Abstract: Systems and methods are provided for simulating a patient health state by determining one or more relationships between patient data and historical data, creating enriched data elements based on the determined relationships, and using a machine learning module to compute a current health state for a patient and to simulate a future health state of the patient.
    Type: Application
    Filed: March 17, 2021
    Publication date: July 1, 2021
    Applicant: hc1.com Inc.
    Inventors: Bradley A. Bostic, Charles J. Clarke, Ryan C. Kennedy, Peter J. Plantes, Charles David Girard, JR.
  • MODELING AND PREDICTING INSURANCE REIMBURSEMENT FOR MEDICAL SERVICES
    Publication number: 20210202099
    Abstract: Systems and methods are provided for monitoring insurance billing events using patient data, healthcare services data, insurance reimbursement criteria and insurance reimbursement records to model and calculate an insurance reimbursement score for a future planned health service event using an analytic engine to calculate an insurance reimbursement score for a future planned health service event based at least in part on a comparison to a plurality of calculated insurance reimbursement scores.
    Type: Application
    Filed: March 17, 2021
    Publication date: July 1, 2021
    Applicant: hc1.com Inc.
    Inventors: Bradley A. Bostic, Charles J. Clarke, Ryan C. Kennedy, Peter J. Plantes, Charles David Girard, JR.
  • IDENTIFICATION AND NOTIFICATION OF ABERRANT PRESCRIPTION ACTIVITY
    Publication number: 20210202105
    Abstract: Systems and methods are provided for relationship discovery of physician prescription behavior using patient data received from a plurality of healthcare data providers and physician data from a plurality of physician practices, determining one or more relationships between the patient data and physician data, wherein an enriched data set includes determined relationships with supplemental reference data, and generating an alert based at least in part on an indicator of aberrant prescription activity among the determined one or more relationships within the enriched data set.
    Type: Application
    Filed: March 18, 2021
    Publication date: July 1, 2021
    Applicant: hc1.com Inc.
    Inventors: Bradley A. Bostic, Charles J. Clarke, Ryan C. Kennedy, Peter J. Plantes, Charles David Girard, JR.
  • HEALTHCARE MANAGEMENT USING DIGITAL TWINS
    Publication number: 20210202107
    Abstract: Systems and methods are provided for healthcare data management using a machine learning module to determine patterns related to effects of health behaviors and treatments, forming digital twins of a patient and a population of patients, and presenting the digital twin of said individual patient, the digital twin of said population of patients, and data based on associations among the patient and health data and the patient population health data.
    Type: Application
    Filed: March 18, 2021
    Publication date: July 1, 2021
    Applicant: hc1.com Inc.
    Inventors: Bradley A. Bostic, Charles J. Clarke, Ryan C. Kennedy, Peter J. Plantes, Charles David Girard, JR.
  • Car enzymes and improved production of fatty alcohols
    Patent number: 11034937
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: June 15, 2021
    Assignee: Genomatica, Inc.
    Inventors: Derek L. Greenfield, Elizabeth J. Clarke, Eli S. Groban, Vikranth Arlagadda, Sungwon Lee, Xuezhi Li, Zhihao Hu, Baolong Zhu
  • WEAR-OUT MONITOR DEVICE
    Publication number: 20210088580
    Abstract: The disclosed technology generally relates to integrated circuit devices with wear out monitoring capability. An integrated circuit device includes a wear-out monitor device configured to record an indication of wear-out of a core circuit separated from the wear-out monitor device, wherein the indication is associated with localized diffusion of a diffusant within the wear-out monitor device in response to a wear-out stress that causes the wear-out of the core circuit.
    Type: Application
    Filed: October 2, 2020
    Publication date: March 25, 2021
    Inventors: Edward John Coyne, Alan J. O'Donnell, Shaun Bradley, David Aherne, David Boland, Thomas G. O'Dwyer, Colm Patrick Heffernan, Kevin B. Manning, Mark Forde, David J. Clarke, Michael A. Looby
  • Mass spectrometry assay for congenital adrenal hyperplasia
    Patent number: 10948501
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: March 16, 2021
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • MASS SPECTROMETRY ASSAY FOR ESTROGENIC COMPOUNDS
    Publication number: 20210063418
    Abstract: Methods are provided for detecting the amount of one or more HRT panel analytes (i.e., estrone (E1), estrone sulfate (E1s), 17?-estradiol (E2a), 17?-estradiol (E2b), estradiol sulfate (E2s), estriol (E3), equilin (EQ), 17?-dihydroequilin (EQa), 17?-dihydroequilin (EQb), Equilenin (EN), 17?-dihydroequilenin (ENa), 17?-dihydroequilenin (ENb), and ?8,9-dehydroestrone (dE1)) in a sample by mass spectrometry. The methods generally involve ionizing one or more HRT panel analytes in a sample and quantifying the generated ions to determine the amount of one or more HRT panel analytes in the sample. In methods where amounts of multiple HRT panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Application
    Filed: November 12, 2020
    Publication date: March 4, 2021
    Inventors: Mildred GOLDMAN, Nigel J. CLARKE
  • Methods for detecting vitamin D metabolites by mass spectrometry
    Patent number: 10935558
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally directed to ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: March 2, 2021
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • NOVEL OCCLUSIVE FORMULATIONS
    Publication number: 20210038490
    Abstract: The invention provides a topical o/w emulsion which moisturizes, and protects, repairs or restores the skin lipid barrier of a mammal. The topical o/w emulsion composition comprises: (a) a discontinuous oil phase; (b) a continuous aqueous phase comprising water; (c) a thickening agent; (d) at least one lamellar membrane structure comprising (i) a phospholipid, (ii) a fatty alcohol, and (iii) a fatty acid; and wherein in use the composition has a water vapor transmission rate of less than about 70 g.m?2.hr?1 measured in vitro using the modWVTR test methodology.
    Type: Application
    Filed: May 26, 2020
    Publication date: February 11, 2021
    Inventors: Pallav Arvind BULSARA, Martyn J. CLARKE, Anthony V. RAWLINGS
  • NOVEL METHOD OF USE AND COMPOSITIONS
    Publication number: 20210030638
    Abstract: The present invention is directed to a method for improving the occlusiveness of a topical pharmaceutical or cosmetic formulation in use in a patient in need thereof, comprising adding to the formulation at least 0.1- to about 10% w/w of one or more of a monofatty acid ester of glycerin and/or one or more of a monofatty acid ester of glycol, or mixtures thereof. The present invention is also directed to a method for maintaining skin barrier efficiency of the stratum corneum of a patient in need thereof, comprising applying to the skin of said patient a pharmaceutical or cosmetic formulation containing at least 3% w/w of one or more of a monofatty acid ester of glycerin and/or one or more of a monofatty acid ester of glycol, or mixtures thereof.
    Type: Application
    Filed: May 18, 2020
    Publication date: February 4, 2021
    Inventors: Pallav Arvind BULSARA, Martyn J. CLARKE, Zheng GUO, Bianca PÉREZ, Anthony V. RAWLINGS
  • Battery Charger with Battery State Detection
    Publication number: 20210028511
    Abstract: A battery charger and method is disclosed for detecting when a battery has a low state of health while simultaneously charging or maintaining the battery. A battery charger includes a processor; a non-transitory memory device; a power management device to receive an input power and to output a charging current; a pair of electrical conductors to electrically couple with a battery, and a display electrically coupled to the processor. The display being configured to indicate a bad battery indicator when the battery has a low state of health and whether the battery is good to start.
    Type: Application
    Filed: October 12, 2020
    Publication date: January 28, 2021
    Inventors: Patrick J. Clarke, John S. Whiting