Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.

Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.

Abstract: A flashlight having a housing, a light-end assembly, and a user interface. The light-end assembly, which may be coupled to an end of the housing, may comprise a flexible light component having a proximal end and a distal end. A first plurality of light emitting diodes (LEDs) may be distributed on the first flexible light component between the proximal end and the distal end. The flexible light component may include a flexible, semi-rigid structure to maintain the flexible light component in a desired shape or position.

Abstract: The disclosed technology generally relates to electrical overstress protection devices, and more particularly to electrical overstress monitoring devices for detecting electrical overstress events in semiconductor devices. In one aspect, a device configured to monitor electrical overstress (EOS) events includes a pair of spaced conductive structures configured to electrically arc in response to an EOS event, wherein the spaced conductive structures are formed of a material and have a shape such that arcing causes a detectable change in shape of the spaced conductive structures, and wherein the device is configured such that the change in shape of the spaced conductive structures is detectable to serve as an EOS monitor.

Abstract: Aspects of this disclosure relate to detecting and recording information associated with electrical overstress (EOS) events, such as electrostatic discharge (ESD) events. For example, in one embodiment, an apparatus includes an electrical overstress protection device, a detection circuit configured to detect an occurrence of the EOS event, and a memory configured to store information indicative of the EOS event.

Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.

Abstract: A method and system of ID based content delivery where the selection and transmission of content is facilitated with use of version IDs associated with each available version of each particular piece of content. A relationship may be generated between the available versions in the version IDs to facilitate determining the version ID associated with a version desired for rendering at a particular type of terminal.

Abstract: A battery booster for jumpstarting a vehicle having an external battery. The battery booster may include a processor, a set of terminal connectors, a power supply, and a power-management circuit. The set of terminal connectors may be configured to couple with the external battery or an engine that is electrically coupled with the external battery. The power supply may include a lithium battery configured to supply a starting current to jump start an engine. The external battery may have a first nominal voltage, while the lithium battery may have a second nominal voltage that is greater than the first nominal voltage. The power-management circuit operatively coupled with the at least one processor, wherein the at least one processor is configured to transfer power selectively between the external battery and the power supply. The processor is configured to perform a pre-charge function and/or a back-feed function via the power-management circuit, which may employ a pulse width modulation (PWM) driver.

Abstract: The present disclosure provides methods for determining whether a patient exhibiting cystic fibrosis symptoms, or a patient at risk for cystic fibrosis, will benefit from treatment with one or more anti-cystic fibrosis therapeutic agents. These methods are based on detecting hereditary cystic fibrosis related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device. Kits for use in practicing the methods are also provided.

Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.

Abstract: A method and computing system for prescription drug management program reporting can include receiving laboratory test results corresponding to a patient and being indicative of a toxicology screen of the patient. Controlled substance prescription data for the patient can be retrieved from a prescription drug management program data source and can include prescriptions of controlled substances issued to the patient for a relevant time period. The controlled substance prescription data and the laboratory test results can be analyzed to determine a daily morphine milligram equivalent of the patient for a given time period, an overdose risk score, and a drug consistency assessment. An enhanced toxicology report based on the determined daily morphine milligram equivalent of the patient for the given time period, the overdose risk score, and the drug consistency assessment can be generated output to a requestor computing device.

Abstract: Aspects of this disclosure relate to detecting and recording information associated with electrical overstress (EOS) events, such as electrostatic discharge (ESD) events. For example, in one embodiment, an apparatus includes an electrical overstress protection device, a detection circuit configured to detect an occurrence of the EOS event, and a memory configured to store information indicative of the EOS event.

Abstract: A battery charger and method is disclosed for detecting when a battery has a low state of health while simultaneously charging or maintaining the battery. A battery charger includes a processor; a non-transitory memory device; a power management device to receive an input power and to output a charging current; a pair of electrical conductors to electrically couple with a battery, and a display electrically coupled to the processor. The display being configured to indicate a bad battery indicator when the battery has a low state of health and whether the battery is good to start.

Abstract: A method and system of ID based content delivery where the selection and transmission of content is facilitated with use of version IDs associated with each available version of each particular piece of content. A relationship may be generated between the available versions in the version IDs to facilitate determining the version ID associated with a version desired for rendering at a particular type of terminal.

Abstract: The disclosed technology generally relates to integrated circuit devices with wear out monitoring capability. An integrated circuit device includes a wear-out monitor device configured to record an indication of wear-out of a core circuit separated from the wear-out monitor device, wherein the indication is associated with localized diffusion of a diffusant within the wear-out monitor device in response to a wear-out stress that causes the wear-out of the core circuit.

Abstract: An interconnect device is disclosed for detecting whether an vehicle on-board diagnostics (OBD) data port includes a blocking diode or equivalent, that prevents back feeding of power through the OBD data port. If a diode is detected, the interconnect device alerts the user that the power cannot be back fed through the OBD II port connector. In such a condition, an alternate means is used to preserve the data mentioned above. If a diode is not detected by the interconnect device, the interconnect device displays this fact to the user. The interconnect device includes circuitry for detecting and displaying whether a diode is connected in series with a power pin of the OBD II port connector.

Abstract: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.

Abstract: A battery charger and method is disclosed for detecting when a battery has a low state of health while simultaneously charging or maintaining the battery. A battery charger includes a processor; a non-transitory memory device; a power management device to receive an input power and to output a charging current; a pair of electrical conductors to electrically couple with a battery, and a display electrically coupled to the processor. The display being configured to indicate a bad battery indicator when the battery has a low state of health and whether the battery is good to start.

Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.

Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.