Patents by Inventor J. Collins

J. Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12330036
    Abstract: A system and method for controlling an exercise device are provided herein. The system includes a memory having computer-executable instructions and at least one processor to execute the computer-executable instructions to wirelessly connect the exercise device, receive a training mode, receive at least one variable for determining a power set point, determine the power set point responsive to the training mode and the at least one variable and control a magnetic brake assembly in the exercise device responsive to the power set point.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: June 17, 2025
    Assignee: Wahoo Fitness, LLC
    Inventors: Harold M. Hawkins, III, Michael A. Lyle, Bradley J. Collins
  • Publication number: 20250129394
    Abstract: Provided herein are enzymes, cells, and methods to optimize the production of cannabinoids in micro-organisms.
    Type: Application
    Filed: October 17, 2022
    Publication date: April 24, 2025
    Inventors: Carolyn J. Collins, Diep Minh Ngoc Nguyen, Jun Urano, Nicky Christopher Caiazza, Spiros Kambourakis
  • Publication number: 20250075256
    Abstract: Methods for detecting the presence of a pathogen infection are described. In particular, this document provides a method of detecting target nucleic acids, such as pathogen-specific RNA, in a biological sample obtained from a subject, where the method comprises using one or more toehold switch sensors and an isothermal amplification step to detect the target nucleic acid. Methods specific for detecting and identify the presence of a virus such as Zika virus are also provided.
    Type: Application
    Filed: September 10, 2024
    Publication date: March 6, 2025
    Inventors: Alexander Green, Dana Braff, Melissa Takahashi, Keith Pardee, James J. Collins, Guillaume Lambert, Thomas Ferrante
  • Publication number: 20250043334
    Abstract: In some aspects, the present disclosure provides methods and compositions for isothermal low temperature amplification of target polynucleotides, and detection thereof.
    Type: Application
    Filed: December 7, 2022
    Publication date: February 6, 2025
    Applicant: Massachusetts Institute of Technology
    Inventors: Nicolaas Angenent-Mari, James j. Collins
  • Patent number: 12203069
    Abstract: The present disclosure is related to an engineered nucleic acid encoding a post-poly A signal RNA 3? to a terminator for expression of protein, and/or non-coding RNA. Also provided herein are methods for reducing epigenetic silencing, genetic modification, transcriptional regulation of the engineered nucleic acid described herein.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: January 21, 2025
    Assignee: Massachusetts Institute of Technology
    Inventors: Ron Weiss, James J. Collins, Elvira Vitu, Casper Enghuus, Jeremy Jonathan Gam
  • Patent number: 12116623
    Abstract: Methods for detecting the presence of a pathogen infection are described. In particular, this document provides a method of detecting target nucleic acids, such as pathogen-specific RNA, in a biological sample obtained from a subject, where the method comprises using one or more toehold switch sensors and an isothermal amplification step to detect the target nucleic acid. Methods specific for detecting and identify the presence of a virus such as Zika virus are also provided.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: October 15, 2024
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Alexander Green, Dana Braff, Melissa Takahashi, Keith Pardee, James J. Collins, Guillaume Lambert, Thomas Ferrante
  • Publication number: 20240302455
    Abstract: A platform provides precise thermal regulation of cryogenic electronic circuits. The platform includes a cold distribution plate, cold blades, heaters, and a thermal regulator. The cold distribution plate couples to a cryogenic cooler for cooling the cold distribution plate. The cold blades contact and extend from a periphery of the cold distribution plate. The cold blades support and cool the cryogenic electronic circuits, which include a respective cryogenic electronic circuit disposed on each of the cold blades. The heaters heat the cold blades, with the heaters including a respective heater disposed at each of the cold blades. The thermal regulator controls the heaters to maintain a predetermined temperature at each of the cryogenic electronic circuits.
    Type: Application
    Filed: March 9, 2023
    Publication date: September 12, 2024
    Inventors: James J. Collins, IV, Susan Anne Elizabeth Berggren, Erica L. Daly
  • Publication number: 20240292568
    Abstract: A cryogenic platform includes a motor, a computer processor, and a vacuum chamber with a high temperature stage and a low temperature stage. The motor is attached to a cryocooler. The computer processor is connected via one or more connections through one or more feedthrough ports to one or more electronic devices. The vacuum chamber encloses the high temperature stage and the low temperature stage, where the high temperature stage and low temperature stage are attached to the motor via a temperature stage attachment.
    Type: Application
    Filed: February 27, 2023
    Publication date: August 29, 2024
    Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY
    Inventors: Marcio Calixto de Andrade, Susan A. E. Breggren, Anna Leese de Escobar, James J. Collins, Mark Flemon, Michael O'Brien
  • Publication number: 20240206516
    Abstract: The present disclosure generally relates to sugar reduction in foods and, in some aspects, to enzyme-polymer conjugated particles for food and other applications. Certain aspects of the disclosure are directed to compositions for reducing sugar content and/or producing dietary fiber within food products during or after consumption (e.g., in a subject's gastrointestinal (GI) tract), while maintaining the sweetness and flavor of the sugar in food products upon consumption (e.g., in a subject's mouth). For example, in one set of embodiments, a composition may comprise a particle comprising an enzyme capable of converting a sugar into a relatively non-digestible form (e.g., a polymer), optionally an inhibitor that reversibly inhibits the enzyme from converting the sugar, and optionally an additive capable of associating with the inhibitor. The composition may be used for in situ conversion of sugars upon exposure to an environment condition (e.g., pH and/or temperature) in the GI tract.
    Type: Application
    Filed: June 8, 2022
    Publication date: June 27, 2024
    Applicants: President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Donald E. Ingber, Vaskar Gnyawali, Daneille Harrier, Yan Liu, Evan Minghao Zhao, David A. Weitz, James J. Collins, Adama Marie Sesay, Bobby Tyrell Haney
  • Publication number: 20240155978
    Abstract: Hedge trimmers are provided. A hedge trimmer includes an elongated blade assembly; a housing comprising a base portion rotatably connected to a handle portion; a motor disposed in the housing and operable to actuate the elongated blade assembly; and an actuator disposed on the housing, wherein actuation of the actuator causes the motor to actuate the elongated blade assembly.
    Type: Application
    Filed: November 7, 2023
    Publication date: May 16, 2024
    Inventors: Scott J. Collins, Brian A. Merklein, Eric J. Boticki, Vishvajeet M. Ghorpade, Samuel J. Howard
  • Publication number: 20240067957
    Abstract: Genetic circuits that control transgene expression in response to pre-defined transcriptional cues would enable the development of smart therapeutics. The present disclosure relates to engineered programmable single-transcript RNA sensors in which adenosine deaminases acting on RNA (ADARs) autocatalytically convert trigger hybridization into a translational output. This system amplifies the signal from editing by endogenous ADAR through a positive feedback loop. Amplification is mediated by the expression of a hyperactive, minimal ADAR variant and its recruitment to the edit site via an orthogonal RNA targeting mechanism. This topology confers high dynamic range, low background, minimal off-target effects, and a small genetic footprint. The circuits and systems disclosed herein leverage an ability to detect single nucleotide polymorphisms and modulate translation in response to endogenous transcript levels in mammalian cells.
    Type: Application
    Filed: June 22, 2023
    Publication date: February 29, 2024
    Applicants: Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: James J. Collins, Raphael Gayet, Katherine IIia, Shiva Razavi, Nathaniel Tippens, Kehan Zhang, Jack Chen, Jonathan Chen, Makoto Lalwani
  • Publication number: 20240055092
    Abstract: A system and method of using an intelligent telehealth platform to generate a recommended treatment plan based on daypart feedback to treat a malady of a user. The method includes obtaining a user profile dataset of a user. The user profile dataset includes a plurality of user goals for a plurality of dayparts of a day, each daypart of the plurality of dayparts is respectively associated with one or more user goals of the plurality of user goals. The method includes generating a plurality of treatment plans to treat a malady of the user based on the user dataset and a machine learning model trained to predict cannabis treatment responses, each treatment plan is for using one or more cannabis products during a respective daypart of the plurality of dayparts of the day. The method includes transmitting the plurality of treatment plans to a client device.
    Type: Application
    Filed: August 15, 2022
    Publication date: February 15, 2024
    Inventors: David C. Batista, Stacey Batista, Benjamin P. Caplan, Sean J. Collins, Birch Norton, Kristen P. Parton, Christine R. Pillsbury, Geordie McClelland
  • Publication number: 20240004221
    Abstract: The present disclosure relates to ophthalmic devices such as ophthalmic lenses. An ophthalmic device may comprise an ophthalmic lens for at least one of slowing, retarding or preventing myopia progression. The ophthalmic lens may comprise a center zone with a negative power for myopic vision correction; and at least one treatment zone surrounding the center zone, the at least one treatment zone having a power profile comprising an ADD power, the at least one treatment zone having a surface shape comprising a portion of a generally toroidal shape, wherein the at least one treatment zone is arranged as to form a continuous surface with the center zone.
    Type: Application
    Filed: September 15, 2023
    Publication date: January 4, 2024
    Inventors: Noel A. Brennan, Xu Cheng, Jaclyn V. Hernandez, Michael J. Collins, Brett A. Davis, Fan Yi, Derek Dean Nankivil
  • Patent number: 11788156
    Abstract: The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink RNA, and methods of their use for detecting RNAs in a sample such as a well and in modulating protein synthesis and expression.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: October 17, 2023
    Assignees: President and Fellows of Harvard College, Trustees of Boston University
    Inventors: Alexander A. Green, Peng Yin, James J. Collins, Jongmin Kim
  • Patent number: 11789292
    Abstract: The present disclosure relates to ophthalmic devices such as ophthalmic lenses. An ophthalmic device may comprise an ophthalmic lens for at least one of slowing, retarding or preventing myopia progression. The ophthalmic lens may comprise a center zone with a negative power for myopic vision correction; and at least one treatment zone surrounding the center zone, the at least one treatment zone having a power profile comprising an ADD power, the at least one treatment zone having a surface shape comprising a portion of a generally toroidal shape, wherein the at least one treatment zone is arranged as to form a continuous surface with the center zone.
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: October 17, 2023
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Noel A. Brennan, Xu Cheng, Jaclyn V. Hernandez, Michael J. Collins, Brett A. Davis, Fan Yi, Derek Dean Nankivil
  • Patent number: 11781149
    Abstract: Embodiments disclosed herein provide artificial expression systems comprising multivalent transcription factor complexes for cooperative transcription factor assembly and modulating gene expression. More specifically, engineered synthetic transcription factors are recruited and structurally organized on synthetic gene circuits using molecular clamps, where the strength of intra-complex interactions can be modulated for fine tuning of gene expression as desired.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: October 10, 2023
    Assignee: Trustees of Boston University
    Inventors: Ahmad S. Khalil, Caleb J. Bashor, Nikit Patel, James J. Collins
  • Publication number: 20230313215
    Abstract: Embodiments disclosed herein provide artificial expression systems comprising multivalent transcription factor complexes for cooperative transcription factor assembly and modulating gene expression. More specifically, engineered synthetic transcription factors are recruited and structurally organized on synthetic gene circuits using molecular clamps, where the strength of intra-complex interactions can be modulated for fine tuning of gene expression as desired.
    Type: Application
    Filed: May 31, 2023
    Publication date: October 5, 2023
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Ahmad S. Khalil, Caleb J. Bashor, Nikit Patel, James J. Collins
  • Patent number: 11768386
    Abstract: The present disclosure relates to ophthalmic devices such as ophthalmic lenses. An ophthalmic device may comprise an ophthalmic lens for at least one of slowing, retarding or preventing myopia progression. The ophthalmic lens may comprise a center zone with a negative power for myopic vision correction; and at least one treatment zone surrounding the center zone, the at least one treatment zone having a power profile comprising an ADD power, the at least one treatment zone having a surface shape comprising a portion of a generally toroidal shape, wherein the at least one treatment zone is arranged as to form a continuous surface with the center zone.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: September 26, 2023
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Noel A. Brennan, Xu Cheng, Jaclyn V. Hernandez, Michael J. Collins, Brett A. Davis, Fan Yi, Derek Dean Nankivil
  • Patent number: 11754859
    Abstract: The present disclosure relates to ophthalmic devices such as ophthalmic lenses. An ophthalmic device may comprise an ophthalmic lens for at least one of slowing, retarding or preventing myopia progression. The ophthalmic lens may comprise a center zone with a negative power for myopic vision correction; and at least one treatment zone surrounding the center zone, the at least one treatment zone having a power profile comprising an ADD power, the at least one treatment zone having a surface shape comprising a portion of a generally toroidal shape, wherein the at least one treatment zone is arranged as to form a continuous surface with the center zone.
    Type: Grant
    Filed: July 28, 2022
    Date of Patent: September 12, 2023
    Assignee: Johnson & Johnson Vision Care, Inc
    Inventors: Noel A. Brennan, Xu Cheng, Jaclyn V. Hernandez, Michael J. Collins, Brett A. Davis, Fan Yi, Derek Dean Nankivil
  • Publication number: 20230277489
    Abstract: Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific combinations of aminoglycoside antibiotics and treatment with one or more proton motive force (PMF) stimulating compounds. These novel methods are easily adapted to clinical settings as toxicity and efficacy of the antibiotics and metabolites used have already been studied in vivo, and as dosing for both the antibiotics and metabolites are known.
    Type: Application
    Filed: May 25, 2022
    Publication date: September 7, 2023
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, THE GENERAL HOSPITAL CORPORATION
    Inventors: James J. Collins, Sylvain Meylan, Samuel Moskowitz