Patents by Inventor J. Collins
J. Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11965452Abstract: A method for detecting a contaminant in a vehicle coolant system during service includes contacting a chromophore impregnated strip and a heat transfer fluid sample, where the chromophore impregnated strip includes a complexing agent selected to form a complex with the contaminant that causes a color change in the chromophore impregnated strip and thereby indicates the presence of the contaminant in the heat transfer fluid sample.Type: GrantFiled: January 25, 2023Date of Patent: April 23, 2024Assignee: GM GLOBAL TECHNOLOGY OPERATIONS LLCInventors: Thomas J. Chapaton, Nicholas Paul William Pieczonka, William Reginald Collin, Ratandeep Singh Kukreja
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Publication number: 20240123132Abstract: A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly.Type: ApplicationFiled: December 22, 2023Publication date: April 18, 2024Applicant: DEKA Products Limited PartnershipInventors: Kevin L. Grant, Michael J. Wilt, Brian D. Tracey, Brett A. Rudolf, David E. Collins, Lisa A. Gustin, James D. Dale, Jesse T. Bodwell
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Patent number: 11957570Abstract: An ophthalmic device includes an optic including an optic axis and a closed-loop haptic structure coupled to the optic via a frame surrounding the optic, the closed-loop haptic structure including a closed loop extending from first and second attachment points to the frame. The closed loop includes a first hinge and a second hinge. The first hinge has a first section having a first component extending in a first angular direction, a second section having a second component extending in a second angular direction opposite to the first angular direction, and a first connecting section between the first section and the second section. The second hinge has a third section having a third component extending in the second angular direction, a fourth section having a fourth component extending in the first angular direction, the fourth section being connected to the second section to form the closed loop.Type: GrantFiled: June 18, 2021Date of Patent: April 16, 2024Assignee: Alcon Inc.Inventors: Sung Kyu Lee, Stephen John Collins, Ian Michael Marks, Jonathan David Mccann, Jian Liu, Douglas Brent Wensrich, Stephen J. Van Noy
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Publication number: 20240117073Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.Type: ApplicationFiled: April 26, 2023Publication date: April 11, 2024Inventors: Lloyd J. Old, Terrance Grant Johns, Con Panousis, Andrew M. Scott, Christoph Renner, Gerd Ritter, Achim Jungbluth, Elisabeth Stockert, Vincent Peter Collins, Webster K. Cavenee, Huei-Jen Su Huang, Antony Wilks Burgess, Edouard C. Nice, Anne Murray, George Mark
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Publication number: 20240084345Abstract: Methods for converting mixtures of anthocyanins occurring in fruit or vegetable juice or extract into particular anthocyanin molecules having desirable colorant properties are provided herein. The method of the present disclosure can be employed to increase the amount of particular anthocyanin molecules, while lowering the total number of anthocyanin molecules present in the natural juice and/or extract. The disclosure is also directed to anthocyanin molecules prepared by the methods of present disclosure and to enzymes capable of catalyzing reactions that provide such effects.Type: ApplicationFiled: July 21, 2023Publication date: March 14, 2024Applicants: MARS, INCORPORATED, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Thomas M. Collins, Rebecca J. Robbins, Randall Powers, Justin Siegel, Pamela Ruth Denish, Kathryn Gwendolyn Guggenheim
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Patent number: 11920307Abstract: Provided are tissue webs, and products produced therefrom, that are generally durable, flexible and have improved cross-machine direction (CD) properties, such as CD tensile energy absorption (CD TEA), CD stretch and CD modulus. The inventive tissue products generally comprise multiple tissue plies, such as two or more plies, that have been prepared by through-air drying and more preferably by through-air drying without creping. Moreover, the plies may be produced in a through-air drying process that utilizes a transfer fabric positioned between the forming fabric and the through-air drying fabric where the transfer fabric imparts the nascent web with a high degree of CD strain.Type: GrantFiled: July 20, 2022Date of Patent: March 5, 2024Inventors: Mark W. Sachs, Richard A. Zanon, Lynda E. Collins, Kevin J. Vogt, Christopher L. Satori
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Publication number: 20240067957Abstract: Genetic circuits that control transgene expression in response to pre-defined transcriptional cues would enable the development of smart therapeutics. The present disclosure relates to engineered programmable single-transcript RNA sensors in which adenosine deaminases acting on RNA (ADARs) autocatalytically convert trigger hybridization into a translational output. This system amplifies the signal from editing by endogenous ADAR through a positive feedback loop. Amplification is mediated by the expression of a hyperactive, minimal ADAR variant and its recruitment to the edit site via an orthogonal RNA targeting mechanism. This topology confers high dynamic range, low background, minimal off-target effects, and a small genetic footprint. The circuits and systems disclosed herein leverage an ability to detect single nucleotide polymorphisms and modulate translation in response to endogenous transcript levels in mammalian cells.Type: ApplicationFiled: June 22, 2023Publication date: February 29, 2024Applicants: Massachusetts Institute of Technology, President and Fellows of Harvard CollegeInventors: James J. Collins, Raphael Gayet, Katherine IIia, Shiva Razavi, Nathaniel Tippens, Kehan Zhang, Jack Chen, Jonathan Chen, Makoto Lalwani
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Patent number: 11916613Abstract: The present technology provides solutions that enable accurate measuring of frequency response on a network (e.g., cable network, fiber optic network) through frequency sweep testing. In various embodiments, the present technology provides a remote transmitter test unit that can be physically deployed at various points in a network. The present technology provides for on demand sweep testing. A remote transmitter test unit or headend test unit can periodically transmit a query message and, based on a response to the query message, can initiate a sweep test. The present technology provides for automatic generation of a sweep profile for a sweep test. Based on an analysis of a frequency spectrum on a network, the sweep profile provides parameters for conducting a sweep test. The present technology provides for Orthogonal Frequency-Division Multiplexing (OFDM) table generation and OFDM sweep testing.Type: GrantFiled: January 31, 2022Date of Patent: February 27, 2024Assignee: VeEX Inc.Inventors: Christopher C. Collins, Charles J. Kiss, Jr., Michael Collins, Thomas R. Morley
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Publication number: 20240055092Abstract: A system and method of using an intelligent telehealth platform to generate a recommended treatment plan based on daypart feedback to treat a malady of a user. The method includes obtaining a user profile dataset of a user. The user profile dataset includes a plurality of user goals for a plurality of dayparts of a day, each daypart of the plurality of dayparts is respectively associated with one or more user goals of the plurality of user goals. The method includes generating a plurality of treatment plans to treat a malady of the user based on the user dataset and a machine learning model trained to predict cannabis treatment responses, each treatment plan is for using one or more cannabis products during a respective daypart of the plurality of dayparts of the day. The method includes transmitting the plurality of treatment plans to a client device.Type: ApplicationFiled: August 15, 2022Publication date: February 15, 2024Inventors: David C. Batista, Stacey Batista, Benjamin P. Caplan, Sean J. Collins, Birch Norton, Kristen P. Parton, Christine R. Pillsbury, Geordie McClelland
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Publication number: 20240024383Abstract: Provided herein are compositions and methods comprising engineered microorganisms and their use for locally degrading an antibiotic in the gastrointestinal tract to prevent or limit death of beneficial flora.Type: ApplicationFiled: December 1, 2021Publication date: January 25, 2024Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Andres Fernando CUBILLOS, James J COLLINS
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Publication number: 20240004221Abstract: The present disclosure relates to ophthalmic devices such as ophthalmic lenses. An ophthalmic device may comprise an ophthalmic lens for at least one of slowing, retarding or preventing myopia progression. The ophthalmic lens may comprise a center zone with a negative power for myopic vision correction; and at least one treatment zone surrounding the center zone, the at least one treatment zone having a power profile comprising an ADD power, the at least one treatment zone having a surface shape comprising a portion of a generally toroidal shape, wherein the at least one treatment zone is arranged as to form a continuous surface with the center zone.Type: ApplicationFiled: September 15, 2023Publication date: January 4, 2024Inventors: Noel A. Brennan, Xu Cheng, Jaclyn V. Hernandez, Michael J. Collins, Brett A. Davis, Fan Yi, Derek Dean Nankivil
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Publication number: 20230384114Abstract: A system includes a personal protective equipment (PPE) configured to be worn by an agent. The PPE includes a sensor assembly comprising a radar device configured to generate radar data, a microphone configured to capture speech input from the agent, and an inertial measurement device configured to generate inertial data. The system includes a computing device configured to: process sensor data from the sensor assembly, the sensor data including at least the radar data and the inertial data, to generate pose data of the agent based on the processed sensor data, the pose data including a location and an orientation of the agent as a function of time, to process the speech input to identify an item of interest in an environment in which the PPE is deployed, and to form mapping information for the environment with the item of interest being marked, based on the processed speech input.Type: ApplicationFiled: September 1, 2021Publication date: November 30, 2023Inventors: John M. KRUSE, Elisa J. COLLINS, Nicholas T. GABRIEL, Richard J. SABACINSKI, Darin K, THOMPSON, Adam C. NYLAND, Samuel J. FAHEY
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Patent number: 11788156Abstract: The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink RNA, and methods of their use for detecting RNAs in a sample such as a well and in modulating protein synthesis and expression.Type: GrantFiled: September 16, 2021Date of Patent: October 17, 2023Assignees: President and Fellows of Harvard College, Trustees of Boston UniversityInventors: Alexander A. Green, Peng Yin, James J. Collins, Jongmin Kim
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Patent number: 11789292Abstract: The present disclosure relates to ophthalmic devices such as ophthalmic lenses. An ophthalmic device may comprise an ophthalmic lens for at least one of slowing, retarding or preventing myopia progression. The ophthalmic lens may comprise a center zone with a negative power for myopic vision correction; and at least one treatment zone surrounding the center zone, the at least one treatment zone having a power profile comprising an ADD power, the at least one treatment zone having a surface shape comprising a portion of a generally toroidal shape, wherein the at least one treatment zone is arranged as to form a continuous surface with the center zone.Type: GrantFiled: March 9, 2021Date of Patent: October 17, 2023Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Noel A. Brennan, Xu Cheng, Jaclyn V. Hernandez, Michael J. Collins, Brett A. Davis, Fan Yi, Derek Dean Nankivil
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Patent number: 11781149Abstract: Embodiments disclosed herein provide artificial expression systems comprising multivalent transcription factor complexes for cooperative transcription factor assembly and modulating gene expression. More specifically, engineered synthetic transcription factors are recruited and structurally organized on synthetic gene circuits using molecular clamps, where the strength of intra-complex interactions can be modulated for fine tuning of gene expression as desired.Type: GrantFiled: June 28, 2019Date of Patent: October 10, 2023Assignee: Trustees of Boston UniversityInventors: Ahmad S. Khalil, Caleb J. Bashor, Nikit Patel, James J. Collins
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Publication number: 20230313215Abstract: Embodiments disclosed herein provide artificial expression systems comprising multivalent transcription factor complexes for cooperative transcription factor assembly and modulating gene expression. More specifically, engineered synthetic transcription factors are recruited and structurally organized on synthetic gene circuits using molecular clamps, where the strength of intra-complex interactions can be modulated for fine tuning of gene expression as desired.Type: ApplicationFiled: May 31, 2023Publication date: October 5, 2023Applicant: TRUSTEES OF BOSTON UNIVERSITYInventors: Ahmad S. Khalil, Caleb J. Bashor, Nikit Patel, James J. Collins
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Patent number: 11768386Abstract: The present disclosure relates to ophthalmic devices such as ophthalmic lenses. An ophthalmic device may comprise an ophthalmic lens for at least one of slowing, retarding or preventing myopia progression. The ophthalmic lens may comprise a center zone with a negative power for myopic vision correction; and at least one treatment zone surrounding the center zone, the at least one treatment zone having a power profile comprising an ADD power, the at least one treatment zone having a surface shape comprising a portion of a generally toroidal shape, wherein the at least one treatment zone is arranged as to form a continuous surface with the center zone.Type: GrantFiled: December 23, 2019Date of Patent: September 26, 2023Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Noel A. Brennan, Xu Cheng, Jaclyn V. Hernandez, Michael J. Collins, Brett A. Davis, Fan Yi, Derek Dean Nankivil
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Patent number: 11754859Abstract: The present disclosure relates to ophthalmic devices such as ophthalmic lenses. An ophthalmic device may comprise an ophthalmic lens for at least one of slowing, retarding or preventing myopia progression. The ophthalmic lens may comprise a center zone with a negative power for myopic vision correction; and at least one treatment zone surrounding the center zone, the at least one treatment zone having a power profile comprising an ADD power, the at least one treatment zone having a surface shape comprising a portion of a generally toroidal shape, wherein the at least one treatment zone is arranged as to form a continuous surface with the center zone.Type: GrantFiled: July 28, 2022Date of Patent: September 12, 2023Assignee: Johnson & Johnson Vision Care, IncInventors: Noel A. Brennan, Xu Cheng, Jaclyn V. Hernandez, Michael J. Collins, Brett A. Davis, Fan Yi, Derek Dean Nankivil
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Publication number: 20230277489Abstract: Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific combinations of aminoglycoside antibiotics and treatment with one or more proton motive force (PMF) stimulating compounds. These novel methods are easily adapted to clinical settings as toxicity and efficacy of the antibiotics and metabolites used have already been studied in vivo, and as dosing for both the antibiotics and metabolites are known.Type: ApplicationFiled: May 25, 2022Publication date: September 7, 2023Applicants: TRUSTEES OF BOSTON UNIVERSITY, THE GENERAL HOSPITAL CORPORATIONInventors: James J. Collins, Sylvain Meylan, Samuel Moskowitz
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Publication number: 20230242563Abstract: Various processes for preparing C4 aldoses and/or ketones thereof are described. Various processes are described for preparing C4 aldoses and/or ketones thereof from feed compositions comprising glycolaldehyde. Also, various processes for preparing useful downstream products and intermediates, such as erythritol and erythronic acid, from the C4 aldoses and/or ketones thereof are described.Type: ApplicationFiled: April 30, 2021Publication date: August 3, 2023Inventors: William J. Collins, Josh Terrian, James Brazdil, Kevin Martin