Abstract: The present disclosure relates to ophthalmic devices such as ophthalmic lenses. An ophthalmic device may comprise an ophthalmic lens for at least one of slowing, retarding or preventing myopia progression. The ophthalmic lens may comprise a center zone with a negative power for myopic vision correction; and at least one treatment zone surrounding the center zone, the at least one treatment zone having a power profile comprising an ADD power, the at least one treatment zone having a surface shape comprising a portion of a generally toroidal shape, wherein the at least one treatment zone is arranged as to form a continuous surface with the center zone.

Abstract: Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific combinations of aminoglycoside antibiotics and treatment with one or more proton motive force (PMF) stimulating compounds. These novel methods are easily adapted to clinical settings as toxicity and efficacy of the antibiotics and metabolites used have already been studied in vivo, and as dosing for both the antibiotics and metabolites are known.

Abstract: Various processes for preparing C4 aldoses and/or ketones thereof are described. Various processes are described for preparing C4 aldoses and/or ketones thereof from feed compositions comprising glycolaldehyde. Also, various processes for preparing useful downstream products and intermediates, such as erythritol and erythronic acid, from the C4 aldoses and/or ketones thereof are described.

Abstract: The disclosure describes systems (2) of navigating a hazardous environment (8). The system includes personal protective equipment (PPE) (13) and computing device(s) (32) configured to process sensor data from the PPE (13), generate pose data of an agent (10) based on the processed sensor data, and track the pose data as the agent (10) moves through the hazardous environment (8). The PPE (13) may include an inertial measurement device to generate inertial data and a radar device to generate radar data for detecting a presence or arrangement of objects in a visually obscured environment (8). The PPE (13) may include a thermal image capture device to generate thermal image data for detecting and classifying thermal features of the hazardous environment (8). The PPE (13) may include one or more sensors to detect a fiducial marker (21) in a visually obscured environment (8) for identifying features in the visually obscured environment (8).

Abstract: Various processes for the pyrolysis of carbohydrates to prepare products such as glycolaldehyde are described. Also, various catalysts and processes for preparing catalysts useful for carbohydrate pyrolysis are described.

Abstract: In various embodiments systems and methods for managing a network switch, such as for a VLAN is disclosed. In one example, a method includes responsive to a restart of a port of a network switch, obtaining by the network switch a current policy applied to the port, determining based on a parameter associated with the current policy, to apply a default policy to the port, determining a new policy for the port by: obtaining an identifier for a device associated with the port, obtaining a key based on the identifier, the key associated with a plurality of devices of the same type as the device, and determining the new policy for the port using an association between the key and the new policy stored locally at the network switch, and applying the new policy to the port.

Abstract: Methods for generating multiple orthodontic treatment options for a digital 3D model of teeth in malocclusion. The method generates a plurality of different orthodontic treatment plans for the teeth and displays in a user interface the digital 3D model of teeth in malocclusion with a visual indication of each of the plurality of different orthodontic treatment plans. The visual indication of the treatment plans can be overlaid on the digital 3D model of teeth in malocclusion and possibly include aligners, brackets, or a combination of aligners and brackets. A doctor, technician, or other user can then select one of the treatment plans for a particular patient.

Abstract: The present disclosure provides genetic constructs comprising a recombinant internal ribosome entry site (IRES), which may be used as riboswitches to modulate translation of an operably-mRNA sequence encoding a protein of interest. In other aspects, the disclosure provides recombinant cells, methods, kits and systems that utilize the same, e.g., to provide a platform for modulating the expression of essentially any protein of interest in a eukaryotic cell.

Abstract: Methods for generating stages for a portion of orthodontic aligner treatment for a digital 3D model of teeth in malocclusion. The methods generate a subset of stages of setups among a complete set of stages of setups for aligner treatment of the teeth. The subset of stages can be selected from a complete set of stages, based upon a target intermediate setup, or sequentially generated from one stage to the next in the subset. Aligners for the subset of stages of setups can then be manufactured without having to make a complete set of aligners. A method to generate a setup for the aligner treatment compares the digital 3D model of teeth in malocclusion to a plurality of setups for historical cases of teeth in malocclusion that have undergone aligner treatment.

Abstract: Systems and methods for image recognition are provided. A style-transfer neural network is trained for each real image to obtain a trained style-transfer neural network. The texture or style features of the real images are transferred, via the trained style-transfer neural network, to a target image to generate styled images which are used for training an image-recognition machine learning model (e.g., a neural network). In some cases, the real images are clustered and representative style images are selected from the clusters.

Abstract: This disclosure provides riboregulators specific for particular viruses or for particular human transcription factors. The viral-specific riboregulators may be used to detect the presence of the particular virus, and this may enable diagnosis of an infection. The transcription factor specific riboregulators may be used to detect the presence and/or measure the level of the particular transcription factor, and this may enable diagnosis or prognosis of a particular condition such as cancer.

Abstract: The present disclosure relates to ophthalmic devices such as ophthalmic lenses. An ophthalmic device may comprise an ophthalmic lens for at least one of slowing, retarding or preventing myopia progression. The ophthalmic lens may comprise a center zone with a negative power for myopic vision correction; and at least one treatment zone surrounding the center zone, the at least one treatment zone having a power profile comprising an ADD power, the at least one treatment zone having a surface shape comprising a portion of a generally toroidal shape, wherein the at least one treatment zone is arranged as to form a continuous surface with the center zone.

Abstract: Methods for detecting the presence of a pathogen infection are described. In particular, this document provides a method of detecting target nucleic acids, such as pathogen-specific RNA, in a biological sample obtained from a subject, where the method comprises using one or more toehold switch sensors and an isothermal amplification step to detect the target nucleic acid. Methods specific for detecting and identify the presence of a virus such as Zika virus are also provided.

Abstract: Embodiments of various aspects described herein are directed to assays and devices for detecting a target molecule in a sample. In particular, there is described a lateral assay comprising a plurality of serially oriented capture zones, where each capture zone independently comprises an immobilized competitive molecule on a lateral flow matrix. The immobilized competitive molecule and the analyte competitively bind with a capture agent capable of binding the analyte.

Abstract: This disclosure is generally directed to electrochemical readout of rapid diagnostics related to use of CRISPR effector systems. In one aspect, the disclosure provides a nucleic acid detection system. Generally, the system comprises: (1) a detection CRISPR system comprising an effector protein and one or more guide nucleic acid (gNA) strands designed to bind to corresponding target nucleic acid molecules; (2) an effector strand and (3) an electrode.

Abstract: Provided herein, in some embodiments, are engineered phagemids that comprise at least one synthetic genetic circuit, wherein the at least one synthetic genetic circuit comprises gene sequences encoding at least one non-lytic antimicrobial peptides (AMPs) and/or antibacterial toxin proteins, a stable origin of replication, and a bacteriophage-packaging signal, wherein the engineered phagemid does not comprise some or all gene sequences encoding bacteriophage proteins required for assembly of a bacteriophage particle.

Abstract: Provided herein are systems, methods and compositions for rendering cells or the expression of an effector protein sensitive to a predetermined condition. In one aspect, cells can be rendered dependent upon the presence of an environmental agent, e.g., an exogenous agent, without which the cell will default to expression of a death protein and be killed. In another aspect, cells can be rendered sensitive to the presence of a set of predetermined conditions such that cells will only grow when two or more necessary exogenous agents are supplied, and without either of which, the cells are killed. In this aspect, hybrid transcription factors provide a vast array of possible predetermined conditions.

Abstract: The present disclosure provides compositions (e.g., pyrimidines) and methods capable of potentiating the effects of antimicrobial agents and/or antiviral agents against bacterial infections and/or viral infections, respectively. Methods of sensitizing bacteria to antimicrobial agents and/or antiviral agents, as well as pharmaceutical compositions and therapeutic/prophylactic methods directed at microbial infections and/or viral infections are also provided.

Abstract: Described herein are nucleic acid detection systems, devices, and kits having a CRISPR component comprising an effector protein and a guide RNA, and/or a polynucleotide encoding a guide RNA, that binds or hybridizes to a corresponding target molecule. Also described herein are methods that utilize these nucleic acid systems, devices, and kits.

Abstract: A method for determining a shim profile for assembling a first mating surface of a first part with a second mating surface of a second part includes: obtaining a baseline surface model of the first mating surface; scanning the first mating surface when the first part is in a deviated configuration to generate a scan-based surface model of the first mating surface; deforming the scan-based surface model of the first mating surface relative to the baseline surface model of the first mating surface to generate a first deformed surface model of the first mating surface; deforming the first deformed surface model of the first mating surface relative to a surface model of the second mating surface to generate a second deformed surface model of the first mating surface; and comparing the second deformed surface model of the first mating surface to the surface model of the second mating surface.