Abstract: A method and wearable system and for enhancing human balance and gait and preventing foot injury through neurological stimulation of the foot and the ankle. Subthreshold stimulation for neurosensory enhancement is provided via electrodes or vibrational actuators, or combination thereof, disposed in or on a wearable a platform, such as an insole, sock shoe, removable shoe insert, or applied without the support of a platform, to the skin surface of an individual. Suprathreshold stimulation for therapeutic purposes, such as improving blood flow, is also provided by the vibrational actuators. The actuators and electrodes are driven by bias signals generated by a bias signal generator that is coupled to a controller. The signal generator under the control of the controller is adapted to generate a non-deterministic random signal, a repetitive pattern or series of patterns.

Abstract: Disclosed herein are shelf-stable compositions based on synthetic gene networks and/or cell-free systems that are lyophilized on a solid support. The compositions can be easily transported and stored for a period of time, and activation can be done by simply adding water. Methods of use are also disclosed herein, including, but are not limited to, sensing and a variety of logic functions. The invention permits straightforward, sterile and abiotic distribution of synthetic biology-based technology to clinical settings, food processing and industry, the military and consumer products.

Abstract: An adaptive contention-aware thread scheduler may place software threads for pairs of applications on the same socket of a multi-socket machine for execution in parallel. Initial placements may be based on profile data that characterizes the machine and its behavior when multiple applications execute on the same socket. The profile data may be collected during execution of other applications. It may identify performance counters within the cores of the processor sockets whose values are suitable for predicting whether the performance of a pair of applications will suffer when executed together on the same socket (e.g., values indicative of their demands for particular shared resources). During execution, the scheduler may examine the performance counters (or performance metrics derived therefrom) and determine different placement decisions (e.g., placing an application with high demand for resources of one type together with an application with low demand for those resources).

Abstract: A work item (e.g., a voice call) is received by a resource mapper. A request to match the work item is sent to a plurality of resource nodes (e.g., a plurality of different servers) that each manage one or more separate resources (e.g., a plurality of contact center agents). Each resource node determines a best available resource among their respective one or more separate resources. Each resource node sends a bid for the best available resource to a resource selector. The resource selector selects a best resource from among the bids. Each resource node receives an accept or a reject message for the sent bid. Based on the winning bid, the work item is then routed to the resource for processing. This allows for separate processing resources (e.g., distributed in a network) to manage the processing tasks associated with determining the best resource to match to a work item.

Abstract: Embodiments of the present invention provide a method to temporally isolate data accessed by a computing device so that the data accessed by the computing device is limited to a single set of data. The method includes removing any data that is accessed by the computing device when operating in different modes so that the data is inaccessible by the computing device when operating in the mode. The method also includes switching to the mode after the data associated with the modes different from the mode have been removed. The method also includes operating in the mode based on a plurality of rules associated with the security policy in temporal isolation from any other mode associated with the computing device. The computing device is limited to operating in the mode and is prevented from accessing any data that is distinct from the single set of data of the mode.

Abstract: Lenses are designed using the corneal topography or wavefront measurements of the eye derived by subtracting the optical power of the eye after orthokeratology treatment from the optical power before orthokeratology treatment.

Abstract: Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific combinations of aminoglycoside antibiotics and high, localized concentrations of one or more PMF stimulating compounds. These novel methods are easily adapted to clinical settings as toxicity and efficacy of the antibiotics and metabolites used have already been studied in vivo, and as dosing for both the antibiotics and metabolites are known. These approaches and therapeutic methods are also useful with non-metabolic chemicals that induce proton-motive force in bacteria.

Abstract: A method and wearable system and for enhancing human balance and gait and preventing foot injury through neurological stimulation of the foot and the ankle. Subthreshold stimulation for neurosensory enhancement is provided via electrodes or vibrational actuators, or combination thereof, disposed in or on a wearable a platform, such as an insole, sock shoe, removable shoe insert, or applied without the support of a platform, to the skin surface of an individual. Suprathreshold stimulation for therapeutic purposes, such as improving blood flow, is also provided by the vibrational actuators. The actuators and electrodes are driven by bias signals generated by a bias signal generator that is coupled to a controller. The signal generator under the control of the controller is adapted to generate a non-deterministic random signal, a repetitive pattern or series of patterns.

Abstract: A communication system for workforce management is formed of a system controller managing a plurality of badges associated with workplace devices and employees within the workplace. The controller receives event indicators from the badges. These event indicators are analyzed by the controller to determine whether a task should be created and performed by at least one of the workplace devices and/or at least one of the employees. Task lists and device assignments are dynamically updated in response to current workplace conditions.

Abstract: Lenses are designed using the corneal topography or wavefront measurements of the eye derived by subtracting the optical power of the eye after orthokeratology treatment from the optical power before orthokeratology treatment.

Abstract: Embodiments of the present invention provide a method to temporally isolate data accessed by a computing device so that the data accessed by the computing device is limited to a single set of data. The method includes removing any data that is accessed by the computing device when operating in different modes so that the data is inaccessible by the computing device when operating in the mode. The method also includes switching to the mode after the data associated with the modes different from the mode have been removed. The method also includes operating in the mode based on a plurality of rules associated with the security policy in temporal isolation from any other mode associated with the computing device. The computing device is limited to operating in the mode and is prevented from accessing any data that is distinct from the single set of data of the mode.

Abstract: The present invention provides nucleic acid molecules, DNA constructs, plasmids, and methods for post-transcriptional regulation of gene expression using RNA molecules to both repress and activate translation of an open reading frame. Repression of gene expression is achieved through the presence of a regulatory nucleic acid element (the cis-repressive RNA or crRNA) within the 5? untranslated region (5? UTR) of an mRNA molecule. The nucleic acid element forms a hairpin (stem/loop) structure through complementary base pairing. The hairpin blocks access to the mRNA transcript by the ribosome, thereby preventing translation. In particular, in embodiments of the invention designed to operate in prokaryotic cells, the stem of the hairpin secondary structure sequesters the ribosome binding site (RBS). In embodiments of the invention designed to operate in eukaryotic cells, the stem of the hairpin is positioned upstream of the start codon, anywhere within the 5? UTR of an mRNA.

Abstract: An IOL includes a fluid optic body having a cavity defined by a sidewall, a deformable optical membrane intersecting the sidewall around an anterior circumference of the sidewall, and a posterior optic intersecting the sidewall around a posterior circumference of the sidewall. The posterior optic includes a central protrusion extending anteriorly into the cavity and the deformable optical membrane includes a ring-shaped protrusion extending posteriorly into a space between the sidewall and the central protrusion. A second optic body is spaced apart from the fluid optic body and coupled thereto via a plurality of struts. Axial compression causes the plurality of struts to deform the sidewall in a manner that increases the diameter of the cavity, modifying a curvature of the deformable optical membrane is modified. Contact between the ring-shaped protrusion and the central protrusion defines a maximum modification to the curvature of the deformable optical membrane.

Abstract: A system comprises an interface for enabling a user having a web property to input advertisement information including a web property advertisement, criteria indicating when presentation of the advertisement is desired by the user, a bid for the presentation of the advertisement when the criteria are met, and subsequent modifications to the advertisement information; geographically distributed servers, a plurality of the geographically distributed servers for storing the advertisement information, at least one of the geographically distributed servers for receiving a request for advertisement content from an advertising channel, at least one of the geographically distributed servers for determining whether the request meets the criteria, and at least one of the geographically distributed servers for forwarding the advertisement to the advertising channel in response to the request when the criteria have been met; and a distribution component for propagating the advertisement information to the geographically

Abstract: The present disclosure details a system for processing healthcare claims to detect fraud, waste and abuse (“FWA”) and facilitate automatic claim adjudication. The distributed system comprises a Claim Analysis Network (“CAN”) that analyzes claims based on a cumulative record of claims received from various independent claim sources. The CAN analyzes each claim using a network of analytics engines that individually analyze a claim according to respective rule-sets and algorithms concerning FWA and generate raw scores respectively. The CAN further processes the independent analytics results to generate a normalized, aggregate score for the claim and automatically enhances an electronic claim record with the scores and salient metadata from the analysis. In addition, the CAN algorithmically generates a routing decision facilitating claim payment or further claim investigation, as necessary, and automatically distributes the decision to an appropriate claim adjudication system for final adjudication.

Abstract: A method of measuring NMR response in an NMR instrument includes heating a sample at a heater temperature that is higher than the temperature of the interior of the NMR instrument, positioning the heated sample in the NMR instrument, and measuring the NMR response of the heat sample. Typically, the sample is dry and includes fat. Furthermore, a method of determining an amount of a component of a sample includes positioning a sample in an NMR instrument, applying a sequence of radio-frequency pulses to the sample, measuring the amplitudes of the signals produced by the application of the sequence of radio-frequency pulses, and determining the amount of a component in the sample using the measured amplitudes of the signals. The disclosed methods typically provide accurate analysis of samples in a shorter time period than traditional NMR techniques and solvent-based analysis techniques.

Abstract: Provided herein are methods and compositions for treatment of a microbial infection or a microbial biofilm in a subject or on a surface by administering to the subject or surface determined to have or suspected of having a microbial infection/film an antimicrobial agent in combination with a silver-containing compound (e.g., a silver salt). In some embodiments, a silver-containing compound can increase activity of the antimicrobial agent. In other embodiments, addition of a silver-containing compound to an antimicrobial agent can expand the antimicrobial spectrum of the antimicrobial agent such that the antimicrobial agent originally indicated for treatment of one microbial strain (e.g., Gram-positive microbes) becomes effective for treating additional microbial strains (e.g., Gram-negative microbes). Other aspects relating to methods and compositions for delivering an agent to a microbe by increasing the membrane permeability of the microbe are also provided herein.

Abstract: A method comprises providing a first set of geographically distributed pods for storing account information on a first set of advertisements associated with web properties associated with a first set of geographically distributed users; enabling the first set of users to update the account information on the first set of pods, each user being associated with at least one advertisement and a particular pod that is not the most distant pod from the user; recognizing that the first set of pods cannot satisfy a user demand threshold; coupling an additional pod for storing additional account information on a second set of advertisements for a second set of users; enabling the second set of users to update the additional account information, the additional pod being not the most distant pod from the second set of users; receiving a content request; and identifying a particular advertisement based on the content request.

Abstract: Disclosed herein are multiwell plates suitable for spectrophotometry for low-volume liquid samples. For the multiwell plates, the bottom of at least one well has a layer of porous matrix disposed thereon, or is comprised of a layer of porous matrix. The layer of porous matrix permits a low-volume liquid sample to distribute evenly across the porous matrix. Also disclosed herein are methods of performing a photometric or spectrophotometric measurement on a liquid sample having a small volume, by using a multiwell plate comprising a layer of porous matrix.

Abstract: An instrument system for acid digestion is disclosed. The instrument includes a heating block, a reaction vessel formed of a polymer that is resistant to acid and other chemical attack at temperatures above 150° C. and that has a structure (thickness, etc.) sufficient to withstand pressures above atmospheric, a metal sleeve surrounding the polymeric reaction vessel, and an opening in the block that has a cross-section corresponding to the cross-section of the metal sleeve.