Abstract: Embodiments disclosed herein are directed to a stabilization device (100) configured to engage a subcutaneous medical device, or port (40). The device can include a guide cylinder (120) that aligns with a receiving cup (46) of the port when the port is engaged with a bottom surface (116) of the stabilization device. The guide cylinder can be rotatable between a first position and a second position. The guide cylinder can further include a needle channel (122) extending therethrough. An axis of the needle channel can be offset from the central axis of the guide cylinder. As such rotating the guide cylinder between the first position and the second position can align the needle channel with a different insertion site. The needle channel can align with the receiving cup of the port in both the first position and the second position. Accessing the receiving cup through different insertion sites can mitigate the formation of scar tissue.

Abstract: Embodiments disclosed herein are directed to an access system including a flexible needle configured to negotiate a non-linear pathway to access a subcutaneous port. Optionally, the access system can include a needle guide to facilitate alignment of the needle with the subcutaneous port. The needle can be configured to be flexible enough to have some bending, or deflection capability but also possess sufficient columnar strength to prevent buckling when piercing the skin and entering the port. The flexible needle can be deflected from a central axis to overcome any misalignment with the receiving cup and/or conduit of the port. Once within the port conduit the needle can negotiate the non-linear, or tortuous port conduit pathway, and stream-line the insertion procedure.

Abstract: The invention provides a compound of compound of formula (I): or a salt thereof, wherein R1, n, L, and X have any of the values described herein, as well as compositions and lipid nanoparticles comprising a compound of formula I, and their use for delivering therapeutic agents such as siRNA and mRNA.

Abstract: Various embodiments provide for a filter assembly. The filter assembly includes a filter housing, a filter element, and a cover. The filter housing has a first housing end and a second housing end that define an internal cavity. The filter housing has a housing seal member formed on the second housing end. The filter element is disposed in the internal cavity. The filter element includes a filter media, an endplate, and a filter seal member. The filter media has a first media end and a second media end. The endplate is disposed at the first media end. The filter seal member is formed on the endplate. The filter seal member includes an inner seal portion and an outer seal portion. The filter seal member is configured to engage the housing seal member. The cover secures the engagement of the housing seal member and the filter seal member.

Abstract: A system includes a computing device comprising a memory storing instructions configured to cause a processor to receive: purchase data associated with products purchased by a user, online activity data performed by the user and other users and associated with information pertaining to the products, and vendor information comprising retail sales data, after-market sales data, and product availability associated with the products. The processor determines one or more values of the products based on the purchase data, the online activity data, and the vendor information and whether the purchased products correspond to specialty products based on the purchase data, the online activity data, and the values of the products. The processor may then send a notification to the user comprising an offer for insurance for the products in response to determining the products correspond to specialty products.

Abstract: The disclosure relates to USP30 Inhibitor Compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.

Abstract: A zero turning radius mower park brake system includes a park brake pawl on a transmission which engages a park brake to a pair of independently driven traction wheels. A park brake link may be pivotably mounted to the park brake pawl and connected to a left steering lever and a right steering lever. The park brake link may pivot while moving the park brake pawl forward to a park brake engaged position if only one of the steering levers is moved outward from a neutral traction drive position.

Abstract: A method for locating buried utilities in a utility locator is disclosed. The method may include receiving, at an antenna array for receiving magnetic field signals, a plurality of magnetic field signals at predefined signal frequencies in a predefined frequency suite, generating, in a receiver coupled to an output of the antenna array, a first receiver output signal, generating, in a processing element coupled to the receiver, a first set of data associated with the two or more signal components, and storing, in a non-transitory memory of the locator, the first set of data.

Abstract: A gas turbine engine article includes a silicon-containing ceramic wall that has an external combustion gaspath side and an internal side that borders a cooling air cavity. The external combustion gaspath side has an associated combustion gas flow direction there along. An array of cooling holes extends through the silicon-containing ceramic wall and connects the internal side with the external combustion gaspath side. The cooling holes are oriented to discharge cooling air to the external gaspath side in a direction counter to the combustion gas flow direction.

Abstract: Camera head apparatus, systems, and methods for providing wide angle/panoramic images and/or video of the interior of pipes or other cavities using multiple imaging and illumination modules are disclosed.

Abstract: Compositions which include hop materials infused with exogenous flavorant matrix and methods for infusing hop materials with a flavorant matrix are provided, wherein the method includes emulsifying a flavorant additive into a carrier system to provide a flavorant matrix; and infusing the hop material with the flavorant matrix.

Abstract: A method for hierarchical work scheduling includes consuming a work item at a first scheduling domain having a local scheduler circuit and one or more workgroup processing elements. Consuming the work item produces a set of new work items. Subsequently, the local scheduler circuit distributes at least one new work item of the set of new work items to be executed locally at the first scheduling domain. If the local scheduler circuit of the first scheduling domain determines that the set of new work items includes one or more work items that would overload the first scheduling domain with work if scheduled for local execution, those work items are distributed to the next higher-level scheduler circuit in a scheduling domain hierarchy for redistribution to one or more other scheduling domains.

Abstract: A modular platform electric trench heater is provided. The electric trench heater has a case having a first end and a second end, an electrical heating unit disposed in the case and designed to generate heat and create an upward convection current therethrough, a baffle dividing the case in a longitudinal direction into a first portion and a second portion, wherein the baffle is designed to direct the upward convection current from the first portion of the case to the second portion of the case, and a connecting unit provided in the form of a connecting plate and a plate fixing mechanism that couples the connecting plate to the first end of the case.

Abstract: A nuclear reactor includes a heat exchanger that transfers thermal energy from a primary reactor coolant to a secondary coolant. The heat exchanger is formed with a hot flow channel, a cold flow channel, and a porous layer between the hot flow channel and the cold flow channel. The porous layer may be thermally insulative to reduce the efficiency of thermal energy transfer from the hot flow channel to the cold flow channel. The porous layer may have a control gas passed therethrough that can be tailored to control the thermal energy transfer through the porous layer. The control gas can be tested for leakage within the heat exchanger. The control gas may also be used to sequester fission or activation products.

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

Abstract: This application sets forth techniques for variant testing at scale. In particular, the embodiments set forth provide systems and methods for testing, on a large-scale software application store, visual aspects of one or more variants of representative data associated with an application available through the software application store. According to some embodiments, a method may include using a subset of conversion data associated with a control object and a subset of the conversion data associated with at least one variant object to compute at least one conversion metric for the control object and at least one conversion metric for the at least one variant object. The method may also include generating a performance measurement by applying at least one statistical hypothesis testing function to the at least one conversion metric for the control object and the at least one conversion metric for the at least one variant object.