Abstract: A medical device for removing a material from a hollow anatomical structure is provided. The device may include a shaft member. The device may include an expandable centering element near the distal end of the device. The device may include a macerator element either attached to the shaft or independent and freely moveable from the shaft. The device may include an aspiration lumen in for removal of material. The device may include a drive shaft attached to a motor and used to rotate the macerator element.

Abstract: The present disclosure relates to ionizable lipidoid compounds comprising an anisamide moiety, and lipid nanoparticles (LNPs) comprising the same. In certain embodiments, the LNP selectively binds to at least one sigma receptor. In certain embodiments, the LNP specifically targets a cell of interest (e.g., a cell expressing a sigma receptor, fibroblast, cancer cell, stromal cell, and epithelial cell, inter alia). In another aspect, the present disclosure provides methods for in vivo delivery of therapeutic agents to treat, prevent, and/or ameliorate diseases and/or disorders, including but not limited to fibrosis and cancer.

Abstract: A medical device for removing a material from a hollow anatomical structure is provided. The device may include a shaft member. The device may include an expandable centering element near the distal end of the device. The device may include a macerator element either attached to the shaft or independent and freely moveable from the shaft. Alternatively, the device may include a rotating wire attached to the macerator element. The device may include an aspiration lumen in for removal of material. The device may include a drive shaft attached to a motor and used to rotate the macerator element. The device may be used in combination with a distal occlusion element, which may be either a radially expandable filter or balloon member.

Abstract: Techniques for animatronic design are provided. A plurality of simulated meshes is generated using a physics simulation model, where the plurality of simulated meshes corresponds to a plurality of actuator configurations for an animatronic mechanical design. A machine learning model is trained based on the plurality of simulated meshes and the plurality of actuator configurations. A plurality of predicted meshes is generated for the animatronic mechanical design, using the machine learning model, based on a second plurality of actuator configurations. Virtual animation of the animatronic mechanical design is facilitated based on the plurality of predicted meshes.

Abstract: In one aspect, the present disclosure relates to lipid nanoparticles (LNPs) comprising at least one ionizable lipid, at least one helper lipid, cholesterol, at least one conjugated lipid, and at least one nucleic acid cargo (e.g., at least one mRNA and at least one sgRNA). In another aspect, the present disclosure relates to a method of delivering a cargo to the brain of a subject in need thereof. In another aspect, the present disclosure relates to methods of genome editing a mutated gene sequence associated with a disease or disorder in a subject in need thereof. In another aspect, the present disclosure relates to methods of treating a lysosomal storage disease in a subject in need thereof. In certain embodiments, the LNPs of the present disclosure are administrated in utero and/or intracerebroventricularly. In certain embodiments, the subject is embryonic, fetal, neonatal, or perinatal.

Abstract: Provided herein are systems, methods, and software to manage DNS requests to DNS servers. An exemplary method includes, in response to determining a secure DNS server is unavailable, transmitting DNS requests to a local DNS server and generating one or more connections to addresses returned by the local DNS server in response to the DNS requests. The method also includes caching information about the DNS requests in a cache and, in response to determining the secure DNS server is available, sending the information from the cache to the secure DNS server. The secure DNS server processes the information to determine whether a portion of one or more connections is potentially malicious. In response to the secure DNS server indicating the portion of the one or more connections is malicious, the method includes terminating the portion of the one or more connections.

Abstract: A welding system includes a robot having a movable arm. A robot controller is operatively connected to the robot. A welding torch is attached to the robot. A welding power supply is operatively connected to the torch. A teach pendant is in communication with the robot controller and includes a user interface application configured for programming a plurality of welding points of a welding operation performed by the robot, and is configured for programming a workpiece search for a physical location of a workpiece. The user interface application is further configured to receive input of a search start point that is offset from the physical location of the workpiece, and to display a prompt to calibrate the search. Upon receiving user input to calibrate the search, the physical location of the workpiece is automatically detected and a calibrated indication is displayed confirming that the search is currently calibrated.

Abstract: An embodiment includes a robotic welding system for generating a motion program, having a programmable robot controller of a robot having a computer processor and a computer memory. The programmable robot controller is configured to digitally record, in the computer memory, a plurality of spatial points along an operator path in a 3D space taken by a calibrated tool center point (TCP) of the robot as an operator manually moves a robot arm of the robot along the operator path from a start point to a destination point within the 3D space. The programmable robot controller is also configured to identify and eliminate extraneous spatial points from the plurality of spatial points as digitally recorded, leaving a subset of the plurality of spatial points as digitally recorded, where the extraneous spatial points are a result of extraneous movements of the robot arm by the operator.

Abstract: A medical device for removing a material from a hollow anatomical structure is provided. The device may include a shaft member. The device may include an expandable centering element near the distal end of the device. The device may include a macerator element either attached to the shaft or independent and freely moveable from the shaft. The device may include an aspiration lumen in for removal of material. The device may include a drive shaft attached to a motor and used to rotate the macerator element.

Abstract: In an example, a method for assembly of a modular cable connector includes, at an end effector of a robotic insertion system, holding a cable insert module for insertion into a module slot of a module retainer. Two or more images are captured of the module retainer. Image processing is performed to identify a segmented image region corresponding to the module retainer and a virtual plane parallel to a face of the module retainer. The end effector is moved to an alignment pose determined based, at least in part, on the segmented image region and the virtual plane. The end effector is moved from the alignment pose toward an insertion pose. Upon insertion of the cable insert module into the module slot of the module retainer, the cable insert module is released from the end effector.

Abstract: A cable connector assembly includes a module retainer and a set of two or more cable insert modules sized and shaped for removable retention within two or more module slots of the module retainer. A cable insert module of the set of two or more cable insert modules includes a cable insertion recess sized and shaped for insertion of a cable wire of a cable, a connectivity interface on an opposing face of the cable insert module, and a transmission path between the cable insertion recess and the connectivity interface.

Abstract: An automated apparatus for installing a sleeve on a cable includes a split funnel assembly, a cable feeding mechanism, a robot comprising a robot tool mounting flange and a plurality of robot motors, a sleeve gripper mounted to the robot tool mounting flange, a plurality of heaters, and a computer configured to output commands in accordance with a predetermined computer program. The split funnel assembly includes an actuator and a split funnel comprising a pair of funnel halves which are able to open and close in response to activation of the actuator. Each funnel half comprises a cable guide channel and a funnel extension. While the split funnel is in the funnel closed state, the funnel extensions form a seat for the sleeve and the cable guide channels form a repeatable path for the cable to follow through the funnel. The apparatus further includes a cable centering gripper, a cable clamp assembly, a slug puller assembly, and a ground lead management system.

Abstract: A vehicle controller programming system is provided for enabling a user to program a vehicle controller for a vehicle that is being retrofitted with the vehicle controller. The system comprises a data storage unit for storing a database of a plurality of configurators and a corresponding database of a plurality of vehicle product portfolios. Each configurator and its corresponding portfolio are associated with a specific vehicle specification. The system also comprises a user interface unit for (i) receiving a set of vehicle characteristics that is associated with the vehicle, (ii) selecting one of the configurators and its corresponding portfolio based upon the set of vehicle characteristics, and (iii) creating a job based upon the selected configurator and its corresponding portfolio to enable a user to execute the job to program the vehicle controller.

Abstract: A system, method, and computer program product for registering two or more patient images for change assessment over time. An example aspect is configured to: obtain a new image of an area with an image capture system; obtain a reference image of a similar area; perform pre-processing of the new image and the reference image; perform a coarse alignment of the new image and the reference image; perform a high-resolution estimate; perform a high-resolution alignment; cross-check the at least one-point match to eliminate false matches and confirm correct matches of the high-resolution new image and the high-resolution reference image; perform segmentation of the high-resolution new image and the high-resolution reference image; perform analysis on at least one lesion in the high-resolution new image and the high-resolution reference image; and display a result of the analysis on a validator.