Abstract: This invention provides amine-linked C3-glutarimide Degronimers and Degrons for therapeutic applications as described further herein, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: Presented are ramp lock extractor (RLE) lift tools for disassembling multipart assemblies, methods for making/using such lift tools, and vehicles with multipart assembly modules disassembled by such lift tools. A method of separating first and second component bodies joined together via an adhesive includes aligning an RLE lift tool with an RLE key slot that extends through the first component body. The lift tool includes multiple ramp pins projecting outward from lateral sides of a tool stem. The key slot includes multiple helical ramps located on lateral sides of a through-hole. The lift tool inserts into the key slot until a distal tip of the tool stem abuts the second component body. The lift tool rotates within the key slot to slide the ramp pins along the helical ramps, causing the tool stem's distal tip to press against the second component body and thereby separate the two component bodies.

Abstract: This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.

Abstract: This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: A power tool light product includes a light body including a power tool battery pack receptacle, the power tool battery pack receptacle configured to removably receive a power tool battery pack that is configured to selectively power the power tool light product and at least one of a drill, a saw, a sander, or a concrete tool. The power tool light product also includes a lighting module, the lighting module operably coupled to the power tool battery pack receptacle. The lighting module includes a printed circuit board, an LED on the printed circuit board, and an LED driver on the printed circuit board.

Abstract: This disclosure provides systems and methods for controlling a vehicle. The method comprises receiving data from a set of sensors, wherein the data represents objects or obstacles in an environment of the autonomous vehicle; identifying objects or obstacles from the received data; determining multiple sets of attributes of the objects or obstacles, wherein each set of attributes of the objects or obstacles are determined based on data received by an individual sensor; determining a candidate trajectory for the autonomous vehicle based on the multiple sets of attributes of the objects or obstacles; and controlling the autonomous vehicle according to the candidate trajectory.

Abstract: The invention involves a cabana shed having a folding bar surface. The cabana shed is constructed from lightweight blow molded panels that can be shipped in a knocked down state and assembled on site with minimal tools and strength. The cabana shed includes four walls, a floor, and a roof, all secured together into a robust structure capable of withstanding winds, rain, snow loads, and the like, while maintaining a dry interior. An upward lifting panel is provided in a front wall of the structure. The upward lifting panel provides shade for the bar surface while in a lifted position, and allows patrons to sit at the bar even in the rain. The panel is closable when the bar is in a folded state to allow the shed to be completely enclosed.

Abstract: A tracheal tube include a conformable conduit that forms a respiratory passage to transfer respiratory gases to a patient. A helical inflatable lumen is formed in or on an interior surface of the conformable conduit. Fluid transferred into the helical inflatable lumen causes the inflatable lumen to assume an expanded configuration to expand an outer diameter of the conformable conduit relative to an unexpanded configuration of the helical inflatable lumen. When in the expanded configuration and inserted in a patient, conformable walls of the conformable conduit expand outwards to contact the tracheal walls such that the conformable conduit is self-sizing to a patient's trachea size.

Abstract: This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: Disclosed herein are system, method, and computer program product embodiments for allowing completion of cardless transactions at a kiosk using an encoded identifier for that kiosk. A user of a mobile app may begin a transaction on their mobile device and, upon reaching a stage of the transaction where kiosk access is needed, receive instructions to visit a kiosk and scan the encoded identifier displayed by the kiosk. The scanned encoded identifier may be associated with the transaction, and the mobile app may transmit a request to complete the transaction at the kiosk.

Abstract: Methods for producing a single crystal silicon ingot are disclosed. The ingot is doped with boron using solid-phase boric acid as the source of boron. Boric acid may be used to counter-dope the ingot during ingot growth. Ingot puller apparatus that use a solid-phase dopant are also disclosed. The solid-phase dopant may be disposed in a receptacle that is moved closer to the surface of the melt or a vaporization unit may be used to produce a dopant gas from the solid-phase dopant.

Abstract: Compounds capable of binding to and inhibiting the activity of RAS protein are described herein along with compositions and methods useful for treating RAS protein related diseases such as, for example, cancer.

Abstract: This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: Disclosed herein are system, method, and computer program product embodiments for authenticating a mobile user via an authentication method determined based on a token level associated with the action being completed. An authentication token is created corresponding to the token level and the authentication token is sent to the mobile device. This authentication token may be used to authenticate subsequent actions and engage various services to complete the actions using application programming interfaces. The authentication token stored on the mobile device obviates the need for a user to authenticate multiple times to complete actions requiring a similar token level. The system may authenticate the identity of the mobile user using various authentication methods.

Abstract: The technology relates to methods and systems for recognition of conditions from ventilation data. The methods may include acquiring ventilation data for ventilation of a patient during a time period; generating an image based on the acquired ventilation data; providing, as input into a trained machine learning model, the generated image, wherein the trained machine learning model was trained based on images having a same type as the generated image; and based on output from the trained machine learning model, generating a predicted condition of the patient. The image may be generated by storing ventilatory data as pixel channel values to generate a human-indecipherable image.

Abstract: The present invention relates to beverage compositions comprising natural products, particularly beverage compositions comprising a hibiscus extract and magnesium, and their use, for example, in reducing blood pressure, mitigating the progression of sub-clinical cardiovascular, metabolic and/or cardiovascular disorders, and the like.

Abstract: A method for producing a single crystal silicon ingot includes adding polycrystalline silicon to a crucible disposed within a chamber defined by a housing of an ingot puller apparatus, maintaining the chamber at a first pressure, heating the chamber using radiant heat to melt the polycrystalline silicon and form a silicon melt in the crucible, pulling a single crystal silicon ingot from the silicon melt, channeling a liquid dopant at a second pressure greater than the first pressure into a feed tube positioned in the chamber, vaporizing the liquid dopant into a vaporized dopant by flash evaporation at the first pressure within the feed tube, and directing the vaporized dopant from the feed tube toward a surface of the silicon melt to cause the vaporized dopant to enter the silicon melt as a dopant while pulling the single crystal silicon ingot from the silicon melt.