Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Abstract: System and method are provided where parcels or packages are associated or grouped, into logical group or logical containerization of parcels or packages, without need for physical container, such that parcels or packages can be tracked as a group, for example with a unique group ID. Logical group may be tracked within specified logical zone on conveyor, transported, sorted and/or otherwise processed as unique logical group without need to be contained in physical container. System and method for automated sortation can accumulate set number or set volume of packages, and then process the accumulated set number or volume of packages.

Abstract: Disclosed herein are system, method, and computer program product embodiments for using a third party dynamic QR code on a personal mobile device to complete a transaction at an ATM. The customer may stage a transaction using a mobile application on a mobile device. Upon the staged transaction being authenticated and approved, a machine-readable image may be transmitted to the mobile device. When the customer visits the ATM, the machine-readable image on the mobile device may be captured by the ATM and sent to an application server from the ATM. The application server may associate the ATM with the staged transaction that is staged using the mobile application, and send instructions to the ATM to dispense cash according to the staged transaction.

Abstract: A system and computer-implemented method of identifying multiple mortgage ready properties. The method includes receiving, via one or more processors, information from a customer approved for a mortgage about preferences for a real estate property and accessing, at a memory coupled to one or more processors, a memory storage location to retrieve a plurality of mortgage ready real estate properties meeting one or more of the customer preferences information. The method further includes transmitting, via the one or more processors, the plurality of real estate properties meeting one or more of the customer preferences information to the customer.

Abstract: The present disclosure relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods using such ADCs, and methods for making such ADCs.

Abstract: Disclosed herein are system, method, and computer program product embodiments for creating a personalized visual code for completing a transaction at an Automated Teller Machine (ATM). An embodiment operates by receiving a request to complete a transaction from a mobile application on a user device, pairing the transaction with an ATM, retrieving information unique to the user, generating a personalized visual code based on the information unique to the user, and generating a rule for presenting the personalized visual code on the ATM, the rule including at least one of: i) when the personalized visual code should be presented, ii) how long the personalized visual code is to be presented, or iii) how the personalized visual code should move when presented on the ATM.

Abstract: Systems and methods for controlling an exhalation valve to increase flow resistance during exhalation. An example method includes delivering breathing gases for a first breath; controlling the expiratory valve according to a first closure profile during a first exhalation phase of the first breath; detecting, by the flow sensor, an exhaled gas flow rate during the first exhalation phase; determining that the exhaled gas flow rate during the first exhalation phase is indicative of a collapsed airway during the first exhalation phase; based on determining that the exhaled gas flow rate is indicative of the collapsed airway, setting a second closure profile of the expiratory valve for a second exhalation phase wherein the second closure profile of the expiratory valve increases airflow resistance for the second exhalation phase of a second breath; and controlling the expiratory valve according to the second closure profile during the second exhalation phase.

Abstract: The present disclosure relates generally to medical devices and, more particularly, to a gas mixing system for a medical ventilator. A gas mixer is provided to adjust the oxygen concentration of environmental air for a blower-based ventilator, by adjusting the mix of air upstream of the ventilator and providing the mixed air to the ventilator's environmental air inlet.

Abstract: Methods and systems for dynamically adjusting the compliance of a patient circuit. In an example, the technology relates to a medical ventilation system that includes a dynamic compliance circuit. The dynamic compliance circuit includes an inspiratory tube extending from an inhalation port of a medical ventilator, the inspiratory tube defining an inner lumen for carrying breathing gases from the inhalation port towards a patient; and a compliance adjustment covering coupled to the inspiratory tube, wherein adjustments to the compliance adjustment covering alter an effective compliance of the inspiratory tube. The system may also include a processor; and memory storing instructions that, when executed by the processor, cause the system to perform operations including, based a type of ventilation mode of the ventilator, causing an adjustment to the compliance adjustment covering to alter the effective compliance of the inspiratory tube.

Abstract: An acoustic sensor device including a proximal end connectable to a breathing circuit to receive breathing gases; a distal end connectable to the tracheal tube; a housing, between the proximal end and the distal end, defining a lumen through which the breathing gases flow; an acoustic generator within the housing and positioned to emit acoustic pulses into the lumen; an acoustic receiver within the housing and positioned distally from the acoustic generator; and a first gas property sensor within the housing and positioned proximally from the acoustic receiver, the first gas property comprising at least one of a flow sensor, a pressure sensor, a humidity sensor, or a temperature sensor.

Abstract: A method for producing a silicon ingot by the horizontal magnetic field Czochralski method includes rotating a crucible containing a silicon melt, applying a horizontal magnetic field to the crucible, contacting the silicon melt with a seed crystal, and withdrawing the seed crystal from the silicon melt while rotating the crucible to form a silicon ingot. The crucible has a wettable surface with a cristobalite layer formed thereon.

Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: Systems and methods are provided for coordinating an Unmanned Vehicle (UV) to perform authenticated delivery of goods. A method for coordinating a delivery may include instructing, via a communication network, a user device to collect user preferences on delivery logistics. The method may also include receiving the user preferences from the user device. The method may also include receiving user financial data from a financial service provider server. The method may also include receiving real-time information comprising location information of a UV and a user device. The method may also include authorizing the delivery of the package if an authentication process is satisfied based on the user preferences, the user financial data, and the real-time information. The method may also include transmitting to the UV a command to complete the delivery, if the delivery is authorized. The method may also include transmitting to the UV an abort command, if the delivery is not authorized.

Abstract: Disclosed herein are system, method, and computer program product embodiments for allowing completion of cardless transactions at a kiosk using an encoded identifier for that kiosk. A user of a mobile app may begin a transaction on their mobile device and, upon reaching a stage of the transaction where kiosk access is needed, receive instructions to visit a kiosk and scan the encoded identifier displayed by the kiosk. The scanned encoded identifier may be associated with the transaction, and the mobile app may transmit a request to complete the transaction at the kiosk.

Abstract: An ingot puller for producing a doped single crystal silicon ingot includes a housing defining a chamber, a crucible disposed within the chamber, and a dopant injector attached to and extending into the housing. The chamber is maintained at a first pressure. The dopant injector includes a reservoir for containing a liquid dopant, a feed tube positioned within the chamber and connected to the reservoir, and a vaporization cup positioned within the feed tube and the chamber.

Abstract: The present invention relates to a topical composition comprising a cannabinoid, extracellular matrix component or extracellular matrix fragment, and a pharmaceutically acceptable carrier, excipient, diluent, reagent, or combinations thereof, and use thereof in the treatment skin disorders, muscle pain, and arthritic pain.

Abstract: A construction laser level including a housing, a laser mount disposed in the housing and at least one laser generator on the laser mount. The laser mount includes a plurality of heat dissipating fins.

Abstract: The present disclosure relates generally to medical devices and, more particularly, to a gas mixing system for a medical ventilator. A gas mixer is provided to adjust the oxygen concentration of environmental air for a blower-based ventilator, by adjusting the mix of air upstream of the ventilator and providing the mixed air to the ventilator's environmental air inlet.

Abstract: Patient breathing circuits with a boost-heated extension. In an example, a patient breathing circuit includes an outer conduit having a first end connectable to a patient interface and a second end connectable to a humidifier; an inner conduit positioned within the first conduit, wherein a first lumen is defined within an interior of the inner conduit and a second lumen is defined between an exterior of the inner conduit and an interior of the outer conduit; a first heater wire coupled to the inner conduit; and a boost-heated expiratory extension having a first end extending from the outer conduit and a second end connectable to an expiratory port of a ventilator, wherein the boost-heated expiratory extension includes at least one of a second heater wire or a metallic post for heating gases flowing through the boost-heated expiratory extension.

Abstract: The disclosed technology relates to low-profile humidifiers for humidifying breathing gases from a medical ventilator. In an example, the low-profile humidifier includes a humidifier body that includes a liquid port; a pump in fluid communication with the liquid port; a valve in fluid communication with the pump; a nozzle in fluid communication with the valve; a controller that controls the valve and the pump. The low-profile humidifier also includes a removable flow channel that is removable from the humidifier body. The removable flow channel includes a gas inlet sized for connection to a conduit from a medical ventilator; a gas outlet; a conduit between the gas inlet and the gas outlet; a heated surface within the conduit to vaporize liquid droplets injected by the nozzle; and a through hole to receive the nozzle into the conduit.