Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

Abstract: A refrigerant circuit is disclosed. The refrigerant circuit includes a compressor, a condenser, a first expansion device, an economizer, a second expansion device, and an evaporator fluidly connected. A working fluid flows through the refrigerant circuit. A bypass segment is fluidly connected to the refrigerant circuit. A portion of the working fluid is provided from the refrigerant circuit to the bypass segment from a location in the refrigerant circuit disposed between the condenser and the evaporator with respect to flow of the working fluid. The portion of the working fluid flows through the bypass segment in a flow enabled state and is provided to a location in the refrigerant circuit disposed between the economizer and the evaporator with respect to flow of the working fluid. A vortical flow is induced at the location in the refrigerant circuit disposed between the economizer and the evaporator.

Abstract: Disclosed herein are various systems, methods, and apparatuses for providing a system independent Configuration Management Database identification system. In an implementation, a dynamic identification system correlates records of an originating system with records of an Authoritative Configuration Management Database (CMDB) including a set of one or more identifying rules that define a minimum amount of information in order to generate an identifying signature that serves as a common reference between a record of the originating system with a matching Configuration Item (CI) record of the ACMDB, receiving, from the originating system, information to generate an identifying signature, determining that the generated first identifying signature matches a stored identifying signature, and correlating the first record of the originating system corresponding with the generated first identifying signature with the one of the CI records of the ACMDB corresponding with the matching one of the identifying signatures.

Abstract: Compounds having formula (I) (IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX).

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: A is CR1 or N; B is CR3 or N; D is CR4 or N; L1 is —(CR7R7)m—; L2 is —(CR7R7)n—; and X, Z, R1, R2, R3, R4, R5, and R6 are define herein. Also disclosed are methods of using such compounds as modulators of TNF?, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Abstract: The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK 1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications.

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, (I) are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

Abstract: Compounds having the following formula: or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R2 is a monocyclic heteroaryl group, and R1, R3, R4, R5 and R6 are as defined herein, are useful as kinase modulators, including IRAK-4 inhibition.

Abstract: Compounds having formula (I) (IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX).

Abstract: A mobile exercise apparatus performing physical exercises including lifting, pushing, and pulling is provided. The apparatus includes an exercise device having a planar elongated frame. The apparatus further includes a weight receiving portion configured to house one or more weights, a handle portion configured to enable a user to lift the exercise device while maintaining the position of the one or more weights, and a pulling portion configured to securing a pulling aid, wherein the elongated frame is bent at a curved portion at approximately a 90 degree angle.

Abstract: Disclosed herein are various systems, methods, and apparatuses for providing a system independent Configuration Management Database identification system. In an implementation, a dynamic identification system correlates records of an originating system with records of an Authoritative Configuration Management Database (CMDB) including a set of one or more identifying rules that define a minimum amount of information in order to generate an identifying signature that serves as a common reference between a record of the originating system with a matching Configuration Item (CI) record of the ACMDB, receiving, from the originating system, information to generate an identifying signature, determining that the generated first identifying signature matches a stored identifying signature, and correlating the first record of the originating system corresponding with the generated first identifying signature with the one of the CI records of the ACMDB corresponding with the matching one of the identifying signatures.

Abstract: Compounds having Formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK3 modulation. All the variables defined herein.

Abstract: Compounds having the following formula: or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein X is N or C—R7, are useful as kinase modulators, including IRAK-4 modulation.

Abstract: Disclosed herein are various systems, methods, and apparatuses for providing a system independent Configuration Management Database identification system. In an implementation, a dynamic identification system correlates records of an originating system with records of an Authoritative Configuration Management Database (CMDB) including a set of one or more identifying rules that define a minimum amount of information in order to generate an identifying signature that serves as a common reference between a record of the originating system with a matching Configuration Item (CI) record of the ACMDB, receiving, from the originating system, information to generate an identifying signature, determining that the generated first identifying signature matches a stored identifying signature, and correlating the first record of the originating system corresponding with the generated first identifying signature with the one of the CI records of the ACMDB corresponding with the matching one of the identifying signatures.

Abstract: Compounds having the following formula: or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R2 is a monocyclic heteroaryl group, and R1, R3, R4, R5 and R6 are as defined herein, are useful as kinase modulators, including IRAK-4 inhibition.

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: A is CR1 or N; B is CR3 or N; D is CR4 or N; L1 is —(CR7R7)m—; L2 is —(CR7R7)n—; and X, Z, R1, R2, R3, R4, R5, and R6 are define herein. Also disclosed are methods of using such compounds as modulators of TNF?, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Abstract: Compounds having the following formula: or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R2 is a monocyclic heteroaryl group, and R1, R3, R4, R5 and R6 are as defined herein, are useful as kinase modulators, including IRAK-4 inhibition.

Abstract: A refrigerant circuit is disclosed. The refrigerant circuit includes a compressor, a condenser, a first expansion device, an economizer, a second expansion device, and an evaporator fluidly connected. A working fluid flows through the refrigerant circuit. A bypass segment is fluidly connected to the refrigerant circuit. A portion of the working fluid is provided from the refrigerant circuit to the bypass segment from a location in the refrigerant circuit disposed between the condenser and the evaporator with respect to flow of the working fluid. The portion of the working fluid flows through the bypass segment in a flow enabled state and is provided to a location in the refrigerant circuit disposed between the economizer and the evaporator with respect to flow of the working fluid. A vortical flow is induced at the location in the refrigerant circuit disposed between the economizer and the evaporator.

Abstract: Automatically mapping and importing accounting application data into to a tax preparation application. Account data including an account name is received from an accounting application. A tax category corresponding to the account name is determined automatically, and a tax line assignment or line of a form of the tax preparation application is automatically assigned to the account name such that the corresponding account data can be mapped to and imported into the appropriate section of a tax return. For this purpose, a table or spreadsheet of search terms may be used to correlate an account name selected by a user to a tax category, which is used to determine the appropriate tax line assignment or line of a tax form for that particular account.

Abstract: Compounds having the following formula: or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein X is N or C—R7, are useful as kinase modulators, including IRAK-4 modulation.