Patents by Inventor J. Simons

J. Simons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240069041
    Abstract: The present disclosure provides methods and materials for screening a compound or monitoring a subjects response to a compound or dosing regimen for treating frontotemporal dementia (FTD). Methods and materials for identifying and treating a subject having FTD are also provided.
    Type: Application
    Filed: October 13, 2021
    Publication date: February 29, 2024
    Applicant: Denali Therapeutics Inc.
    Inventors: Giuseppe Astarita, Sarah L. Devos, Gilbert Di Paolo, Meng Fang, Fen Huang, Todd P. Logan, Matthew J. Simon
  • Publication number: 20240058605
    Abstract: Systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache and trigeminal neuralgia and the like. The system comprises a stimulator configured for wireless coupling to a mobile device and comprising a signal generator that generates an electrical impulse and an energy source. The stimulator includes a contact surface configured to contact an outer skin surface of a head of a patient and a user interface for selecting a therapy regimen. The stimulator transmits the electrical impulse transcutaneously through the outer skin surface to a nerve at a target region of the head, wherein the electrical impulse is sufficient to modulate the nerve and modify the medical condition. The system further comprises a software program downloadable onto the mobile device and configured to communicate with the stimulator.
    Type: Application
    Filed: November 1, 2023
    Publication date: February 22, 2024
    Applicant: ElectroCore, Inc.
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Publication number: 20240050733
    Abstract: Systems and methods are provided for delivering energy impulses (and/or fields) to bodily tissues. In certain aspects, the systems and methods are particularly useful for temporarily or permanently improving intelligence, learning capacity, memory retention, recall, mood, alertness and/or sleep efficiency in human beings. In certain embodiments, the methods and devices enhance neurostructural development over a period of time by increasing neurogenesis, neuronal plasticity and/or neural connectivity efficiency, and/or by improving the chemical microenvironment of the evolving neural network. In some embodiments, these enhancements may provide temporary improvement to enable an individual to, for example, accomplish a particular task while under duress, sleep deprivation, stress, anxiety or the like. In other embodiments, these changes permanently enhance the intelligence, emotional stability, and overall brain health of the treated individual.
    Type: Application
    Filed: October 23, 2023
    Publication date: February 15, 2024
    Applicant: ElectroCore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Publication number: 20240042023
    Abstract: Chimeric antigen receptors with an antibody-binding domain are presented that are preferably expressed from a recombinant cell in a therapeutic cell, and particularly in an NK-92 cell or derivative thereof. Notably, such modified cells have multiple modes of cytotoxicity, improved on-target cell killing, decreased off-target cell killing, show significant expression of the recombinant CAR, and/or increased CAR-mediated cytotoxicity.
    Type: Application
    Filed: December 20, 2021
    Publication date: February 8, 2024
    Applicant: ImmunityBio, Inc.
    Inventors: Laurent H. Boissel, Barry J. Simon, Wenjie Hu, Hans G. Klingemann
  • Patent number: 11889837
    Abstract: A portable baking oven has an upper portion and a lower portion that define a baking chamber. A baking chamber opening may be defined entirely by the oven upper portion. The upper portion may pivot away from the lower portion to allow access to the interior of the oven for cleaning. The oven may include a gas-powered infrared bottom burner and a gas-powered curved back burner.
    Type: Grant
    Filed: April 29, 2022
    Date of Patent: February 6, 2024
    Assignee: Halo Products Group, LLC
    Inventors: Paul J. Simon, Michael R. Giebel
  • Patent number: 11894148
    Abstract: Systems and methods are provided for treating an inflammatory or allergic response associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient, provide relief for bronchoconstriction that results in the tightening of airways and the inability to breath without ventilator support and/or lessen the abnormal blot clotting that develops in some patients. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: February 6, 2024
    Inventors: Joseph P. Errico, Bruce J. Simon, Peter Staats, Thomas Errico
  • Patent number: 11865329
    Abstract: Devices, systems and methods are disclosed for treating one or more symptoms of post-traumatic stress disorder (PTSD) in a patient. A method includes positioning a contact surface of a device in contact with an outer skin surface of patient and applying an electrical impulse transcutaneously from the device through the outer skin surface of the patient to a vagus nerve in the patient for about 90 seconds to about 3 minutes. The electrical impulse is sufficient to modify the vagus nerve such that the symptoms of PTSD are reduced. For chronic treatment of PTSD, a stimulation protocol is provided that includes two or more doses administered per day for a period of time sufficient to relieve the symptoms.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: January 9, 2024
    Assignee: ElectroCore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Patent number: 11855915
    Abstract: A base station may generate and transmit a transport stream including a sequence of frames. A frame may include a plurality of partitions, where each partition includes a corresponding set of OFDM symbols. For each partition, the OFDM symbols in that partition may have a corresponding cyclic prefix size and a corresponding FFT size, allowing different partitions to be targeted for different collections of user devices, e.g., user devices having different expected values of maximum delay spread and/or different ranges of mobility. The base station may also dynamically re-configure the sample rate of each frame, allowing further resolution in control of subcarrier spacing. By allowing the cyclic prefixes of different OFDM symbols to have different lengths, it is feasible to construct a frame that confirms to a set payload duration and has arbitrary values of cyclic prefix size per partition and FFT size per partition. The partitions may be multiplexed in time and/or frequency.
    Type: Grant
    Filed: October 7, 2021
    Date of Patent: December 26, 2023
    Assignee: One Media, LLC
    Inventors: Michael J. Simon, Kevin A. Shelby, Mark Earnshaw
  • Patent number: 11850056
    Abstract: Systems and methods for remote therapy and patient monitoring are provided. A method comprises contacting an outer skin surface of a patient with a contact surface of a stimulator and transmitting an electrical impulse from the stimulator transcutaneously through the outer skin surface to a nerve within the patient. Data related to parameters of the electrical impulse applied to the nerve is stored and transmitted to a remote source. The data may include duration of treatment, amplitude of the electrical impulse, compliance with a prescribed therapy regimen or other relevant data related to the therapy. The method may further include collecting patient status data, such as symptoms of a medical condition (e.g., severity of a headache) before, during and/or after stimulation. The patient status data is correlated with the treatment data to monitor compliance and/or the effectiveness of the therapy.
    Type: Grant
    Filed: July 27, 2022
    Date of Patent: December 26, 2023
    Assignee: ElectroCore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Publication number: 20230405319
    Abstract: Devices, systems and methods are provided for treating various symptoms, disorders and medical conditions through noninvasive stimulation of a nerve. A system comprises a stimulator including an electrode configured to contact an outer skin surface of a patient and a user interface for turning the stimulator ON to enable the stimulator to operate. An energy source is coupled to the stimulator to generate an electrical impulse, wherein the stimulator transmits the electrical impulse from the electrode transcutaneously through an outer skin surface of an individual to a selected nerve within the individual. The system further comprises a software application coupled to the stimulator and configured to transmit data to the stimulator. The data may include authorization for the stimulator to transmit the electrical impulse.
    Type: Application
    Filed: June 6, 2023
    Publication date: December 21, 2023
    Applicant: ElectroCore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Publication number: 20230405306
    Abstract: Systems and methods are provided for delivering energy impulses (and/or fields) to bodily tissues. In certain aspects, the systems and methods are particularly useful for temporarily or permanently improving intelligence, learning capacity, memory retention, recall, mood, alertness and/or sleep efficiency in human beings. In certain embodiments, the methods and devices enhance neurostructural development over a period of time by increasing neurogenesis, neuronal plasticity and/or neural connectivity efficiency, and/or by improving the chemical microenvironment of the evolving neural network. In some embodiments, these enhancements may provide temporary improvement to enable an individual to, for example, accomplish a particular task while under duress, sleep deprivation, stress, anxiety or the like. In other embodiments, these changes permanently enhance the intelligence, emotional stability, and overall brain health of the treated individual.
    Type: Application
    Filed: June 20, 2022
    Publication date: December 21, 2023
    Applicant: ElectroCore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Publication number: 20230398352
    Abstract: Devices, systems and methods are disclosed for treating symptoms of a user, such as anxiety, depression and/or epileptic seizures, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A stimulator has a contact surface for contacting an outer skin surface of a patient. The stimulator is configured to wirelessly receive a signal from the software application that includes an electrical stimulation signal comprising at least one electrical impulse sufficient to modulate a nerve within a patient and to ameliorate one or more symptoms in the patient. The stimulator is configured to transmit the electrical impulse through the contact surface and the outer skin surface of the user.
    Type: Application
    Filed: August 15, 2023
    Publication date: December 14, 2023
    Applicant: ElectroCore, Inc.
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Patent number: 11839764
    Abstract: Systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache and trigeminal neuralgia and the like, by noninvasive electrical stimulation of nerves of the head, particularly supraorbital, supratrochlear, infraorbital, and mental nerves in the vicinity of their foramen or notch. The system comprises a stimulator having one or more electrodes that apply electrical impulses transcutaneously through the patient's skin to the targeted nerve. The stimulator may be coupled to a handheld mobile device, such as a smartphone, for receiving a treatment regimen to treat the medical condition. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.
    Type: Grant
    Filed: June 13, 2021
    Date of Patent: December 12, 2023
    Assignee: ElectroCore, Inc.
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Patent number: 11838224
    Abstract: Techniques are disclosed relating to generating and receiving radio frames with multiple portions that have different target geographic areas. A data frame may include a first partition that includes a physical layer encoding of first data to be transmitted in a first geographic area, where the first geographic area is defined by a first threshold distance from the one or more transmitters. The data frame may include a second that includes a physical layer encoding of second data to be transmitted in a second geographic area, where the second geographic area is defined by a second, greater threshold distance from the one or more transmitters.
    Type: Grant
    Filed: December 15, 2022
    Date of Patent: December 5, 2023
    Assignee: ONE MEDIA , LLC
    Inventors: Michael J. Simon, Kevin A. Shelby, Mark Earnshaw
  • Publication number: 20230381313
    Abstract: Cells and cell-based therapeutic compositions and methods are presented in which the cells are CD16+CD57+NK-92MI cells that natively express CD16 and CD57 and that exhibit IL-2 independent growth.
    Type: Application
    Filed: May 10, 2023
    Publication date: November 30, 2023
    Applicant: ImmunityBio, Inc.
    Inventors: Scotty Cadet, Syed Raza Ali, Manju Saxena, Barry J. Simon
  • Publication number: 20230381507
    Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the trigeminal nerve. A system comprises one or more electrodes configured for contacting an outer skin surface of a patient and a stimulator coupled to the one or more electrodes. The stimulator is configured to transmit an electrical impulse from the electrodes through the outer skin surface to a target site within a patient. A software application coupled to the stimulator. The software application may, for example, be downloadable onto a mobile device and may allow the user to transmit data to and from the stimulator and/or control operation of the stimulator.
    Type: Application
    Filed: May 25, 2023
    Publication date: November 30, 2023
    Applicant: ElectroCore, Inc.
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Publication number: 20230381499
    Abstract: Devices, systems and methods are disclosed for electrical stimulation of nerves to treat one or more symptoms in a user. The methods comprise transcutaneously transmitting electrical impulses to the nerve according to a treatment paradigm. The treatment paradigm may include generating and transmitting the electrical impulse as a single dose from about 30 seconds to about 5 minutes. The treatment paradigm may comprise a treatment session of 2 to 4 times within an hour time period and/or as a single dose from 2 to 5 times during a day.
    Type: Application
    Filed: August 1, 2023
    Publication date: November 30, 2023
    Applicant: ElectroCore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico
  • Publication number: 20230358407
    Abstract: A solid pellet fueled apparatus having a duel auger system and multi/high speed auger motor is disclosed. The duel auger may include first and second auger blades mounted on a single auger shaft having blade pitches configured to convey solid fuel in opposite directions towards a central burn pot. Each auger blade may service a separate solid fuel compartment provided in a single hopper. The auger motor may have a high-speed setting that may be selected for solid fuel clean out.
    Type: Application
    Filed: July 17, 2023
    Publication date: November 9, 2023
    Applicant: Halo Products Group, LLC
    Inventors: Paul J. Simon, Michael R. Giebel, Xianjia Fan
  • Publication number: 20230337857
    Abstract: A griddle having a grease management system and independent cooking zones is disclosed. The griddle may have a cooking surface back wall with an opening provided therein for grease removal. A grease drip flange may extend away from the cooking surface at a downward angle at or near the back wall opening. A removable grease receptacle having a pivotable handle, as well as a squeegee element, may be provided below the grease drip flange. The independent cooking zones may be provided by burner assemblies having front and rear burners that provide different levels of heat using a single dual gas control valve.
    Type: Application
    Filed: June 26, 2023
    Publication date: October 26, 2023
    Applicant: Halo Products Group, LLC
    Inventors: Paul J. Simon, Michael R. Giebel
  • Publication number: 20230337156
    Abstract: Disclosed herein are method and apparatus for Advanced Television Systems Committee (ATSC) 3.0 and non-ATSC 3.0 broadcast Direct to Mobile (D2M) co-exist aligned open radio access network (O-RAN). One aspect of this disclosure operates by generating a broadcast frame conforming to a first communications protocol, where the broadcast frame conforming to the first communication protocol includes a slice start (SS) portion. The embodiment further generates a broadcast virtual frame container including the broadcast frame conforming to the first communication protocol and a broadcast frame conforming to a second communication protocol, where the broadcast virtual frame container further includes a virtual frame start (VFS) portion, and transmits the broadcast virtual frame container.
    Type: Application
    Filed: February 3, 2023
    Publication date: October 19, 2023
    Applicant: Sinclair Broadcast Group, Inc.
    Inventors: Michael J. SIMON, Mark A. AITKEN, Louis Herbert LIBIN