Abstract: Transcutaneous electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including nasal or paranasal sinus symptoms that resemble an immune-mediated response (“sinus” headaches). The devices and methods may also be used to treat rhinitis, sinusitis, or rhinosinusitis, irrespective of whether those disorders are co-morbid with a headache. They may also be used to treat other disorders that may be co-morbid with migraine or cluster headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.

Abstract: Devices, systems and methods are provided for treating a disease or disorder in a patient. The methods include positioning a surface of a housing in contact with an outer skin surface of the patient and applying sufficient energy to an energy transmitter within the housing via a power supply to generate an electrical impulse at or near a vagus nerve of the patient. The electrical impulse is sufficient to modulate fibers of the vagus nerve and treat the disease or disorder.

Abstract: A griddle having a grease management system and independent cooking zones is disclosed. The griddle may have a cooking surface back wall with an opening provided therein for grease removal. A grease drip flange may extend away from the cooking surface at a downward angle at or near the back wall opening. A removable grease receptacle having a pivotable handle, as well as a squeegee element, may be provided below the grease drip flange. The independent cooking zones may be provided by burner assemblies having front and rear burners that provide different levels of heat using a single dual gas control valve.

Abstract: A griddle having a grease management system and independent cooking zones is disclosed. The griddle may have a cooking surface back wall with an opening provided therein for grease removal. A grease drip flange may extend away from the cooking surface at a downward angle at or near the back wall opening. A removable grease receptacle having a pivotable handle, as well as a squeegee element, may be provided below the grease drip flange. The independent cooking zones may be provided by burner assemblies having front and rear burners that provide different levels of heat using a single dual gas control valve.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A nerve stimulator is configured for coupling to a mobile device configured to receive a wireless signal, such as a mobile phone. The stimulator is further configured to generate an electrical impulse and to transmit the electrical impulse through one or more electrodes and the outer skin surface of the patient to modulate a nerve within the patient.

Abstract: A pellet fueled apparatus having a continuous spark ignition system and swing-away warming rack is disclosed. The apparatus may include a power supply controller configured to cause a spark generator to create a continuous spark in a gap space between two electrodes for a duration greater than 2 seconds and up to 20 minutes uninterrupted. The apparatus, when embodied as a grill may include a warming rack that swings away from an underlying cooking surface when the grill lid is opened.

Abstract: A solid pellet fueled apparatus having a duel auger system and multi/high speed auger motor is disclosed. The duel auger may include first and second auger blades mounted on a single auger shaft having blade pitches configured to convey solid fuel in opposite directions towards a central burn pot. Each auger blade may service a separate solid fuel compartment provided in a single hopper. The auger motor may have a high-speed setting that may be selected for solid fuel clean out.

Abstract: A pellet fueled apparatus having a continuous spark ignition system and swing-away warming rack is disclosed. The apparatus may include a power supply controller configured to cause a spark generator to create a continuous spark in a gap space between two electrodes for a duration greater than 2 seconds and up to 20 minutes uninterrupted. The apparatus, when embodied as a grill may include a warming rack that swings away from an underlying cooking surface when the grill lid is opened.

Abstract: A solid pellet fueled apparatus having a duel auger system and multi/high speed auger motor is disclosed. The duel auger may include first and second auger blades mounted on a single auger shaft having blade pitches configured to convey solid fuel in opposite directions towards a central burn pot. Each auger blade may service a separate solid fuel compartment provided in a single hopper. The auger motor may have a high-speed setting that may be selected for solid fuel clean out.

Abstract: Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The devices comprise a housing and an energy source for generating an electric current and transmitting the electric current from the electrode through an interface and the outer skin surface of the patient to a selected nerve fiber within the patient as the interface contacts the outer skin surface. The electric current is sufficient to modulate the selected nerve fiber to at least one of treat or prevent at least one of gastroparesis, functional dyspepsia, or ileus in the patient.

Abstract: Cancer is treated using coordinated treatment regimens that uses various compounds and compositions that drive a tumor from the escape phase of cancer immunoediting to the elimination and equilibrium phase of cancer immunoediting.

Abstract: Systems and methods for remote therapy and patient monitoring are provided. A method comprises contacting an outer skin surface of a patient with a contact surface of a stimulator and transmitting an electrical impulse from the stimulator transcutaneously through the outer skin surface to a nerve within the patient. Data related to parameters of the electrical impulse applied to the nerve is stored and transmitted to a remote source. The data may include duration of treatment, amplitude of the electrical impulse, compliance with a prescribed therapy regimen or other relevant data related to the therapy. The method may further include collecting patient status data, such as symptoms of a medical condition (e.g., severity of a headache) before, during and/or after stimulation. The patient status data is correlated with the treatment data to monitor compliance and/or the effectiveness of the therapy.

Abstract: Systems and methods for treating diseases and disorders in a patient are provided. A device comprises a stimulator comprising an electrode and an energy source. The energy source is configured to generate an electrical impulse and transmit the electrical impulse to the electrode through an outer skin surface to a vagus nerve of the patient. The device further comprises a sensor for detecting a physiological parameter of a patient's heart and a controller coupled to the stimulator and the sensor and configured to activate the stimulator based on the physiological parameter to cause the stimulator to generate the electrical impulse. In some aspects, the electrical impulse is sufficient to modulate the vagus nerve to treat a cardiac arrhythmia of the patient.

Abstract: Devices, systems and methods for treating various disorders and medical conditions through noninvasive stimulation of a nerve. A system comprises a stimulator including an electrode configured to contact an outer skin surface of a patient and an energy source coupled to the housing, The energy source generates an electrical impulse and the stimulator transmits the electrical impulse from the electrode transcutaneously through an outer skin surface of the patient to a selected nerve within the patient. The system further includes an application on a mobile device that receives data from a remote source. The mobile device couples to the stimulator and the application causes the mobile device to transmit the data to the stimulator.

Abstract: Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.

Abstract: A method disclosed includes receiving data from a plurality of data sources in a broadcast core network for transmission over a radio access network (RAN). The method includes assigning radio spectrum resources for transmitting the data over the RAN according to a policy guidance set by a plurality of network operators for sharing the radio spectrum resources and generating a baseband packet corresponding to the data at a distributed unit (DU) in the RAN. The method includes collecting transmission data from a plurality of user equipments (UEs) in the RAN for training a machine learning algorithm and scheduling transmission of the generated baseband packet to a remote unit (RU) over a fronthaul in a radio topology of a plurality of radio topologies under control of the machine learning algorithm according to the policy guidance. The generated baseband packet is compatible for transmission in the plurality of radio technologies.

Abstract: An acoustic microphone assembly for surveillance into a protected space includes a microphone including a transducer and a diagram adapted for picking up acoustic sound waves, electronic circuitry for processing input, a power source, and an audio output wire or trace for delivering processed digital sound to a sound system, a cover plate having at least two bolt openings for mounting to a base plate on a wall or structure the cover plate covering an opening there through into the protected space, the cover plate accepting an orthogonal mounting of the microphone, and a sound diffraction pattern of different sized openings placed through the cover plate, the sound diffraction pattern located in alignment to the mounted microphone head and having a foot print roughly equal to the circumference of the head of the microphone.

Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat neurodegenerative diseases, such as dementia, Alzheimer's disease, ischemic stroke, post-concussion syndrome, chronic traumatic encephalopathy and the like by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.

Abstract: A method for modulating a nerve within a body of a patient includes generating a single signal comprising an electrical impulse, contacting an interface with an outer skin surface of a patient and delivering the electrical impulse from an electrode through the interface and the outer skin surface of the patient to a vagus nerve, thereby modulating the vagus nerve. The electrical impulse may comprise bursts of pulses with a silent intra-burst interval between each of the bursts based on the single signal, wherein each of the bursts has a frequency of about 5 Hz to about 100 Hz and each of the pulses has a duration from about 50 microseconds to about 1000 microseconds. The electrode may be spaced from the interface by a distance of about 0.25 to about 4 times an outer dimension of the interface.

Abstract: Devices and methods for the non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode coupled to the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is coupled to the housing and operably coupled to the electrode. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve.