Abstract: A turbine assembly adapted for use with a gas turbine engine includes a turbine shroud assembly and a turbine vane. The turbine shroud assembly includes a carrier segment arranged circumferentially at least partway around an axis and a blade track segment supported by the carrier segment to locate the blade track segment radially outward of the axis. The turbine vane is located axially forward of the turbine shroud assembly and cooperates with the turbine shroud assembly to form a tortuous flow path therebetween.

Abstract: A turbine assembly includes a turbine case, a vane assembly, and a locating plate. The vane assembly includes a first vane and an outer platform arranged on a radially outer end of the first vane, the outer platform including a first anti-rotation protrusion extending radially outwardly away from a radially outwardly-facing surface of the outer platform. The locating plate is radially outside of the vane assembly and includes a main wall and two anti-rotation extensions extending radially inwardly. The first anti-rotation protrusion of the vane assembly is arranged to engage with one of the anti-rotation extensions so as to block circumferential movement of the vane assembly relative to the locating plate.

Abstract: A device may include a body at least partially defining a cavity configured to receive and retain a tracking device. An attachment mechanism connected to the body may have: a first arm configured to slide inward towards a centerline of the body from a first side, a second arm configured to oppose the first arm and slide inward towards the centerline of the body from a second side, and a tamperproof screw removably connecting the first arm to the second arm such that rotation of the screw adjusts a distance between the first arm and the second arm, wherein at least a portion of an item to be tracked is configured to be retained between the first arm and the second arm, and wherein, when the attachment mechanism retains the body in an engaged state, the tracking device coupling mechanism is immobilized with respect to the item to be tracked.

Abstract: An endpoint coupled in a communicating relationship with an enterprise network may include a data recorder configured to store an event stream of data indicating events on the endpoint including types of changes to computing objects, a filter configured to locally process the event stream into a filtered event stream including a subset of types of changes to the computing objects, and a local security agent. The local security agent may be configured to transmit the filtered event stream to a threat management facility, respond to a filter adjustment from the threat management facility by adjusting the filter to modify the subset of types of changes included in the filtered event stream, and respond to a query from the threat management facility by retrieving data stored in the data recorder over a time window before the query and excluded from the filtered event stream.

Abstract: Isolated monoclonal agonistic antibodies which bind to human CD40 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

Abstract: Security is improved by adding a security heartbeat for and endpoint as a factor in a multi-factor authentication system. The security heartbeat may be used directly as an authentication factor, e.g., where the heartbeat provides a reliable and verifiable indication of identity, or the security heartbeat may be used as a gating input for some other verification method, e.g., where a text message with a temporary security code can only be transmitted to a user when the user's endpoint is providing a secure heartbeat.

Abstract: In one example in accordance with the present disclosure, a fluidic die is described. The fluidic die includes a plurality of ejection subassemblies. Each ejection subassembly includes an ejection chamber to hold a volume of fluid and an opening through which the volume of fluid is ejected via a fluid actuator. A pitch of the ejection subassemblies aligns with a spatial arrangement of nanowells in an array of nanowells on a substrate.

Abstract: A disposable cassette for detecting nucleic acids or performing other assays. The cassette can be inserted into a base station during use. The cassette has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The cassette also can have a gasket to ensure free air movement between open vent pockets. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with the vent pockets and the chambers.

Abstract: An application executing on an endpoint accesses remote resources using a gateway. In response to a requested remote access, the application may be marked with a descriptor that specifies a target action and a pattern of occurrences of the target action. When a second observable action on the endpoint includes the pattern of events following the first observable action, a reportable event may be generated indicating a compromised state of the endpoint. The gateway can then regulate usage of the remote resource based on the reportable event.

Abstract: A turbine shroud assembly comprising a first shroud segment, a second shroud segment, and a plurality of seals. The first shroud segment includes a first carrier segment and a first blade track segment having a first shroud wall that is formed to include a first recess that extends circumferentially into the first shroud wall. The second shroud segment includes a second carrier segment and a second blade track having a second shroud wall that is formed to include a second recess that extends circumferentially into the second shroud wall. The plurality of seals extend circumferentially into the first shroud segment and the second shroud segment to block gases from escaping the gas path radially between the first shroud segment and the second shroud segment.

Abstract: Memory having internal processors, and methods of data communication within such a memory are provided. In one embodiment, an internal processor may concurrently access one or more banks on a memory array on a memory device via one or more buffers. The internal processor may be coupled to a buffer capable of accessing more than one bank, or coupled to more than one buffer that may each access a bank, such that data may be retrieved from and stored in different banks concurrently. Further, the memory device may be configured for communication between one or more internal processors through couplings between memory components, such as buffers coupled to each of the internal processors. Therefore, a multi-operation instruction may be performed by different internal processors, and data (such as intermediate results) from one internal processor may be transferred to another internal processor of the memory, enabling parallel execution of an instruction(s).

Abstract: A turbine vane assembly includes a flow path ring, an airfoil heat shield, and a seal. The flow path ring is made of ceramic matrix composite materials. The airfoil heat shield is made of ceramic matrix composite materials. The seal resists passage of gases through a gap formed between the flow path ring and the airfoil heat shield along an interface at the airfoil aperture.

Abstract: A turbine assembly includes a turbine case, a turbine shroud assembly including a carrier segment, and a locating plate. The locating plate is coupled with the turbine case axially forward of the carrier segment to block axially forward movement of the carrier segment and prevent separation of the carrier segment from the turbine case. The locating plate includes a main wall, a raised portion extending upwardly a first radial distance, and two circumferentially spaced apart extensions extending upwardly a second radial distance. The second radial distance is greater than the first radial distance such that, in a first arrangement, only the extensions contact the turbine case and such that, in a second arrangement, the raised portion is pulled toward the turbine case via a fastener so as to contact the turbine case in addition to the extensions.

Abstract: A firewall uses information about an application that originates a network request to determine whether and how to forward the request over a network. The firewall may more generally rely on the identity of the originating application, the security state of the originating application, the security state of the endpoint, and any other information that might provide an indication of malicious activity, to make routing and forwarding decisions for endpoint-originated network traffic.

Abstract: In some aspects, the present disclosure provides a nanoparticle composition comprising tRNA and an aminolipid delivery compound. The aminolipid delivery compound may be a dendrimer, dendron, or dendritic lipid, a polymer such as a polyamide or polyester, or a lipid with one or more hydrophobic components. In some embodiments, these compositions may be administered to a patient to treat a genetic disease or disorder such as cystic fibrosis, Duchene muscular dystrophy, or cancer.

Abstract: A faucet for dispensing a fluid includes a spout, a pull-out spray head removably coupled to the spout and including an outlet, and a valve assembly in fluid communication with the outlet. Additionally, the faucet includes a fluid treatment assembly configured to output a treatment into the fluid.

Abstract: The invention provides CD27 agonists comprising a first component that is an anti-CD27 antibody, or antigen-binding fragment thereof, linked to a second component comprising one or more cross-linking moieties. At least one of the cross-linking moieties does not bind to an Fc receptor and the CD27 agonist stimulates T cell activity without the need for Fc receptor interaction. The cross-linking molecule(s) can be, for example, an anti-CD27, antibody, or antigen-binding fragment thereof, that can be the same or different than the first component. Alternatively, the cross-linking molecule(s) can be a CD27 ligand or a molecule (e.g., antibody) that binds a molecule on a cell such as a T cell, a tumor cell or a stromal cell. Pharmaceutical compositions comprising the CD27 agonists, and methods of using the CD27 agonists, are also provided.

Abstract: A turbine shroud assembly includes a first shroud segment, a second shroud segment, and a plurality of seals. The first shroud segment includes a first carrier segment and a first blade track segment having a first shroud wall. The second shroud segment includes a second carrier segment and a second blade track. The plurality of seals extend circumferentially into the first shroud segment and the second shroud segment to block gases from escaping the gas path radially between the first shroud segment and the second shroud segment.

Abstract: A threat management facility receives data from a variety of sources such as compute instances within an enterprise network, cloud service providers supporting the enterprise network, and third-party data providers such as geolocation services. In order to facilitate prompt notification of potential risks, the threat management facility may incrementally update data for use in threat assessments as the data becomes available from these different sources, and create suitable alerts or notifications whenever the currently accumulated data provides an indication of threat meeting a predetermined threshold.

Abstract: A turbine shroud assembly includes a first shroud segment, a second shroud segment, and a seal assembly. The first shroud segment includes a first carrier segment arranged circumferentially at least partway around a central axis and a first blade track segment supported by the first carrier segment. The second shroud segment is arranged circumferentially adjacent the first shroud segment about the central axis. The seal assembly is configured to block gases from escaping the gas path radially between the first shroud segment and the second shroud segment.