Abstract: Disclosed are methods, systems, and computer-readable medium to perform operations including: receiving a query specifying one or more criteria for a travel reservation, transmitting, over a network, one or more requests for live travel data satisfying the one or more criteria, determining one or more query results that satisfy the one or more criteria, retrieving cached travel data for at least one of the one or more query results, and while responses to the one or more requests for live travel data are still being received over the network, generating, using a prediction engine, live travel data predictions for the one or more query results based at least in part on the cached travel data.

Abstract: The present invention relates to methods and uses of a biologically derived nucleosome preparation which contains a defined amount or concentration of nucleosomes expressed in absolute units of mass or concentration as a calibrant in a comparative analytical procedure.

Abstract: The invention relates to methods for detecting disease in a subject by means of a minimally invasive body fluid test for non-nucleosomal cell free DNA fragments. The invention also relates to the measurement or detection of circulating cell free DNA fragments that include a transcription factor binding site sequence as an indicator of the presence of disease in a subject.

Abstract: The invention relates to methods for detecting disease in a subject by means of a minimally invasive body fluid test for the detection of circulating chromatin fragments that include a transcription factor and associated DNA sequence as an indicator of the presence of disease in the subject, e.g. cancer. The methods may comprise sequencing the associated DNA sequence and/or removing cell free nucleosomes from the body fluid.

Abstract: Systems, methods, and computer-program products for online booking of lodging location reservations include receiving desired reservation information from a user; updating information stored in cache using a price and availability predictive machine learning model using the received desired reservation information; performing a search in the cache for solutions to the received desired reservation information; constructing all possible solutions available in the cache that satisfy the received desired reservation information, including splits in stays between more than one lodging locations; determining a score for each solution using a scoring machine learning model that considers the user's preferences; identifying a subset of solutions based on the score of each solution; performing live pricing and availability verification for the subset of solutions by querying a provider corresponding to each of the subset of solutions; and presenting the subset of solutions to the user with the verified pricing and ava

Abstract: Systems and methods for providing a Basic Input/Output System (BIOS) enforced blocklisting of harmful applications are described. In one embodiment, an Information Handling System (IHS) may include a processor and a BIOS coupled to the processor, the BIOS having program instructions that, upon execution, cause the IHS to download an Unsafe Application List (UAL) from an online source, and during a bootstrap process of the IHS, compare a plurality of Applications (Apps) installed on the IHS against a list of harmful applications included in a UAL. When a harmful application is found by the comparison, the instructions enforce one or more policies to restrict the harmful application from being executed on the IHS.

Abstract: The invention relates to methods and uses of a panel of biomarkers in a body fluid sample for diagnosing and/or monitoring lung cancer, in particular early stage lung cancer. The biomarkers include particular histone modifications present on cell free nucleosomes, in combination with Carcinoembryonic Antigen (CEA).

Abstract: The invention relates methods for diagnosing patients with multiple sclerosis by detecting cell free nucleosomes as biomarkers in body fluid samples.

Abstract: Disclosed are methods, systems, and computer-readable medium to perform operations including: receiving a query specifying one or more criteria for a travel reservation, transmitting, over a network, one or more requests for live travel data satisfying the one or more criteria, determining one or more query results that satisfy the one or more criteria, retrieving cached travel data for at least one of the one or more query results, and while responses to the one or more requests for live travel data are still being received over the network, generating, using a prediction engine, live travel data predictions for the one or more query results based at least in part on the cached travel data.

Abstract: The present invention relates to an extracorporeal device or an ex vivo organ perfusion device comprising an inline monitoring method or device for measuring cell free nucleosomes, particularly an apheresis device comprising a monitoring method or device for measuring cell free nucleosomes in the blood of a subject.

Abstract: Systems and methods for providing a Basic Input/Output System (BIOS) enforced blocklisting of harmful applications are described. In one embodiment, an Information Handling System (IHS) may include a processor and a BIOS coupled to the processor, the BIOS having program instructions that, upon execution, cause the IHS to download an Unsafe Application List (UAL) from an online source, and during a bootstrap process of the IHS, compare a plurality of Applications (Apps) installed on the IHS against a list of harmful applications included in a UAL. When a harmful application is found by the comparison, the instructions enforce one or more policies to restrict the harmful application from being executed on the IHS.

Abstract: The invention relates to using cell free nucleosome levels to identify patients at risk of developing a NETosis associated adverse reaction to the infection. The methods are used to monitor the progress of a disease and assigning a risk of an adverse outcome in a patient suffering from an infection.

Abstract: A method for binding applications to a platform root of trust includes pre-provisioning application binding components in an information handling system. An application requesting OS access sends its access control list (ACL) and application metadata to the BIOS, which performs initial checks. The BIOS responds with platform metadata and a first nonce. The application communicates the metadata, the first nonce and a second nonce to a server. The server checks the nonces and metadata, creates a third nonce and an application binding object (ABO). The application checks the nonces and sends a binding certificate to the BIOS. The BIOS checks the nonces, creates a binding certificate, verifies the binding certificate and sends a binding session credential (BSC) to the application. The application binds the BSC with platform credentials.

Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular histone variants and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying histone variant biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.

Abstract: The invention relates to using cell free nucleosome levels to identify patients at risk of developing a NETosis associated adverse reaction to the infection. The methods are used to monitor the progress of a disease and assigning a risk of an adverse outcome in a patient suffering from an infection.

Abstract: The invention relates to cell free nucleosomes as biomarkers in plasma samples for vascular or haematological cancers.

Abstract: A method for binding applications to a platform root of trust includes pre-provisioning application binding components in an information handling system. An application requesting OS access sends its access control list (ACL)and application metadata to the BIOS, which performs initial checks. The BIOS responds with platform metadata and a first nonce. The application communicates the metadata, the first nonce and a second nonce to a server. The server checks the nonces and metadata, creates a third nonce and an application binding object (ABO). The application checks the nonces and sends a binding certificate to the BIOS. The BIOS checks the nonces, creates a binding certificate, verifies the binding certificate and sends a binding session credential (BSC) to the application. The application binds the BSC with platform credentials.

Abstract: The invention relates to the use of histone binding agents for detecting, isolating and/or purifying cell free nucleosomes of tumor origin or circulating tumor DNA from a biological sample. The invention also relates to methods and kits using said histone binding agents.

Abstract: The invention relates to a body fluid test method for the detection and treatment of prostate cancer, in particular aggressive prostate cancer. It also relates to monitoring of patients with low risk prostate tumours and selection of patients for prostate biopsy as well as selection of patients for prostate surgery or therapy.

Abstract: The invention relates to methods for separating circulating cell free nucleosomes comprising linker DNA from a biological fluid sample, in particular nucleosomes of disease origin. Such methods allow for improved analysis of genetic and epigenetic markers associated with nucleosomes of disease origin.