Abstract: The invention relates to the use of histone binding agents for detecting, isolating and/or purifying cell free nucleosomes of tumor origin or circulating tumor DNA from a biological sample. The invention also relates to methods and kits using said histone binding agents.

Abstract: The invention relates to methods for separating circulating cell free nucleosomes comprising linker DNA from a biological fluid sample, in particular nucleosomes of disease origin. Such methods allow for improved analysis of genetic and epigenetic markers associated with nucleosomes of disease origin.

Abstract: The invention relates to a body fluid test method for the detection and treatment of prostate cancer, in particular aggressive prostate cancer. It also relates to monitoring of patients with low risk prostate tumours and selection of patients for prostate biopsy as well as selection of patients for prostate surgery or therapy.

Abstract: According to one illustrative, non-limiting embodiment, a first IHS may include computer-executable instructions for performing at least one artificial intelligence (AI) service to optimize a performance of the first IHS. In response to determining that an AI workload of the AI service exceeds a specified threshold, the first IHS selects a second IHS to perform at least a portion of the AI workload, and transmits the at least one portion of the AI workload to the second IHS. When a processed AI workload is received from the second IHS, the first IHS applies one or more profile recommendations included in the processed AI workload.

Abstract: The invention relates to body fluid test methods for the detection of cancer using a combination biomarker panel comprising at least one cytokine molecule and at least one cell free chromatin fragment.

Abstract: The invention relates to a method for detecting and measuring the presence of nucleosome-protein adducts and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome adduct biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.

Abstract: Devices, systems, and methods for promoting hand sanitization which may be mounted above or near a door handle. Hand sanitization devices include a sanitizer agent cartridge disposed inside a housing body and fluidically coupled to an actuating pump. The pump is configured to dispense the sanitizer when an actuation mechanism is pushed or pulled. The cartridge is also coupled to a pump sheath disposed below the pump so as to protect the internal components of the devices from unintentional splashing by the sanitizer agent. The hand sanitization devices may also record when the door is opened, when the sanitizer is dispensed, if the cartridge is empty, and when a user is approaching the door. The hand sanitization devices also have a user interface system configured to encourage the approaching user to sanitize their hands.

Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular nucleotides and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome associated nucleotide biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.

Abstract: The invention relates to the use of tissue specific transcription factor-nucleosome adducts or transcription cofactor-nucleosome adducts as biomarkers in a biological fluid for the detection or diagnosis of a cancer in a subject. The invention further relates to using said tissue specific transcription factor or cofactor adducts to identify the site of development of a cancer in a subject.

Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular nucleotides and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome associated nucleotide biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.

Abstract: The present invention relates to the use of a histone H1 binding agent for detecting, isolating and/or purifying cell free nucleosomes of tumor origin from a biological sample. The invention also describes methods of negative or positive selection using histone H1 binding agents, in order to enrich a sample for cell free nucleosomes of tumor origin.

Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular histone variants and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying histone variant biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.

Abstract: The present invention relates to a method for detecting and measuring the presence of cell free mono-nucleosomes and oligo-nucleosomes that contain histone H1 or a histone H1 modification, variant or isoform, and the use of such measurements for the detection and diagnosis of disease.

Abstract: The present invention relates to the use of a histone H1 binding agent for detecting, isolating and/or purifying cell free nucleosomes of tumor origin from a biological sample. The invention also describes methods of negative or positive selection using histone H1 binding agents, in order to enrich a sample for cell free nucleosomes of tumor origin.

Abstract: The present invention relates to methods of detecting and/or screening for colorectal cancer (CRC), a colorectal adenoma or a polyp in a patient comprising identifying patients found to be positive for fecal occult blood and further testing for one or more additional factors. Said methods can be used to assess the suitability of a patient for colonoscopy.

Abstract: Devices, systems, and methods for promoting hand sanitization which may be mounted above or near a door handle. Hand sanitization devices include a sanitizer agent cartridge disposed inside a housing body and fluidically coupled to an actuating pump. The pump is configured to dispense the sanitizer when an actuation mechanism is pushed or pulled. The cartridge is also coupled to a pump sheath disposed below the pump so as to protect the internal components of the devices from unintentional splashing by the sanitizer agent. The hand sanitization devices may also record when the door is opened, when the sanitizer is dispensed, if the cartridge is empty, and when a user is approaching the door. The hand sanitization devices also have a user interface system configured to encourage the approaching user to sanitize their hands.

Abstract: Devices, systems, and methods for promoting hand sanitization which may be mounted above or near a door handle. Hand sanitization devices include a sanitizer agent cartridge disposed inside a housing body and fluidically coupled to an actuating pump. The pump is configured to dispense the sanitizer when an actuation mechanism is pushed or pulled. The cartridge is also coupled to a pump sheath disposed below the pump so as to protect the internal components of the devices from unintentional splashing by the sanitizer agent. The hand sanitization devices may also record when the door is opened, when the sanitizer is dispensed, if the cartridge is empty, and when a user is approaching the door. The hand sanitization devices also have a user interface system configured to encourage the approaching user to sanitize their hands.

Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular histone variants and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying histone variant biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.

Abstract: Apparati and methods for dispensing sanitizer fluid via handles on doors and equipment, and data and recording events pertaining to hand sanitization, are disclosed.

Abstract: The present invention relates to a method for detecting and measuring the presence of cell free mono-nucleosomes and oligo-nucleosomes that contain histone H1 or a histone H1 modification, variant or isoform, and the use of such measurements for the detection and diagnosis of disease.