Abstract: The present invention relates to the use of a histone H1 binding agent for detecting, isolating and/or purifying cell free nucleosomes of tumor origin from a biological sample. The invention also describes methods of negative or positive selection using histone H1 binding agents, in order to enrich a sample for cell free nucleosomes of tumor origin.

Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular histone variants and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying histone variant biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.

Abstract: The invention relates to the use of a cell-free nucleosome as a biomarker in a sputum sample for the diagnosis or detection of cancer, adenoma, autoimmune disease or inflammatory disease. The invention also relates to methods of detecting said cell free nucleosomes in sputum samples, in particular in methods of diagnosis.

Abstract: The invention relates to the use of a cell-free nucleosome as a biomarker in a fecal sample for the diagnosis or detection of cancer, adenoma, autoimmune disease or inflammatory disease. The invention also relates to methods of detecting said cell free nucleosomes in fecal samples, in particular in methods of diagnosis.

Abstract: A cleaning system for use with a heat exchanger and a fluid pressurizing assembly includes a wand assembly, a pivot assembly, and a movement mechanism having a body and a piston rod moveable relative the body in response to fluid pressurization. The wand assembly includes a wand in fluid communication with the fluid pressurizing assembly, and having a first orifice configured to eject fluid toward the heat exchanger. The wand is supported by the pivot assembly such that the wand is selectively pivotable about a first pivot axis. The movement mechanism connects to the pivot assembly at a second pivot axis offset from the first pivot axis such that selective movement of the piston rod produces pivotal movement of the wand about the first pivot axis.

Abstract: The invention relates to the use of histone binding agents for detecting, isolating and/or purifying cell free nucleosomes of tumor originor circulating tumor DNA from a biological sample. The invention also relates to methods and kits using said histone binding agents.

Abstract: The invention relates to a method for detecting the presence of a gynaecological growth, in particular for the diagnosis of endometriosis. The invention also relates to a method of identifying a biomarker for detecting the presence of a gynaecological growth and to biomarkers identified by said method.

Abstract: The invention relates to the use of cell free nucleosome bound nuclear hormone receptor variant adducts for detecting the progression of hormone dependent disease to hormone therapy resistant disease or the effectiveness of a drug treatment in a patient. The invention also relates to methods for detecting said cell free nucleosome bound nuclear hormone receptor variant adducts.

Abstract: Devices, systems, and methods for promoting hand sanitization which may be mounted above or near a door handle. Hand sanitization devices include a sanitizer agent cartridge disposed inside a housing body and fluidically coupled to an actuating pump. The pump is configured to dispense the sanitizer when an actuation mechanism is pushed or pulled. The cartridge is also coupled to a pump sheath disposed below the pump so as to protect the internal components of the devices from unintentional splashing by the sanitizer agent. The hand sanitization devices may also record when the door is opened, when the sanitizer is dispensed, if the cartridge is empty, and when a user is approaching the door. The hand sanitization devices also have a user interface system configured to encourage the approaching user to sanitize their hands.

Abstract: The invention relates to a method for detecting and measuring the presence of nucleosome-protein adducts and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome adduct biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.

Abstract: Apparati and methods for dispensing sanitizer fluid via handles on doors and equipment, and data and recording events pertaining to hand sanitization, are disclosed.

Abstract: The invention relates to a method for detecting and measuring the presence of nucleosome-protein adducts and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome adduct biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.

Abstract: A volleyball practice assembly includes a target unit that may be mounted to a support thereby facilitating the target unit to have a ball launched toward the target unit. The target unit registers when the ball strikes the target unit thereby facilitating the target unit to aid in accuracy training with respect to the ball. A control circuit is coupled to the target unit and the control circuit detects when the ball strikes the target unit. A remote unit is provided. The remote unit is in communication with the target unit such that the remote unit controls operational parameters of the target unit.

Abstract: Apparatus and methods for dispensing sanitizer fluid via handles on doors and equipment, and data and recording events pertaining to hand sanitization, are disclosed.

Abstract: A cleaning system for use with a heat exchanger and a fluid pressurizing assembly includes a wand assembly, a pivot assembly, and a movement mechanism having a body and a piston rod moveable relative the body in response to fluid pressurization. The wand assembly includes a wand in fluid communication with the fluid pressurizing assembly, and having a first orifice configured to eject fluid toward the heat exchanger. The wand is supported by the pivot assembly such that the wand is selectively pivotable about a first pivot axis. The movement mechanism connects to the pivot assembly at a second pivot axis offset from the first pivot axis such that selective movement of the piston rod produces pivotal movement of the wand about the first pivot axis.

Abstract: A volleyball practice assembly includes a target unit that may be mounted to a support thereby facilitating the target unit to have a ball launched toward the target unit. The target unit registers when the ball strikes the target unit thereby facilitating the target unit to aid in accuracy training with respect to the ball. A control circuit is coupled to the target unit and the control circuit detects when the ball strikes the target unit. A remote unit is provided. The remote unit is in communication with the target unit such that the remote unit controls operational parameters of the target unit.

Abstract: A cleaning system for use with a heat exchanger and a fluid pressurizing assembly includes a wand assembly, a pivot assembly, and a movement mechanism having a body and a piston rod moveable relative the body in response to fluid pressurization. The wand assembly includes a wand in fluid communication with the fluid pressurizing assembly, and having a first orifice configured to eject fluid toward the heat exchanger. The wand is supported by the pivot assembly such that the wand is selectively pivotable about a first pivot axis. The movement mechanism connects to the pivot assembly at a second pivot axis offset from the first pivot axis such that selective movement of the piston rod produces pivotal movement of the wand about the pivot axis.

Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular histone variants and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying histone variant biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.

Abstract: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular histone variants and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying histone variant biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.