Abstract: A method, system, and computer program product for enabling quantum machine learning to be used effectively with classical data. Classical data, which may consist of a large sample size and a large number of features, is mapped into quantum state space forming quantum data using a classical machine learning model. Classical data refers to data subject to the laws of classical physics. Quantum state space refers to an abstract space in which different “positions” represent, not literal locations, but rather quantum states of a physical system. The dimensionality of the quantum state space corresponds to 2 raised to the power of the number of qubits. Quantum machine learning may then be performed on a quantum computer using the formed quantum data. As a result, quantum machine learning is enabled to be used effectively with classical data while utilizing a small number of qubits.

Abstract: A lens including a light entering part having a concave shape in a lower region of the lens, and on which light emitted from a light emitting device is to be incident, and a light exiting part through which the incident light is emitted to an outside of the lens, in which each of the light entering part and the light exiting part has a major axis and a minor axis in plan view, and the major axis of the light entering part is orthogonal to the major axis of the light exiting part, the light entering part includes a light incident vertical surface extending from a lower surface of the lens, and a light incident inclined surface extending upward from the light incident vertical surface, and the light incident vertical surface surrounds the light emitting device.

Abstract: The present invention relates to a PD-L1 specific chimeric antigen receptor and an immune cell comprising the same. Particularly, the PD-L1 specific chimeric antigen receptor comprises a binding domain that specifically binds to programmed death-ligand 1 (PD-L1), thus having excellent PD-L1 specific targeting efficiency, and exhibits excellent anticancer effects against cancer cells expressing PD-L1, and thus can be effectively used in the prevention or treatment of cancer.

Abstract: The present invention relates to a novel ATP synthase variant and a method of producing an L-aromatic amino acid using the same. The ATP synthase variant is obtained by substituting one or more amino acids in the amino acid sequence constituting ATP synthase to change the enzymatic activity of the ATP synthase, and a recombinant microorganism comprising the ATP synthase variant is capable of efficiently producing an L-aromatic amino acid.

Abstract: A system to train multiple combined quantum classical kernels can comprise a memory that stores, and a processor that executes, computer executable components that perform operations comprising determining a set of kernel bandwidths, calculating a plurality of kernels, based on the kernel bandwidths, for subsets of features of a feature map, centering the plurality of kernels within a feature space of the feature map, regularizing parameters to combine the plurality of kernels, and combining the plurality of kernels into a combined kernel. Feature subsampling and data subsampling can be employed to compute a finite set subsampled kernels. Furthermore, the finite set of subsampled kernels can be combined classically to create a combined kernel that can represent an arbitrary target kernel function of a target dataset.

Abstract: Techniques are described herein regarding utilizing a quantum transformation to generate a transformed dataset from an original dataset and a quantum feature map. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can include operations to transform a qubit of a quantum feature map from an initial state to a transformed state based on an input value of a first classical dataset. The computer executable components can further include operations that generate a second classical dataset based on the input value and the transformed state.

Abstract: A lens including a light entering part having a concave shape in a lower region of the lens, and on which light emitted from a light emitting device is to be incident, and a light exiting part through which the incident light is emitted to an outside of the lens, in which each of the light entering part and the light exiting part has a major axis and a minor axis in plan view, and the major axis of the light entering part is orthogonal to the major axis of the light exiting part, the light entering part includes a light incident vertical surface extending from a lower surface of the lens, and a light incident inclined surface extending upward from the light incident vertical surface, and the light incident vertical surface surrounds the light emitting device.

Abstract: A light emitting module including a substrate having an insulating region and including a conductive pattern, a light source disposed on an upper surface of the substrate and electrically connected to the conductive pattern, a lens including a lower surface, a light incident region, a light exit portion, a leg protruding from the lower surface of the lens, and an adhesion material coupling the leg to the upper surface of the substrate, in which the light incident region has a central axis, the light incident region includes a protrusion facet, the protrusion facet having a first end and a second end opposite to the first end, and the protrusion facet is protruded toward the central axis with respect to an imaginary linear line connecting the first end and the second end of the protrusion facet.

Abstract: The present invention relates to an antibody against resistin and use thereof and, more specifically, to a resistin antibody or antigen-binding fragment thereof that inhibits the activity of resistin by blocking resistin/CAP1 binding, a nucleic acid encoding same, a vector comprising the nucleic acid, a cell transformed with the vector, a method for preparing the antibody or antigen-binding fragment thereof, an antibody-drug conjugate comprising the antibody or antigen-binding fragment thereof, a bi- or multi-specific antibody, a chimeric antigen receptor, an immune cell containing same, and a composition for the prevention or treatment of diseases that can be treated through the inhibition of resistin activity, the composition comprising same.

Abstract: Systems and methods for quantum machine learning are described. A plurality of qubits can be entangled to create a cluster state. The plurality of qubits can include at least an input qubit, an output qubit, and at least one ancilla qubit. The input qubit can represent data among a training data set of a machine learning model represented by a unitary operation. Sequential local measurements of the cluster state can be performed to generate a plurality of measurement outcomes. At least one of the plurality of qubits can be rotated according to the plurality of measurement outcomes and rotation parameters of the unitary operation. The sequential local measurements and rotation of the plurality of qubits can transform an input state of the input qubit into an output state of the output qubit. The machine learning model can be trained based on the output state of the output qubit.

Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-B7-H3 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind B7-H3, as well as methods of making and using these anti-B7-H3 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: A light emitting module including a substrate having an insulating region and including a conductive pattern, a light source disposed on an upper surface of the substrate and electrically connected to the conductive pattern, a lens including a lower surface, a light incident region, a light exit surface, a leg protruding from the lower surface of the lens, and an adhesion material coupling the leg to the upper surface of the substrate, in which the light incident region has a central axis, the light incident region includes a protrusion facet, the protrusion facet having a first end and a second end opposite to the first end, and the protrusion facet is protruded toward the central axis with respect to an imaginary linear line connecting the first end and the second end of the protrusion facet.

Abstract: The present invention relates to a novel antibody specifically binding to OX40L and a bispecific antibody specifically binding to OX40L and TNF? and, specifically, to an antibody or a bispecific antibody specifically binding to human OX40L to effectively inhibit the binding of OX40 to an OX40 receptor; a nucleic acid encoding the antibody; an expression vector comprising the nucleic acid; a transformant comprising the expression vector; a method for preparing the antibody; a pharmaceutical composition for treating autoimmune diseases or inflammatory diseases, comprising the antibody; a composition for diagnosing autoimmune diseases or inflammatory diseases, comprising the antibody; a method for diagnosing autoimmune diseases or inflammatory diseases by using the antibody; a method for providing information on diagnosis of autoimmune diseases or inflammatory diseases by using the antibody; and a kit for providing the same.

Abstract: New anti-VSIG4 (V-set Ig domain-containing 4) antibodies or an antigen-binding fragments are disclosed. Uses of these antibodies, including methods of treatment, are also provided.

Abstract: A monoclonal antibody or an antigen-binding fragment thereof according to an embodiment of the present invention can bind to lymphocyte-activation gene 3 (LAG-3) including a heavy chain variable region and a light chain variable region and inhibit the activity thereof. Thus it is expected to be useful for the development of immunotherapeutic agents for various disorders that are associated with LAG-3.

Abstract: A processor can control quantum hardware to transform qubit states associated with a plurality of pairs of data points in a training dataset using a circuit parameter representing a rotation angle. Inner products of transformed qubit states associated with the plurality of pairs of data points can be computed. The processor can minimize an objective function based on the inner products, where the minimizing finds a target circuit parameter representing a target rotation angle that minimizes the objective function. A processor can build a kernel matrix based on the inner products computed for a sample dataset and the target circuit parameter passed to the quantum hardware. A classification algorithm can use the kernel matrix to classify the sample dataset.

Abstract: A light emitting module including a substrate having an insulating region and including a conductive pattern, a light source disposed on an upper surface of the substrate and electrically connected to the conductive pattern, a lens including a lower surface, a light incident region, a light exit surface, a leg protruding from the lower surface of the lens, and an adhesion material coupling the leg to the upper surface of the substrate, in which the light incident region has a central axis, the light incident region includes a protrusion facet, the protrusion facet having a first end and a second end opposite to the first end, and the protrusion facet is protruded toward the central axis with respect to an imaginary linear line connecting the first end and the second end of the protrusion facet.

Abstract: A lens for dispersing light emitted from a light emitting device, the lens including a lower surface, a light incident portion having a concave shape from the lower surface, the light incident portion having a light incident surface, and a light exit portion through which light having entered the lens through the light incident portion exits the lens to an outside of the lens, in which the light incident surface includes at least one protruding light incident facet.

Abstract: A lens including a light entering part having a concave shape in a lower region of the lens, and on which light emitted from a light emitting device is to be incident, and a light exiting part through which the incident light is emitted to an outside of the lens, in which each of the light entering part and the light exiting part has a major axis and a minor axis in plan view, and the major axis of the light entering part is orthogonal to the major axis of the light exiting part, the light entering part includes a light incident vertical surface extending from a lower surface of the lens, and a light incident inclined surface extending upward from the light incident vertical surface, and the light incident vertical surface surrounds the light emitting device.

Abstract: A lens including a light entering part having a concave shape in a lower region of the lens, and on which light emitted from a light emitting device is to be incident, and a light exiting part through which the incident light is emitted to an outside of the lens, in which each of the light entering part and the light exiting part has a major axis and a minor axis in plan view, and the major axis of the light entering part is orthogonal to the major axis of the light exiting part, the light entering part includes a light incident vertical surface extending from a lower surface of the lens, and a light incident inclined surface extending upward from the light incident vertical surface, and the light incident vertical surface surrounds the light emitting device.