Patents by Inventor Jakob Ley

Jakob Ley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10251409
    Abstract: Suggested is a mixture of matter, comprising: (a) steviol glycosides, (b) starch degradation products and (c) one or more phenolic sweetness-enhancing aroma substances selected from the group formed by hesperetin, phloretin, 1-(2,4-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one, 7,3-dihydroxy-4?-methoxyflavan and 5-hydroxy-4-(4-hydroxy-3-methoxyphenyl)-7-methoxy-2-chromanone. On condition that components (a+b) and (c) are present in a ratio by weight of from 1.99 to 99:1.
    Type: Grant
    Filed: October 26, 2014
    Date of Patent: April 9, 2019
    Assignee: SYMRISE AG
    Inventors: Uwe Schafer, Gerhard Krammer, Gerald Glaubitz, Thomas Riess, Jakob Ley, Susanne Paetz
  • Patent number: 10226445
    Abstract: Pharmaceutical preparations are proposed, comprising bitter-masking acting substances for reducing and/or inhibiting gastric acid secretion induced by food constituents.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: March 12, 2019
    Assignee: Symrise AG
    Inventors: Elke Köck, Jakob Ley, Veronika Somoza, Kathrin Liszt, Sabine Widder
  • Publication number: 20190021378
    Abstract: The invention relates to a foodstuff, containing: a) juice, pith, flesh, skins; or other constituents of at least one citrus fruit, b) at least one 4-hydroxyflavanone of the formula (I), in which R1 represents hydrogen or a hydroxy group a or methoxy group and the carbon atom at the position (C2) designated by * is present in a (2S) or a (2R) configuration or in any mixture of the two configurations, and also, if applicable, c) further flavorings or flavoring preparations, with the proviso that the constituent (b) is present in a sufficient quantity to improve the acidic and/or bitter taste of the constituent (a).
    Type: Application
    Filed: September 1, 2015
    Publication date: January 24, 2019
    Applicant: Symrise AG
    Inventors: Johannes KIEFL, Susanne Paetz, Jakob Ley, Gerhard Krammer, Thomas Riess, Kathrin Langer, Gunter Kindel, Morine Verqohlt
  • Publication number: 20180360086
    Abstract: Suggested is a food product comprising (a) juice, marrow, flesh or peels or other components of at least one citrus fruit, (b) at least one neoflavonoid as well as optionally (c) further flavoring agents or flavor preparations, providing that the component (b) is present in a sufficient amount to improve the sour and/or bitter taste of the component (a).
    Type: Application
    Filed: November 14, 2015
    Publication date: December 20, 2018
    Inventors: Johannes KIEFL, Susanne PAETZ, Jakob LEY, Michael BACKES, Joachim HANS
  • Publication number: 20180311132
    Abstract: The present invention relates primarily to the use of certain hydroxybenzoic acid amides or the salts or mixtures thereof for masking an unpleasant taste impression, preferably of a bitter, adstringent, dusty, dry, floury, rancid, metallic and/or cardboard taste or aftertaste, of one or more unpleasant-tasting peptides or of certain amino acid mixtures. The invention further relates to a corresponding method for masking unpleasant taste impressions and to novel preparations.
    Type: Application
    Filed: September 30, 2015
    Publication date: November 1, 2018
    Inventors: Joachim HANS, Jakob LEY, Kathrin LANGER, Susanne PAETZ
  • Publication number: 20180216152
    Abstract: The invention relates to a method for producing flavone glycoside dihydrochalcones, having the following steps: (a) providing a transgenic microorganism containing (i) a first nucleic acid portion (A) containing a gene which codes for a bacterial chalcone isomerase and (ii) a second nucleic acid portion (B) containing a gene which codes for a bacterial enoate reductase, (b) adding one or more flavone glycosides to the transgenic microorganism under conditions which allow the simultaneous isomerization and reduction of the flavone glycoside into the flavone glycoside dihydrochalcone, and optionally (d) isolating and purifying the final product, wherein the nucleic acid portion (A) (1) is a nucleotide sequence according to SEQ ID NO:1, in which the nucleic acid portion (A?) according to SEQ ID NO:3 has been cut out, or (2) is an amino acid sequence according to SEQ ID NO:2, in which the amino acid portion (A?) according to SEQ ID NO:4 has been cut out.
    Type: Application
    Filed: June 27, 2015
    Publication date: August 2, 2018
    Inventors: Maren Thomsen, Jakob Ley, Egon Gross, Winfried Hinrichs, Uwe Bornscheuer
  • Patent number: 10028967
    Abstract: Suggested is a medicament which is particularly useful for preventing, curing or abating of cough and inflammations of the respiratory system, comprising or consisting of active pharmaceutical ingredients and 1,3-propandiol.
    Type: Grant
    Filed: June 27, 2015
    Date of Patent: July 24, 2018
    Assignee: Symrise AG
    Inventors: Donna Rosa, Jakob Ley, Gerhard Krammer, Deborah Kennison
  • Publication number: 20180135029
    Abstract: A method is proposed for producing flavonoids, comprising the steps: (a) providing of a transgenic microorganism, containing (i) a first nucleic acid section (A), comprising or consisting of a gene coding for a CYP450 oxidase, (ii) a second nucleic acid section (B), comprising or consisting of a gene coding for a plant O-methyltransferase, and (b) adding of one or more flavanones to the transgenic microorganism, (c) the conversion of the substrate flavanones by the transgenic microorganism to the corresponding flavonoids, and optionally (d) isolating and purifying of the final products.
    Type: Application
    Filed: September 27, 2015
    Publication date: May 17, 2018
    Inventors: Ludger Wessjohann, Anne-Kathrin Bauer, Jakob Ley, Torsten Geissier, Katrin Geissler
  • Publication number: 20170196898
    Abstract: Suggested is a medicament which is particularly useful for preventing, curing or abating of cough and inflammations of the respiratory system, comprising or consisting of active pharmaceutical ingredients and 1,3-propandiol.
    Type: Application
    Filed: June 27, 2015
    Publication date: July 13, 2017
    Applicant: Symrise AG
    Inventors: Donna Rosa, Jakob Ley, Gerhard Krammer, Deborah Kennison
  • Publication number: 20170190727
    Abstract: The invention relates to novel substance mixtures which can be used as aroma compositions to enhance the sweet taste of oral preparations.
    Type: Application
    Filed: June 11, 2015
    Publication date: July 6, 2017
    Applicant: Symrise AG
    Inventors: Gerhard Krammer, Christoph SABATER, Thomas RIESS, Jakob LEY, Thorsten GEIßLER
  • Publication number: 20170135982
    Abstract: The invention relates to compounds of formula (I) or the salts thereof, said compounds of formula (I) being selected from among the group consisting of homoeriodictyol (1), eriodictyol (2), hesperetin (3) and sterubin (4), for use in the treatment of an ailment which can be alleviated or prevented by influencing the serotonin level and the concentration of free fatty acids in the blood.
    Type: Application
    Filed: July 26, 2015
    Publication date: May 18, 2017
    Applicant: Symrise AG
    Inventors: Veronika Somoza, Barbara Rohn, Kathrin Liszt, Marc Pignitter, Christina Hochkogler, Jakob Ley, Sabine Widder, Gerhard Krammer
  • Patent number: 9642381
    Abstract: The invention relates to triterpenes and triterpene glycosides of the formula (I) and/or physiologically acceptable salts thereof, preferably naturally occurring triterpenes and triterpene glycosides from Mycetia balansae and/or physiologically acceptable salts thereof and orally consumable formulations comprising one or a plurality of these triterpenes and triterpene glycosides and/or physiologically acceptable salts thereof. The invention further relates to the use of these triterpenes and triterpene glycosides and/or physiologically acceptable salts thereof, preferably an extract of Mycetia balansae, for generating a sweet impression in an orally consumable formulation or for reinforcing the sweet impression of an orally consumable formulation comprising at least one further, preferably naturally occurring, sweet-tasting substance.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: May 9, 2017
    Assignee: Symrise AG
    Inventors: Jakob Ley, Katharina Reichelt, Katja Obst, Ludger Wessjohann, Sabine Wessjohann, Tran Van Sung, The Anh Nguyen, Ngo Van Trai
  • Patent number: 9468225
    Abstract: Suggested are new compositions for oral ingestion, comprising at least one active agent from the group of alkamides. The compositions which are orally ingested reduce the uptake of free fatty acids in the adipocytes and at the same time stimulate the release of serotonin and dopamine, which leads to a reduction of appetite, a feeling of satiety and a positive mood. In doing so, the new compositions are thus perfectly suitable to counteract any undesired gain of weight.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: October 18, 2016
    Assignee: Symrise AG
    Inventors: Jakob Ley, Sabine Widder, Veronika Somoza, Barbara Rohm, Matthias Zaunschirm, Gerhard Krammer
  • Publication number: 20160295892
    Abstract: Suggested is a mixture of matter, comprising: (a) steviol glycosides, (b) starch degradation products and (c) one or more phenolic sweetness-enhancing aroma substances selected from the group formed by hesperetin, phloretin, 1-(2,4-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one, 7,3-dihydroxy-4?-methoxyflavan and 5-hydroxy-4-(4-hydroxy-3-methoxyphenyl)-7-methoxy-2-chromanone. On condition that components (a+b) and (c) are present in a ratio by weight of from 1.
    Type: Application
    Filed: October 26, 2014
    Publication date: October 13, 2016
    Applicant: Symrise AG
    Inventors: Uwe SCHÄFER, Gerhard KRAMMER, Gerald GLAUBITZ, Thomas RIESS, Jakob LEY, Susanne PAETZ
  • Patent number: 9445606
    Abstract: The invention provides the use of a 4-hydroxydihydrochalcone of the formula (I) wherein R1, R2, R3 and R4 each, independently, represent H, OH or O-alkyl, with the proviso that at least one of the groups R1, R2 or R3 represents OH, a salt of such a 4-hydroxydihydrochalcone of the formula (I), a mixture containing or consisting of two or more different 4-hydroxydihydrochalcones of the formula (I), wherein R1, R2, R3 and R4 are each defined in the way given above, a mixture containing or consisting of salts of two or more different 4-hydroxydihydrochalcones of the formula (I), wherein R1, R2, R3 and R4 are each defined in the way given above or a mixture containing or consisting of a 4-hydroxydihydrochalcone of the formula (I) or two or more different 4-hydroxydihydrochalcones of the formula (I), wherein R1, R2, R3 and R4 are each defined in the way given above, and a salt of a 4-hydroxydihydrochalcone of the formula (I) or two or more salts of different 4-hydroxydihydrochalcones of the formula
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: September 20, 2016
    Assignee: SYMRISE AG
    Inventors: Gerhard Krammer, Jakob Ley, Thomas Riess, Martin Haug, Susanne Paetz, Günter Kindel, Ralph Schmidtmann
  • Patent number: 9386787
    Abstract: Preparations for oral consumption are proposed, comprising (a) lactic acid 1-menthyl ester of the general formula (I) its stereoisomers or mixtures thereof, (b) at least one substance having a bitter, astringent and/or metallic taste impression, and optionally (c) further flavorings.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: July 12, 2016
    Assignee: Symrise AG
    Inventors: Gerhard Krammer, Jakob Ley, Katja Obst, Katharina Reichelt
  • Publication number: 20160081977
    Abstract: Pharmaceutical preparations are proposed, comprising bitter-masking acting substances for reducing and/or inhibiting gastric acid secretion induced by food constituents.
    Type: Application
    Filed: January 15, 2014
    Publication date: March 24, 2016
    Applicant: SYMRISE AG
    Inventors: Elke Köck, Jakob Ley, Veronika Somoza, Kathrin Liszt, Sabine Widder
  • Publication number: 20150362481
    Abstract: The present invention is directed to a method for the identification of bitter tasting compounds and bitter taste modulating compounds, in particular bitter taste masking compounds (bitter antagonists) and bitter taste enhancing compounds (bitter agonists) by monitoring the change in the intracellular pH value and/or proton secretion.
    Type: Application
    Filed: January 17, 2014
    Publication date: December 17, 2015
    Inventors: Veronika Somoza, Kathrin Ingrid Liszt, Elke Köck, Jakob Ley
  • Publication number: 20150259319
    Abstract: What are proposed are primarily aromatic alkenoic acid derivatives of the formula I for use in a therapeutic method as (a) means for reducing appetite and/or (b) means for causing a feeling of satiation and/or as (c) means for reducing energy intake and/or as (d) mood enhancers, and the non-therapeutic use of the aromatic alkenoic acid derivatives of formula I as (a) means for reducing appetite and/or (b) means for causing a feeling of satiation and/or as (c) means for reducing energy intake and/or as (d) mood enhancers.
    Type: Application
    Filed: March 11, 2015
    Publication date: September 17, 2015
    Inventors: Jakob Ley, Katja Obst, Katharina Reichelt, Veronika Somoza, Barbara Rohm
  • Patent number: 8906958
    Abstract: The invention relates to certain compounds, salts of these compounds and mixtures containing or consisting of two or more such compounds, two or more such salts or one or more such compounds and one or more such salts, each for use in a method for the prophylaxis and/or treatment of inflammation, in particular of inflammation of the skin.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: December 9, 2014
    Assignee: Symrise AG
    Inventors: Katharina Reichelt, Jakob Ley, Marcus Götz, Maria Blings