Patents by Inventor Jakob Ley

Jakob Ley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11759435
    Abstract: The present invention belongs to the area of pharmaceutical and cosmetic compositions and refers to compounds, novel mixtures and preparations comprising certain compound(s) of formula (I) which show anti-inflammatory properties.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: September 19, 2023
    Assignee: SYMRISE AG
    Inventors: Veronika Somoza, Katharina Schüller, Joachim Hans, Jakob Ley
  • Patent number: 11485930
    Abstract: The present invention primarily relates to a method for producing an aromatic blend comprising unsaturated dienals. The invention further relates to aromatic blends obtained or obtainable by a method according to the invention and compositions or semi-finished products for producing said compositions, comprising aromatic blends according to the invention. A further aspect of the present invention relates to the use of an aromatic blend according to the invention for aromatizing a composition, preferably a composition serving for food or pleasure, or a semi-finished product for producing such a composition.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: November 1, 2022
    Assignee: SYMRISE AG
    Inventors: Michael Backes, Jekaterina Ongouta, Jakob Ley, Tobias Vössing, Volkmar Koppe, Jens Koch
  • Publication number: 20220226261
    Abstract: The present invention belongs to the area of pharmaceutical and cosmetic compositions and refers to compounds, novel mixtures and preparations comprising certain compound(s) of formula (I) which show anti-inflammatory properties.
    Type: Application
    Filed: April 28, 2016
    Publication date: July 21, 2022
    Inventors: Veronika SOMOZA, Katharina SCHÜLLER, Joachim HANS, Jakob LEY
  • Publication number: 20220071933
    Abstract: The present invention primarily relates to a combination agent for reducing appetite and/or for providing a feeling of satiety and/or for reducing energy intake and/or for reducing body weight. In addition, the present invention relates to a medical use of the combination agent, in particular for the treatment of overweight and obesity and for the prevention of cardiovascular disease, stroke, diabetes, and joint damage and wear of the spine, and to a non-therapeutic use of the combination agent. In particular, the focus of the present invention is on the use of the combination agent to provide a feeling of satiety and/or to reduce energy intake and/or to reduce body weight. Finally, the present invention relates to the use of the combination agent for the preparation of an orally consumable preparation or food ingredient and an orally consumable preparation or food ingredient prepared therefrom.
    Type: Application
    Filed: January 18, 2019
    Publication date: March 10, 2022
    Inventors: Jakob Ley, Veronika Somoza, Verena Stöger, Joachim Hans
  • Publication number: 20210386686
    Abstract: The present invention refers to a composition comprising guaifenesin and one or more flavour compound(s) containing an isovanillyl group. In particular, the present invention refers to a composition comprising guaifenesin and one or more flavour compound(s) containing an isovanillyl group, said composition being for medical use, in particular for use in the prevention and treatment of respiratory diseases. Moreover, the present invention relates to the use of guaifenesin and one or more flavour compounds containing an isovanillyl group for the preparation of a pharmaceutical composition. Finally, the present invention relates to the use of one or more flavour compound(s) containing an isovanillyl group for masking or inhibiting the bitter taste of guaifenesin or of guaifenesin comprising compositions.
    Type: Application
    Filed: October 9, 2018
    Publication date: December 16, 2021
    Inventors: Veronika Somoza, Leopoldo Beltran, Joachim Hans, Jakob Ley
  • Publication number: 20210330641
    Abstract: Pharmaceutical preparations are proposed, comprising bitter-masking acting substances for reducing and/or inhibiting gastric acid secretion induced by food constituents.
    Type: Application
    Filed: June 4, 2021
    Publication date: October 28, 2021
    Inventors: Elke Köck, Jakob Ley, Veronika Somoza, Kathrin Liszt, Sabine Widder
  • Publication number: 20210290528
    Abstract: The present invention refers to a composition comprising eriodictyol and guaifenesin. In particular, the present invention refers to a composition comprising eriodictyol and guaifenesin, said composition being for medical use, in particular for use in the prevention and treatment of respiratory diseases. Moreover, the present invention relates to the use of eriodictyol and guaifenesin for the preparation of a pharmaceutical composition. Finally, the present invention relates to the use of eriodictyol for masking or inhibiting the bitter taste of guaifenesin or guaifenesin comprising compositions.
    Type: Application
    Filed: April 30, 2019
    Publication date: September 23, 2021
    Inventors: Joachim Hans, Jakob Ley, Martin Guerney, Veronika Somoza, Leopoldo Beltran
  • Publication number: 20200367542
    Abstract: Suggested is an aroma composition comprising (a) hesperetin dihydrochalcone or a salt thereof, and (b) high fructose corn syrup (HFCS), providing a high degree of sweetness, but low caloric input.
    Type: Application
    Filed: October 23, 2017
    Publication date: November 26, 2020
    Inventors: Fabia HENTSCHEL, Jakob LEY, Thomas RIESS, Susanne PAETZ, Jens FAHLE, Katja OBST
  • Patent number: 10765134
    Abstract: The invention relates to a foodstuff, containing: a) juice, pith, flesh, skins; or other constituents of at least one citrus fruit, b) at least one 4-hydroxyflavanone of the formula (I), in which R1 represents hydrogen or a hydroxy group a or methoxy group and the carbon atom at the position (C2) designated by * is present in a (2S) or a (2R) configuration or in any mixture of the two configurations, and also, if applicable, c) further flavorings or flavoring preparations, with the proviso that the constituent (b) is present in a sufficient quantity to improve the acidic and/or bitter taste of the constituent (a).
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: September 8, 2020
    Assignee: SYMRISE AG
    Inventors: Johannes Kiefl, Susanne Paetz, Jakob Ley, Gerhard Krammer, Thomas Riess, Kathrin Langer, Günter Kindel, Morine Verwohlt
  • Patent number: 10767198
    Abstract: A method for producing branched aldehydes is proposed, the method comprising the following steps: (a) providing a culture of one or more fungi of the genus Conidiobolus and producing biomass containing branched carboxylic acids in free and/or bound form; (b) extracting the biomass from step (a) to produce a first intermediate containing free and/or bound carboxylic acids; (c) optionally chemically, enzymatically or microbially hydrolyzing the bound carboxylic acids from the first intermediate; (d) treating the first intermediate with a reducing agent of a chemical nature to convert the free and/or bound carboxylic acids into the corresponding alcohols and optionally separating one or more alcohols from interfering by-products and producing the chemically produced second intermediate containing these alcohols as a mixture or in enriched form; (e) treating the first intermediate with a reducing agent of a biological nature to convert the free and/or bound carboxylic acids into the corresponding aldehydes havin
    Type: Grant
    Filed: November 28, 2015
    Date of Patent: September 8, 2020
    Assignee: SYMRISE AG
    Inventors: Marco A. Fraatz, Holger Zorn, Johanna Rost, Michael Goldmann, Egon Gross, Jakob Ley, Katrin Geissler, Torsten Geissler, Michael Backes, Fabia Hentschel, Jens-Michael Hilmer
  • Patent number: 10736829
    Abstract: The present invention relates primarily to the use of certain hydroxybenzoic acid amides or the salts or mixtures thereof for masking an unpleasant taste impression, preferably of a bitter, adstringent, dusty, dry, floury, rancid, metallic and/or cardboard taste or aftertaste, of one or more unpleasant-tasting peptides or of certain amino acid mixtures. The invention further relates to a corresponding method for masking unpleasant taste impressions and to novel preparations.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: August 11, 2020
    Assignee: SYMRISE AG
    Inventors: Joachim Hans, Jakob Ley, Kathrin Langer, Susanne Paetz
  • Patent number: 10702484
    Abstract: The present invention concerns the use of 3-(3-Hydroxy-4-methoxy-phenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one for masking, reducing or suppressing an unpleasant taste impression, preferably bitter, sour and/or astringent taste impression of unpleasant-tasting substances or mixture of substances, preferably bitter-, sour-, and/or astringent-tasting substances or mixtures of substances, and in particular the bitter taste impression of bitter-tasting substances, and/or modulating the taste impressions selected from the group consisting of cooling, umami, fruity and spicy notes of cooling-, umami-, fruity- or spicy-tasting substances or mixture of substances, and simultaneously intensifying the sweet-taste impression of sweet-tasting substances or mixtures of substances or both sweet- and bitter-tasting tasting substances or mixture of substances.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: July 7, 2020
    Assignee: SYMRISE AG
    Inventors: Gerhard Krammer, Jakob Ley, Fabia Hentschel, Susanne Paetz, Thomas Riess, Michael Backes
  • Publication number: 20200080023
    Abstract: The present invention primarily relates to a method for producing an aromatic blend comprising unsaturated dienals. The invention further relates to aromatic blends obtained or obtainable by a method according to the invention and compositions or semi-finished products for producing said compositions, comprising aromatic blends according to the invention. A further aspect of the present invention relates to the use of an aromatic blend according to the invention for aromatizing a composition, preferably a composition serving for food or pleasure, or a semi-finished product for producing such a composition.
    Type: Application
    Filed: June 1, 2017
    Publication date: March 12, 2020
    Inventors: Michael BACKES, Jekaterina ONGOUTA, Jakob LEY, Tobias VÖSSING, Volkmar KOPPE, Jens KOCH
  • Patent number: 10561633
    Abstract: The invention relates to compounds of formula (I) or the salts thereof, said compounds of formula (I) being selected from among the group consisting of homoeriodictyol (1), eriodictyol (2), hesperetin (3) and sterubin (4), for use in the treatment of an ailment which can be alleviated or prevented by influencing the serotonin level and the concentration of free fatty acids in the blood.
    Type: Grant
    Filed: July 26, 2015
    Date of Patent: February 18, 2020
    Assignee: SYMRISE AG
    Inventors: Veronika Somoza, Barbara Rohm, Kathrin Liszt, Marc Pignitter, Christina Hochkogler, Jakob Ley, Sabine Widder, Gerhard Krammer
  • Patent number: 10538548
    Abstract: The invention relates to novel substance mixtures which can be used as aroma compositions to enhance the sweet taste of oral preparations.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: January 21, 2020
    Assignee: SYMRISE AG
    Inventors: Gerhard Krammer, Christoph Sabater, Thomas Riess, Jakob Ley, Thorsten Geiβler
  • Patent number: 10538797
    Abstract: The invention relates to a method for producing flavone glycoside dihydrochalcones, having the following steps: (a) providing a transgenic microorganism containing (i) a first nucleic acid portion (A) containing a gene which codes for a bacterial chalcone isomerase and (ii) a second nucleic acid portion (B) containing a gene which codes for a bacterial enoate reductase, (b) adding one or more flavone glycosides to the transgenic microorganism under conditions which allow the simultaneous isomerization and reduction of the flavone glycoside into the flavone glycoside dihydrochalcone, and optionally (d) isolating and purifying the final product, wherein the nucleic acid portion (A) (1) is a nucleotide sequence according to SEQ ID NO:1, in which the nucleic acid portion (A?) according to SEQ ID NO:3 has been cut out, or (2) is an amino acid sequence according to SEQ ID NO:2, in which the amino acid portion (A?) according to SEQ ID NO:4 has been cut out.
    Type: Grant
    Filed: June 27, 2015
    Date of Patent: January 21, 2020
    Assignee: SYMRISE AG
    Inventors: Maren Thomsen, Jakob Ley, Egon Gross, Winfried Hinrichs, Uwe Bornscheuer
  • Publication number: 20190367954
    Abstract: A method for producing branched aldehydes is proposed, the method comprising the following steps: (a) providing a culture of one or more fungi of the genus Conidiobolus and producing biomass containing branched carboxylic acids in free and/or bound form; (b) extracting the biomass from step (a) to produce a first intermediate containing free and/or bound carboxylic acids; (c) optionally chemically, enzymatically or microbially hydrolyzing the bound carboxylic acids from the first intermediate; (d) treating the first intermediate with a reducing agent of a chemical nature to convert the free and/or bound carboxylic acids into the corresponding alcohols and optionally separating one or more alcohols from interfering by-products and producing the chemically produced second intermediate containing these alcohols as a mixture or in enriched form; (e) treating the first intermediate with a reducing agent of a biological nature to convert the free and/or bound carboxylic acids into the corresponding aldehydes havin
    Type: Application
    Filed: November 28, 2015
    Publication date: December 5, 2019
    Inventors: Mario FRAATZ, Holger ZORN, Johanna ROST, Michael GOLDMAN, Egon GROSS, Jakob LEY, Katrin GEISSLER, Torsten GEISSLER, Michael BACKES, Fabia HENTSCHEL, Jens-Michael HILMER
  • Publication number: 20190343777
    Abstract: The present invention concerns the use of 3-(3-Hydroxy-4-methoxy-phenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one for masking, reducing or suppressing an unpleasant taste impression, preferably bitter, sour and/or astringent taste impression of unpleasant-tasting substances or mixture of substances, preferably bitter-, sour-, and/or astringent-tasting substances or mixtures of substances, and in particular the bitter taste impression of bitter-tasting substances, and/or modulating the taste impressions selected from the group consisting of cooling, umami, fruity and spicy notes of cooling-, umami-, fruity- or spicy-tasting substances or mixture of substances, and simultaneously intensifying the sweet-taste impression of sweet-tasting substances or mixtures of substances or both sweet- and bitter-tasting tasting substances or mixture of substances.
    Type: Application
    Filed: April 28, 2016
    Publication date: November 14, 2019
    Inventors: Gerhard KRAMMER, Jakob LEY, Fabia HENTSCHEL, Susanne PAETZ, Thomas RIESS, Michael BACKES
  • Patent number: 10435673
    Abstract: A method is proposed for producing flavonoids, comprising the steps: (a) providing of a transgenic microorganism, containing (i) a first nucleic acid section (A), comprising or consisting of a gene coding for a CYP450 oxidase, (ii) a second nucleic acid section (B), comprising or consisting of a gene coding for a plant O-methyltransferase, and (b) adding of one or more flavanones to the transgenic microorganism, (c) the conversion of the substrate flavanones by the transgenic microorganism to the corresponding flavonoids, and optionally (d) isolating and purifying of the final products.
    Type: Grant
    Filed: September 27, 2015
    Date of Patent: October 8, 2019
    Assignee: SYMRISE AG
    Inventors: Ludger Wessjohann, Anne-Kathrin Bauer, Jakob Ley, Torsten Geissler, Katrin Geissler
  • Publication number: 20190289886
    Abstract: Proposed are mixtures of substances containing (a) phloretin, (b) naringenin, (c) at least one further sweet substance other than phloretin and naringenin, and optionally (d) at least one flavoring substance.
    Type: Application
    Filed: December 1, 2015
    Publication date: September 26, 2019
    Inventors: Johannes KIEFL, Susanne PAETZ, Jakob LEY, Gerhard KRAMMER, Thomas RIESS, Kathrin LANGER, Günter KINDEL, Morine VERWOHLT, Torsten GEISSLER, Egon GROSS