Patents by Inventor James A. Bradley

James A. Bradley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C40-, C28-, and C-32-Linked Rapamycin Analogs as mTOR Inhibitors
    Publication number: 20210338824
    Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.
    Type: Application
    Filed: October 28, 2020
    Publication date: November 4, 2021
    Inventors: Jennifer Pitzen, Micah James Evans Gliedt, G. Leslie Burnett, James Bradley Aggen, Gert Kiss, James Joseph Cregg, Christopher Michael Semko, Walter Won, Gang Wang, Julie Chu-Li Lee, Arun P. Thottumkara, Adrian Liam Gill, Kevin T. Mellem
  • Context based messaging
    Patent number: 11127077
    Abstract: Systems and methods are provided for monitoring a plurality of chat messages. Values are extracted from multiple chat messages between a first party and a second party. Context is determined for the values and/or messages. The context is used to determine the relationship between the values, messages, and one or more transactions. Once all values of a transaction are identified, an order ticket is generated.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: September 21, 2021
    Assignee: Chicago Mercantile Exchange Inc.
    Inventors: Carrick Pierce, Matthew Morano, James Bradley
  • Antibacterial aminoglycoside analogs
    Patent number: 11117915
    Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: September 14, 2021
    Assignee: CIPLA USA, INC.
    Inventors: James Bradley Aggen, Adam Aaron Goldblum, Martin Sheringham Linsell, Paola Dozzo, Heinz Ernst Moser, Darin James Hildebrandt, Micah James Gliedt
  • FLUID FLOW RATE DETERMINATIONS USING VELOCITY VECTOR MAPS
    Publication number: 20210244291
    Abstract: A method of determining volume flow rate of a bodily fluid in a biological conduit includes determining a cross-sectional area of a biological conduit using a velocity vector map representing moving entities or moving fluid portions in a bodily fluid flowing within the biological conduit, calculating an average speed of the moving entities or moving fluid portions in the bodily fluid flowing across the determined cross-sectional area of the biological conduit, and calculating volume flow rate of the bodily fluid in the biological conduit from the determined cross-sectional area and the calculated instantaneous or average speed. A series of velocity vector maps may be collected over time so as to generate a flow rate profile representing flow rate as a function of time.
    Type: Application
    Filed: April 30, 2021
    Publication date: August 12, 2021
    Inventors: James Bradley Sund, David S. Cohen, Heinrich Ziegler
  • STEPPER MOTOR DRIVE SYSTEMS AND TUBING OCCLUDER SYSTEM
    Publication number: 20210236704
    Abstract: This document describes stepper motor drive systems. The stepper motor drive systems can be used in many different applications including, for example, to drive a stepper motor of an occluder device in association with a heart-lung machine.
    Type: Application
    Filed: January 30, 2020
    Publication date: August 5, 2021
    Inventor: James Bradley Atherton
  • METHODS AND SYSTEMS TO DETECT ROGUE HOTSPOTS
    Publication number: 20210227394
    Abstract: Methods, systems, and apparatuses are described for identifying unauthorized (e.g., rogue) access points. Authorized access points can detect the presence of rogue access points by determining signal strengths associated with other access points. A detected variance from an expected signal strength can indicate a presence of a rogue access point.
    Type: Application
    Filed: December 21, 2020
    Publication date: July 22, 2021
    Inventors: Ryan Van Antwerp, James Bradley Hein
  • METHODS OF MODIFYING MATERIAL FLOW MODE DURING MACHINING AND PRODUCTS FORMED THEREBY
    Publication number: 20210205940
    Abstract: Methods of inducing segmented flow in a material in which a ductile flow mode would otherwise occur during machining. A monolayer molecular film is formed on a surface of a body of a material in a state such that the material exhibits ductile flow when subjected to shear. The monolayer molecular film has molecules each having a head group adsorbed to the surface, a terminal group, and a hydrocarbon chain therebetween having a chain length of greater than 6. A surface portion of the body is removed by engaging the body with a tool in a contact region below the surface of the body and moving the tool relative to the body to remove the surface portion and the monolayer molecular film thereon. The monolayer molecular film induces segmented flow in the material during the removing of the surface portion.
    Type: Application
    Filed: November 6, 2020
    Publication date: July 8, 2021
    Inventors: Tatsuya Sugihara, Srinivasan Chandrasekar, Anirudh Udupa, Koushik Viswanathan, Kevin Paul Trumble, James Bradley Mann
  • Device and Method for measuring the mass of a polarisable fluid in a container
    Publication number: 20210190576
    Abstract: A method and a device for determining the amount of fill volume in a container. A mass of polarizable liquid in a container is positioned within the measurement region of a shielding antenna and a measuring pulse antenna. The shielding antenna is connected to both a measuring device that measures a time-dependent voltage value of an external interference signal and to a compensation signal generator that generates a time-dependent compensation signal compensating this interference signal. The measuring pulse antenna is connected to both a measuring pulse generator that generates a polarization signal to transmit to the fluid fill in the container and to a second measuring device that measures a response signal to derive the mass of the fluid from said response signal.
    Type: Application
    Filed: December 11, 2020
    Publication date: June 24, 2021
    Inventors: JAMES BRADLEY, ROBERT ANDREE EMIL GRIEBEL, BERND STROETER
  • Anti-Axl Antagonistic Antibodies
    Publication number: 20210171643
    Abstract: The present disclosure relates to antibodies that specifically bind a novel epitope on the Axl protein. Also disclosed are methods for the production and use of the anti-Axl antibodies.
    Type: Application
    Filed: June 21, 2017
    Publication date: June 10, 2021
    Applicants: BERGEN TEKNOLOGIOVERFØRING AS, BERGENBIO ASA
    Inventors: David Robert MICKLEM, Sergej KIPRIJANOV, James Bradley LORENS, Lavina AHMED, Linn NILSSON, Tone SANDAL
  • Malicious activity detection in a memory
    Patent number: 11023579
    Abstract: A method and apparatus for monitoring a volatile memory in a computer system. Samples of compressed data from locations in the volatile memory in the computer system are read. Data in the volatile memory is reconstructed using the samples of compressed data. The data is an image of the volatile memory. The image enables determining whether an undesired process is present in the volatile memory.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: June 1, 2021
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Jason W. Wheeler, Tu-Thach Quach, Conrad D. James, James Bradley Aimone, Arun F. Rodrigues
  • C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors
    Patent number: 10980889
    Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: April 20, 2021
    Assignee: REVOLUTION MEDICINES, INC.
    Inventors: Jennifer Pitzen, Micah James Evans Gliedt, G. Leslie Burnett, James Bradley Aggen, Gert Kiss, Christopher Michael Semko, Walter Won, Gang Wang, Julie Chu-Li Lee, Arun P. Thottumkara, Adrian Liam Gill, Kevin T. Mellem
  • Neuromorphic computing architecture with dynamically accessible contexts
    Patent number: 10970630
    Abstract: Various technologies pertaining to allocating computing resources of a neuromorphic computing system are described herein. Subgraphs of a neural algorithm graph to be executed by the neuromorphic computing system are identified. The subgraphs are each executed by a group of neuron circuits serially. Output data generated by execution of the subgraphs are provided to the same or a second group of neuron circuits at a same time or with associated timing data indicative of a time at which the output data was generated. The same or second group of neuron circuits performs one or more processing operations based upon the output data.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: April 6, 2021
    Assignees: National Technology & Engineering Solutions of Sandia, LLC, Lewis Rhodes Labs, Inc.
    Inventors: James Bradley Aimone, John H. Naegle, Jonathon W. Donaldson, David Follett, Pamela Follett
  • RAPAMYCIN ANALOGS AS MTOR INHIBITORS
    Publication number: 20210094975
    Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.
    Type: Application
    Filed: October 30, 2019
    Publication date: April 1, 2021
    Inventors: James Bradley AGGEN, Arun P. THOTTUMKARA, G. Leslie BURNETT, Micah James Evans GLIEDT, Gert KISS, Walter WON, Julie Chu-Li LEE, Adrian Liam GILL, Christopher SEMKO, Jennifer PITZEN, Gang WANG, Nidhi TIBREWAL
  • Reel based outlet relocation/extension system
    Patent number: 10950990
    Abstract: A power adapter may include a base wall mounted power adapter configured to be plugged into a wall power outlet and at least one extension adapter unit electrically coupled to the base wall mounted power adapter and configured to be extended away from the wall power outlet. The at least one extension adapter unit may include an electrical conduit reel configured to unravel in response to the at least one extension adapter unit being extended.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: March 16, 2021
    Assignee: One-Eyed Pilot Innovations, Inc.
    Inventor: James Bradley Post
  • Semi-automated wood-cutting machine and method
    Patent number: 10919177
    Abstract: A semi-automated wood-cutting machine includes a receiving/alignment stage adapted to receive a piece of wood, the receiving/alignment stage having an alignment aid adapted to facilitate manual alignment of the piece of wood, and a cutting stage spaced from the receiving/alignment stage, the cutting stage being configured to cut the piece of wood along a predetermined cut pathway.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: February 16, 2021
    Assignee: INDEPENDENT STAVE COMPANY, LLC
    Inventors: James Bradley Boswell, Michael Joel Nagy, Patrick Jean-Marie Eisen
  • Methods and systems to detect rogue hotspots
    Patent number: 10911956
    Abstract: Methods, systems, and apparatuses are described for identifying unauthorized (e.g., rogue) access points. Authorized access points can detect the presence of rogue access points by determining signal strengths associated with other access points. A detected variance from an expected signal strength can indicate a presence of a rogue access point.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: February 2, 2021
    Assignee: COMCAST CABLE COMMUNICATIONS, LLC
    Inventors: Ryan Van Antwerp, James Bradley Hein
  • State-preserving upgrade of an intelligent server adapter
    Patent number: 10908895
    Abstract: Methods and systems for upgrading an intelligent server adapter (ISA) with reduced downtime that affects performance are provided. The method includes, from a main agent, initiating a backup agent that includes critical functions of the ISA and runs in a tight loop, isolated from other components. The main agent transfers critical duties to the backup agent and shuts down before performing the upgrade. After upgrading itself and other system components, the main agent retrieves the duties from the backup agent, and may terminate the backup agent.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: February 2, 2021
    Assignee: PENSANDO SYSTEMS INC.
    Inventors: Barun Amalkumar Halder, Alok Rathore, Neel Patel, James Bradley Smith, David Antony Clear
  • Adaptive neural network management system
    Patent number: 10891540
    Abstract: A method and computer system for managing a neural network. Data is sent into an input layer in a portion of layers of nodes in the neural network. The data moves on an encode path through the portion such that an output layer in the portion outputs encoded data. The encoded data is sent into the output layer on a decode path through the portion back to the input layer to obtain a reconstruction of the data by the input layer. A determination is made as to whether an undesired amount of error has occurred in the output layer based on the data sent into the input layer and the reconstruction of the data. A number of new nodes is added to the output layer when a determination is present that the undesired amount of the error occurred, enabling reducing the error using the number of the new nodes.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: January 12, 2021
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Timothy J. Draelos, James Bradley Aimone
  • FLUORESCENCE BASED FLOW IMAGING AND MEASUREMENTS
    Publication number: 20210000352
    Abstract: Fluorescence based tracking of a light-emitting marker in a bodily fluid stream is conducted by: providing a light-emitting marker into a fluid stream; establishing field of view monitoring by placement of a sensor, such as a high speed camera, at a region of interest; recording image data of light emitted by the marker at the region of interest; determining time characteristics of the light output of the marker traversing the field of view; and calculating flow characteristics based on the time characteristics. Furthermore generating a velocity vector map may be conducted using a cross correlation technique, leading and falling edge considerations, subtraction, and/or thresholding.
    Type: Application
    Filed: September 24, 2020
    Publication date: January 7, 2021
    Inventors: James Bradley Sund, SR., David S. Cohen
  • Signage system
    Patent number: D931369
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: September 21, 2021
    Assignee: INTERNATIONAL PAPER COMPANY
    Inventors: Danielle Helms Graham, James Bradley Griffin