Abstract: This invention relates to methods and compositions for detecting, identifying and treating glaucoma diseases. More particularly, this invention discloses compositions and methods for affecting intraocular pressure and increasing ocular outflows in glaucoma. Compositions and methods provided include purified and synthesized extracellular vesicle complexes from glaucoma ocular humor for use in methods and devices for detecting, characterizing and treating glaucoma diseases along with active agents. The presence of extracellular vesicle complexes in glaucoma can also be used as a biomarker.

Abstract: Surgical instruments and methods for delivering bone anchor assemblies into bone are disclosed herein. Use of these anchors or instruments can eliminate one or more of the steps in a conventional bone anchor installation procedure, improving surgical efficiency and safety. In general, a surgical instrument can include a handle assembly having an elongate shaft extending distally therefrom. The handle assembly can be configured to axially translate a carrier assembly that secures a stylet extending therethrough. Translation of the stylet can be made relative to a distal end of the elongate shaft. The surgical instruments can include various carrier assemblies for positioning the distal end of the stylet relative to the distal end of the elongate shaft based on a length of bone anchor to be installed by the surgical instrument.

Abstract: A lock mechanism having a bolt movable between a thrown position and a retracted position, and a deadbolt assembly includes a sliding deadbolt configured to slide between a locked position in which the sliding deadbolt inhibits retraction of the bolt and an unlocked position. The sliding deadbolt includes a first anti-thrust cam configured to restrain the sliding deadbolt in the locked position, and a release driver arranged such that, when driven, the release driver releases the first anti-thrust cam from restraining the sliding deadbolt in the locked position and slides the deadbolt to the unlocked position.

Abstract: Embodiments herein describe partitioning hardware and software in a system on a chip (SoC) into a hierarchy. In one embodiment, the hierarchy includes three levels of hardware-software configurations, enabling security and/or safety isolation across those three levels. The levels can cover the processor subsystem with compute, memory, acceleration, and peripheral resources shared or divided across those three levels.

Abstract: Provided herein are synthetic methods for the preparation of intermediates that are utilized in the synthesis of omecamtiv mecarbil dihydrochloride.

Abstract: A medical implant comprises a central flow portion having a first network of struts forming two or more cells, a first set of anchoring arms, and a second set of anchoring arms. The two or more cells are arranged linearly and extend from the first set of anchoring arms to the second set of anchoring arms.

Abstract: This invention relates to methods and compositions for treating diseases of intraocular pressure. More particularly, this invention discloses a range of compounds, devices and methods for detecting and/or affecting intraocular pressure, treating glaucoma diseases, and increasing ocular outflows. Compositions of this disclosure can be used for reducing ocular extracellular complexes.

Abstract: Surgical instruments and methods for delivering bone anchor assemblies into bone are disclosed herein. Use of these anchors or instruments can eliminate one or more of the steps in a conventional bone anchor installation procedure, improving surgical efficiency and safety. In general, a surgical instrument can include a handle assembly having an elongate shaft extending distally therefrom. The handle assembly can be configured to axially translate a carrier assembly that secures a stylet extending therethrough. Translation of the stylet can be made relative to a distal end of the elongate shaft. The surgical instruments can include various carrier assemblies for positioning the distal end of the stylet relative to the distal end of the elongate shaft based on a length of bone anchor to be installed by the surgical instrument.

Abstract: Systems, methods, and devices for Bluetooth numeric comparison pairing between a handheld payment terminal and a base station that is incapable of displaying digits of a base station Bluetooth pairing code are disclosed. A handheld payment terminal computer program may initiate Bluetooth numeric pairing with a base station; generate a handheld payment terminal Bluetooth pairing code; capture a coded light sequence emitted by LEDs on the base station; decode the coded light sequence to determine the base station Bluetooth pairing code; cause the base station Bluetooth pairing code and the handheld payment terminal Bluetooth pairing code to be displayed on a display; and in response to Bluetooth pairing code match, pairing the handheld payment terminal with the base station. The base station provides access to one or more networks and/or data communication to the handheld payment terminal when paired.

Abstract: Embodiments herein describe memories in a processor system in an integrated circuit (IC) that can be assigned to either a cache coherent domain or an I/O domain, rather than being statically assigned by a designer of the IC. That is, the user or customer can assign the memories to domain that best suits their desires. Further, the memories can be reassigned to a different domain if the user later changes her mind.

Abstract: Devices, methods and systems are provided for isolating extracellular matrix bodies. More particularly, this invention discloses devices, methods and systems for isolating extracellular matrix bodies from a biological sample for use in diagnosis and prognosis of a subject. A device may have restriction channels for isolating extracellular matrix bodies and uniform flow channels for precise pressure measurements.

Abstract: A method for determining the activity of creatininase includes providing an amount of creatininase to be measured for enzyme activity and providing an excess amount of creatinine, the excess amount being greater than an amount that will ordinarily react with the amount of creatininase. The method further includes reacting the amount of creatininase with the excess amount of creatinine to produce creatine. The method further includes reacting the creatine with diacetyl and 1-naphatol and producing a pink color. The method further includes measuring an intensity of the pink color and determining an amount of the creatine that was created based on the intensity. The method further includes calculating a specific activity of the creatininase based on the amount of creatine.

Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.

Abstract: A sensor-retention structure includes a sensor-support strut and a means for securing a sensor device to the sensor-support strut. A sensor-support arm can be configured to have disposed thereon an at least partially cylindrical sensor device and be associated with one or more sensor-retention fingers projecting from the sensor-support arm and/or a cage structure configured to be secured to the sensor device.

Abstract: Provided herein are synthetic methods for the preparation of intermediates that are utilized in the synthesis of omecamtiv mecarbil dihydrochloride.

Abstract: A medical implant delivery system can comprise a puncture needle, a medical implant delivery catheter and the puncture needle being configured to be slidably advanced through a puncture needle lumen of the medical implant delivery catheter, a medical implant device positioned on the medical implant delivery catheter, and an outer delivery catheter comprising a medical implant delivery lumen, the medical implant delivery catheter being configured to slidably extend through the medical implant delivery lumen. A medical implant delivery system can comprise a puncture needle, a medical implant delivery catheter and the puncture needle being configured to slidably extend through the puncture needle lumen of the medical implant delivery catheter, a medical implant device positioned on the medical implant delivery catheter, an elongate housing adjacent to the medical implant delivery catheter, and an outer sheath around a portion of the medical implant delivery catheter and the elongate housing.

Abstract: Systems and methods herein provide for improved handling of oversized email attachments. An example system can identify an oversized email attachment before an email is sent, by comparing the size of the attachment to a maximum file size at an email server. The user can then be notified that the attachment is over the allowable file size before sending the email. The system can also un-attach the oversized file, compress it using a suitable compression method, and reattach a compressed file. The compression can be done at the sender's request or automatically.

Abstract: A system includes a lock and release connector, an implantable medical device, and an outer tube. The lock and release connector includes a connector body defining a recess having planar lateral head portions extending to and intersecting with a cylindrical surface of the connector body, and a longitudinal neck portion extending from the head portion. The implantable medical device has an extension including a neck portion receivable in the longitudinal neck portion of the recess and a head portion receivable in the lateral head portions of the recess. The outer tube extends over the recess to retain the extension in the recess.