Abstract: A hollow CMC article, a mandrel for forming the article and a method for forming the article are disclosed. The article includes a ply-wrap layer defining a cavity. The ply-wrap layer includes a first face, a second face, a root portion bridging the faces, and a plurality of CMC wrap plies. The root portion defines a terminus of the ply-wrap layer including a cross-sectional conformation consisting of a curve having a single turning point. Each of the plurality of CMC wrap plies are disposed along the first face, wrap over the root portion, and extend along the second face. The hollow article further includes a plurality of CMC lateral plies disposed along the faces.

Abstract: This invention relates to methods and compositions for detecting, identifying and treating glaucoma diseases. In addition, this invention discloses compositions and methods for affecting intraocular pressure and increasing ocular outflows in glaucoma. Compositions are provided for treating a glaucoma disease, reducing intraocular pressure, and/or reducing ocular extracellular vesicle complexes in a subject.

Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.

Abstract: A system for delivering flowable biomaterial to an intervertebral disc space between adjacent vertebral bodies includes a delivery body defining a proximal end, a distal end spaced from the proximal end along a longitudinal direction, a cannulation extending from the proximal end to an opening adjacent the distal end, and a distal region including a tip that extends to the distal end. The distal region defines a maximum height at a location proximal of the distal end and measured along a second direction perpendicular to the longitudinal direction. The distal region is for indicating a distance between the adjacent vertebral bodies. The system includes a carrier having a longitudinally elongate channel for carrying biomaterial and being insertable within the cannulation, as well as an advancement member configured for insertion within the cannulation to forcibly advance the biomaterial from the cannulation, through the opening, and into the disc space.

Abstract: In an embodiment, a system attaches a patient reference array of a computer-assisted surgery system to a patient. The system includes a fixation post having a shaft having proximal and distal ends that are offset from. A threaded fastener is coupled to the shaft at the distal end that rotates relative to the shaft so as to engage internal threads of a pedicle screw, thereby causing the distal end of the shaft to translate in the anchor seat and urge the pedicle screw to transition from an unlocked configuration to a locked configuration. The attachment assembly has an arm that supports the patient reference array, and a coupler supported by the arm. The coupler has a fixation body that defines a recess that receives at least a portion of the fixation post, and an actuator that secures the attachment assembly to the fixation post.

Abstract: A puncture needle can comprise an elongate portion, a puncture component associated with a distal end of the elongate portion, and a spacer associated with a distal portion of the elongate portion, where the spacer can be configured to contact a wall of the delivery catheter lumen to prevent contact between the puncture component and the wall. A puncture needle can comprise an elongate portion and a puncture component associated with a distal end of the elongate portion, where the puncture component comprises a blade edge on a distal edge, and where the puncture component is configured to be advanceable through a lumen of a delivery catheter without the blade edge sticking to a wall of the lumen.

Abstract: Driver instruments and related methods are disclosed herein, e.g., for applying a fastener to a bone anchor. Various features are disclosed for retaining the fastener to the driver instrument, such as tapered drive tips, as are various features for impacting the driver instrument into the fastener, such as slidable slap-hammer type handles. Driver instruments with interchangeable handles or handle geometries that can be changed without separating the instrument from an attached fastener are also disclosed.

Abstract: Delivery systems and catheters including lock and release connectors for implantable devices and methods for retaining, positioning, and deploying a medical device are disclosed. The lock and release connectors can include a body and at least one door engaged with the body, wherein the door is moveable from a first position to a second position. The lock and release connectors can further include at least one fastener connecting at least one end of the door to the body. The door can be integral with the body or connected and can comprise a shape memory material and/or other materials.

Abstract: Screw inserter instruments and methods for implanting a bone screw are disclosed herein. In one exemplary embodiment, a screw inserter instrument can include a screw drive assembly having a first handle and a driver shaft coupled to the first handle, and a stylet assembly having a second handle and a stylet extending through the driver shaft. The first handle can have a locked configuration, in which the first handle and the driver shaft are coupled such that the first handle can maintain the driver shaft in a fixed position while the second handle is rotated relative to the first handle, and an unlocked configuration, in which the first handle and the driver shaft can rotate simultaneously in a first direction and the first handle can rotate independent of the driver shaft in a second opposite direction.

Abstract: A system for delivering flowable biomaterial to an intervertebral disc space between adjacent vertebral bodies includes a delivery body defining a proximal end, a distal end spaced from the proximal end along a longitudinal direction, a cannulation extending from the proximal end to an opening adjacent the distal end, and a distal region including a tip that extends to the distal end. The distal region defines a maximum height at a location proximal of the distal end and measured along a second direction perpendicular to the longitudinal direction. The distal region is for indicating a distance between the adjacent vertebral bodies. The system includes a carrier having a longitudinaly elongate channel for carrying biomaterial and being insertable within the cannulation, as well as an advancement member configured for insertion within the cannulation to forcibly advance the biomaterial from the cannulation, through the opening, and into the disc space.

Abstract: Docking stations for transcatheter valves are described. The docking stations can include an expandable frame, at least one sealing portion, and a valve seat. The expandable frame can be configured to conform to an interior shape of a portion of the circulatory system when expanded inside the circulatory system. The sealing portion can be configured to contact an interior surface of the circulatory system to create a seal. The valve seat can be connected to the expandable frame and can be configured to support an expandable transcatheter valve. The docking stations are adaptable to different anatomies/locations to allow implantation of a transcatheter valve in a variety of anatomies/locations.

Abstract: In an embodiment, a system attaches a patient reference array of a computer-assisted surgery system to a patient. The system includes a fixation post having a shaft having proximal and distal ends that are offset from. A threaded fastener is coupled to the shaft at the distal end that rotates relative to the shaft so as to engage internal threads of a pedicle screw, thereby causing the distal end of the shaft to translate in the anchor seat and urge the pedicle screw to transition from an unlocked configuration to a locked configuration. The attachment assembly has an arm that supports the patient reference array, and a coupler supported by the arm. The coupler has a fixation body that defines a recess that receives at least a portion of the fixation post, and an actuator that secures the attachment assembly to the fixation post.

Abstract: This disclosure describes compounds of Formula (I), stereoisomers, side compounds thereof, pharmaceutical compositions and methods of manufacturing such compounds, using silylation reagents and producing compositions and products made using such methods. More particularly, this disclosure describes manufacture of trofinetide and side products, compositions and products containing such compounds, for pharmaceutical uses to treat neurodegenerative or neurodevelopmental disorders.

Abstract: A mechanism is provided to implement a chatbot application for providing contextual help recommendations based on conversational context and interaction patterns. The chatbot application receives a query from a user and applies natural language processing (NLP) to the query to determine an objective of the query and a confidence of the objective. Responsive to determining the confidence of the objective is below a predetermined threshold, the chatbot application automatically generates a first set of recommendations to the user based on the conversation context and activates a contextual help recommendation button to indicate to the user that the first set of recommendations are available to be viewed.

Abstract: Screw inserter instruments and methods for implanting a bone screw are disclosed herein. In one exemplary embodiment, a screw inserter instrument can include a screw drive assembly having a first handle and a driver shaft coupled to the first handle, and a stylet assembly having a second handle and a stylet extending through the driver shaft. The first handle can have a locked configuration, in which the first handle and the driver shaft are coupled such that the first handle can maintain the driver shaft in a fixed position while the second handle is rotated relative to the first handle, and an unlocked configuration, in which the first handle and the driver shaft can rotate simultaneously in a first direction and the first handle can rotate independent of the driver shaft in a second opposite direction.

Abstract: The present invention relates to a tape comprising an epoxy based resin having ester groups and ethylenically unsaturated groups, alternatively a hybrid resin. The tape of the invention can be used for insulation in electrical machines, especially in high voltage machines. Preferably, the tape of the invention is used in combination with a composition for impregnating and/or coating a substrate comprising the tape of the invention, wherein the composition further comprises a second epoxy based resin having ester groups and ethylenically unsaturated groups, also an hybrid resin, a diluent and an initiator for a radical polymerization.

Abstract: The present invention relates to a composition comprising an epoxy and ester based resin, a reactive diluent and an initiator for a radical polymerization. Furthermore, the invention relates to a process for providing such composition, to a process for applying the composition, to the use of the composition as coating material and to the materials coated with the polymerized composition.

Abstract: A mechanism is provided to implement a chatbot application for providing contextual help recommendations based on conversational context and interaction patterns. The chatbot application receives a query from a user and applies natural language processing (NLP) to the query to determine an objective of the query and a confidence of the objective. Responsive to determining the confidence of the objective is below a predetermined threshold, the chatbot application automatically generates a first set of recommendations to the user based on the conversation context and activates a contextual help recommendation button to indicate to the user that the first set of recommendations are available to be viewed.

Abstract: Disclosed is a high-penetration two-component polyurethane adhesive for separation apparatus, such as thin film composite reverse osmosis filtration membranes. The polyisocyanate reactive side of the two-component adhesive comprises hydrogenated castor oil or derivative thereof to increase the viscosity and provide a thixotropic property. Surprisingly, these high-viscosity polyisocyanate reactive components provide a two-component polyurethane adhesive exhibiting excellent penetration of the membranes used in such separation apparatus. Also disclosed is a method of using these two component polyurethane adhesives to bond these membranes to one or more other components of a separation apparatus.

Abstract: Disclosed is a two-component curable polymeric system having increased viscosity. One component contains a homogeneous blend of a polyisocyanate and a homopolymer or copolymer of vinyl acetate. This component has a higher viscosity than the polyisocyanate alone, thereby increasing the viscosity of the two-component curable system. The other component of the two-component curable system is a composition containing an isocyanate reactive component. The polyisocyanate and the isocyanate reactive component react together (“cure”) to form a polymer. Typically, but not always, the isocyanate reactive component is a polyol or polyamine that is capable of reacting with the polyisocyanate, thereby forming a polyurethane (polyol) or polyurea (polyamine).