Abstract: A display system includes (i) a plurality of picture elements supported on a single semiconductor substrate and (ii) a backplane including electronic circuitry supported thereon and electronically connected with the picture elements. Each picture element includes a light steering optical element and an array of light emitting elements. The array of light emitting elements includes a first set, a second set, and a third set of inorganic LEDs that (i) are monolithically integrated on the single semiconductor substrate and (ii) emit, respectively, light at a first, a second, and a third wavelength, which are mutually distinct. The light steering optical element is configured for steering the light from the first set, second set, and third set of LEDs in a predetermined direction. The electronic circuitry is configured for individually driving each light emitting element of the array of light emitting elements.

Abstract: The present invention relates to TLR7 agonists according to Formula I and their use in the treatment of diseases such as cancer and infectious disease.

Abstract: A vehicle battery jump starter with air pump device includes a vehicle battery jump starter and an air pump disposed within a cover. An internal battery is also disposed within the cover and connected to the vehicle battery jump starter and the air pump. A port is provided so as to provide connection to the device from an external vehicle battery. The air pump is configured such that it is powered by the external battery in a first mode of operation.

Abstract: Provided are CD8 binding agents comprising a VHH domain that specifically binds human CD8. Also provided are nucleic acids encoding such CD8 binding agents, vectors comprising such nucleic acids, host cells comprising same, and methods of making such CD8 binding agents. Also provided are CD8 binding agents having the VHH domain conjugated to a detectable label. Provided are methods of using such CD8 binding agents to detect CD8+ T cells, monitor disease progress, and monitor treatment progress in a subject having cancer, autoimmune disease or condition, transplant rejection or graft-versus-host disease.

Abstract: An electrically isolated coupler may include a driven body, a drive body and an insulating member. The drive body is made of first metallic material and has a driven end configured to interface with a fastening component. The driven body includes a first interface portion and the drive body includes a second interface portion. The drive body is made of a second metallic material and has a drive end configured to interface with a driving tool. The insulating member is disposed between the drive body and the driven body to electrically isolate the drive body and the driven body from each. The first interface portion includes at least one axially extending portion that extends toward the drive body, and the second interface portion includes at least one axially extending portion that extends toward the driven body. The insulating member is disposed between the respective at least one axially extending portions of the first and second interface portions.

Abstract: A handheld device for jump starting a vehicle engine includes a rechargeable lithium ion battery pack (32) and a microcontroller (1). The lithium ion battery is coupled to a power output port of the device through a power switch circuit (15) actuated by the microcontroller. A vehicle battery isolation sensor (12) connected in circuit with positive and negative polarity outputs detects the presence of a vehicle battery (72) connected between the positive and negative polarity outputs. A reverse polarity sensor (10) connected in circuit with the positive and negative polarity outputs detects the polarity of a vehicle battery connected between the positive and negative polarity outputs, such that the microcontroller will enable power to be delivered from the lithium ion power pack to the output port only when a good battery is connected to the output port and only when the battery is connected with proper polarity of positive and negative terminals.

Abstract: A soft error-mitigating semiconductor design system and associated methods that tailor circuit design steps to mitigate corruption of data in storage elements (e.g., flip flops) due to Single Events Effects (SEEs). Required storage elements are automatically mapped to triplicated redundant nodes controlled by a voting element that enforces majority-voting logic for fault-free output (i.e., Triple Modular Redundancy (TMR)). Storage elements are also optimally positioned for placement in keeping with SEE-tolerant spacing constraints. Additionally, clock delay insertion (employing either a single global clock or clock triplication) in the TMR specification may introduce useful skew that protects against glitch propagation through the designed device. The resultant layout generated from the TMR configuration may relax constraints imposed on register transfer level (RTL) engineers to make rad-hard designs.

Abstract: The present invention provides a compound of Formula I: Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the compound and to methods of using the compound to treat physiological disorders.

Abstract: Generation of bubbles is disclosed to occur within a flow of an aqueous fluid. The bubbles may be formed within a tube of a selected diameter and the bubbles are controlled to exit the tube at a selected diameter. Generally, bubbles are formed to include a diameter of less than 1 millimeter, including less than about 20 microns.

Abstract: A rechargeable battery jump starting device with a dual battery diode bridge system. The dual battery diode bridge, for example, is configured to protect against a back-charge to a first 12V battery and/or a second 12V battery after a vehicle has been jump charged to prevent damage thereto.

Abstract: A knit sock is integrally formed of a body yarn in circumferential courses and axial wales, and includes a foot portion having a heel and a toe, and an ankle portion joined to the foot portion and defining an open leg end of the sock. A first targeted compression zone is formed with the foot portion between the heel and the toe, and includes spaced-apart axial compression ridges extending axially outward from the heel at a first end of the first compression zone to a second end of the first compression zone. A second targeted compression zone is formed with the ankle portion between the heel and the open leg end of the sock, and includes spaced-apart axial compression ridges extending axially outward from the heel at a first end of the second compression zone to a second end of the second compression zone.

Abstract: A power cylinder system for a reciprocating engine includes a piston configured to move within a cylinder of the reciprocating engine. The system also includes a groove extending circumferentially about the piston and configured to support a ring. An axially-facing surface of the groove has circumferential undulations at ambient temperatures that are configured to compensate for distortions to the groove caused by operation of the reciprocating engine.

Abstract: A system is disclosed to provide a DTS machine that is simple to operate and can through human operator control provide economic and competitive throughput speeds as compared to more complex DTS machines utilizing multiple printing tunnels and material handlers. The present invention utilizes a repositionable print carriage and a re-configurable inkjet printhead bank. The printing carriage is vertically positionable and tiltable, and includes a resizable spindle so that varying geometries of print media may be accommodated. The printer prints a single piece of media at each printing event, but maintains a printing throughput similar to DTS machines having the capability to print media in parallel printing events. Media is moved from a media loading area on the machine by a single operator into a printing tunnel and then the operator adjusts the angle of the media relative to a reconfigurable array of ink-heads to meet inkjet expression distance requirements.

Abstract: The disclosure relates to USP30 Inhibitor Compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.

Abstract: A method is disclosed to provide a DTS machine that is simple to operate and can through human operator control provide economic and competitive throughput speeds as compared to more complex DTS machines utilizing multiple printing tunnels and material handlers. The present method repositions a print carriage and a reconfigures an inkjet printhead bank to accommodate different sizes and shapes of media. The allows for the printing of a single piece of media in a single each printing event, but maintains a printing throughput similar to DTS machines having the capability to print media in parallel printing events. Media is moved from a media loading area on the machine by a single operator into a printing tunnel and then the operator adjusts the angle of the media relative to a reconfigurable array of ink-heads to meet inkjet expression distance requirements.

Abstract: The compositions and methods of the invention relate generally to detection of biomarkers for the diagnosis, prognosis, and monitoring of solid tumor cancers. In particular, the invention relates to compositions and methods for detection of B-cell maturation antigen (BCMA) for the diagnosis, prognosis, and monitoring of solid tumor type of cancers.

Abstract: A process is disclosed for creating a print profile to control the operation of a direct-to-shape printing system for applying images on the exterior of an axially symmetrical media object that has a contoured, varying exterior surface, such as occurs on curved wine bottles and sports equipment like bats. The process takes a media recipe holding media geometry information and an image intended to be printed and processes that information to control a motion control subsystem and a print engine subsystem. The geometry information is manipulated to generate a CAM table suitable for the motion control subsystem, and the image file is processed to create a raster image file suitable for ink head expression. Various setup values are included in the process to prepare the direct-to-shape printing system for use of the media recipe.

Abstract: According to examples, an apparatus may include a processor and a memory on which is stored machine readable instructions that may cause the processor to determine whether a request is stored in a message queue, in which the apparatus may be inside of a domain and the message queue may be outside of the domain. Based on a determination that a request is stored in the message queue, the processor may pull the request from the message queue through a domain boundary, fulfill the request to cause a response to the request to be generated, and forward the response to the message queue through the domain boundary.