Abstract: A method for treating an inflammatory or autoimmune disease with compounds of Formula 0, Formula I, and Formula II and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

Abstract: An assembly for an image forming device includes an access door movable between an open position permitting replacement of a replaceable unit and a closed position. An electrical connector in the image forming device is movable between a retracted position and an extended position. In the retracted position the electrical connector is disengaged from a corresponding electrical connector of the replaceable unit when the replaceable unit is installed in the image forming device. In the extended position the electrical connector is engaged with the corresponding electrical connector of the replaceable unit. The electrical connector is operatively connected to the access door such that movement of the access door from the closed to the open position moves the electrical connector from the extended to the retracted position and movement of the access door from the open to the closed position moves the electrical connector from the retracted to the extended position.

Abstract: Embodiments of the invention provide a customizable bicycle saddle for a bicycle. The bicycle saddle has been designed to allow it to be adjusted to match the ischial tuberosities of each rider's pelvis in order to minimize the pressure placed on other portions of the rider's body while seated on the bicycle. The bicycle saddle comprises a first seating portion that has been configured to allow a rider to sit on the bicycle, a second seating portion that has been configured to allow the rider to sit on the bicycle. The bicycle saddle also includes a first adjustment means configured to allow the first seating portion to be moved closer to the second seating portion, and a second adjustment means configured to allow the saddle to be moved closer to a forward portion on the bicycle.

Abstract: A series of substituted fused bicyclic imidazole derivatives, including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: There is provided a milking cluster (102) for milking an animal, the milking cluster comprising a plurality of teat cups (1) connected to a clawpiece (106). The clawpiece comprises a plurality of milk inlets that are connected to the plurality of teat cups via respective short milk tubes (11). A milk flow passageway begins at the barrel of the teat cup and ends at the clawbowl of the clawpiece, and a valve system is present within each milk flow passageway. The valve system comprises a first pressure-actuated valve through which milk flowing along the milk flow passageway must pass.

Abstract: An electric vehicle (EV) charging station for fast charging (e.g. 5 to 15 minutes) an electric vehicle (EV). The EV charging station can be configured to charge multiple EVs and multiple conventional vehicles at the same time. The EV charging station can include a power source, an electric reservoir receiving power from the power source, an AC to DC power converter for receiving AC power from the power source and converting the AC power to DC power for supplying DC power to the electric reservoir, an EV charger receiving DC power from the electric reservoir; and a first DC to DC converter receiving DC power from the electrical reservoir and converting the DC power to DC power suitable for charging the electrical vehicle.

Abstract: The disclosure describes various aspects of a partial light field display architecture. In an aspect, a light field display includes multiple picture elements (e.g., super-raxels), where each picture element includes a first portion having a first set of light emitting elements, where the first portion is configured to produce light outputs that contribute to at least one a two-dimensional (2D) view. Each picture element also includes a second portion including a second set of light emitting elements (e.g., sub-raxels) configured to produce light outputs (e.g., ray elements) that contribute to at least one three-dimensional (3D) view. The light field display also includes electronic means configured to drive the first set of light emitting elements and the second set of light emitting elements in each picture element. The light field display can also dynamically identify the first portion and the second portion and allocate light emitting elements accordingly.

Abstract: A knit sock is integrally formed of a body yarn in circumferential courses and axial wales, and includes a foot portion having a heel and a toe, and an ankle portion joined to the foot portion and defining an open leg end of the sock. A first targeted compression zone is formed with the foot portion between the heel and the toe, and includes spaced-apart axial compression ridges extending axially outward from the heel at a first end of the first compression zone to a second end of the first compression zone. A second targeted compression zone is formed with the ankle portion between the heel and the open leg end of the sock, and includes spaced-apart axial compression ridges extending axially outward from the heel at a first end of the second compression zone to a second end of the second compression zone.

Abstract: Provided is a rechargeable battery jump starting device with a discharged battery pre-conditioning system to facilitate boosting or charging a depleted or discharged battery, for example, to jump start a vehicle or equipment engine. The pre-conditioning increases the operating voltage to the depleted or discharged battery during the pre-conditioning phase.

Abstract: A handheld device for jump starting a vehicle engine includes a rechargeable lithium ion battery pack and a microcontroller. The lithium ion battery is coupled to a power output port of the device through a FET smart switch actuated by the microcontroller. A vehicle battery isolation sensor connected in circuit with positive and negative polarity outputs detects the presence of a vehicle battery connected between the positive and negative polarity outputs. A reverse polarity sensor connected in circuit with the positive and negative polarity outputs detects the polarity of a vehicle battery connected between the positive and negative polarity outputs, such that the microcontroller will enable power to be delivered from the lithium ion power pack to the output port only when a good battery is connected to the output port and only when the battery is connected with proper polarity of positive and negative terminals.

Abstract: Merchandise security systems and methods are provided. In one example, a merchandise security system includes a plurality of security devices arranged in a wireless network, wherein the plurality of security devices are arranged in a planogram and each configured to protect one or more items from theft, each of the plurality of security devices configured to wirelessly communicate data with a remote device. The system also includes a plurality of electronic keys arranged in the wireless network and configured to wirelessly communicate data with the plurality of security devices and/or the remote device. Each of the plurality of electronic keys is configured to operate the plurality of security devices. The system also includes a gateway configured to receive the data from the plurality of security devices and electronic keys via wireless communication, wherein the gateway is configured to communicate the data to the remote computing device.

Abstract: Merchandise security systems and methods are provided. In one example, a merchandise security system includes a plurality of security devices arranged in a wireless network, wherein the plurality of security devices are arranged in a planogram and each configured to protect one or more items from theft, each of the plurality of security devices configured to wirelessly communicate data with a remote device. The system also includes a plurality of electronic keys arranged in the wireless network and configured to wirelessly communicate data with the plurality of security devices and/or the remote device. Each of the plurality of electronic keys is configured to operate the plurality of security devices. The system also includes a gateway configured to receive the data from the plurality of security devices and electronic keys via wireless communication, wherein the gateway is configured to communicate the data to the remote computing device.

Abstract: A rechargeable battery jump starting device with a leapfrog charging system. The leapfrog charging system, for example, can sequentially charge multiple batteries of the rechargeable battery jump starting device.

Abstract: A rechargeable battery jump starting device having a highly conductive electrical pathway from a rechargeable battery of the device to a vehicle battery being jump started. The highly conductive pathway can be provided by a highly electrically conductive frame connecting one or more batteries of the rechargeable battery jump starting device to battery clamps of the rechargeable battery jump starting device.

Abstract: This invention relates to a filter which is especially for filtering microfibres which can, for example, originate from the washing of textiles. The filter is rotatable around an axis of rotation. The filter provides good filtering efficiency and improved resistance to blocking.

Abstract: A handheld device for jump starting a vehicle engine includes a rechargeable lithium ion battery pack and a microcontroller. The lithium ion battery is coupled to a power output port of the device through a FET smart switch actuated by the microcontroller. A vehicle battery isolation sensor connected in circuit with positive and negative polarity outputs detects the presence of a vehicle battery connected between the positive and negative polarity outputs. A reverse polarity sensor connected in circuit with the positive and negative polarity outputs detects the polarity of a vehicle battery connected between the positive and negative polarity outputs, such that the microcontroller will enable power to be delivered from the lithium ion power pack to the output port only when a good battery is connected to the output port and only when the battery is connected with proper polarity of positive and negative terminals.

Abstract: Disclosed are methods and devices for isolating all three of the left subclavian, left common carotid and brachiocephalic arteries from embolic debris that might flow through the aortic arch, via a single access point. A system may include an elongate flexible tubular sheath, having a proximal end and a distal end, and an inner member extending through the sheath and moveable relative to the sheath. A left subclavian element may be supported by the inner member. A filter membrane may be configured to isolate the aorta from the brachiocephalic, left common carotid and left subclavian arteries when the left subclavian element is expanded within the left subclavian artery and the sheath is retracted to expose the membrane. The left subclavian element may include a self expandable frame, which may carry a left subclavian filter.