Abstract: Presented are techniques of identifying, processing and displaying data point clusters associated with map information in an efficient manner. Methods and systems are disclosed which process map information to identify clusters of requested data points for display, based on iterative clustering and filtering of the data points. Methods and systems are also disclosed which generate polygons representing the clusters. The amount of data to be processed and/or displayed can be reduced, without loss of any associated information content in a displayed map.

Abstract: Disclosed are systems and methods for computing an object's weight or the quantity of items within the object based on activations of different robot actuators used in retrieving the object from a storage location. Specifically, the robot may activate one or more actuators during retrieval of an object, may obtain a measurement in response to activating a particular actuator, and may derive a weight of the object based on the measurement by converting the measurement from a first range of values that are associated with activations of the particular actuator to a second range of values that are disassociated with activations of the particular actuator. The robot may then modify its operation in response to the weight that is derived for the object matching or being mismatched to an expected or last tracked weight.

Abstract: Disclosed is a robot for performing three-dimensional (“3D”) or multi-plane sortation and/or order fulfillment. The robot may include a motorized base to move about a first plane, a lift that raises and lowers a dispensing receptacle atop the lift about a second plane, and one or more actuators that modify a position of the dispensing receptacle from an upright position to a first tilted position in which the dispensing receptacle is tilted towards a first side of the robot and to a second tilted position in which the dispensing receptacle is tilted towards an opposite second side of the robot. The robot may receive and carry items when the dispensing receptacle is in the upright position, and may dispense the items to a destination on either side of the robot by tilting the dispensing receptacle to the first tilted position or the second tilted position.

Abstract: A clarifier can comprise a floor, inner and outer walls that each extends upwardly from the floor such that a tank is at least partially defined by the inner wall and a launder channel is at least partially defined between the inner and outer walls and is disposed along at least a majority of a periphery of the tank. A launder cover comprising one or more flexible sheets can be disposed over at least a majority of the launder channel. Each of the sheet(s) can have opposing inner and outer edges, the inner edge coupled to the inner wall and the outer edge coupled to the outer wall, and can be configured such that, when a single one of the inner and outer edges is decoupled from the inner and outer walls, the sheet is deformable to at least partially uncover the launder channel.

Abstract: A method and a case management system are described. The case management system enables the user to generate and update a case plan for a client of an organization. The case plan includes a set of goals and a set of action items for each one of the goals that are defined based on goal templates and action item templates.

Abstract: A surgical component, a kit including the surgical component, and a surgical method. The surgical component includes a body portion. The surgical component also includes an elongate stem for inserting into an intramedullary canal of a patient. The elongate stem extends distally from the body portion. The elongate stem has a longitudinal axis; a proximal end; a distal end; and a plurality of splines located on an outer surface of the stem. The splines are circumferentially arranged around the stem. At least some of the splines are tapered such that each tapered spline is narrower at a distal part of that spline than at a part of that spline that is proximal with respect to the distal part. The surgical component further includes an elongate neck portion extending from the body portion at a non-zero angle with respect to the longitudinal axis of the stem.

Abstract: Embodiments of the invention are directed to methods, apparatuses, computer readable media and systems for providing, along with a token, a token assurance level and data used to generate the token assurance level. At the time a token is issued, one or more Identification and Verification (ID&V) methods may be performed to ensure that the token is replacing a PAN that was legitimately used by a token requestor. A token assurance level may be assigned to a given token in light of the type of ID&V that is performed and the entity performing the ID&V. Different ID&Vs may result in different token assurance levels. An issuer may wish to know the level of assurance and the data used in generating the level of assurance associated with a token prior to authorizing a payment transaction that uses the token.

Abstract: A vehicle including a plurality of truck assemblies is provided. Each truck assembly includes a truck axle, a first wheel fixed to the truck axle, a second wheel selectively coupled to the truck axle, a motor configured to rotate the truck axle, and a clutch operatively coupled to the second wheel. The clutch is positionable between a coupled position and a decoupled position. When the clutch is in the coupled position, the second wheel rotates with the truck axle, and when the clutch is in the decoupled position, the second wheel is free to rotate relative to the truck axle.

Abstract: A method for determining a subject's risk for developing chronic kidney disease (CKD) combined with determining a subject's pharmacogenomic (PGX) profile is described. The method involves obtaining a sample of genetic material from the subject. The genetic material is amplified using primers specific for the genes underlying CKD and PGX. The DNA sequence of the amplified genetic material is determined and compared with the human reference genome sequence. One or more DNA sequence alterations in the amplified genetic material not present in the human reference genome sequence determines the PGX profile of the subject and may indicate that the subject is at risk for developing CKD.

Abstract: Embodiments of the invention are directed to methods, apparatuses, computer readable media and systems for providing, along with a token, a token assurance level and data used to generate the token assurance level. At the time a token is issued, one or more Identification and Verification (ID&V) methods may be performed to ensure that the token is replacing a PAN that was legitimately used by a token requestor. A token assurance level may be assigned to a given token in light of the type of ID&V that is performed and the entity performing the ID&V. Different ID&Vs may result in different token assurance levels. An issuer may wish to know the level of assurance and the data used in generating the level of assurance associated with a token prior to authorizing a payment transaction that uses the token.

Abstract: The present disclosure relates to an immediate release tablet of daprodustat having good tensile strength. In other aspects, medical uses of the immediate release tablet and dosage regimens for using the immediate release tablet are disclosed.

Abstract: In some aspects, the present disclosure provides a delivery device for delivering a detachable medical implant that comprises an elongated delivery member and a first engagement portion. The first engagement portion comprises a first proximal-facing surface, a first distal-facing surface, and a first lumen that is configured to accommodate an activation wire, wherein at least 50% of a surface area of the first proximal-facing surface is angled away from a proximal end of the first engagement portion. In other aspects, the present disclosure provides a medical delivery system comprising: such a delivery device; an implantable device comprising a medical device portion and a second engagement portion, the second engagement portion comprising a second lumen configured to accommodate an activation wire, a second proximal-facing surface and a second distal-facing surface; and an activation wire. Other aspects pertain to methods of medical device delivery using such a medical delivery system.

Abstract: A wheel assembly including a rim including a first rim hole extending through an inner surface and an outer surface of a rim at a first angle, the first angle being defined with respect to a center line through the wheel in a direction of travel at the location of the first rim hole and with respect to an axis radially normal to the rim, the first angle having a non-zero first component relative to the center line and a non-zero second component relative to the radially normal axis, a hub including a first hub hole, the first hub hole being formed at the first angle such that the first rim hole and the first hub hole are co-axial, and a first spoke extending between the first rim hole and the first hub hole, the first spoke being co-axial with the first rim hole and the first hub hole.

Abstract: A surgical component, a kit including the surgical component, and a surgical method. The surgical component includes a body portion. The surgical component also includes an elongate stem for inserting into an intramedullary canal of a patient. The elongate stem extends distally from the body portion. The elongate stem has a longitudinal axis; a proximal end; a distal end; and a plurality of splines located on an outer surface of the stem. The splines are circumferentially arranged around the stem. At least some of the splines are tapered such that each tapered spline is narrower at a distal part of that spline than at a part of that spline that is proximal with respect to the distal part. The surgical component further includes an elongate neck portion extending from the body portion at a non-zero angle with respect to the longitudinal axis of the stem.

Abstract: Orthopaedic instruments for use in a direct anterior approach orthopaedic surgical hip replacement procedure on a patient's femur are disclosed. One such orthopaedic instrument may be embodied as a cement nozzle sized for insertion in a medullary canal of the patient's femur. The cement nozzle may include a first lumen for introducing a bone cement composition into the medullary canal. The cement nozzle may also include a second lumen for removing one or more bodily fluids from the medullary canal during introduction of the bone cement composition. The first and second lumens may each be curved along a distal portion of the cement nozzle.

Abstract: An inclination guide for use with an implant insertion tool during a surgical procedure includes a unitary body having a clip configured to be coupled to a mounting surface of the implant insertion tool, an elongated riser extending from the clip, and an elongated indicator extending from the elongated riser to a distal end. Such a design allows for an inexpensive and lightweight inclination guide that may be easily and quickly adjusted after assembly.

Abstract: Described herein are methods of treating cancer in a subject in need thereof comprising administering to the subject a pharmaceutical composition comprising 1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide, or a pharmaceutically acceptable salt thereof, whereby the subject experiences a therapeutic response.

Abstract: A replacement heart valve prosthesis is loaded onto a balloon mounted onto a balloon shaft of a catheter system. The balloon shaft is rotatably engaged with an actuator on the handle of the catheter system. Rotation of the actuator by a first amount in a first direction permits rotation of the heart valve prosthesis by a known amount during the procedure so that alignment of the commissures of the replacement valve with the commissures of the existing valve can be predictably achieved.

Abstract: A surgical reamer and a method of reaming a bone using a surgical reamer. The reamer has a distal part comprising a proximal end coupleable to a surgical rotational driver; a distal end; a rotational axis extending between the proximal end and the distal end; and a cutting surface located between the proximal end and the distal end. The reamer also has a proximal part comprising a proximal end coupleable to a surgical rotational driver; a distal end; a rotational axis extending between the proximal end and the distal end; a cutting surface located between the proximal end and the distal end; and a cavity extending proximally from the distal end for receiving the proximal end of the distal part. An inner surface of the cavity is shaped to allow the proximal part to be tilted with respect to the distal part during rotation of the proximal part.

Abstract: A resource-efficient technique is described for producing and utilizing a set of trained embeddings. With respect to its training phase, the technique receives a group of sparsely-expressed training examples of high dimensionality. The technique processes the training examples using a distributed training framework of computing devices. With respect to its inference stage, the technique draws on the embeddings produced by the training framework. But in one implementation, the inference-stage processing applies a different prediction function than that used by the training framework. One implementation of interference-stage processing involves determining a distance between a query embedding and a candidate item embedding, where each such embedding is obtained or derived from the trained embeddings produced by the training framework. Another manifestation of inference-stage processing involves adjusting click counts based on identified relations among items embeddings.