Abstract: The present invention provides a compound of Formula I: wherein R is hydrogen, —P(?O)(OH)2, or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I, or pharmaceutically acceptable salt thereof is useful for treating autoimmune and inflammatory diseases, such as atopic dermatitis, rheumatoid arthritis, systemic lupus erythematosus, lupus nephritis, and inflammatory bowel disease.

Abstract: Camera arrays for mediated-reality systems and associated methods and systems are disclosed herein. In some embodiments, a camera array includes a support structure having a center, and a depth sensor mounted to the support structure proximate to the center. The camera array can further include a plurality of cameras mounted to the support structure radially outward from the depth sensor, and a plurality of trackers mounted to the support structure radially outward from the cameras. The cameras are configured to capture image data of a scene, and the trackers are configured to capture positional data of a tool within the scene. The image data and the positional data can be processed to generate a virtual perspective of the scene including a graphical representation of the tool at the determined position.

Abstract: An electronic display device includes: a chassis including a plurality of mounting elements and a controller, and a media player; and a display panel comprising at least one display module mounted to the mounting elements, wherein each display module includes a video display on a front surface of the display module and is positioned relative to the chassis using one or more locating pins located on a back surface of the display module that cooperate with one or more receiving holes in a front surface of the mounting elements and is secured to the chassis; wherein the controller causes the media player to display media content on the display panel.

Abstract: A system and method are provided for proactively buffering quantum key distribution (QKD) key material. The method includes monitoring key generation rates and surpluses at QKD devices at each node of a QKD link in a QKD network, retrieving surplus key material from the QKD devices at one or both nodes of the QKD link, and buffering the surplus key material in a local storage at one or both nodes in the QKD link. The surplus key material can be used to offset overhead introduced in securely relaying keys between non-adjacent demand pairs in the QKD network. The surplus key material can also be used to offset future transient decreases in key generation rates.

Abstract: A system and method are described for proactively performing key swaps among nodes in a quantum key distribution (QKD) network. The method includes determining a routing solution for nodes in the QKD network; making the routing solution available to the nodes in the QKD network; and initiating key swaps among the nodes in the QKD network according to the routing solution, prior to key requests being made within the QKD network. The method can also include continuously performing key swaps among the nodes in the QKD network according to the routing solution; detecting a change in capacity and/or a change in demand on one or more links within the QKD network; determining a new routing solution based on the detected change; and continuously preforming subsequent key swaps according to the new routing solution.

Abstract: A safety valve replaces a tire valve. The valve includes a generally elongate hollow main body having an upper portion, a lower flex hose connector, a side tubular branch having a valve seat with a ball valve, an electronics housing having a battery, motor and a drive pin for the ball valve. The lower flex hose connector is adapted for connection to a flex hose or valve stem of the vehicle tire. The side branch branches from the main body and communicates with the hollow interior of the main body. The side branch has a plurality of air exit apertures at its periphery. The valve seat includes a base with an aperture therein through which the drive pin can extend through to engage the ball valve. The ball valve sits in the base and is biased in the valve seat via a spring to cover the aperture.

Abstract: A system for providing gamification of a destination such as a theme park where guests use a venue app with an optional electronic ticket that allows for both self-serve access into the destination and tracking of individual guests throughout various access points. An extended range ID such as an RFID is provided to the guest either in the electronic ticket or in a wearable. Using combinations of RFID readers, pressure sensors and cameras the system tracks guests down the ride seat and tracks the movements of guided, free-floating and free-ranging vehicles. Using the combination of guest and vehicle tracking information along with information provided by a destination gaming system, the destination guest experience is customized including various effects for rides and attractions. Spot cameras are placed at tracked locations such as rides seats, where images are captured in response to either external triggers generated by the system or guest indications.

Abstract: A system for recycling a mobile device. A system configured in accordance with one embodiment of the present technology includes an electrical connector and testing electronics. The electrical connector is configured to be electrically connected to a mobile device, and the testing electronics are configured to produce an electrical measurement by measuring an electrical attribute associated with a hardware component of the mobile device over the electrical connector. The system is further configured to valuate, identify, and/or authenticate the mobile device based at least in part on the electrical measurement.

Abstract: Non-personal network attributes of a user's network connection are detected. A user's physical location is classified as being onsite or remote based upon the non-personal network attributes. Connectivity performance information is generated indicative of a performance of a user device in connecting with the host computing system over the network, and a control signal is generated to surface performance information through an administrative system.

Abstract: Herein is disclosed a composition comprising: a layer of water-swellable hydrogel, wherein the hydrogel has embedded therein a reinforcement sheet of liquid-water-permeable material, wherein the layer of hydrogel has a wound-facing side and a non-wound-facing side and apertures extend through the layer of hydrogel from the wound-facing side to the non-wound-facing side and through the reinforcement sheet, wherein the mean area of the apertures on at least one of the wound-facing side and non-wound-facing side of the hydrogel is at least 5 mm2.

Abstract: The invention relates to oxopyrimidinyl-methyl-benzamide derivatives, for example in a pharmaceutically acceptable salt form or crystal form, pharmaceutical compositions comprising the derivatives, and their medical use, in particular for use in the treatment of ?1-antitrypsin deficiency (A1AD or AATD).

Abstract: A device to measure the amount of light able to transmit through a liquid. The device uses a light detector and multiple light emitting diodes (LED's) along with an optical unit such that the light detector, LED's, and an optical unit define a path of light emitted by each individual LED or subgroup of LED's and detected by the detector. The device uses a structure designed to surround the LED's and light detector such that the structure allows the device to be immersed in the liquid and such that the structure is shaped to allow a volume of liquid to be between the LED's and detector, intersecting the light path.

Abstract: A mediated-reality system for surgical applications incorporates pre-operative images and real-time captured images of a surgical site into a visualization presented on a head-mounted display worn by a surgeon during a surgical procedure. The mediated-reality system tracks the surgeon's head position and generates real-time images of the surgical site from a virtual camera perspective corresponding to the surgeon's head position to mimic the natural viewpoint of the surgeon. The mediated-reality system furthermore aligns the pre-operative images with the real-time images from the virtual camera perspective and presents a mediated-reality visualization of the surgical site with the aligned pre-operative three-dimensional images or a selected portion thereof overlaid on the real-time images representing the virtual camera perspective.

Abstract: A lipid capsid comprising at least one S type protein for attachment to the ACE2 receptor of a cancer cell is provided. The lipid capsid encloses an inner package, comprising histone or a histone eviction compound. The S type protein of the lipid capsid attaches to the ACE2 receptor of a targeted cancer cell, enabling the outer lipid envelope of the capsid to be absorbed through the cell wall of the targeted cell, after which the inner package of the lipid capsid is delivered to the cancer cell. In some embodiments, the histone is selected from the H2AX histone, the H3K27 histone or the H3K9 histone, each histone having a different mechanism of action to disable the cancer cell or repair the DNA of the cancer cell. In another embodiment, the inner package contains a histone eviction compound for evicting histone from the cancer cell.

Abstract: A method for replacing a damaged sleeve lining a tube passing through a nuclear reactor pressure vessel. The damaged sleeve has an end including a radially enlarged end portion for resting on a support section of the tube for retaining the damaged sleeve in the tube. The method includes removing the damaged sleeve from a tube; providing a sleeve assembly including a first sleeve with a radially variable end and a retainer; installing the sleeve assembly in the tube so the radially variable end of the first sleeve is received by the support section, the radially variable end being in a radially contracted configuration during installation and being in a radially expanded configuration after the sleeve assembly is installed in the tube; and deforming the retainer from an installation configuration to a retention configuration to retain the radially variable end of the first sleeve in the radially expanded configuration.

Abstract: The present invention relates to a method for receiving data transmitted acoustically. The method includes receiving an acoustically transmitted signal encoding data; processing the received signal to minimise environmental interference within the received signal; and decoding the processed signal to extract the data. The data encoded within the signal using a sequence of tones. A method for encoding data for acoustic transmission is also disclosed. This method includes encoding data into an audio signal using a sequence of tones. The audio signal in this method is configured to minimise environmental interference. A system and software are also disclosed.

Abstract: An electronic material sensor for a container, such as a dispenser for paper or liquid materials, or a waste receptacle, in a facility such as a restroom. The material sensor may be adapted to fit inside an existing material dispenser. The material sensor provides wireless data transmission of the level of liquid or paper material in the container. A traffic sensor senses presence of people in the facility. An electronic beacon assigned to a user, such as a cleaning staff, tracks location of the user in the facility. In a system employing one or more sensors, including material sensors, traffic sensors, and beacons, the sensors send real-time data to a base station running a software application, to give details about levels of the materials and facility usage, and the location of cleaning staff.

Abstract: An apparatus includes first, second, and third glass portions, with the third glass portion between the first and the second, where the first, second, and third glass portions are configured in spaced relation from each other. The third glass portion is substantially parallel to the first glass portion. A light source emits light into the third glass portion via an edge of the third glass portion. Light-scattering structures scatter at least a portion of the light emitted by the light source into the third glass portion in a direction substantially perpendicular to a primary face of the third glass portion.

Abstract: An ROV docked to a tether management system (TMS) is lifted outboard into water beside a vessel while deploying an umbilical that effects communication with the ROV via a tether of the TMS. After undocking the ROV to swim away from the TMS while deploying the tether, the TMS is suspended over the water while the ROV performs a subsea mission. A mobile or transportable ROV support unit can be positioned on a deck of a vessel of opportunity to facilitate deployment of the ROV, the TMS and the umbilical and to control the ROV during the mission.