Abstract: Drug delivery devices are described that provide hybrid forms with gripping and stability functionalities, such as a grip portion on a skin contact surface. In some versions, the drug delivery devices can include a cap having a release liner such that removal of the cap exposes the grip portion. In some versions, the drug delivery devices include a retractable needle guard having the grip portion extending therearound.

Abstract: A method for determining if a tissue is ganglionic is provided. The method comprises a) generating at least one hyperspectral Raman image of a tissue from a region of interest in a tissue suspected to contain ganglion cells that was optionally identified by a method comprising autofluorescence (AF) and Second Harmonic generation (SHG) imaging of the tissue; and b) analyzing any of the images for one or more of the following: i) optical excitation; ii) chemical information or emission spectra; or iii) AF, SHG, and/or Raman signatures, wherein the analysis provides indicators that the region of interest is either ganglionic or non-ganglionic. A system for analysis of in vivo tissue or ex vivo tissue samples including a multiphoton autofluorescence microscope, a Second Harmonic Generation microscope, and a hyperspectral Raman microscope in operative communication is also provided.

Abstract: An example method can comprise receiving content for presentation at a user device. The content can comprise a plurality of sections, and each section can comprise a video portion and an audio portion. The user device can also receive content metadata regarding one or more features of the content, where the features of the content comprise one or more candidate sections of the content for modification. The user device can apply one or more rules to the received content based on the content metadata to modify one or more of the audio portion and the video portion of at least one section of the content, creating modified content, and can cause presentation of the modified content on a display device.

Abstract: Drug delivery devices are described that provide hybrid forms with gripping and stability functionalities, such as a grip portion on a skin contact surface. In some versions, the drug delivery devices can include a cep having a release liner such that removal of the cap exposes the grip portion. In some versions, the drug delivery devices include a retractable needle guard having the grip portion extending therearound.

Abstract: Delivery devices for administering drugs are disclosed. An example apparatus, includes a body including: a handle in which a syringe assembly is to be disposed; a base having a bottom face to be disposed adjacent a user; and an absorbent material attached to the bottom face, the absorbent material structured to hold a fluid to be released onto the user prior to or during an injection procedure.

Abstract: An example method can comprise receiving content for presentation at a user device. The content can comprise a plurality of sections, and each section can comprise a video portion and an audio portion. The user device can also receive content metadata regarding one or more features of the content, where the features of the content comprise one or more candidate sections of the content for modification. The user device can apply one or more rules to the received content based on the content metadata to modify one or more of the audio portion and the video portion of at least one section of the content, creating modified content, and can cause presentation of the modified content on a display device.

Abstract: An example method can comprise receiving content for presentation at a user device. The content can comprise a plurality of sections, and each section can comprise a video portion and an audio portion. The user device can also receive content metadata regarding one or more features of the content, where the features of the content comprise one or more candidate sections of the content for modification. The user device can apply one or more rules to the received content based on the content metadata to modify one or more of the audio portion and the video portion of at least one section of the content, creating modified content, and can cause presentation of the modified content on a display device.

Abstract: Systems, apparatuses, and methods are described for establishing, or re-establishing, trust for a network device. A user device may send, via a network device, a service request to establish trust for the network device in a network. The service request may comprise, or may allow look up of, identifying information for the network device, such as a network address. Trust of the network device may be established, at least in part, by confirming the network address (or other identifying information) associated with the network device, and/or by confirming certain devices that are in communication with the network device. An authentication token may be sent to the network device for reconnecting to the network.

Abstract: In accordance with one or more embodiments, aspects of the disclosure may provide efficient, effective, and convenient ways of managing network devices. In particular, a client router may connect to an upstream virtual gateway. The virtual gateway may manage a large number of client devices. Each client router may be represented virtually within the gateway as a virtual router. The virtual gateways may be distributed regionally, in order to manage large numbers of client routers and/or to reduce transmission delays. The virtual gateways may be managed by a gateway controller. The gateway controller may be centralized, and perform various configuration functions, such as configurations for hardware, logical networking, or content access policies. In some instances, messages sent between the gateway controller using a first protocol and the client router using a second protocol may be translated by a protocol agent.

Abstract: In accordance with one or more embodiments, aspects of the disclosure may provide efficient, effective, and convenient ways of managing network devices. In particular, a client router may connect to an upstream virtual gateway. The virtual gateway may manage a large number of client devices. Each client router may be represented virtually within the gateway as a virtual router. The virtual gateways may be distributed regionally, in order to manage large numbers of client routers and/or to reduce transmission delays. The virtual gateways may be managed by a gateway controller. The gateway controller may be centralized, and perform various configuration functions, such as configurations for hardware, logical networking, or content access policies. In some instances, messages sent between the gateway controller using a first protocol and the client router using a second protocol may be translated by a protocol agent.

Abstract: A wearable drug delivery device includes an injector having a housing, a reservoir, a needle or cannula, a drive mechanism for urging drug product out of the reservoir, through the needle or cannula, and to a patient, and an activator mechanism disposed on a surface of the housing for activating the drive mechanism. An activation prevention mechanism is coupled to the injector housing and/or activation prevention mechanism to prevent inadvertent actuation of the activator mechanism.

Abstract: An example method can comprise receiving content for presentation at a user device. The content can comprise a plurality of sections, and each section can comprise a video portion and an audio portion. The user device can also receive content metadata regarding one or more features of the content, where the features of the content comprise one or more candidate sections of the content for modification. The user device can apply one or more rules to the received content based on the content metadata to modify one or more of the audio portion and the video portion of at least one section of the content, creating modified content, and can cause presentation of the modified content on a display device.

Abstract: Systems, apparatuses, and methods are described for establishing, or re-establishing, trust for a network device. A user device may send, via a network device, a service request to establish trust for the network device in a network. The service request may comprise, or may allow look up of, identifying information for the network device, such as a network address. Trust of the network device may be established, at least in part, by confirming the network address (or other identifying information) associated with the network device, and/or by confirming certain devices that are in communication with the network device. An authentication token may be sent to the network device for reconnecting to the network.

Abstract: An example method can comprise receiving content for presentation at a user device. The content can comprise a plurality of sections, and each section can comprise a video portion and an audio portion. The user device can also receive content metadata regarding one or more features of the content, where the features of the content comprise one or more candidate sections of the content for modification. The user device can apply one or more rules to the received content based on the content metadata to modify one or more of the audio portion and the video portion of at least one section of the content, creating modified content, and can cause presentation of the modified content on a display device.

Abstract: A method for determining if a tissue is ganglionic is provided. The method comprises a) generating at least one hyperspectral Raman image of a tissue from a region of interest in a tissue suspected to contain ganglion cells that was optionally identified by a method comprising autofluorescence (AF) and Second Harmonic generation (SHG) imaging of the tissue; and b) analyzing any of the images for one or more of the following: i) optical excitation; ii) chemical information or emission spectra; or iii) AF, SHG, and/or Raman signatures, wherein the analysis provides indicators that the region of interest is either ganglionic or non-ganglionic. A system for analysis of in vivo tissue or ex vivo tissue samples including a multiphoton autofluorescence microscope, a Second Harmonic Generation microscope, and a hyperspectral Raman microscope in operative communication is also provided.

Abstract: Systems, apparatuses, and methods are described for establishing, or re-establishing, trust for a network device. A user device may send, via a network device, a service request to establish trust for the network device in a network. The service request may comprise, or may allow look up of, identifying information for the network device, such as a network address. Trust of the network device may be established, at least in part, by confirming the network address (or other identifying information) associated with the network device, and/or by confirming certain devices that are in communication with the network device. An authentication token may be sent to the network device for reconnecting to the network.

Abstract: The subject invention provides a method of preventing or treating a condition associated with a defect in, or damage to, an organ in a subject with, or at risk for, such defect or damage to such organ which comprises administering to the subject a therapeutically effective amount of the fully reduced (all thiol) form of HMGB1 or a biologically active truncated form of HMGB1, so as to prevent or treat such condition. The subject invention also provides a method of improving regeneration of blood in a subject comprising administering a therapeutically effective amount of the fully reduced (all thiol) form of HMGB1 or a biologically active truncated form of HMGB1, effective to improve regeneration of blood.

Abstract: Delivery devices for administering drugs are disclosed. An example apparatus, includes a body including: a handle in which a syringe assembly is to be disposed; a base having a bottom face to be disposed adjacent a user; and an absorbent material attached to the bottom face, the absorbent material structured to hold a fluid to be released onto the user prior to or during an injection procedure.

Abstract: The subject invention provides a method of preventing a consequence of an anticipated injury in a subject which comprises administering to the subject a therapeutically effective amount of the fully reduced (all thiol) form of HMGB1 or a biologically active truncated form of HMGB1, so as to prevent the consequence of the anticipated injury.

Abstract: Drug delivery devices are described that provide hybrid forms with gripping and stability functionalities, such as a grip portion on a skin contact surface. In some versions, the drug delivery devices can include a cap having a release liner such that removal of the cap exposes the grip portion. In some versions, the drug delivery devices include a retractable needle guard having the grip portion extending therearound.