Abstract: An example method can comprise receiving content for presentation at a user device. The content can comprise a plurality of sections, and each section can comprise a video portion and an audio portion. The user device can also receive content metadata regarding one or more features of the content, where the features of the content comprise one or more candidate sections of the content for modification. The user device can apply one or more rules to the received content based on the content metadata to modify one or more of the audio portion and the video portion of at least one section of the content, creating modified content, and can cause presentation of the modified content on a display device.

Abstract: A method for determining if a tissue is ganglionic is provided. The method comprises a) generating at least one hyperspectral Raman image of a tissue from a region of interest in a tissue suspected to contain ganglion cells that was optionally identified by a method comprising autofluorescence (AF) and Second Harmonic generation (SHG) imaging of the tissue; and b) analyzing any of the images for one or more of the following: i) optical excitation; ii) chemical information or emission spectra; or iii) AF, SHG, and/or Raman signatures, wherein the analysis provides indicators that the region of interest is either ganglionic or non-ganglionic. A system for analysis of in vivo tissue or ex vivo tissue samples including a multiphoton autofluorescence microscope, a Second Harmonic Generation microscope, and a hyperspectral Raman microscope in operative communication is also provided.

Abstract: Systems, apparatuses, and methods are described for establishing, or re-establishing, trust for a network device. A user device may send, via a network device, a service request to establish trust for the network device in a network. The service request may comprise, or may allow look up of, identifying information for the network device, such as a network address. Trust of the network device may be established, at least in part, by confirming the network address (or other identifying information) associated with the network device, and/or by confirming certain devices that are in communication with the network device. An authentication token may be sent to the network device for reconnecting to the network.

Abstract: The subject invention provides a method of preventing or treating a condition associated with a defect in, or damage to, an organ in a subject with, or at risk for, such defect or damage to such organ which comprises administering to the subject a therapeutically effective amount of the fully reduced (all thiol) form of HMGB1 or a biologically active truncated form of HMGB1, so as to prevent or treat such condition. The subject invention also provides a method of improving regeneration of blood in a subject comprising administering a therapeutically effective amount of the fully reduced (all thiol) form of HMGB1 or a biologically active truncated form of HMGB1, effective to improve regeneration of blood.

Abstract: Delivery devices for administering drugs are disclosed. An example apparatus, includes a body including: a handle in which a syringe assembly is to be disposed; a base having a bottom face to be disposed adjacent a user; and an absorbent material attached to the bottom face, the absorbent material structured to hold a fluid to be released onto the user prior to or during an injection procedure.

Abstract: The subject invention provides a method of preventing a consequence of an anticipated injury in a subject which comprises administering to the subject a therapeutically effective amount of the fully reduced (all thiol) form of HMGB1 or a biologically active truncated form of HMGB1, so as to prevent the consequence of the anticipated injury.

Abstract: Drug delivery devices are described that provide hybrid forms with gripping and stability functionalities, such as a grip portion on a skin contact surface. In some versions, the drug delivery devices can include a cap having a release liner such that removal of the cap exposes the grip portion. In some versions, the drug delivery devices include a retractable needle guard having the grip portion extending therearound.

Abstract: An example drug delivery device includes a syringe assembly including a needle. The drug delivery device includes a handle carrying the syringe assembly and including a first portion, a second portion, a tapered surface, and a window. The first portion being wider than the second portion. The tapered surface extending from the first portion to the second portion. The needle of the syringe assembly adapted to extend from adjacent the second portion during an injection procedure. The window positioned between the first portion and the second portion and adapted to allow contents of the drug delivery device to be viewed. The drug delivery device includes a base adapted to be positioned adjacent the second portion of the handle during at least the injection procedure. The base being wider than the second portion of the handle and adapted to increase stability of the drug delivery device during the injection procedure.

Abstract: Systems, apparatuses, and methods are described for establishing, or re-establishing, trust for a network device. A user device may send, via a network device, a service request to establish trust for the network device in a network. The service request may comprise, or may allow look up of, identifying information for the network device, such as a network address. Trust of the network device may be established, at least in part, by confirming the network address (or other identifying information) associated with the network device, and/or by confirming certain devices that are in communication with the network device. An authentication token may be sent to the network device for reconnecting to the network.

Abstract: In accordance with one or more embodiments, aspects of the disclosure may provide efficient, effective, and convenient ways of managing network devices. In particular, a client router may connect to an upstream virtual gateway. The virtual gateway may manage a large number of client devices. Each client router may be represented virtually within the gateway as a virtual router. The virtual gateways may be distributed regionally, in order to manage large numbers of client routers and/or to reduce transmission delays. The virtual gateways may be managed by a gateway controller. The gateway controller may be centralized, and perform various configuration functions, such as configurations for hardware, logical networking, or content access policies. In some instances, messages sent between the gateway controller using a first protocol and the client router using a second protocol may be translated by a protocol agent.

Abstract: A wearable drug delivery device includes an injector having a housing, a reservoir, a needle or cannula, a drive mechanism for urging drug product out of the reservoir, through the needle or cannula, and to a patient, and an activator mechanism disposed on a surface of the housing for activating the drive mechanism. An activation prevention mechanism is coupled to the injector housing and/or activation prevention mechanism to prevent inadvertent actuation of the activator mechanism.

Abstract: In accordance with one or more embodiments, aspects of the disclosure may provide efficient, effective, and convenient ways of managing network devices. In particular, a client router may connect to an upstream virtual gateway. The virtual gateway may manage a large number of client devices. Each client router may be represented virtually within the gateway as a virtual router. The virtual gateways may be distributed regionally, in order to manage large numbers of client routers and/or to reduce transmission delays. The virtual gateways may be managed by a gateway controller. The gateway controller may be centralized, and perform various configuration functions, such as configurations for hardware, logical networking, or content access policies. In some instances, messages sent between the gateway controller using a first protocol and the client router using a second protocol may be translated by a protocol agent.

Abstract: A patient warming device with patient access for maintaining normothermia and/or treating hypothermia is provided. The device includes a first compliant layer and a second compliant layer sealed together around an outer border to contain a liquid between the two layers and to form a wrap that surrounds and conforms to a body portion of a patient. A plurality of flaps extends from opposite sides of a generally longitudinal central portion of the wrap, such that one or more flaps from the opposite sides fasten to each other to surround the body portion. The flaps are openable during functional use to provide access to an underlying patient body surface. A continuous fluid flow path extends between the first compliant layer and the second compliant layer between a fluid inlet and a fluid outlet to carry liquid and deliver heat through the wrap.

Abstract: An example method can comprise receiving content for presentation at a user device. The content can comprise a plurality of sections, and each section can comprise a video portion and an audio portion. The user device can also receive content metadata regarding one or more features of the content, where the features of the content comprise one or more candidate sections of the content for modification. The user device can apply one or more rules to the received content based on the content metadata to modify one or more of the audio portion and the video portion of at least one section of the content, creating modified content, and can cause presentation of the modified content on a display device.

Abstract: The unit comprises an assembly for clasping-escaping and a receptacle-terminal assembly. The assembly for clasping-escaping includes an L-shape subassembly having a vertical wall provided with backwards projecting, vertically spaced and inverted at 90? T-beams for connecting the L-shape subassembly to a parallelepipedic open box subassembly of a receptacle-terminal assembly. A bottom plate, located at the lowest part of the vertical wall extends outwardly. A passage above the bottom plate has a base terminating in a pair of serrations. The clasping-escaping includes a flat bar that after folding itself extends into a diverging strip provided with a multitude of serrations for meshing with the pair of serrations when a component is clasped. The parallelepipedic open box subassembly incorporates a plurality of T profile protrusions for connecting with the backwards projecting, vertically spaced and inverted at 90? T-beams.

Abstract: A patient warming device with patient access for maintaining normothermia and/or treating hypothermia is provided. The device includes a first compliant layer and a second compliant layer sealed together around an outer border to contain a liquid between the two layers and to form a wrap that surrounds and conforms to a body portion of a patient. A plurality of flaps extends from opposite sides of a generally longitudinal central portion of the wrap, such that one or more flaps from the opposite sides fasten to each other to surround the body portion. The flaps are openable during functional use to provide access to an underlying patient body surface. A continuous fluid flow path extends between the first compliant layer and the second compliant layer between a fluid inlet and a fluid outlet to carry liquid and deliver heat through the wrap.

Abstract: A compressive patient warming device is provided. The device includes an elastic inner layer that conforms snugly to a shape of an appendage of a patient so that the inner layer wraps around and substantially contacts most of an underlying surface area of the appendage. An outer layer is attached to and covers the inner layer to form a space that holds a heat transfer medium between the inner layer and the outer layer while the inner layer is wrapped around the appendage. The outer layer may be a rigid layer, and a predetermined compressive load may be applied to the outer layer to encourage blood flow in the appendage. A source of heat may be applied to the device to maintain normothermia and/or treat hypothermia.

Abstract: In accordance with one or more embodiments, aspects of the disclosure may provide efficient, effective, and convenient ways of managing network devices. In particular, a client router may connect to an upstream virtual gateway. The virtual gateway may manage a large number of client devices. Each client router may be represented virtually within the gateway as a virtual router. The virtual gateways may be distributed regionally, in order to manage large numbers of client routers and/or to reduce transmission delays. The virtual gateways may be managed by a gateway controller. The gateway controller may be centralized, and perform various configuration functions, such as configurations for hardware, logical networking, or content access policies. In some instances, messages sent between the gateway controller using a first protocol and the client router using a second protocol may be translated by a protocol agent.

Abstract: A method of providing access to a secure receptacle to complete a package delivery is implemented through a storage compartment, a central server, a recipient computing device, and a courier computing device. The overall process includes a generation of a one-time key code by the central server upon completion of a purchase order, wherein the recipient computing device completes and transmits the purchase order. The one-time key code is then provided to the storage compartment and the courier computing device. The one-time key code allows a courier that assigned to the courier computing device to unlock the storage compartment and place a purchased product in the storage compartment. This ensures the secure placement of the purchased product. Additionally, when the storage compartment is unlocked through the one-time key code, the recipient computing device is notified that the package delivery process completed.

Abstract: A patient warming device with patient access for maintaining normothermia and/or treating hypothermia is provided. The device includes a first compliant layer and a second compliant layer sealed together around an outer border to contain a liquid between the two layers and to form a wrap that surrounds and conforms to a body portion of a patient. A plurality of flaps extends from opposite sides of a generally longitudinal central portion of the wrap, such that one or more flaps from the opposite sides fasten to each other to surround the body portion. The flaps are openable during functional use to provide access to an underlying patient body surface. A continuous fluid flow path extends between the first compliant layer and the second compliant layer between a fluid inlet and a fluid outlet to carry liquid and deliver heat through the wrap.