Abstract: According to the present invention, techniques for high power gallium and nitrogen containing laser diode devices are provided. Such high power devices include straight lasers, tapered lasers, distributed feedback lasers, distributed Bragg reflector laser devices, and master oscillator power amplifier devices, among others configured with improved mode quality.

Abstract: A gaming device comprises a display, a processor, and a memory storing (a) a current symbol position state defining, for each of a plurality of columns of symbol positions, a number of symbol positions for which symbols are to be selected; (b) a pay table; and (c) instructions. The instructions cause the processor to control the display to display a plurality of columns of symbol positions corresponding to the current symbol position state, select symbols for the displayed symbol positions by selecting stopping positions of a plurality of reel strips, wherein at least one of the reel strips comprises at least one designated symbol, evaluate the symbols for winning combinations based on the pay table, and responsive to the selected symbols of a column including a designated symbol, modify the symbol position state for the respective column to include at least one additional symbol position for a next symbol selection.

Abstract: Several embodiments of the methods and compositions disclosed herein relate to immune cells that are engineered to express chimeric antigen receptors (CAR) and/or genetically modified to reduce potential side effects of cellular immunotherapy. Several embodiments relate to genetic modifications to the immune cells, such as Natural Killer (NK) cells, to reduce, substantially, reduce, or eliminate expression of a marker by the immune cells that would otherwise cause them to be self-targeted by the CAR. In several embodiments, the CAR targets CD70, and in some embodiments is used for renal cell carcinoma immunotherapy.

Abstract: Gaming systems, methods, and machines provided herein may be used to provide bonus games that are associated with two different classes of awards, e.g., one or more first awards and one or more second awards. The first award(s) may generally be much more desirable to players than the second award(s), e.g., the first awards may be large-denomination jackpot awards, whereas the second awards may be small-denomination credit awards, e.g., non-jackpot awards. During play of such bonus games, selection of a stop position associated with a second award may cause that stop position to be instead associated with one of the one or more first awards for future play of the bonus game, thereby increasing the opportunities to win a first award in subsequent play of the bonus game.

Abstract: A partially assembled vehicle that autonomously completes its own assembly, including a chassis, wheels that are rotationally coupled to the chassis, a drive system mounted on the chassis and in operational communication with the wheels, a navigation system, a central platform controller, and a position determining system. Added thereto is a safety sensor guidance system and a controller circuit programmed to begin a temporary takeover of the central platform controller, responsive to an external fleet control. The temporary takeover including the steps of identifying a plurality of assembly stations that the partially assembled vehicle must visit to complete its own assembly; constructing a sequence in which to visit each of the plurality of assembly stations; and commanding the drive system to propel and steer the partially assembled vehicle through the sequence of the plurality of assembly stations, responsive to sensor input from the safety sensor guidance system.

Abstract: Drug delivery devices are described that provide hybrid forms with gripping and stability functionalities, such as a grip portion on a skin contact surface. In some versions, the drug delivery devices can include a cep having a release liner such that removal of the cap exposes the grip portion. In some versions, the drug delivery devices include a retractable needle guard having the grip portion extending therearound.

Abstract: Several embodiments of the methods and compositions disclosed herein relate to immune cells that are engineered to Mexpress chimeric antigen receptors as well as genetically edited or otherwise engineered to alter the effectiveness with which another immune cell can target and induce cytotoxic effects on the engineered cells. In several embodiments, the methods and compositions disclosed herein reduce fratricide within a therapeutic cell population, which in some instances comprises mixture of immune cell types. Additionally, the methods and compositions disclosed herein enhance one or more aspects of the efficacy of the immune cells in cellular immunotherapy including cytotoxicity and/or persistence, as well as reduced graft versus host or host versus graft effects.

Abstract: The present disclosure describes devices, systems, and methods for intravascularly delivering an implantable device to a targeted anatomical site such as the mitral annulus. A delivery system includes a delivery member coupled to a handle assembly and extending distally from the handle assembly. A delivery catheter is concentrically positioned within an outer member and configured to advance the intravascular device relative to the outer member. The delivery catheter includes a distal can structure configured to house at least a portion of the intravascular device in a compressed, pre-deployed position.

Abstract: The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.

Abstract: A lever-based clamping device.

Abstract: A gaming device include a processor, and a memory storing (a) reel strip data defining a set of reel strips and (b) instructions. The reel strips may be used to select symbols to populate positions of a playing field shown on a display. When two or more of the same special symbols occupy adjacent positions of the playing field, they may merge into a single position occupied by one of the special symbols in question. If three or more special symbols are adjacent, all merge into a single position and a higher-value special symbol. The higher-value special symbol thus replaces one of the adjacent special symbols while the rest are removed or disappear.

Abstract: Gaming systems, methods, and machines provided herein may be used to provide bonus games that are associated with two different classes of awards, e.g., one or more first awards and one or more second awards. The first award(s) may generally be much more desirable to players than the second award(s), e.g., the first awards may be large-denomination jackpot awards, whereas the second awards may be small-denomination credit awards, e.g., non-jackpot awards. During play of such bonus games, selection of a stop position associated with a second award may cause that stop position to be instead associated with one of the one or more first awards for future play of the bonus game, thereby increasing the opportunities to win a first award in subsequent play of the bonus game.

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

Abstract: Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and/or track coronary artery disease.

Abstract: A toy figurine and/or toy includes a body portion having an internal cavity, a substantially transparent portal through which contents of the internal cavity are viewable, and a die. The internal cavity includes a fluid and the die is freely floating in the fluid, and the die includes a plurality of faces. Each of these faces includes a visual element.

Abstract: Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.