Abstract: The present disclosure relates to antimicrobial compositions, particularly to antibiotic compositions; to methods for identification of antimicrobial compositions involving in silico prediction of antimicrobial activity; and to use of antimicrobial compositions and methods.

Abstract: Described herein are NLRP3 modulators and methods of utilizing NLRP3 modulators in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

Abstract: An endograft delivery device assembly a guide wire cannula extending distally from the tip to a handle assembly at the distal end. A positioner is disposed around the guide wire cannula. A sheath extends from the handle assembly over the positioner towards the tip. A sheath splitter assembly is within the handle assembly, and includes a splitter body attached to the positioner and disposed within the sheath and at least one splitter arm. The splitter body defines a through-hole through which a guide wire cannula passes. The splitter arm extends laterally from the splitter body though a slit though the sheath to a support within the handle assembly. The splitter body includes a circumferential sealing surface extending towards the tip, the sealing surface and the inner surface of the sheath dimensioned such that the sheath is circumferentially stretched over the sealing surface thereby forming a seal.

Abstract: A system and method for simulation of fluid flow. The system being configured to remove loops in a vortex filament in a simulation model and reconnect the filament. The system may also be configured to model fluid flow in relation to a moving object and to correct errors in surface vorticity.

Abstract: Described herein are NLRP3 modulators and methods of utilizing NLRP3 modulators in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

Abstract: An endovascular system is disclosed. The system includes deployment device and a stent-graft assembly. The stent-graft assembly includes an elongate vessel wall engaging graft portion and a proximal-end self-expanding stent comprising a plurality of terminal portions. The deployment device includes an elongate guide wire catheter adapted to be deployed over a guide wire; a tip at a proximal end of the guide wire catheter. The tip has a proximal nose and a distal receiving zone. The distal receiving zone comprises a plurality of circumferentially spaced apart elongate recesses, each recess receiving at least one of the terminal portions. A trigger wire arrangement retaining the at least one terminal portions within each corresponding recess of the receiving zone is also provided. Retention of the terminal portions within the recess of the receiving zone constrains against relative twisting between the stent-graft assembly and the tip.

Abstract: The present disclosure relates to antimicrobial compositions, particularly to antibiotic compositions; to methods for identification of antimicrobial compositions involving in silico prediction of antimicrobial activity; and to use of antimicrobial compositions and methods.

Abstract: The present disclosure provides compositions and methods capable of potentiating the effects of antibiotics against bacterial infections that either have developed, or that possess the potential to develop, antibiotic tolerance. Methods of sensitizing antibiotic tolerant bacteria to antibiotics, as well as pharmaceutical compositions and therapeutic/prophylactic methods directed at antibiotic tolerant bacteria are also provided.

Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.

Abstract: Amino acid compositions useful for increasing the amount of the divalent metal-ion transporter 1, DMT1 (encoded by the gene SLC11A2), on the duodenal bmsh border membrane (BBM) are described herein. Methods for increasing the concentration of DMT1 on the duodenal BBM (on trafficking) and increasing iron uptake are also presented. Compositions and methods described herein are useful for treating a disorder or disease associated with iron deficiency in subjects afflicted with such disorders or diseases. Use of these compositions for the treatment of disorders or diseases associated with iron deficiency and in the preparation of a medicament for the treatment of disorders or diseases associated with iron deficiency are also encompassed herein.

Abstract: An exoskeleton frame having a frame body that includes a front torso member and a back torso member. The frame body further includes a first shoulder band and a second shoulder band each extending from the front torso member to the back torso member, and an opening positioned between the first shoulder band and second shoulder band. The exoskeleton frame further has an adjustable belt removably attached to the front torso and back torso member that is configured to direct a weight of apparel that is worn by the user over the exoskeleton frame to a weight-bearing area of the user located between knees and abdomen of the user, wherein the first shoulder band and second shoulder band are configured to support the weight of the apparel such that the weight of the apparel is not applied to a first shoulder or a second shoulder of the user.

Abstract: A line pull assembly for a prosthetic delivery device includes a rail assembly defining a rail cavity, a longitudinal axis and a hand-gripable slider assembly. The slider is mounted to the rail assembly for sliding movement along it. The slider has a body slidably mounted to the rail assembly, the body having an inner body portion within the rail cavity. A line receiver for receiving a pullable line sits within the inner body portion. A release ring is mounted around the rail assembly and is operably connected to the inner body portion. The slider is locked against sliding movement until the release ring is moved the unlocked position. In the unlocked position, the inner body portion is slideably moveable by sliding movement of the release ring to transfer a pulling force through the line receiver.

Abstract: An endovascular delivery device is disclosed. The device comprises a handle assembly at a distal end thereof and a top-cap assembly at a proximal end thereof. The top-cap assembly has an open configuration and a closed configuration and comprises: a capsule comprising an inner portion and an outer tubular portion and defining a cavity within the outer tubular portion, the cavity receiving the proximal portion of the endograft in the open configuration; and a retriever assembly having a body portion arranged and constructed to fit within the cavity of the capsule in the closed configuration. The device further comprises: a guide wire catheter extending through the handle assembly, the guide wire catheter being affixed at a proximal end thereof to the top-cap assembly; and an endograft receiving portion extending distally with respect to the top-cap assembly. In the closed configuration, the cavity is closed by the body portion of the retriever assembly.

Abstract: An endovascular delivery device comprises an outer handle with a track; an inner handle moveable relative to the outer handle; a tip assembly slider mounted on the track; the tip assembly having a top cap and a retriever, the top cap comprising a mouth receiving a proximal portion of the endograft and closable by the retriever; a connector extending from the tip to the inner handle and including a distal portion slidably engaging the inner handle; a pusher catheter extending from the outer handle assembly; a guidewire catheter; a distal trigger wire operable to release the distal end of the endograft; a proximal trigger wire release slider mounted on the track and movable from an initial to a triggered position, wherein the tip assembly slider engages the trigger wire release slider to prevent distal movement until the trigger wire release slider is moved distally.

Abstract: A line puller assembly for an endo-luminal delivery device is disclosed. The assembly comprises: a line puller body having a proximal end and a distal end; a line puller actuator assembly mounted to the line puller body for rotation about the line puller body, the actuator assembly including a line deflector ring, the ring including a first deflector line guide; a line anchor location on the line puller body; a first body line guide on the body, the line anchor location and the first body line guide positioned on opposite sides of the ring; and a line having an end portion anchored at the line anchor location on the line puller body, the line extending through the first line deflector ring, whereby a line path extends from the anchor location, through the first deflector line guide and past the first body line guide, the line path having a variable length.

Abstract: A system and method for simulation of fluid flow. The system being configured to remove loops in a vortex filament in a simulation model and reconnect the filament. The system may also be configured to model fluid flow in relation to a moving object and to correct errors in surface vorticity.

Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.