Abstract: A line puller assembly for an endo-luminal delivery device is disclosed. The assembly comprises: a line puller body having a proximal end and a distal end; a line puller actuator assembly mounted to the line puller body for rotation about the line puller body, the actuator assembly including a line deflector ring, the ring including a first deflector line guide; a line anchor location on the line puller body; a first body line guide on the body, the line anchor location and the first body line guide positioned on opposite sides of the ring; and a line having an end portion anchored at the line anchor location on the line puller body, the line extending through the first line deflector ring, whereby a line path extends from the anchor location, through the first deflector line guide and past the first body line guide, the line path having a variable length.

Abstract: A system and method for simulation of fluid flow. The system being configured to remove loops in a vortex filament in a simulation model and reconnect the filament. The system may also be configured to model fluid flow in relation to a moving object and to correct errors in surface vorticity.

Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.

Abstract: An especially robust compound and its derivative metal complexes that are approximately one hundred-fold superior in catalytic performance to the previously invented TAML analogs is provided having the formula (I) wherein Y1, Y2, Y3 and Y4 are oxidation resistant groups which are the same or different and which form 5- or 6-membered rings with a metal, M, when bound to D; at least one Y incorporates a group that is significantly more stable towards nucleophilic attack than the organic amides of TAML activators; D is a metal complexing donor atom, preferably N; each X is a position for addition of a labile Lewis acidic substituent such as (i) H, denterium, (ii) Li, Na, K, alkali metals, (iii) alkaline earth metals, transition metals, rare earth metals, which may be bound to one or more than one D, (iv) or is unoccupied with the resulting negative charge being balanced by a nonhonded counter-action; at least one Y may contain a site that is labile to acid dissociation, providing a mechanism for shortening compl

Abstract: An especially robust compound and its derivative metal complexes that are approximately one hundred-fold superior in catalytic performance to the previously invented TAML analogs is provided having the formula: wherein Y1, Y2, Y3 and Y4 are oxidation resistant groups which are the same or different and which form 5- or 6-membered rings with a metal, M, when bound to D; at least one Y incorporates a group that is significantly more stable towards nucleophilic attack than the organic amides of TAML activators; D is a metal complexing donor atom, preferably N; each X is a position for addition of a labile Lewis acidic substituent such as (i) H, deuterium, (ii) Li, Na, K, alkali metals, (iii) alkaline earth metals, transition metals, rare earth metals, which may be bound to one or more than one D, (iv) or is unoccupied with the resulting negative charge being balanced by a nonbonded countercation; at least one Y may contain a site that is labile to acid dissociation, providing a mechanism for shortening co

Abstract: A computer-implemented method according to one embodiment includes identifying an event within a system; applying a model to the event to create an aggregated event; and storing the aggregated event.

Abstract: A low flying unmanned vehicle is disclosed that may be able to determine whether a collision is possible and may take evasive action in response to the possible collision. The vehicle may wirelessly communicate and may use a standard protocol such that a variety of additional objects may be taken into account when determining the possible collision risk.

Abstract: A line pull assembly 10 for a prosthetic delivery device is disclosed. The assembly comprises: a rail assembly 250 defining a rail cavity 290 and having a longitudinal axis 251 and a hand-gripable slider assembly 1000. The slider is mounted to the rail assembly for sliding movement along it. The slider has a body 1100 slidably mounted to the rail assembly, the body having an inner body portion 1150 within the rail cavity. A line receiver 1170 for receiving a pullable line 1032 sits within the inner body portion. A release ring 1600 is mounted around the rail assembly and is operably connected to the inner body portion. The slider is locked against sliding movement until the release ring is moved the unlocked position. In the unlocked position, the inner body portion is slideably moveable by sliding movement of the release ring to transfer a pulling force through the line receiver.

Abstract: A retaining clip tower includes a locking feature with a circular opening for a clip stem to be inserted and a rectangular opening disposed below the circular opening that can allow for a lower flange of a clip to be inserted at an angle into the locking feature wherein that the clip can complete the angled slide in such that the entire clip sits level inside the locking feature with the lower flange disposed below the locking feature and such that the clip resists extraction against vertical and horizontal forces.

Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.

Abstract: Provided herein are microorganisms engineered with hybrid receptors and genetic circuits. Also provided are hybrid receptors having a CqsS polypeptide and a heterologous histidine kinase domain of a two-component system. Methods for using engineered microorganisms to sense and destroy pathogens (e.g., Vibrio cholerae) are also provided.

Abstract: A method, system, and computer program product for identifying and linking communicating devices using live camera data includes: identifying a visible device that is visible to a linking device; identifying a connected device that is connected to the linking device; determining visible movement of the visible device; requesting video information from the connected device; calculating, using the video information, video movement of the connected device; determining that the visible movement matches the video movement; concluding, based on the determining, that the visible device is the connected device; and linking, based on the concluding, the visible device and the connected device.

Abstract: An endovascular delivery device is disclosed. The device comprises a handle assembly at a distal end thereof and a top-cap assembly at a proximal end thereof. The top-cap assembly has an open configuration and a closed configuration and comprises: a capsule comprising an inner portion and an outer tubular portion and defining a cavity within the outer tubular portion, the cavity receiving the proximal portion of the endograft in the open configuration; and a retriever assembly having a body portion arranged and constructed to fit within the cavity of the capsule in the closed configuration. The device further comprises: a guide wire catheter extending through the handle assembly, the guide wire catheter being affixed at a proximal end thereof to the top-cap assembly; and an endograft receiving portion extending distally with respect to the top-cap assembly. In the closed configuration, the cavity is closed by the body portion of the retriever assembly.

Abstract: An exoskeleton frame having a frame body that includes a front torso member and a back torso member. The frame body further includes a first shoulder band and a second shoulder band each extending from the front torso member to the back torso member, and an opening positioned between the first shoulder band and second shoulder band. The exoskeleton frame further has an adjustable belt removably attached to the front torso and back torso member that is configured to direct a weight of apparel that is worn by the user over the exoskeleton frame to a weight-bearing area of the user located between knees and abdomen of the user, wherein the first shoulder band and second shoulder band are configured to support the weight of the apparel such that the weight of the apparel is not applied to a first shoulder or a second shoulder of the user.

Abstract: Provided herein are microorganisms engineered with hybrid receptors and genetic circuits. Also provided are hybrid receptors having a CqsS polypeptide and a heterologous histidine kinase domain of a two-component system. Methods for using engineered microorganisms to sense and destroy pathogens (e.g., Vibrio cholerae) are also provided.

Abstract: A low flying unmanned vehicle is disclosed that may be able to determine whether a collision is possible and may take evasive action in response to the possible collision. The vehicle may wirelessly communicate and may use a standard protocol such that a variety of additional objects may be taken into account when determining the possible collision risk.