Abstract: A robotic surgical system is provided with a central drive unit that supports and operates one or more robotic tools and a robotic arm and boom assembly that movably supports the control unit assembly in space. The robotic arm and boom assembly selectively allows movement of the control unit assembly along a plane, as well as in pitch and yaw, upon actuation of one or more actuators of the robotic arm and boom assembly to allow movement of the central drive unit.

Abstract: Techniques are disclosed herein for generating predictions of gut microbiome diversity for a user. In some examples, a nutritional service may utilize data associated with a gut transit time and user data to generate a prediction of gut microbiome diversity for a user. For example, the nutritional service may perform an analysis of the data associated with gut transit time and the answers to questions to generate the prediction. In some examples, the nutritional service identifies a uniqueness of the microbiome, identify interesting species, and the like. The information determined and/or otherwise generated by the nutritional service may be presented to the user on a display.

Abstract: Techniques are disclosed herein for generating personalized glucose ranges. In some examples, during a calibration period, a user may consume foods that they normally consume, as well as some standardized meals. Personalized upper limits and lower limits to the glucose range can be determined (e.g., using machine learning techniques) that account for the shape of glucose trace for the particular user, the food consumed during the calibration period, as well as other non-glucose factors such as questionnaires, the user's lipid profile, obesity or other health risks, and the like. In some cases, food recommendations may also be provided to the user (e.g., using machine learning techniques). The personalized glucose range and other information may be presented to the user on a display.

Abstract: In some aspects, a non-transitory computer readable storage medium includes instructions stored thereon that, when executed by a processor, cause the processor to detect that system software is proceeding to swap memory content of a virtual machine (VM) from memory to storage, wherein the memory is allocated to the VM; buffer the memory content; and perform alternative memory reclamation of the memory.

Abstract: Various embodiments disclosed herein are related to a non-transitory computer readable storage medium. In some embodiments, the medium includes instructions stored thereon that, when executed by a processor, cause the processor to receive, from a user-space application, a request to detect swapping activity satisfying a threshold condition, detect the swapping activity satisfying the threshold condition, and, in response to occurrence of the threshold condition, send a response that indicates that the swapping activity satisfies the threshold condition.

Abstract: A vapor provision system includes a reservoir containing liquid for vaporization; a vaporizer; a liquid transport element arranged to transport liquid from the reservoir to the vaporizer for vaporization, wherein the liquid transport element extends into the reservoir through an opening in a wall of the reservoir; and a collar mounted around the liquid transport element where it passes through the opening in the wall of the reservoir.

Abstract: Techniques are disclosed herein for improving the accuracy of nutritional responses measured in a non-clinical setting. Using the technologies described herein, different techniques can be utilized to improve the accuracy of test data associated with one or more “at home” tests. In some examples, more than one test is utilized to improve the accuracy of test data associated with a particular biomarker. In other examples, a data accuracy service can programmatically analyze data received from an individual and determine whether the data is accurate. In some examples, a computing device is utilized to assist in determining what food item(s) are consumed, as well as determine whether a test protocol was followed.

Abstract: In order to provide a reliable interconnection between a wireless mesh network and an external network, more than one border router device may be deployed. A novel load balancing method, and the related system and devices, are disclosed in this invention. By embedding actual traffic load information in the frequency of sending the border router advertisements, automatic traffic load balancing among multiple border routers is realized in 5 the system, without extra signaling overhead or any change to the beacon packet structure.

Abstract: Systems and methods are disclosed for digital design tools. One example method comprises obtaining an electronic model of a structure, the electronic model including a objects, and the objects representing physical objects to be constructed. Dependencies between the objects are determined, with the determined dependencies indicating that a first object is to be constructed prior to a second object. Construction orderings are generated based on the determined dependencies, with each construction ordering indicating a unique order in which the objects are to be constructed. A user interface is presented via a user device describing the construction orderings, with a system being configured to trigger updates to the electronic model in response to received material changes associated with the electronic model.

Abstract: Techniques are disclosed herein for using standardized meals and digital devices can be utilized outside a clinical setting to assist in determining/predicting one or more clinical states associated with one or more individuals. Using the technologies described herein, different techniques can be utilized to for using nutritional response measurements. For example, response measurements can be obtained for two fat meals instead of a single fat meal. Data associated with a circadian rhythm (e.g., sleep times, awake times) can also be utilized to improve the accuracy of the measured biomarkers. In other examples, biome data and other data can be utilized.

Abstract: The present invention relates to a process for producing a chromatin conformation capture (3C) library. This may be used for identifying nucleic acid regions within a nucleic acid sample which interact with one another. The process comprises treating nucleic acids in a population of eukaryotic cells, the process comprising the steps: (i) immobilising the nucleic acids within the cells in a population of eukaryotic cells; (ii) permeabilising or removing the cell membranes of the eukaryotic cells; and (iii) fragmenting the immobilised nucleic acids within the cells to produce nucleic acid fragments.

Abstract: Examples disclosed herein are relevant to monitoring and treating sensory conditions affecting an individual. Sensors and intelligence integrated within a sensory prosthesis (e.g., an auditory prosthesis) can automatically obtain objective data regarding the ability of one or more of an individuals senses during day-to-day activities. A treatment action can be taken based on the objective data. Further disclosed herein are techniques relating to reducing the gathering of irrelevant sensory input and automatically transmitting relevant data to a caregiver device.

Abstract: The present invention relates to a process for producing a modified nucleic acid, wherein the nucleic acid comprises a mutant haemoglobin B (HBB) gene encoding a mutant Hb-? polypeptide. The process comprises using a base editor, preferably with a gRNA, to edit the mutant HBB gene to change a first (mutant) codon in that gene into a second, non-wild-type codon, wherein the Hb-? polypeptide encoded by that edited HBB gene has a non-wild-type, yet phenotypically-viable, amino acid sequence. The invention also provides a population of isolated haematopoietic stem cells, the stem cells comprising edited HBB genes.

Abstract: Treatment actions can be taken based on an analysis of the ability of a recipient of an auditory prosthesis to perceive musical activities. The occurrence of musical activities and the recipients response thereto can be determined based on transducers. The recipients musical perception can be determined by analyzing the signals from the transducers as stand-alone measures or by comparing the signals against known music. The treatment actions can relate to the treatment of a hearing-impairment of the recipient of the auditory prosthesis, such as by modifying the settings of the auditory prosthesis to affect the ongoing operation of the auditory prosthesis.

Abstract: A drug container assembly for use with a parenteral drug delivery device is disclosed. The container assembly includes a container configured to hold the medication and an intermediate port connector. The port connector may be fixedly coupled to the container and removably coupled to the delivery device in a convenient, reliable, and sealed manner In use, the port connector may convey the medication from the container to the delivery device for delivery to the patient.

Abstract: A mobile object configured for movement in an area equipped with VLC illumination sources comprises a light sensor arranged to detect illumination from at least one of the illumination sources within the view of the light sensor; a computer arranged to determine from the detected illumination (i) a position of the mobile object relative to the at least one illumination source and (ii) the identifier of the at least one illumination source; and a transceiver. The transceiver can receive from another mobile object a message comprising the position of the other mobile object relative to a source of illumination, and the identifier of that source of illumination. From this, the computer determines from its position and the message a distance from the other mobile object. A mobile object which transmits such a message is also envisaged.

Abstract: Techniques are disclosed herein for generating personalized nutritional recommendations using predicted values of target biomarkers. Using the technologies described herein, a programmatic analysis is performed on different data to predict values of target biomarkers that are associated with an individual. Personalized nutritional recommendations are then generated, using the predicted values, and provided to the individual. The predictions are based on data that is associated with the individual, such as microbiome data, ketone data, glucose data, nutritional data, questionnaire data, and the like. A prediction service can utilize a machine learning mechanism to generate the predicted value of the target biomarkers. A nutrition service utilizes the predicted value of the target biomarkers when generating the personalized nutritional recommendations.

Abstract: Techniques are disclosed herein for generating personalized nutritional recommendations using predicted values of target biomarkers. Using the technologies described herein, a programmatic analysis is performed on different data to predict values of target biomarkers that are associated with an individual. Personalized nutritional recommendations are then generated, using the predicted values, and provided to the individual. The predictions are based on data that is associated with the individual, such as microbiome data, ketone data, glucose data, nutritional data, questionnaire data, and the like. A prediction service can utilize a machine learning mechanism to generate the predicted value of the target biomarkers. A nutrition service utilizes the predicted value of the target biomarkers when generating the personalized nutritional recommendations.

Abstract: A drug container assembly for use with a parenteral drug delivery device is disclosed. The container assembly includes a container configured to hold the medication and an intermediate port connector. The port connector may be fixedly coupled to the container and removably coupled to the delivery device in a convenient, reliable, and sealed manner. In use, the port connector may convey the medication from the container to the delivery device for delivery to the patient.

Abstract: Techniques are disclosed herein for generating microbiome fingerprints, dietary fingerprints, and microbiome ancestry. Microbiome data associated with an individual is analyzed to generate a microbiome fingerprint, and a dietary fingerprint for a user. A “microbiome fingerprint” uniquely identifies the microbiome of a user at a particular point in time and is based on a combination of different profiles generated from the microbiome data. The dietary fingerprint identifies how the microbiome of a user is associated with one or more different indexes, such as a dietary index and/or a particular characteristic (e.g., a Mediterranean diet index, a vegetarian diet index, a fast food index, an internal fat index, a fat-digesting index, a carbohydrate-digesting index, a health index, a fasting index, a ketogenic index, . . . ). The microbiome data may also be utilized to determine microbiome ancestry for the user that indicates other users to which the user is related to.