Patents by Inventor James E. Vath

James E. Vath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL COMPOSITIONS OF METAP-2 INHIBITORS
    Publication number: 20200030278
    Abstract: Disclosed herein, in part, are pharmaceutical compositions comprising a MetAp-2 inhibitor and a pharmaceutically acceptable excipient. The pharmaceutical compositions are contemplated to be useful, for example in the treatment of obesity.
    Type: Application
    Filed: February 12, 2018
    Publication date: January 30, 2020
    Inventors: James E. Vath, Bryan Burkey
  • METHODS FOR IDENTIFYING METAP-2 MODULATORS
    Publication number: 20200003759
    Abstract: Disclosed herein, in part, are methods for identifying MetAP-2 inhibitors to address the treatment of obesity and related diseases as well as other ailments favorably responsive to MetAP-2 modulator treatment.
    Type: Application
    Filed: February 12, 2018
    Publication date: January 2, 2020
    Inventors: James E. Vath, Bryan Burkey
  • FUMAGILLOL TYPE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20190388380
    Abstract: The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Application
    Filed: January 23, 2019
    Publication date: December 26, 2019
    Inventors: Robert Zahler, James E. Vath
  • Methods of treating an overweight subject
    Patent number: 10406134
    Abstract: The invention generally relates in part to methods of effecting weight loss and/or improving glucose tolerance in a patient in need thereof, comprising administering a MetAP2 inhibitor.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: September 10, 2019
    Assignees: Zafgen, Inc., Vanderbilt University
    Inventors: Thomas E. Hughes, James E. Vath, Alan D. Cherrington
  • Methods of Treating an Overweight or Obese Subject
    Publication number: 20190224156
    Abstract: The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions. In certain embodiments, the invention provides a method of treating an overweight or obese subject including administering a MetAP2 inhibitor in which the amount administered does not substantially modulate angiogenesis.
    Type: Application
    Filed: August 27, 2018
    Publication date: July 25, 2019
    Inventors: Thomas E. Hughes, James E. Vath
  • METHODS OF TREATING AGE RELATED DISORDERS
    Publication number: 20190175542
    Abstract: The invention generally relates to methods of treating a patient having, and/or at risk of, oxidative distress disorders and/or age-related disorders. The disclosure also generally relates to methods of treating memory impairment or enhancing the cognitive function of a patient in need thereof. Such methods may include administering a therapeutically effective amount of a MetAP2 inhibitor.
    Type: Application
    Filed: June 27, 2018
    Publication date: June 13, 2019
    Inventors: Thomas E. Hughes, James E. Vath
  • FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20190169181
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: August 11, 2017
    Publication date: June 6, 2019
    Inventors: Robert Zahler, James E. Vath
  • Oxaspiro[2.5]octane derivatives and analogs
    Patent number: 10259796
    Abstract: The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: April 16, 2019
    Assignee: Zafgen, Inc.
    Inventors: James E. Vath, Stuart Chaffee
  • FUMAGILLOL SPIROCYCLIC COMPOUNDS AND FUSED BICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20190092781
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: November 21, 2018
    Publication date: March 28, 2019
    Inventors: Robert Zahler, Zhenwei Cai, Zhixing Wu, James E. Vath
  • FUMAGILLOL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20190084969
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: November 20, 2018
    Publication date: March 21, 2019
    Inventors: Robert Zahler, James E. Vath
  • FUMAGILLOL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20190084968
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: November 20, 2018
    Publication date: March 21, 2019
    Inventors: Robert Zahler, James E. Vath
  • Methods of treating ischemic organ damage and other disorders
    Patent number: 10231946
    Abstract: The invention generally relates to methods of treating a patient suffering from renal disorders or other disorders related to low levels of sRAGE, and/or low levels of adiponectin (e.g., high molecular weight adiponectin) and/or high levels of thrombomodulin, using effective of amounts of a MetAP-2 inhibitor.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: March 19, 2019
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • Fumigillol compounds and methods of making and using same
    Patent number: 10220015
    Abstract: The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: March 5, 2019
    Assignee: Zafgen, Inc.
    Inventors: Robert Zahler, James E. Vath
  • METHODS OF TREATING AN OVERWEIGHT OR OBESE SUBJECT
    Publication number: 20190022051
    Abstract: The invention herein generally relates to pharmaceutical formulations and methods of treating an overweight or obese subject, and overweight- or obesity-related conditions.
    Type: Application
    Filed: February 14, 2018
    Publication date: January 24, 2019
    Inventor: James E. Vath
  • FUMAGILLOL SPIROCYCLIC COMPOUNDS AND FUSED BICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20190023716
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: March 15, 2018
    Publication date: January 24, 2019
    Inventors: Robert Zahler, Zhenwei Cai, Zhixing Wu, James E. Vath
  • FUMIGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20180360795
    Abstract: The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Application
    Filed: January 12, 2018
    Publication date: December 20, 2018
    Inventors: Robert Zahler, James E. Vath
  • Oxaspiro[2.5]Octane Derivatives and Analogs
    Publication number: 20180354924
    Abstract: The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.
    Type: Application
    Filed: May 31, 2017
    Publication date: December 13, 2018
    Inventors: James E. Vath, Stuart Chaffee
  • Methods of treating liver diseases
    Patent number: 10064839
    Abstract: The invention provides tricyclic compounds and their use in treating liver disorders, such as non-alcoholic steatohepatitis and related disorders (e.g., fibrosis). The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: September 4, 2018
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • FUMAGILLOL SPIROCYCLIC COMPOUNDS AND FUSED BICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20180237449
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: August 11, 2016
    Publication date: August 23, 2018
    Inventors: Robert Zahler, Zhenwei Cai, Zhixing Wu, James E. Vath
  • FUMAGILLOL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20180230137
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: August 11, 2016
    Publication date: August 16, 2018
    Inventors: Robert Zahler, James E. Vath