Patents by Inventor James E. Vath

James E. Vath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating an overweight or obese subject
    Patent number: 9656979
    Abstract: The disclosure herein generally relates to methods of treating an overweight or obese condition, and overweight or obesity-related conditions. In one embodiment, the disclosure provides a method of treating an overweight or obese condition involving administering to the subject in need thereof, an amount of a pharmaceutical composition including a MetAp-2 inhibitory compound, or a salt, ester, or prodrug thereof, effective to result in weight loss in the subject.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: May 23, 2017
    Assignee: Zafgen, Inc.
    Inventor: James E. Vath
  • Methods of treating an overweight subject
    Patent number: 9649293
    Abstract: The invention generally relates in part to methods of effecting weight loss and/or improving glucose tolerance in a patient in need thereof, comprising administering a MetAP2 inhibitor.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: May 16, 2017
    Assignees: Zafgen, Inc., Vanderbilt University
    Inventors: Thomas E. Hughes, James E. Vath, Alan D. Cherrington
  • Methods of treating renal disease and other disorders
    Patent number: 9597309
    Abstract: The invention generally relates to methods of treating a patient suffering from renal disorders or other disorders related to low levels of sRAGE, and/or low levels of adiponectin (e.g., high molecular weight adiponectin) and/or high levels of thrombomodulin, using effective of amounts of a MetAP-2 inhibitor.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 21, 2017
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • FUMAGILLOL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20170066749
    Abstract: Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: November 17, 2016
    Publication date: March 9, 2017
    Inventors: James E. Vath, Robert Zahler
  • METHODS OF TREATING AN OVERWEIGHT OR OBESE SUBJECT
    Publication number: 20170056364
    Abstract: The invention herein generally relates to pharmaceutical formulations and methods of treating an overweight or obese subject, and overweight- or obesity-related conditions.
    Type: Application
    Filed: April 8, 2016
    Publication date: March 2, 2017
    Inventor: James E. Vath
  • Fumigillol compounds and methods of making and using same
    Patent number: 9573918
    Abstract: The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Grant
    Filed: May 8, 2013
    Date of Patent: February 21, 2017
    Assignee: Zafgen, Inc.
    Inventors: Robert Zahler, James E. Vath
  • Oxaspiro[2.5]Octane Derivatives and Analogs
    Publication number: 20170044122
    Abstract: The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.
    Type: Application
    Filed: March 14, 2016
    Publication date: February 16, 2017
    Applicant: Zafgen, Inc.
    Inventors: James E. Vath, Stuart Chaffee
  • Methods of treating liver diseases
    Patent number: 9561209
    Abstract: The invention provides tricyclic compounds and their use in treating liver disorders, such as non-alcoholic steatohepatitis and related disorders (e.g., fibrosis). The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: February 7, 2017
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • Methods of treating age related disorders
    Patent number: 9446016
    Abstract: The invention generally relates to methods of treating a patient having, and/or at risk of, oxidative distress disorders and/or age-related disorders. The disclosure also generally relates to methods of treating memory impairment or enhancing the cognitive function of a patient in need thereof. Such methods may include administering a therapeutically effective amount of a MetAP2 inhibitor.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: September 20, 2016
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • Oxaspiro[2.5]octane derivatives and analogs
    Patent number: 9328082
    Abstract: The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: May 3, 2016
    Assignee: Zafgen, Inc.
    Inventors: James E. Vath, Stuart Chaffee
  • FUMAGILLOL TYPE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20160106703
    Abstract: The disclosure provides a fumagillol type compound and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Application
    Filed: May 21, 2015
    Publication date: April 21, 2016
    Inventor: James E. Vath
  • METHODS OF TREATING LIVER DISEASES
    Publication number: 20160058731
    Abstract: The invention provides tricyclic compounds and their use in treating liver disorders, such as non-alcoholic steatohepatitis and related disorders (e.g., fibrosis). The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: November 5, 2013
    Publication date: March 3, 2016
    Applicant: ZAFGEN, INC.
    Inventors: Thomas E. HUGHES, James E. VATH
  • METHODS OF TREATING RENAL DISEASE AND OTHER DISORDERS
    Publication number: 20160038453
    Abstract: The invention generally relates to methods of treating a patient suffering from renal disorders or other disorders related to low levels of sRAGE, and/or low levels of adiponectin (e.g., high molecular weight adiponectin) and/or high levels of thrombomodulin, using effective of amounts of a MetAP-2 inhibitor.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Inventors: Thomas E. Hughes, James E. Vath
  • Methods of Treating an Overweight or Obese Subject
    Publication number: 20150361061
    Abstract: The disclosure herein generally relates to methods of treating an overweight or obese condition, and overweight- or obesity-related conditions. In one embodiment, the disclosure provides a method of treating an overweight or obese condition involving administering to the subject in need thereof, an amount of a pharmaceutical composition including a MetAP-2 inhibitory compound, or a salt, ester, or prodrug thereof, effective to result in weight loss in the subject.
    Type: Application
    Filed: July 17, 2015
    Publication date: December 17, 2015
    Inventor: James E. Vath
  • METHODS OF TREATING AN OVERWEIGHT SUBJECT
    Publication number: 20150335608
    Abstract: The invention generally relates in part to methods of effecting weight loss and/or improving glucose tolerance in a patient in need thereof, comprising administering a MetAP2 inhibitor.
    Type: Application
    Filed: December 17, 2014
    Publication date: November 26, 2015
    Inventors: Thomas E. Hughes, James E. Vath, Alan D. Cherrington
  • METHODS OF TREATING AN OVERWEIGHT OR OBESE SUBJECT
    Publication number: 20150216835
    Abstract: The invention herein generally relates to pharmaceutical formulations and methods of treating an overweight or obese subject, and overweight- or obesity-related conditions.
    Type: Application
    Filed: September 16, 2014
    Publication date: August 6, 2015
    Inventor: James E. Vath
  • METHODS OF TREATING AN OVERWEIGHT OR OBESE SUBJECT
    Publication number: 20150209320
    Abstract: The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions. In certain embodiments, the invention provides a method of treating an overweight or obese subject including administering a MetAP2 inhibitor in which the amount administered does not substantially modulate angiogenesis.
    Type: Application
    Filed: December 27, 2013
    Publication date: July 30, 2015
    Inventors: Thomas E. Hughes, James E. Vath
  • Fumigillol type compounds and methods of making and using same
    Patent number: 9067913
    Abstract: The disclosure provides a fumagillol type compound and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: June 30, 2015
    Assignee: Zafgen, Inc.
    Inventor: James E. Vath
  • METHODS OF TREATING A SUBJECT WITH BENIGN PROSTATE HYPERPLASIA
    Publication number: 20150157595
    Abstract: The invention generally relates to methods of treating a male subject with a prostate condition, for example, benign prostate hyperplasia (BPH). In certain embodiments, the invention provides methods of treating a male subject with a prostate condition, which include administering a MetAP2 inhibitor at a dose that does not substantially modulate angiogenesis.
    Type: Application
    Filed: July 9, 2014
    Publication date: June 11, 2015
    Inventor: James E. Vath
  • Methods of Treating an Overweight or Obese Subject
    Publication number: 20150150857
    Abstract: The disclosure herein generally relates to methods of treating an overweight or obese condition, and overweight- or obesity-related conditions. In one embodiment, the disclosure provides a method of treating an overweight or obese condition involving administering to the subject in need thereof, an amount of a pharmaceutical composition including MetAp-2 inhibitory compound, or s salt, ester, or prodrug thereof, effective to result in weight loss in the subject.
    Type: Application
    Filed: February 6, 2015
    Publication date: June 4, 2015
    Inventor: James E. Vath