Patents by Inventor James E. Vath

James E. Vath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Treating Hypothalamic Obesity
    Publication number: 20150150840
    Abstract: The invention generally relates to methods of treating a patient suffering from hypothalamic obesity using effective of amounts of a MetAP-2 inhibitor.
    Type: Application
    Filed: May 8, 2013
    Publication date: June 4, 2015
    Applicant: Zafgen, Inc.
    Inventor: James E. Vath
  • FUMIGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20150126489
    Abstract: The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Application
    Filed: May 8, 2013
    Publication date: May 7, 2015
    Applicant: ZAFGEN, INC.
    Inventors: Robert Zahler, James E. Vath
  • FUMIGILLOL TYPE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20150111963
    Abstract: The disclosure provides a fumagillol type compound and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Application
    Filed: May 22, 2014
    Publication date: April 23, 2015
    Applicant: ZAFGEN, INC.
    Inventor: James E. Vath
  • Oxaspiro[2.5]Octane Derivatives and Analogs
    Publication number: 20150045427
    Abstract: The invention provides oxaspiro[2.5]octane derivatives and analogs, methods for preparation thereof, intermediates thereto, pharmaceutical compositions, and uses thereof in the treatment of various disorders and conditions, such as overweight and obesity.
    Type: Application
    Filed: March 7, 2012
    Publication date: February 12, 2015
    Inventors: James E. Vath, Stuart Chaffee
  • METHODS OF TREATING AGE RELATED DISORDERS
    Publication number: 20140336251
    Abstract: The invention generally relates to methods of treating a patient having, and/or at risk of, oxidative distress disorders and/or age-related disorders. The disclosure also generally relates to methods of treating memory impairment or enhancing the cognitive function of a patient in need thereof. Such methods may include administering a therapeutically effective amount of a MetAP2 inhibitor.
    Type: Application
    Filed: April 3, 2014
    Publication date: November 13, 2014
    Applicant: ZAFGEN, INC.
    Inventors: Thomas E. Hughes, James E. Vath
  • Methods of treating a subject with benign prostate hyperplasia
    Patent number: 8815309
    Abstract: The invention generally relates to methods of treating a male subject with a prostate condition, for example, benign prostate hyperplasia (BPH). In certain embodiments, the invention provides methods of treating a male subject with a prostate condition, which include administering a MetAP2 inhibitor at a dose that does not substantially modulate angiogenesis.
    Type: Grant
    Filed: January 7, 2011
    Date of Patent: August 26, 2014
    Assignee: Zafgen, Inc.
    Inventor: James E. Vath
  • Fumigillol type compounds and methods of making and using same
    Patent number: 8772333
    Abstract: The disclosure provides a fumagillol type compound and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Grant
    Filed: January 7, 2011
    Date of Patent: July 8, 2014
    Assignee: Zafgen, Inc.
    Inventor: James E. Vath
  • Methods of treating an overweight or obese subject
    Patent number: 8642650
    Abstract: The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions. In certain embodiments, the invention provides a method of treating an overweight or obese subject including administering a MetAP2 inhibitor in which the amount administered does not substantially modulate angiogenesis.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: February 4, 2014
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • METHODS OF TREATING AN OVERWEIGHT SUBJECT
    Publication number: 20130266578
    Abstract: The invention generally relates in part to methods of effecting weight loss and/or improving glucose tolerance in a patient in need thereof, comprising administering a MetAP2 inhibitor.
    Type: Application
    Filed: April 7, 2011
    Publication date: October 10, 2013
    Inventors: Thomas E. Hughes, James E. Vath, Alan D. Cherrington
  • Methods for Treating Obesity
    Publication number: 20130210821
    Abstract: The disclosure provides for methods of treating obesity and related disorders. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Application
    Filed: May 27, 2011
    Publication date: August 15, 2013
    Inventor: James E. Vath
  • Methods of Treating a Subject with Benign Prostate Hyperplasia
    Publication number: 20130052283
    Abstract: The invention generally relates to methods of treating a male subject with a prostate condition, for example, benign prostate hyperplasia (BPH). In certain embodiments, the invention provides methods of treating a male subject with a prostate condition, which include administering a MetAP2 inhibitor at a dose that does not substantially modulate angiogenesis.
    Type: Application
    Filed: January 7, 2011
    Publication date: February 28, 2013
    Inventor: James E. Vath
  • Methods of treating an overweight or obese subject
    Patent number: 8367721
    Abstract: The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions. In certain embodiments, the invention provides a method of treating an overweight or obese subject including administering a MetAP2 inhibitor in which the amount administered does not substantially modulate angiogenesis.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: February 5, 2013
    Assignee: Zafgen, Inc.
    Inventors: Thomas E. Hughes, James E. Vath
  • Fumigillol Type Compounds and Methods of Making and Using Same
    Publication number: 20130018095
    Abstract: The disclosure provides a fumagillol type compound and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
    Type: Application
    Filed: January 7, 2011
    Publication date: January 17, 2013
    Inventor: James E. Vath
  • Methods of Treating an Overweight or Obese Subject
    Publication number: 20120322867
    Abstract: The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions. In certain embodiments, the invention provides a method of treating an overweight or obese subject including administering a MetAP2 inhibitor in which the amount administered does not substantially modulate angiogenesis.
    Type: Application
    Filed: August 7, 2012
    Publication date: December 20, 2012
    Inventors: Thomas E. Hughes, James E. Vath
  • Methods of Treating an Overweight or Obese Subject
    Publication number: 20120034233
    Abstract: The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions. In certain embodiments, the invention provides a method of treating an overweight or obese subject including administering a MetAP2 inhibitor in which the amount administered does not substantially modulate angiogenesis.
    Type: Application
    Filed: December 4, 2009
    Publication date: February 9, 2012
    Inventors: Thomas E. Hughes, James E. Vath
  • Methods of Treating an Overweight or Obese Subject
    Publication number: 20120010259
    Abstract: The invention herein generally relates to methods of treating a subject having an overweight or obese condition, and overweight- or obesity-related conditions. In one embodiment, the invention herein provides a method of treating a subject having an overweight or obese condition involving administering to the subject in need thereof, an amount of a pharmaceutical composition including a MetAP-2 inhibitory compound, or a salt, ester, or prodrug thereof, effective to result in weight loss in the subject.
    Type: Application
    Filed: December 4, 2009
    Publication date: January 12, 2012
    Inventor: James E. Vath
  • Methods of Treating an Overweight or Obese Subject
    Publication number: 20120010290
    Abstract: The invention herein generally relates to methods of treating a subject having an overweight or obese condition, and overweight- or obesity-related conditions. In one embodiment, the invention herein provides a method of treating a subject having overweight or obese condition involving administering to the subject in need thereof, an amount of a pharmaceutical composition including a MetAP-2 inhibitory compound, or a salt, ester, or prodrug thereof, effective to result in weight loss in the subject.
    Type: Application
    Filed: December 4, 2009
    Publication date: January 12, 2012
    Inventor: James E. Vath
  • Methods of Treating an Overweight or Obese Subject
    Publication number: 20120004162
    Abstract: The disclosure herein generally relates to methods of treating an over eight or obese condition, and overweight- or obesity-related conditions. In one embodiment, the disclosure provides a method of treating an overweight or obese condition involving administering to the subject in need thereof, an amount of a pharmaceutical composition including a MctAP-2 inhibitory compound, or a salt, ester, or prodrug thereof, effective to result in weight loss in the subject.
    Type: Application
    Filed: December 4, 2009
    Publication date: January 5, 2012
    Inventor: James E. Vath