Patents by Inventor James Eberwine

James Eberwine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rapid, sensitive and quantitative methods for tissue and cell-based proteomics via consecutive addition of quantifiable extenders
    Patent number: 7550268
    Abstract: Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen bound complexes of immunogen binding agent attached to a DNA containing an RNA polymerase promoter.
    Type: Grant
    Filed: July 28, 2006
    Date of Patent: June 23, 2009
    Assignee: Trustees of the University of Pennsylvania
    Inventor: James Eberwine
  • Methods and compositions for identifying RNA-binding proteins
    Publication number: 20080199854
    Abstract: The present invention includes compositions, methods and kits for the identification of a polypeptide that binds to a predetermined RNA sequence. The invention comprises, in part, a photoreactive moiety to aid in identification of such a polypeptide.
    Type: Application
    Filed: June 20, 2006
    Publication date: August 21, 2008
    Inventors: James Eberwine, Ulo Langel, Kalle Kilk, Jennifer Zielinski
  • Method, systems and kits for immuno-detection of epitopes expressed on molecules
    Patent number: 7361464
    Abstract: Methods, systems and kits are provided for detecting molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific.CDR attached to an oligonucleotide.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: April 22, 2008
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, James Eberwine, Janet Estee Kacharmina, Hongtao Zhang
  • Extranuclear RNA splicing in neuronal dendrites
    Publication number: 20070196921
    Abstract: The present invention relates to methods of synaptic network remodeling by means of extranuclear RNA splicing. The present invention also provides methods of extranuclear RNA splicing, and methods of protein translation based on extranuclear RNA splicing.
    Type: Application
    Filed: October 5, 2006
    Publication date: August 23, 2007
    Inventors: James Eberwine, Kevin Miyashiro, Jason Glanzer
  • Rapid, sensitive and quantitative methods for tissue and cell-based proteomics via consecutive addition of quantifiable extenders
    Publication number: 20070178484
    Abstract: Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen bound complexes of immunogen binding agent attached to a DNA containing an RNA polymerase promoter.
    Type: Application
    Filed: July 28, 2006
    Publication date: August 2, 2007
    Inventor: James Eberwine
  • Compositions and methods for modulating and monitoring neurotransmitter receptor populations
    Publication number: 20070105802
    Abstract: Compositions and methods modulating neurotransmitter receptor populations are provided.
    Type: Application
    Filed: April 21, 2006
    Publication date: May 10, 2007
    Inventors: James Eberwine, Janet Kacharmina
  • Methods and kits for identifying and quantifying RNAs and DNAs associated with RNA and DNA binding proteins
    Publication number: 20070003973
    Abstract: Methods and kits for identifying RNAs and DNAs associated with an RNA or DNA binding protein via a detector specific for the binding protein or protein bound thereto which is linked to an oligonucleotide capable of directing the synthesis of cDNA copies of RNA or DNA that are in close proximity to or in the vicinity of the bound detector are provided.
    Type: Application
    Filed: September 11, 2006
    Publication date: January 4, 2007
    Inventor: James Eberwine
  • Rapid, sensitive and quantitative methods for tissue and cell-based proteomics via consecutive addition of quantifiable extenders
    Patent number: 7115371
    Abstract: Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen bound complexes of immunogen binding agent attached to a DNA containing an RNA polymerase promoter.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: October 3, 2006
    Assignee: Trustees of the University of Pennsylvania
    Inventor: James Eberwine
  • Method, systems and kits for immuno-detection of epitopes expressed on molecules
    Publication number: 20050003413
    Abstract: Methods, systems and kits are provided for detecting molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific.CDR attached to an oligonucleotide.
    Type: Application
    Filed: May 28, 2004
    Publication date: January 6, 2005
    Inventors: Mark Greene, James Eberwine, Janet Kacharmina, Hongtao Zhang
  • Methods, systems and kits for immuno-detection of epitopes expressed on molecules
    Patent number: 6743592
    Abstract: Methods, systems and kits are provided for detecting molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or a constrained epitope specific CDR attached to an oligonucleotide.
    Type: Grant
    Filed: July 25, 2000
    Date of Patent: June 1, 2004
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, James Eberwine, Janet Estee Kacharmina, Hong Tao Zhang
  • Compositions and methods for modulating and monitoring neurotransmitter receptor populations
    Publication number: 20040067906
    Abstract: Compositions and methods modulating neurotransmitter receptor populations are provided.
    Type: Application
    Filed: September 26, 2003
    Publication date: April 8, 2004
    Inventors: James Eberwine, Janet Estee Kacharmina
  • Rapid, sensitive and quantitative methods for tissue and cell-based proteomics via consecutive addition of quantifiable extenders
    Publication number: 20030124574
    Abstract: Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen bound complexes of immunogen binding agent attached to a DNA containing an RNA polymerase promoter.
    Type: Application
    Filed: August 14, 2002
    Publication date: July 3, 2003
    Inventor: James Eberwine
  • COMPOSITIONS AND METHODS FOR MODULATING AND MONITORING NEUROTRANSMITTER RECEPTOR POPULATIONS
    Publication number: 20020187924
    Abstract: Compositions and methods modulating neurotransmitter receptor populations are provided.
    Type: Application
    Filed: December 17, 1999
    Publication date: December 12, 2002
    Inventors: JAMES EBERWINE, JANET ESTEE KACHARMINA
  • Diagnostic methods for Alzheimer's disease by detection of multiple mRNAs
    Publication number: 20020102594
    Abstract: Methods of detecting RNA in brain tissue of patients with Alzheimer's disease are provided. Methods of diagnosing Alzheimer's disease by detection of these RNAs are also provided.
    Type: Application
    Filed: January 16, 2002
    Publication date: August 1, 2002
    Inventors: Stephen Ginsberg, John Q. Trojanowski, Virginia M. Y. Lee, James Eberwine
  • Diagnostic methods for alzheimer's disease by detection of multiple mRNAs
    Patent number: 6358681
    Abstract: Methods of detecting RNA in brain tissue of patients with Alzheimer's disease are provided. Methods of diagnosing Alzheimer's disease by detection of these RNAs are also provided.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: March 19, 2002
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Stephen Ginsberg, John Q. Trojanowski, Virginia M.-Y. Lee, James Eberwine
  • Method of determining multiple mRNAs in dying cells
    Patent number: 6326146
    Abstract: A method for determining expression levels of multiple mRNAs in single, dying cells from a selected tissue is provided. The method utilizes terminal deoxynucleotidyl-transferase mediated biotin-dUTP nick end labeling to identify dying cells and measures multiple mRNA expression levels in single, isolated dying cells or portions thereof by amplified antisense RNA techniques.
    Type: Grant
    Filed: March 23, 1999
    Date of Patent: December 4, 2001
    Inventors: Dianne M. O'Dell, Ramesh Raghupathi, Tracy Kahl McIntosh, Peter Crino, James Eberwine
  • DIAGNOSTIC METHODS FOR ALZHEIMER'S DISEASE BY DETECTION OF MULTIPLE MRNAS
    Publication number: 20010026916
    Abstract: Methods of detecting RNA in brain tissue of patients with Alzheimer's disease are provided. Methods of diagnosing Alzheimer's disease by detection of these RNAs are also provided.
    Type: Application
    Filed: October 30, 1998
    Publication date: October 4, 2001
    Inventors: STEPHEN GINSBERG, JOHN Q. TROJANOWSKI, VIRGINIA M.-Y. LEE, JAMES EBERWINE
  • Method of detecting protein by immuno RNA
    Patent number: 6255060
    Abstract: A method for the detection of a selected protein is provided wherein mRNA levels are correlated with the presence of protein using the technique referred to herein as immuno-aRNA.
    Type: Grant
    Filed: June 22, 1999
    Date of Patent: July 3, 2001
    Assignee: Trustees of the University of Pennsylvania
    Inventors: James Eberwine, Lori Rodgers
  • Identification of functional transcription factors synthesized in developing neurons
    Patent number: 6020136
    Abstract: The present invention relates to the identification of biologically active transcription factors which are synthesized and modified in the dendritic compartment of neurons and uses thereof.
    Type: Grant
    Filed: September 16, 1998
    Date of Patent: February 1, 2000
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: James Eberwine
  • Characterization of mRNA patterns in neurites and single cells for medical diagnosis and therapeutics
    Patent number: 5958688
    Abstract: A method of identifying neurite cDNA clones by determining and comparing mRNA expression in selected neurites is provided. cDNA clones identified by this method are also provided. In addition, methods of profiling mRNA expression and diagnosing and treating conditions associated with a pattern of mRNA expression by determining an mRNA expression profile in selected cells are provided.
    Type: Grant
    Filed: April 28, 1997
    Date of Patent: September 28, 1999
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James Eberwine, Marc Dichter, Kevin Miyashiro