Abstract: The invention relates to LAG-3 binding agents, in particular variable heavy chain (VH) sdAbs and bispecific agents that target both LAG-3 and PD-1, and the use of such binding agents in the treatment, prevention and detection of disease.

Abstract: A process for preparing a Mn+4 doped phosphor of formula I Ax[MFy]:Mn+4??I includes combining a first solution comprising a source of A and a second solution comprising H2MF6 in the presence of a source of Mn, to form the Mn+4 doped phosphor; wherein A is Li, Na, K, Rb, Cs, or a combination thereof; M is Si, Ge, Sn, Ti, Zr, Al, Ga, In, Sc, Y, La, Nb, Ta, Bi, Gd, or a combination thereof; x is the absolute value of the charge of the [MFy] ion; y is 5, 6 or 7; and wherein a value of a Hammett acidity function of the first solution is at least ?0.9. Particles produced by the process may have a particle size distribution with a D50 particle size of less than 10 ?m.

Abstract: Example methods, apparatuses, and/or articles of manufacture are disclosed that may be implemented, in whole or in part, techniques to select between and/or among multiple available alternative approaches to perform a temporal anti-aliasing operation in processing an image.

Abstract: Apparatus and methods employing dual triggered feeding of projectiles from plural or multiple magazine clips with multiple interlock features in a rapid fire toy launcher employing a clips carriage mounted for translatable movement using a carriage selector separately positions clips in line for individual projectile feeding and launch. A propelling mechanism receives projectiles from an elongated projectile checking subassembly using a reversible projectile advancing feeder with a gear combination that advances and returns a pusher extension for feeding projectiles through the clips carriage upper portion. The reversible projectile advancing feeder is positioned in the housing forward the inserted magazine clips. Triggers including a propelling mechanism trigger activates a key and a fire key is activated with a fire trigger.

Abstract: Described herein are systems and methods for performing peritoneal dialysis. According to one aspect, the disclosure provides a sterile interface connection for connecting a water purification system to a disposable source of dialysate concentrates. The sterile interface connection can include a chamber comprising an inlet adapted to be connected to the water purification system on a proximal end and a valve on a distal end. The sterile interface connection can also include spring-loaded needle disposed in the chamber. The spring-loaded needle can move between a retracted configuration in which the spring-loaded needle is fully retracted into the chamber and the valve is closed and sealed, and an extended configuration in which the spring-loaded needle extends through the valve into the disposable source of dialysate concentrates.

Abstract: A process of forming a sintered article includes heating a green portion of a tape of polycrystalline ceramic and/or minerals in organic binder at a binder removal zone to a temperature sufficient to pyrolyze the binder; horizontally conveying the portion of tape with organic binder removed from the binder removal zone to a sintering zone; and sintering polycrystalline ceramic and/or minerals of the portion of tape at the sintering zone, wherein the tape simultaneously extends through the removal and sintering zones.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: An example method of monitoring computing resources in a cloud computing environment may include receiving a request to subscribe to a monitoring service with respect to computing resources associated with a user account, the request specifying access information for a cloud computing system comprising a plurality of virtual machines associated with the computing resources. The method may further include monitoring, using the access information, the plurality of virtual machines. The method may further include identifying, in view of the monitoring, a virus-infected application running on a virtual machine of the plurality of virtual machines. The method may further include terminating the virus-infected application. The method may further include receiving, in view of the monitoring, resource usage data reflecting types and duration of usage of the computing resources. The method may further include generating, in view of the usage data, a report reflecting usage of the computing resources.

Abstract: Securement arrangements for use in securing a patient interface to the skin of a patient include a substrate material having a first surface and an adhesive material disposed on the first surface. The locations of the adhesive material are varied so as to minimize repetitious adherence of the adhesive material to the patient during repeated applications.

Abstract: A method at an electronic device with a display includes: displaying a user interface having a first region and a second region; receiving, and displaying in the first region of the user interface, a live video stream of a physical environment captured by a remote video camera; displaying, in the second region, a timeline corresponding to a timespan for a first portion of a duration during which the live video stream may have been recorded; in response to receiving a user interaction to move the timespan to a second portion of the duration, transitioning the displayed timeline to a new timeline that corresponds to the timespan for the second portion, and while transitioning, displaying, in the first region, a subset of video frames representing the first and/or second portion of the duration.

Abstract: Techniques for distributed offload leveraging different offload devices are disclosed. In some embodiments, a system, process, and/or computer program product for distributed offload leveraging different offload devices includes receiving a flow at a firewall of a security service (e.g., a cloud-based security service); inspecting the flow at the firewall to determine meta information associated with the flow; and offloading the flow to an offload entity (e.g., a SmartNIC, software executed on a Network Interface Card (NIC), and/or a network device, such as a network router and/or network switch) based on the meta information associated with the flow (e.g., an application identification associated with the flow determined using deep packet inspection) and based on a policy.

Abstract: A shape-morphing fin includes a fixed portion, a multistable portion, a coupling portion, and a vibration source. The multistable portion functions as a negative stiffness element. The multistable portion is selectively movable between a first position and a second position. The movement between first position and the second position is configured to remove the ice formation from the structure. The coupling portion couples the fixed portion to the multistable portion. The vibration source is configured to produce a resonant vibration to engage the movement of the multistable portion from the first position to the second position.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Embodiments of the present invention provide an apparatus and method for a MAP wireless network that includes a collaborative channel sounding measurement phase to determine channel state information between devices (e.g., the channel state between an STA and a collaborative AP) for efficient configuration of the MAP wireless network and to improve the performance of the MAP wireless networks. The wireless AP and wireless STAs associated with the collaborative APs can simultaneously transmit by applying collaborative beamforming where the interferences between channels nullify each other (e.g., nulling), and the beamforming is performed based on a sounding phase performed by the collaborative APs.

Abstract: A system and method for sensing an edge of a region includes at least one distance sensor configured to detect a plurality of distances of objects along a plurality of adjacent scan lines. A controller is in communication with the at least one distance sensor and is configured to determine a location of an edge of a region within the plurality of adjacent scan lines. The controller includes a comparator module configured to compare values corresponding to the detected plurality of distances, and an identification module configured to identify the location of the edge of the region according to the compared values. In one example, the values corresponding to the detected plurality of distances include couplets of standard deviations that are analyzed and selected to identify the location of the edge.

Abstract: A method for operating a gate driver system includes measuring a first parameter according to a first priority schedule synchronously to a first edge of a switching signal generated by a gate driver integrated circuit and having a variable duty cycle. The method includes after measuring the first parameter of the gate driver system and prior to a second edge of the switching signal, measuring at least a second parameter of the gate driver system according to a first round-robin schedule synchronously to the first edge of the switching signal.

Abstract: The invention provides a method of treating a tumor in a human patient comprising (i) identifying a patient as having a LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor, or an anti-CTLA4 antibody. In some embodiments, the method further comprises identifying the patient as having a LAG-3 positive PD-L1 positive tumor. In some embodiments, the LAG-3 inhibitor is an anti-LAG-3 antibody and the PD-1 pathway inhibitor is an anti-PD-1 antibody. The methods of the invention can improve response rates to treatment with a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, or a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor.

Abstract: A method for operating a twin-row metering system including a first seed meter and a second seed meter. Each of the first seed meter and the second seed meter includes a motor with a driveshaft and a seed disc operably coupled with the motor via the driveshaft. The method includes a step of measuring a position of the driveshaft of the first motor. An additional step includes measuring a position of the driveshaft of the second motor. An additional step includes determining an angular offset between the position of the driveshaft of the first motor and a position of the driveshaft of the second motor. And a further step includes adjusting a rotational speed of the driveshaft of the second motor based on the determined angular offset.