Abstract: A shape-morphing fin includes a fixed portion, a multistable portion, a coupling portion, and a vibration source. The multistable portion functions as a negative stiffness element. The multistable portion is selectively movable between a first position and a second position. The movement between first position and the second position is configured to remove the ice formation from the structure. The coupling portion couples the fixed portion to the multistable portion. The vibration source is configured to produce a resonant vibration to engage the movement of the multistable portion from the first position to the second position.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Embodiments of the present invention provide an apparatus and method for a MAP wireless network that includes a collaborative channel sounding measurement phase to determine channel state information between devices (e.g., the channel state between an STA and a collaborative AP) for efficient configuration of the MAP wireless network and to improve the performance of the MAP wireless networks. The wireless AP and wireless STAs associated with the collaborative APs can simultaneously transmit by applying collaborative beamforming where the interferences between channels nullify each other (e.g., nulling), and the beamforming is performed based on a sounding phase performed by the collaborative APs.

Abstract: A method for operating a gate driver system includes measuring a first parameter according to a first priority schedule synchronously to a first edge of a switching signal generated by a gate driver integrated circuit and having a variable duty cycle. The method includes after measuring the first parameter of the gate driver system and prior to a second edge of the switching signal, measuring at least a second parameter of the gate driver system according to a first round-robin schedule synchronously to the first edge of the switching signal.

Abstract: A system and method for sensing an edge of a region includes at least one distance sensor configured to detect a plurality of distances of objects along a plurality of adjacent scan lines. A controller is in communication with the at least one distance sensor and is configured to determine a location of an edge of a region within the plurality of adjacent scan lines. The controller includes a comparator module configured to compare values corresponding to the detected plurality of distances, and an identification module configured to identify the location of the edge of the region according to the compared values. In one example, the values corresponding to the detected plurality of distances include couplets of standard deviations that are analyzed and selected to identify the location of the edge.

Abstract: The invention provides a method of treating a tumor in a human patient comprising (i) identifying a patient as having a LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor, or an anti-CTLA4 antibody. In some embodiments, the method further comprises identifying the patient as having a LAG-3 positive PD-L1 positive tumor. In some embodiments, the LAG-3 inhibitor is an anti-LAG-3 antibody and the PD-1 pathway inhibitor is an anti-PD-1 antibody. The methods of the invention can improve response rates to treatment with a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, or a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor.

Abstract: A method for operating a twin-row metering system including a first seed meter and a second seed meter. Each of the first seed meter and the second seed meter includes a motor with a driveshaft and a seed disc operably coupled with the motor via the driveshaft. The method includes a step of measuring a position of the driveshaft of the first motor. An additional step includes measuring a position of the driveshaft of the second motor. An additional step includes determining an angular offset between the position of the driveshaft of the first motor and a position of the driveshaft of the second motor. And a further step includes adjusting a rotational speed of the driveshaft of the second motor based on the determined angular offset.

Abstract: A method for calibrating a seed meter. The method comprises a step of providing the seed meter and a calibration disc. The seed meter comprises a motor with a driveshaft, and the driveshaft is configured to be positioned by the motor in an uncorrected home position. An additional step includes engaging the calibration disc with the seed meter, with the calibration disc including a plurality of indicia on a surface of the calibration disc. A further step includes identifying a corrected home position for the driveshaft, with such identifying step including determining, via the calibration disc's indicia, an angular offset between the uncorrected home position and the corrected home position of the driveshaft.

Abstract: According to an aspect, an inflatable penile prosthesis includes a fluid reservoir configured to hold fluid, an inflatable member, and a pump assembly configured to transfer the fluid between the fluid reservoir and the inflatable member. The pump assembly includes a pump bulb, a valve body, a valve disposed within the valve body, a first fluid port configured to be fluidly coupled to the fluid reservoir, and a second fluid port configured to be fluidly coupled to the inflatable member. The valve is configured to move between an inflation position and a deflation position. The valve includes a first member and second member, the first member being configured to move with respect to the second member.

Abstract: A system may provide an eco-feedback and gaming platform for home energy management. The system may generate daily energy scores for a plurality of households. The system may prepare a community energy conservation game in which community conservation goals and participation thresholds are generated. The system may execute the game by receiving time series date from each of the households and rewards the households for participating in achieving the community goal.

Abstract: A ball dropping tool includes an outer and inner body, side bore, ball and an actuator. The outer body has an axial bore extending between a first and second end of the outer body and forming a flow path. The inner body forms a bypass passage extending between a first and second end of the inner body. The side bore is defined by the inner body and is disposed at an angle relative to the axial bore of the outer body. The bypass passage is disposed in a portion of the flow path and is in communication with the side bore. The ball is disposed within the side bore. The actuator, disposed within the outer body, is movable between a retaining position wherein the ball is retained within the side bore and a release position wherein the ball is released from the side bore and into the bypass passage.

Abstract: Provided is a process including: obtaining criteria to select plain-text values in a lower-trust database; selecting, based on the criteria, a first plain-text value; in response, determining a first reference value; storing the first plain-text value in a higher-trust database in a second entry identified by the first reference value; storing the first reference value in the first entry of the lower-trust database; selecting another instance of the first plain-text value stored requested to be stored in a third entry in the lower-trust database; and in response, storing the first reference value in the third entry.

Abstract: An interfacing structure for a mask system includes a cushion component adapted to contact the patient's face in use and a cushion-to-frame component provided to the cushion component. The cushion-to-frame component is structured to secure the cushion component to a mask frame of the mask system. The cushion-to-frame component includes a cushion side adapted to interface with the cushion component and a frame side adapted to interface with the mask frame. The cushion side includes a platform to engage and support the cushion component. The platform provides an engagement surface to engage the cushion component and inner and outer flanges provided to opposing ends of the platform to guide, support and/or retain the cushion component on the platform.

Abstract: A folding trailing arm landing gear assembly having a main fitting configured to couple to a hinge positioned at a proximal end; a swing arm rotatably coupled at a proximal end to a distal end of the main fitting; a shock coupled at a distal end to a distal end of the swing arm; a bellcrank coupled at a distal end to a proximal end of the shock, and coupled at a proximal end to the main fitting; and a wheel coupled to the swing arm.

Abstract: A control device includes a button assembly having one or more buttons and a button carrier that includes a plurality of resilient, independently deflectable spring arms. The control device may be configured as a wall-mounted keypad to control a load control device, or as a thermostat to control a temperature regulation appliance. The button carrier may be configured to prevent interference between the buttons during operation of the control device. The button assembly may be captured between a faceplate of the control device and a housing that is attached to a rear side of the faceplate. The control device may include one or more button retainers that are attached to the buttons and that are configured to align respective outer surfaces of the buttons relative to each other, and relative to the faceplate of the control device, when the buttons are in respective rest positions.

Abstract: The disclosed computer-implemented methods and systems provide solutions for mitigating misdetection of display devices in connection with a subscription service. In some examples, the described methods and systems receive a content request from a display device, where the content request is correlated with a particular subscription service account. In some examples, the systems and methods further determine that the display device is not associated with the particular subscription service account. To verify the display device, the systems and methods utilize display timings and scan timings associated with a verification token to prove that the display device is validly located and can therefore be trusted in connection with the subscription service account. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The invention provides anti-KLK7 antibodies, anti-KLK5 antibodies, anti-KLK5/KLK7 multispecific antibodies, and methods of using the same.

Abstract: A heavy equipment recovery winch system includes a winch assembly mountable to a drive end of a heavy equipment vehicle, a hydraulic assembly and a fairlead assembly. The hydraulic assembly is mounted to a portion of the heavy equipment vehicle and the hydraulic assembly is operatively connected to the winch assembly. The fairlead assembly is mountable to the drive end of the heavy equipment vehicle to assist with guiding a cable from the winch assembly.

Abstract: Machine-learning-based determination of event stability is provided to facilitate loose coupling of event coordination systems. The method includes training a machine learning model to determine stability of events of an event coordination system based on a plurality of attributes of the events, and using the machine learning model to determine an event stability for an event of the event coordination system. Further, the method includes comparing the determined event stability for the event to a stability threshold, and determining that the event is a stable event based on the event stability extending the stability threshold. Based on determining that the event is the stable event, the stable event is propagated from the event coordination system to another event coordination system.