Abstract: The invention relates to novel trifluoromethyl-oxadiazole derivatives of formula (I), and pharmaceutically acceptable salts thereof, (I) in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, pharmaceutical combinations thereof, and their use as medicaments, particularly for the treatment of neurodegeneration, muscle atrophy or metabolic syndrome via inhibition of HDAC4.

Abstract: A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyzer. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyzer.

Abstract: An electrosurgical system includes an electrosurgical generator, a power source configured to deliver power to at least one load connected to the generator, a master configured to generate an initial pulse, and a plurality of slaves connected in series to the master. The initial pulse cooperates with a first floating power supply configured to create an electrical connection between at least one first load and the power source. A first slave is configured to generate a subsequent pulse based on the initial pulse. The subsequent pulse cooperates with a second floating power supply configured to create an electrical connection between at least one second load and the power source. The subsequent pulse is configured to cause an ensuing slave to generate an additional pulse. The additional pulse cooperates with a corresponding floating power supply configured to create an electrical connection between at least one additional load and the power source.

Abstract: The present disclosure is directed to an electrosurgical generator including a tank configured to output energy and an H-bridge configured to drive the tank. The generator also includes a choke. The choke impedes a common mode current generated by the H-bridge and provides a leakage inductance for the tank.

Abstract: The electrosurgical systems and methods of the present disclosure monitor power dosage delivered to tissue being treated with improved speed and accuracy. The electrosurgical systems include an output stage, sensors, analog all-pass filters, an analog multiplier, an average power calculation circuit, and a controller. The output stage generates electrosurgical energy to treat tissue. The plurality of sensors sense voltage and current waveforms of the generated electrosurgical energy. The plurality of analog all-pass filters filter the sensed voltage and current waveforms. The plurality of analog all-pass filter may have lagging or leading phase. The analog multiplier multiplies the filtered voltage and current waveforms to obtain a real power waveform. The average power calculation circuit calculates a real average power based on the real power waveform. The controller then generates a control signal to control the output stage based on the real average power.

Abstract: The present disclosure is directed to an electrosurgical generator including a resonant inverter having an H-bridge and a tank. The generator also includes a pulse width modulation (PWM) controller configured to output PWM timing signals to the H-bridge. A switch is configured to select a modality from among a plurality of modalities and the PWM controller adjusts a frequency of the PWM timing signals based on the selected modality.

Abstract: The present disclosure is directed to an electrosurgical generator including a resonant inverter having an H-bridge and a tank. The tank includes a transformer including a first core half, a second core half, a primary winding, and a secondary winding having a number of turns, wherein each turn is separated by a gap. The transformer is configured to provide a parallel capacitance based on the gap.

Abstract: A method of improving efficiency of an electrosurgical generator is presented, the method including controlling an output of an electrosurgical generator by converting a direct current (DC) to an alternating current (AC) using an inverter, and sensing a current and a voltage at an output of the inverter. The method further includes the steps of determining a power level based on the sensed voltage and the sensed current, determining an efficiency of the electrosurgical generator, and inserting a predetermined integer number of off cycles when the efficiency of the electrosurgical generator reaches a threshold power efficiency.

Abstract: An electrosurgical generator is presented including a radio frequency (RF) amplifier coupled to an electrical energy source and configured to generate electrosurgical energy, the RF amplifier including an inverter configured to convert a direct current (DC) to an alternating current (AC), and a plurality of sensors configured to sense voltage and current of the generated electrosurgical energy. The electrosurgical generator further includes a controller coupled to the RF amplifier and the plurality of sensors. The electrosurgical may be further configured to determine a power level based on the sensed voltage and the sensed current, determine an efficiency of the electrosurgical generator, and insert a predetermined integer number of off cycles when the efficiency of the electrosurgical generator reaches a threshold power efficiency.

Abstract: A positioning system comprising a mounting assembly arranged to move a positioning device via a magnetic coupling interaction between the mounting assembly and the positioning device. The positioning device is configured to limit the spread of flux away from the device.

Abstract: The disclosed electrosurgical systems and methods accurately determine the power actually applied to a load by using equalizers to calibrate the power measurements. The electrosurgical systems include an electro surgical generator and an electrosurgical instrument coupled to the electrosurgical generator through an electrosurgical cable. The electrosurgical generator includes an electrical energy source, voltage and current detectors, equalizers that estimate the voltage and current applied to a load, and a power calculation unit that calculates estimated power based upon the estimated voltage and current.

Abstract: An ion detector for a Time of Flight mass spectrometer is disclosed comprising a single Microchannel Plate which is arranged to receive ions and output electrons. The electrons are directed onto an array of photodiodes which directly detects the electrons. The output from each photodiode is connected to a separate Time to Digital Converter provided on an ASIC.

Abstract: An electrosurgical system includes an electrosurgical generator, a power source configured to deliver power to at least one load connected to the generator, a master configured to generate an initial pulse, the initial pulse cooperating with a first floating power supply configured to create an electrical connection between at least one first load and the power source, and a plurality of slaves connected in series to the master, wherein a first slave is configured to generate a subsequent pulse based on the initial pulse, the subsequent pulse cooperating with a second floating power supply configured to create an electrical connection between at least one second load and the power source, the subsequent pulse configured to cause an ensuing slave to generate an additional pulse, the additional pulse cooperating with a corresponding floating power supply configured to create an electrical connection between at least one additional load and the power source.

Abstract: An electrosurgical generator is provided. The electrosurgical generator includes at least one converter configured to output a DC waveform and a nonlinear carrier control current. At least one boost inverter is coupled to the at least one converter and is configured to convert the DC waveform to generate at least one electrosurgical waveform. At least one inductor is connected in series with the at least one converter and at least one boost inverter and is configured to output an inductor current. A controller is coupled to the at least one converter and the at least one boost inverter and is configured to maintain the inductor current at a predetermined value by controlling a pulse duration of a duty cycle of the at least one converter based on a comparison of inductor current and the nonlinear control current.

Abstract: An electrosurgical generator is provided. The electrosurgical generator includes: a non-resonant radio frequency output stage configured to output a substantially square electrosurgical waveform; and a controller coupled to the non-resonant radio frequency output stage, the controller configured to adjust a crest factor of the substantially square electrosurgical waveform on a cycle-by-cycle basis.

Abstract: An electrosurgical system and method are disclosed. The system includes an electrosurgical generator adapted to supply electrosurgical energy to tissue. The generator is further adapted to supply an electrosurgical signal at a variable power level. The generator includes sensor circuitry adapted to sense tissue impedance and/or an electrosurgical signal zero crossing. The generator also includes a controller, which may include a microprocessor, that is adapted to receive a tissue impedance signal and/or a waveform zero crossing signal. The controller is configured to monitor tissue impedance, and in response to a threshold value of impedance being reached, to cause a power level of the electrosurgical energy to transition from a first power level to a second power level. The slew rate of the power transition may be in accordance with a transition function, such as a cosine function.

Abstract: The present disclosure is directed to an electrosurgical generator including a resonant inverter having an H-bridge and a tank. A sensor array measures at least one property of the tank. A pulse width modulation (PWM) controller outputs a first PWM timing signal and a second PWM timing signal to the H-bridge. The PWM controller controls a dead-time between the first PWM timing signal and the second PWM timing signal based on the at least one property measured by the sensor array.

Abstract: A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyzer. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyzer.